Title:
空胞型(H+)-ATPアーゼ抑制化合物、組成物、およびそれらの使用
Document Type and Number:
Japanese Patent JP4807903
Kind Code:
B2
Abstract:
The present invention provides vacuolar-type (H+)-ATPase-inhibiting compounds, compositions thereof, and methods of using them to treat or prevent a condition treatable by the inhibition of a vacuolar-type (H+)-ATPase. The composition of the present invention comprises a compound of the present invention and a carrier. The method of the present invention includes administering a vacuolar-type (H+)-ATPase inhibiting-effective amount of a compound of the present invention. The compound of the present invention has the formula: wherein R1 and R2 are H, saturated or unsaturated alkyl, aryl, R6CH2-, R6CO-, or R6SO2-, wherein R6 is H, saturated or unsaturated alkyl, or aryl; R3 is H, alkyl, aryl, an oxime, or an oxime methyl ether; the aromatic ring is unsubstituted or substituted; and Z is a contiguous linker comprising a chain of 0 - 10 atoms which, together with the five atoms beginning with the carbon of the aromatic ring in meta-relationship with OR1 and ending with the carbon directly attached to the alkyl oxygen of the lactone, integrally form a 5 - 17 membered ring; or a pharmaceutically acceptable salt, an ester, or a prodrug thereof.
Inventors:
Boyd, Michael Earl.
Application Number:
JP2000602057A
Publication Date:
November 02, 2011
Filing Date:
March 03, 2000
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
A61K31/365; A61K31/00; A61K31/335; A61K31/336; A61K31/357; A61K31/7048; A61K45/06; A61P13/02; A61P15/18; A61P19/00; A61P19/10; A61P25/28; A61P27/06; A61P43/00; C07D313/00; C07D321/00; C07D493/04; C07D493/06
Foreign References:
| WO1999005136A1 | 1999-02-04 |
Attorney, Agent or Firm:
Takashima Ichi