スチラキスリグノリドＡまたはそのアグリコンを有効成分として含む喘息の予防または治療用組成物

Japanese Patent JP5806324

B2

The present invention relates to a pharmaceutical composition for preventing or treating asthma, the composition containing styraxlignolide A or an aglycone thereof as an active ingredient. More particularly, styraxlignolide A compound is one separated from stems and barks of Styrax japonica, and styraxlignolide A or homoegonol, which is an aglycone of styraxlignolide A and which has improved safety, has the effect of attenuating weight loss and airway hyperresponsiveness, inhibiting the generation of reactive oxygen species in airway, inhibiting generation of IgE, TGF-²1, and IL-17 in the serum and bronchoalveolar lavage fluid, inhibiting endobronchial inflammatory cell infiltration, and inhibiting the formation of a mucous plug and subepithelial fibrosis in an asthma-induced mouse model. Therefore, styraxlignolide or homoegonol can be effectively used as the active ingredient of a pharmaceutical composition for preventing or treating bronchial asthma in which airway remodeling has progressed.

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Ahn Kyung Sop
Jang Ha Young
Ausseil
Lee Hyun Kyu
Kwon Ok-Kyeon
Kim cicada
Kim Jun Hee
Kim Do-Young

JP2013539765A

November 10, 2015

November 17, 2011

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KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

A61K31/343; A61K31/7048; A61K36/18; A61P11/06

Planta medica,2004年,No.70,p.1210-1215
呼吸,2006年,25巻,6号,p.590-602

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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