Title:
線維症、炎症性および新血管形成症状の処置および予防のための組成物および方法
Document Type and Number:
Japanese Patent JP2009513668
Kind Code:
A
Abstract:
Monotherapies and combination therapies for treating hyperproliferative disorders are described, as are compositions for performing such methods.
Inventors:
Roger A. Sabadini
William A. Garland
Glen El Stoller
William A. Garland
Glen El Stoller
Application Number:
JP2008538001A
Publication Date:
April 02, 2009
Filing Date:
October 27, 2006
Export Citation:
Assignee:
Lpath, Inc.
International Classes:
A61K45/00; A61K9/08; A61K9/107; A61K9/12; A61K9/14; A61K39/395; A61K47/02; A61K47/04; A61P27/02; A61P29/00; A61P31/22; A61P33/00; A61P43/00
Domestic Patent References:
JP2002243737A | 2002-08-28 | |||
JP2008518946A | 2008-06-05 | |||
JP2002243737A | 2002-08-28 |
Foreign References:
WO2002017899A2 | 2002-03-07 | |||
US6858383B2 | 2005-02-22 | |||
US20060171946A1 | 2006-08-03 | |||
US6098631A | 2000-08-08 | |||
US20030027304A1 | 2003-02-06 | |||
US20030026799A1 | 2003-02-06 | |||
US20060171946A1 | 2006-08-03 | |||
WO2002017899A2 | 2002-03-07 | |||
US6858383B2 | 2005-02-22 |
Other References:
JPN6012045928; THORESON, W.B., et al.: 'Lysophosphatidic Acid Receptor Signaling in Mammalian Retinal Pigment Epithelial Cells' Investigative Opthalamology & Visual Science Vol.43, No.7, 200207, p.2450-2461
JPN6012045930; LEBRUN-JULIEN, F., et al.: 'Lysophosphatidic Acid Receptor Type-1 (LPA1) Expression in Normal and Glaucomatous Adult Rat Retina' Investigative Ophthalmology & Visual Science Vol.46, 2005, E-Abstract 1319
JPN6012045932; ANLINKER, B., et al.: 'Lysophospholipid G Protein-coupled Receptors' THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol.279, No.20, 20010514, p.20555-20558
JPN6012045935; PYNE, S., et al.: 'Sphingosine 1-phosphate signalling in mammalian cells' Biochem. J. Vol.349, 2000, p.385-402
JPN5008017660; SVETLOV, S.I., et al.: 'EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury' BIOCHIMICA ET BIOPHYSICA ACTA Vol.1582, 2002, p.251-256
JPN5010004174; VISENTIN: CANCER CELL V9, 200603, P225-238
JPN6012061191; Biochim. Biophys. Acta, 2002, Vol.1582, pp.168-174
JPN6012061190; Cancer Cell, 2006, Vol.9, pp.225-238
JPN6014017509; メルクマニュアル第17版日本語版、1999年、日経BP社発行、435頁、716頁
JPN6012045928; THORESON, W.B., et al.: 'Lysophosphatidic Acid Receptor Signaling in Mammalian Retinal Pigment Epithelial Cells' Investigative Opthalamology & Visual Science Vol.43, No.7, 200207, p.2450-2461
JPN6012045930; LEBRUN-JULIEN, F., et al.: 'Lysophosphatidic Acid Receptor Type-1 (LPA1) Expression in Normal and Glaucomatous Adult Rat Retina' Investigative Ophthalmology & Visual Science Vol.46, 2005, E-Abstract 1319
JPN6012045932; ANLINKER, B., et al.: 'Lysophospholipid G Protein-coupled Receptors' THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol.279, No.20, 20010514, p.20555-20558
JPN6012045935; PYNE, S., et al.: 'Sphingosine 1-phosphate signalling in mammalian cells' Biochem. J. Vol.349, 2000, p.385-402
JPN5008017660; SVETLOV, S.I., et al.: 'EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury' BIOCHIMICA ET BIOPHYSICA ACTA Vol.1582, 2002, p.251-256
JPN5010004174; VISENTIN: CANCER CELL V9, 200603, P225-238
JPN6012045930; LEBRUN-JULIEN, F., et al.: 'Lysophosphatidic Acid Receptor Type-1 (LPA1) Expression in Normal and Glaucomatous Adult Rat Retina' Investigative Ophthalmology & Visual Science Vol.46, 2005, E-Abstract 1319
JPN6012045932; ANLINKER, B., et al.: 'Lysophospholipid G Protein-coupled Receptors' THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol.279, No.20, 20010514, p.20555-20558
JPN6012045935; PYNE, S., et al.: 'Sphingosine 1-phosphate signalling in mammalian cells' Biochem. J. Vol.349, 2000, p.385-402
JPN5008017660; SVETLOV, S.I., et al.: 'EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury' BIOCHIMICA ET BIOPHYSICA ACTA Vol.1582, 2002, p.251-256
JPN5010004174; VISENTIN: CANCER CELL V9, 200603, P225-238
JPN6012061191; Biochim. Biophys. Acta, 2002, Vol.1582, pp.168-174
JPN6012061190; Cancer Cell, 2006, Vol.9, pp.225-238
JPN6014017509; メルクマニュアル第17版日本語版、1999年、日経BP社発行、435頁、716頁
JPN6012045928; THORESON, W.B., et al.: 'Lysophosphatidic Acid Receptor Signaling in Mammalian Retinal Pigment Epithelial Cells' Investigative Opthalamology & Visual Science Vol.43, No.7, 200207, p.2450-2461
JPN6012045930; LEBRUN-JULIEN, F., et al.: 'Lysophosphatidic Acid Receptor Type-1 (LPA1) Expression in Normal and Glaucomatous Adult Rat Retina' Investigative Ophthalmology & Visual Science Vol.46, 2005, E-Abstract 1319
JPN6012045932; ANLINKER, B., et al.: 'Lysophospholipid G Protein-coupled Receptors' THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol.279, No.20, 20010514, p.20555-20558
JPN6012045935; PYNE, S., et al.: 'Sphingosine 1-phosphate signalling in mammalian cells' Biochem. J. Vol.349, 2000, p.385-402
JPN5008017660; SVETLOV, S.I., et al.: 'EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury' BIOCHIMICA ET BIOPHYSICA ACTA Vol.1582, 2002, p.251-256
JPN5010004174; VISENTIN: CANCER CELL V9, 200603, P225-238
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto