Title:
１型プロピオン酸フルチカゾンの調製のための方法
Document Type and Number:
Japanese Patent JP2014520848
Kind Code:
A
Abstract:
The invention relates to a novel crystallisation process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronisation. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then adding this solution to water or to a mixture of water 10 and acetone, thereby causing fluticasone propionate to crystallise out of the solution as crystalline form.
Inventors:
Theiss Hearst, Martin David
マルツィアーノ, Ivan
クグロス, エレフテリオス
マルツィアーノ, Ivan
クグロス, エレフテリオス
Application Number:
JP2014520224A
Publication Date:
August 25, 2014
Filing Date:
July 06, 2012
Export Citation:
Assignee:
Pfizer Limited Pfizer Limited
International Classes:
C07J3/00; A61K31/56; A61P11/00; A61P11/02; A61P17/00; A61P17/06; A61P29/00
Foreign References:
| WO2001032125A2 | 2001-05-10 | |||
| WO2000038811A1 | 2000-07-06 | |||
| WO2003061816A1 | 2003-07-31 | |||
| WO2004001369A2 | 2003-12-31 | |||
| WO2003066653A2 | 2003-08-14 |
Other References:
STECKEL H. ET AL., INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 258, JPN6015032629, 2003, pages 65 - 75, ISSN: 0003137133
MURNANE D. ET AL., CRYSTAL GROWTH & DESIGN, vol. 8, no. 8, JPN6015032631, 2008, pages 2753 - 64, ISSN: 0003137134
医薬審発第５６８号, JPN7016001044, 1 May 2001 (2001-05-01), ISSN: 0003306184
平山令明, 有機化合物結晶作製ハンドブック−原理とノウハウ−, JPN6015026565, 25 July 2008 (2008-07-25), JP, pages 59 - 60, ISSN: 0003306185
MURNANE D. ET AL., CRYSTAL GROWTH & DESIGN, vol. 8, no. 8, JPN6015032631, 2008, pages 2753 - 64, ISSN: 0003137134
医薬審発第５６８号, JPN7016001044, 1 May 2001 (2001-05-01), ISSN: 0003306184
平山令明, 有機化合物結晶作製ハンドブック−原理とノウハウ−, JPN6015026565, 25 July 2008 (2008-07-25), JP, pages 59 - 60, ISSN: 0003306185
Attorney, Agent or Firm:
Ono Shinjiro
Kobayashi 泰
Shigeo Takeuchi
Yamamoto 修
Reiko Izumiya
Kobayashi 泰
Shigeo Takeuchi
Yamamoto 修
Reiko Izumiya