Title:
A benzamide derivative for checking the activity of ABL1, ABL2, and BCR-ABL1
Document Type and Number:
Japanese Patent JP6078640
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
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Inventors:
Furet, Pascal
Grozfeld, Robert Martin
Janke, wolf gang
Jones, Daryl Brynley
Manly paul
Martzing, Andreas
Pelle, Xavier Francois André
Salem, Baha
Shop fur, joseph
Spieser, Erich Alois
Grozfeld, Robert Martin
Janke, wolf gang
Jones, Daryl Brynley
Manly paul
Martzing, Andreas
Pelle, Xavier Francois André
Salem, Baha
Shop fur, joseph
Spieser, Erich Alois
Application Number:
JP2015512170A
Publication Date:
February 08, 2017
Filing Date:
May 09, 2013
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D401/04; A61K9/20; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4725; A61K31/498; A61K31/506; A61K31/5377; A61K31/551; A61K31/553; A61K45/00; A61K47/02; A61K47/10; A61K47/12; A61K47/14; A61K47/20; A61K47/32; A61K47/36; A61K47/38; A61K47/42; A61K47/44; A61P31/12; A61P35/00; A61P35/04; C07D213/22; C07D401/10; C07D401/14; C07D403/10; C07D405/14; C07D413/10; C07D413/14; C07D471/04; C07D487/04; C07D487/10; C07D491/107; C07D498/04
Domestic Patent References:
| JP2015520157A | ||||
| JP2005533827A | ||||
| JP2015521185A | ||||
| JP2015520158A |
Foreign References:
| WO2003055477A1 | ||||
| WO2008059023A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Saori Oga
Yasuhito Suzuki
Norio Omori
Saori Oga
Yasuhito Suzuki