Title:
酸化窒素(NO)生成を抑制する新規抗炎症性および鎮痛性複素環式アミジン化合物
Document Type and Number:
Japanese Patent JP4896415
Kind Code:
B2
Abstract:
Heterocyclic amidines with anti-inflammatory and analgesic activity that inhibit nitrogen oxide production, of formula (I): in which: G1 and G2 are hydrogen, halogen, hydroxyl, C1-C4 alkoxy, C1-C4 alkyl, and an amidino substituent of formula Q, provided that, for each compound of formula (I), only one of the two substituents G1 or G2 is an amidino substituent of formula Q: and in which the substituents W, Y and X are combined to form 9- or 10-membered bicyclic heteroaromatic derivatives containing up to 2 hetero atoms in the same ring; and Z is an aryl or heteroaryl group, a linear or branched C1-C6 alkyl or alkenyl chain, a C1-C4 alkyl-aryl group or a C1-C4 alkyl-heteroaryl group.
Inventors:
Francesco Makovek
Antonio Giordani
Robert Altusi
Stefano Mandelli
Ilario Verplio
Simona Tsanzala
Lucho claudio lovati
Antonio Giordani
Robert Altusi
Stefano Mandelli
Ilario Verplio
Simona Tsanzala
Lucho claudio lovati
Application Number:
JP2005056076A
Publication Date:
March 14, 2012
Filing Date:
March 01, 2005
Export Citation:
Assignee:
ROTTAPHARM S.p.A.
International Classes:
C07D209/08; A61K31/343; A61K31/4045; A61K31/4184; A61K31/423; A61K31/428; A61K31/4439; A61K31/47; A61K31/517; A61K45/00; A61K47/00; A61P1/04; A61P19/02; A61P29/00; A61P37/06; A61P43/00; C07D215/38; C07D217/02; C07D235/08; C07D235/10; C07D235/12; C07D235/18; C07D237/28; C07D239/74; C07D263/56; C07D263/57; C07D277/64; C07D277/66; C07D307/79; C07D333/54; C07D403/04; C07D405/04; C07D409/04; C07D417/04
Domestic Patent References:
| JP2001515892A | ||||
| JP10265450A |
Foreign References:
| WO1996019440A1 | ||||
| WO2004014885A1 |
Attorney, Agent or Firm:
Kyousei Tamura
Nagatoshi Shinagawa
Nagatoshi Shinagawa