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Title:
VIRUS FILTRATION
Document Type and Number:
Japanese Patent JP2022058979
Kind Code:
A
Abstract:
To provide methods of performing viral filtration on a fluid including a recombinant antibody, and the use of these methods in methods of manufacturing or producing the recombinant antibody.SOLUTION: A method of performing viral filtration comprises: (a) adjusting (e.g., increasing or decreasing) the pH of a fluid comprising a recombinant antibody to between about 5.0 and about 6.7 (e.g., between about 5.0 and about 6.5, between about 5.0 and about 6.0, or between about 5.5 and about 6.0.); and (b) flowing the fluid through a virus filter to produce a filtrate including the recombinant antibody.SELECTED DRAWING: None

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Inventors:
BIANCA OLSON
SARAVANAMOORTHY RAJENDRAN
RYAN TEDSTONE
Application Number:
JP2022020411A
Publication Date:
April 12, 2022
Filing Date:
February 14, 2022
Export Citation:
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Assignee:
ALEXION PHARMA INC
International Classes:
C07K1/34; B01D61/14; B01D61/16; B01D69/08; B01D71/10; B01D71/34; B01D71/68
Domestic Patent References:
JP2013501075A2013-01-10
JP2014517047A2014-07-17
JP2012244993A2012-12-13
JP2010510963A2010-04-08
Foreign References:
WO2012176876A12012-12-27
WO2010109920A12010-09-30
WO2010001659A12010-01-07
US9079949B12015-07-14
Other References:
BIOTECHNOLOGY PROGRESS, vol. 26(4), JPN6020002399, 2010, pages 1080 - 1087, ISSN: 0004999364
Attorney, Agent or Firm:
Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe



 
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