Title:
ｃ－ＫＩＴ陽性腫瘍特異的抗体断片
Document Type and Number:
Japanese Patent JP7460063
Kind Code:
B2
Abstract:
The purpose of the present invention is to provide a detecting agent (diagnostic agent) and a treatment agent that are taken into tumors in vivo promptly and that bind to c-KIT target molecules. In the quest for a molecular species that specifically binds to c-KIT, and a labelling agent and a treatment agent that bind to said molecular species, the inventors found that by combining an anti-c-KIT antibody fragment and IR700, rapid accumulation into tumors takes place in just several hours after administration, and detection and treatment becomes possible. Accordingly, the present invention pertains to an antigen-binding fragment of anti-c-KIT antibody, IR700, and a composite body, and also pertains to a detecting agent and a treatment agent that contain said composite body as an active ingredient. Specifically, the present invention pertains to: a complementary determining region (CDR) in the antibody heavy chain which has the amino acid sequence described in SEQ ID NO: 2; and a composite body having IR700 and an antigen-binding fragment of an antibody having a CDR in the antibody light chain which has the amino acid sequence described in SEQ ID NO: 4.
Inventors:
Tsutomu Kiyoto
Tatsuya Segawa
Akira Shimizu
Tetsuji Takayama
Naoki Mutsumura
Shota Fujimoto
Takanori Kashihara
Tatsuya Segawa
Akira Shimizu
Tetsuji Takayama
Naoki Mutsumura
Shota Fujimoto
Takanori Kashihara
Application Number:
JP2023543774A
Publication Date:
April 02, 2024
Filing Date:
August 02, 2022
Export Citation:
Assignee:
Immunobiological Research Institute Co., Ltd.
Tokushima University
Tokushima University
International Classes:
A61K47/68; A61K31/409; A61K39/395; A61K41/00; A61K49/00; A61P35/00; C07K16/28
Foreign References:
| WO2020179749A1 |
Other References:
FUJIMOTO S. et al.,A Novel Theranostic Combination of Near-infrared Fluorescence Imaging and Laser Irradiation Targetin,Theranostics,2018年,Vol. 8, Issue 9,2313-2328
MAO C. et al.,P-glycoprotein Targeted Photodynamic Therapy of Chemoresistant Tumors using Recombinant Fab Fragment,Biomaterials Science,2018年,Vol.6, No.11,3063-3074
WEI D. et al.,Selective Photokilling of Colorectal Tumors by Near-Infrared Photoimmunotherapy with a GPA33-Targete,molecular pharmaceutics,2020年,17,2508-2517
MAO C. et al.,P-glycoprotein Targeted Photodynamic Therapy of Chemoresistant Tumors using Recombinant Fab Fragment,Biomaterials Science,2018年,Vol.6, No.11,3063-3074
WEI D. et al.,Selective Photokilling of Colorectal Tumors by Near-Infrared Photoimmunotherapy with a GPA33-Targete,molecular pharmaceutics,2020年,17,2508-2517
Attorney, Agent or Firm:
Patent Attorney Corporation Shuwa Patent Office