Title:
The new constituent for the disposal of cystic fibrosis
Document Type and Number:
Japanese Patent JP5997182
Kind Code:
B2
Abstract:
The present invention provides a composition comprising at least one prostacyclin or prostacyclin analog or a pharmaceutically acceptable salt thereof and at least one phosphodiesterase (PDE) 4 inhibitor and optionally a further PDE inhibitor for use in preventing or treating cystic fibrosis by selectively increasing the cAMP levels in bronchoepithelial cells.
Inventors:
Freissmut, Michael
Groeckel, Christina
Konig, Kusafer
Koierebe, Gimon
Groeckel, Christina
Konig, Kusafer
Koierebe, Gimon
Application Number:
JP2013552912A
Publication Date:
September 28, 2016
Filing Date:
February 03, 2012
Export Citation:
Assignee:
SciPharm S.a r.l.
International Classes:
A61K31/5585; A61K31/18; A61K31/192; A61K31/343; A61K31/352; A61K31/4015; A61K31/403; A61K31/416; A61K31/4166; A61K31/44; A61K31/4439; A61K31/4709; A61K31/472; A61K31/4985; A61K31/5025; A61K31/506; A61K31/519; A61K31/5578; A61K45/00; A61P3/00; A61P11/00
Domestic Patent References:
| JP2003525273A | ||||
| JP2009513660A | ||||
| JP2005504836A | ||||
| JP2002537383A | ||||
| JP2001519347A | ||||
| JP2001519344A | ||||
| JP2008507585A | ||||
| JP2010518122A | ||||
| JP2008534634A | ||||
| JP2007506752A | ||||
| JP2010513533A | ||||
| JP2013501032A | ||||
| JP2013515023A |
Foreign References:
| US20070249668 | ||||
| WO2009012223A1 | ||||
| US20060083714 | ||||
| US20010006979 | ||||
| WO2010106494A1 |
Other References:
The Journal of Pharmacology and Experimental Therapeutics, 2000, Vol.292(2), p.512-520
COBB BRYAN R,ADENOSINE RECEPTORS AND PHOSPHODIESTERASE INHIBITORS STIMULATE CL- SECRETION IN CALU-3 CELLS,AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY,2003年 9月,V29 N3 PT1,P410-418
TISSIERES PIERRE,AEROSOLIZED ILOPROST AS A BRIDGE TO LUNG TRANSPLANTATION IN A PATIENT 以下備考,THE ANNALS OF THORACIC SURGERY,ELSEVIER,2004年 9月 1日,V78 N3,P E48 - E50,WITH CYSTIC FIBROSIS AND PULMONARY HYPERTENSION
LUBAMBA BOB,PRECLINICAL EVIDENCE THAT SILDENAFIL AND VARDENAFIL ACTIVATE CHLORIDE TRANSPORT IN CYSTIC FIBROSIS,AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,2008年 3月 1日,V177 N5,P506-515
CLARKE LANE L,PHOSPHODIESTERASE 5 INHIBITORS AND CYSTIC FIBROSIS: CORRECTING CHLORIDE CHANNEL DYSFUNCTION,AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,2008年 3月 1日,V177 N5,P469-470
YU-CHUAN FANG,MANAGEMENT FOR M2M DEVICES,IEEE 802.16P-10/0039 [ONLINE],2011年 1月 7日,P1-9,URL,http://dot16.org/ul_archive/archive10/C80216p-10_0039.ppt
Pflugers Arch-Eur J Physiol, 1999, Vol.437, p.553-561
COBB BRYAN R,ADENOSINE RECEPTORS AND PHOSPHODIESTERASE INHIBITORS STIMULATE CL- SECRETION IN CALU-3 CELLS,AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY,2003年 9月,V29 N3 PT1,P410-418
TISSIERES PIERRE,AEROSOLIZED ILOPROST AS A BRIDGE TO LUNG TRANSPLANTATION IN A PATIENT 以下備考,THE ANNALS OF THORACIC SURGERY,ELSEVIER,2004年 9月 1日,V78 N3,P E48 - E50,WITH CYSTIC FIBROSIS AND PULMONARY HYPERTENSION
LUBAMBA BOB,PRECLINICAL EVIDENCE THAT SILDENAFIL AND VARDENAFIL ACTIVATE CHLORIDE TRANSPORT IN CYSTIC FIBROSIS,AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,2008年 3月 1日,V177 N5,P506-515
CLARKE LANE L,PHOSPHODIESTERASE 5 INHIBITORS AND CYSTIC FIBROSIS: CORRECTING CHLORIDE CHANNEL DYSFUNCTION,AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,2008年 3月 1日,V177 N5,P469-470
YU-CHUAN FANG,MANAGEMENT FOR M2M DEVICES,IEEE 802.16P-10/0039 [ONLINE],2011年 1月 7日,P1-9,URL,http://dot16.org/ul_archive/archive10/C80216p-10_0039.ppt
Pflugers Arch-Eur J Physiol, 1999, Vol.437, p.553-561
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Takeda Takeshi
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Takeda Takeshi
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