Title:
A manufacturing method of compound Granules containing hydroxypropylcellulose
Document Type and Number:
Japanese Patent JP6022410
Kind Code:
B2
Abstract:
Provided is a base material for dry direct tableting, the material being excellent in a binding property and disintegrability. More specifically, provided is a method of preparing a composite granule comprising at least a step of granulating a second sugar or sugar alcohol while adding thereto an aqueous dispersion comprising at least low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of 5 to 16% by weight, polyvinyl alcohol, a first sugar or sugar alcohol, and water.
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Inventors:
Naosuke Maruyama
Yasuyuki Hirama
Yasuyuki Hirama
Application Number:
JP2013126689A
Publication Date:
November 09, 2016
Filing Date:
June 17, 2013
Export Citation:
Assignee:
Shin-Etsu Chemical Co., Ltd.
International Classes:
A61K47/38; A61K9/14; A61K9/22; A61K47/10; A61K47/26; A61K47/32
Domestic Patent References:
| JP2002138034A | ||||
| JP2007314529A | ||||
| JP2010189384A |
Foreign References:
| WO2009069280A1 | ||||
| WO2010113841A1 | ||||
| WO2009101940A1 | ||||
| WO2011019043A1 |
Other References:
口腔内崩壊錠(ODT)用の直打用賦形剤「SmartExTM」を開発,2013年10月 7日,URL,http://www.metolose.jp/pdf/news_20131007.pdf
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Ayako Nakamura
Satoshi Morimoto
Kyoko Tsunoda
Yu Tanaka
Tokumoto Koichi
Atsushi Watanabe
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Ayako Nakamura
Satoshi Morimoto
Kyoko Tsunoda
Yu Tanaka
Tokumoto Koichi
Atsushi Watanabe
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