Title:
Zaltoprofen and a manufacturing method of the derivative
Document Type and Number:
Japanese Patent JP5937679
Kind Code:
B2
Abstract:
The present invention relates to a method for preparing zaltoprofen or a zaltoprofen derivative by a Friedel-Crafts reaction type intramolecular cyclization reaction in an industrial scale at an industrially acceptable yield and a purity sufficient for use as an active ingredient of medicaments in a simple and economical manner, without generating a detectable amount of impurities such as dimmers, by using polyphosphoric acid in an amount of 6.5 times or less of amount of a starting material compound before cyclization. More specifically, the present invention relates to such a method for preparing zaltoprofen or a zaltoprofen derivative as mentioned above, which comprises cyclizing a starting material compound before cyclization by an intramolecular cyclization reaction thereof in the presence of one or more kinds of organic solvents selected from the group consisting of 1,1,2-trichloroethene, methylcyclohexane, cyclohexane, n-heptane and the like.
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Inventors:
Tendo On
Application Number:
JP2014512628A
Publication Date:
June 22, 2016
Filing Date:
April 24, 2013
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO.,LTD.
International Classes:
C07D337/14
Domestic Patent References:
| JP2005289949A | ||||
| JP2005247778A | ||||
| JP61251682A | ||||
| JP57171991A |
Attorney, Agent or Firm:
Satoshi Hashimoto
Chikusa Shinichi
Chikusa Shinichi