獲得免疫機構を有する生物に感染する病原微生物に対し抗菌活性を有する化合物を自然免疫機構のみを有する生物を利用してスクリーニングする方法、および該抗菌活性を自然免疫機構のみを有する生物を利用して評価する方法 - Genome Drug Discovery Research Institute Co., Ltd.

Title:

獲得免疫機構を有する生物に感染する病原微生物に対し抗菌活性を有する化合物を自然免疫機構のみを有する生物を利用してスクリーニングする方法、および該抗菌活性を自然免疫機構のみを有する生物を利用して評価する方法

Document Type and Number:

Japanese Patent JP4733080

Kind Code:

B2

Abstract:

To provide a model useful for developing an antimicrobial agent for a microbial infectious disease in a living thing having an acquired immunologic mechanism, which is a model for microbial infection utilizing a living thing having only a natural immunologic mechanism.

It is studied whether a silkworm larva having only the natural immunologic mechanism is useful as an antimicrobial agent evaluation system or not. It is found that the silkworm larva dies of infection by injection of Staphylococcus aureus or Pseudomonas aeruginosa into the silkworm larva. Surprisingly, the effect of the antimicrobial agent to the silkworm larva agrees with clinical effectiveness of medicines to a human which is a living thing having the acquired immunologic mechanism.

More Like This:

JPH03172183	BRAIN FACTOR EXPRESSION SYSTEM
JP2012105661	METAPNEUMOVIRUS STRAIN AND ITS USE IN VACCINE FORMULATION AND AS VECTOR FOR EXPRESSION OF ANTIGENIC SEQUENCE
WO2000015178	COMPUTER IMPLEMENTED PHARMACOKINETICS METHOD AND PROGRAM

Inventors:

Kazuhisa Sekimizu

Application Number:

JP2007185802A

Publication Date:

July 27, 2011

Filing Date:

July 17, 2007

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Genome Drug Discovery Research Institute Co., Ltd.

International Classes:

G01N33/50; A61K45/00; A61P31/04; C12Q1/02; G01N33/15

Domestic Patent References:

JP5306238A
JP6228120A
JP8103292A
JP11221096A

Other References:

LEE A. BULLA JR.,ANNU. REV. MICROBIOL.,1975年,V29,P163-190

Attorney, Agent or Firm:

Tokuaki Takahashi

Previous Patent: JPS4733079

Next Patent: JPS4733081