Title:
iRNA AGENT TARGETING VEGF
Document Type and Number:
Japanese Patent JP2011188866
Kind Code:
A
Abstract:
To provide compounds, compositions, and methods useful for modulating the expression of VEGF.
There are provided the compounds, compositions, and methods useful for modulating the expression of vascular endothelial growth factor (VEGF), such as by the mechanism of RNA interference (RNAi). The compositions include iRNA agents that can be unmodified or chemically-modified. The present invention also relates to the use of siRNA targeting VEGF sequences to treat conditions or disorders related to unwanted expression of VEGF, e.g., age-related macular degeneration or diabetic retinopathy.
Inventors:
DE FOUGEROLLES ANTONIN
FRANK-KAMENETSKI MARIA
MANOHARAN MUTHIAH
RAJEEV KALLANTHOTTAHIL G
HADWIGER PHILLIPP
FRANK-KAMENETSKI MARIA
MANOHARAN MUTHIAH
RAJEEV KALLANTHOTTAHIL G
HADWIGER PHILLIPP
Application Number:
JP2011121050A
Publication Date:
September 29, 2011
Filing Date:
May 30, 2011
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS INC
International Classes:
C12N15/113; A61K31/7088; A61K31/7105; A61K31/712; A61K31/7125; A61K35/74; A61K35/76; A61K47/48; A61K48/00; A61P9/10; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P37/06; A61K9/00; A61K47/02; A61K47/10; A61K47/12
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita