Title:
COVALENT DIABODY AND USAGE THEREOF
Document Type and Number:
Japanese Patent JP2016166209
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers.SOLUTION: The diabody molecule of the invention comprises two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecule of the present invention further comprises an Fc region, which allows antibody-like functionality to be engineered into the molecule.SELECTED DRAWING: None
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Inventors:
JOHNSON LESLIE S
HUANG LING
HUANG LING
Application Number:
JP2016058944A
Publication Date:
September 15, 2016
Filing Date:
March 23, 2016
Export Citation:
Assignee:
MACROGENICS INC
International Classes:
C07K16/46; A61K39/395; A61P31/00; A61P35/00; C07K17/02; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Foreign References:
| US20040220388A1 | 2004-11-04 | |||
| WO2004016750A2 | 2004-02-26 |
Other References:
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ASANO R. ET AL.: "A diabody for cancer immunotherapy and its functional nhancement by fusion of human Fc region", 生化学, vol. 76, no. 8, JPN6011053014, 25 August 2004 (2004-08-25), pages 9 - 2
PROTEIN ENG. DES. SEL., vol. 17, no. 1, JPN6011053017, January 2004 (2004-01-01), pages 21 - 27
生化学, vol. 76, no. 8, JPN6011053014, 25 August 2004 (2004-08-25), pages 9 - 2
ACTA. PHARMACOL. SIN., vol. 26, no. 1, JPN6013044649, January 2005 (2005-01-01), pages 1 - 9
CANCER LETT., vol. 177, no. 1, JPN6013044650, 8 March 2002 (2002-03-08), pages 29 - 39
LEUKEMIA, vol. 18, no. 3, JPN6013044651, March 2004 (2004-03-01), pages 513 - 520
FEBS LETT., vol. Vol.454, No.1-2, JPN6015026406, 2 July 1999 (1999-07-02), pages 90 - 94
ASANO R. ET AL.: "A diabody for cancer immunotherapy and its functional nhancement by fusion of human Fc region", 生化学, vol. 76, no. 8, JPN6011053014, 25 August 2004 (2004-08-25), pages 9 - 2
Attorney, Agent or Firm:
Shiro Isoda