プラバスタチンの微生物学的製法

Japanese Patent JP3645491

B2

The present invention relates to a new microbial process for the preparation of compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6 beta -hydroxylate a compound of Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6 beta -hydroxylate a compound of general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.

Yeckel, Antonia
Konya, Attila
Balta, Istuban
Ircoy, eva
Georges, Somogy
Ambulus, Gabor
Holbats, Jura
Albrecht, Carolyu
Sabo, Istuban M.
Moses Nest, Julianna
Charato, Janos
Andor, Attila
Billinchik, Laslo
Boros, Sandor
Lang, Ildico
Biduroney Higloy, Margit

JP2000597248A

May 11, 2005

February 03, 2000

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Institute for Drug Research Limited

C07B53/00; C07C61/16; C07C67/02; C07C67/28; C07C67/52; C07C69/02; C07C69/30; C07C69/33; C12N1/14; C12P7/62; C12R1/645; C07C; C12P; (IPC1-7): C12P7/62; C12N1/14

JP2002526467A

WO1998045410A1

Takashi Ishida
Jun Tsuruta
Kazuhiro Nakamura
Masaya Nishiyama
Higuchi Souji

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