Title:
USE OF IL-4 RECEPTOR FOR TREATMENT, PREVENTION AND DIAGNOSIS OF ALLERGIC, VIRAL, PARASITIC AND BACTERIAL DISEASES AND MILDEW INFECTIOUS DISEASE
Document Type and Number:
Japanese Patent JP3703103
Kind Code:
B2
Abstract:
PURPOSE: To execute diagnostic and therapeutic and/or preventive procedure for disease which gives rise to a production increase of 2TH type T-helper cells by using an IL-4 receptor (IL-4R) or its deriv.
CONSTITUTION: The mature human IL-4R having three domain structures; an extracellular domain (207 amino acids), membrane passage region (about 24 amino acids) and intracytoplasmic domain (569 amino acids) and the human IL-4R comprising total 825 pieces of amino acids having 25 amino acids functioning as signal peptide at the N terminal or the its deriv.; for example, the functional uniform part of IL-4R, mutant or variant, more particularly the extracellular part of IL-4R, the amino acids 1 to 209 of the mature protein of the human IL-4R as well as its glycosylated variant are used. This receptor is effective for allergic diseases and viral, bacterial, parasitic or mildew infectious diseases and the combination use thereof with γ-interferon, allergen or its part and a material to shut off the interaction between cell surface protein CD40 and its ligand is recommended.
Inventors:
Karl Heinz Ensle
Laurent Courret
Leander Rauffer
Friedrich-Robert Sailer
Laurent Courret
Leander Rauffer
Friedrich-Robert Sailer
Application Number:
JP21385993A
Publication Date:
October 05, 2005
Filing Date:
August 30, 1993
Export Citation:
Assignee:
HOECHST AKTIENGESELLSCHAFT
International Classes:
A61K38/17; A61K39/35; A61P31/04; A61K38/00; A61P31/10; A61P31/12; A61P33/00; A61P37/08; B01D53/50; G01N33/566; G01N33/569; G01N33/68; (IPC1-7): A61K38/00; A61P31/10; A61P33/00
Domestic Patent References:
| JP2215385A |
Other References:
FANSLOW, W.C. et al,Soluble forms of CD40 inhibit biologic responses of human B cells,Journal of immunology,1992年,Vol.149, No.2,pp655-660
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura