Title:
gem-ビスホスホネート誘導体で被覆された磁性粒子の新規組成物
Document Type and Number:
Japanese Patent JP4638738
Kind Code:
B2
Abstract:
Composition (A) comprising acidic magnetic particles (AMP's) based on an iron compound, where the AMP's are complexed with one or more gem-bis-phosphonate compounds (I) containing a reactive function which is optionally partially at least coupled with a biological vector, is new. Composition (A) comprising acidic magnetic particles (AMP's) based on an iron compound, where the AMP's are complexed with one or more gem-bis-phosphonate compounds of formula X-L-CH(PO3H2)2 (I). L = organic linking group; and X = chemical function which can react with a biovector (BV), the X groups being optionally at least partially coupled with the BV. An Independent claim is included for the preparation of (A).
Inventors:
Marc Paul
Claire Coro
Isabelle Renal
Olivier Rousseau
Claire Coro
Isabelle Renal
Olivier Rousseau
Application Number:
JP2004563297A
Publication Date:
February 23, 2011
Filing Date:
December 19, 2003
Export Citation:
Assignee:
GUERBET
International Classes:
A61K49/00; A61K49/18; A61P9/00; A61P29/00; A61P35/00
Domestic Patent References:
| JP2002503814A |
Foreign References:
| GB1435295B | ||||
| US4440646 | ||||
| US20020098149 | ||||
| US20020122806 | ||||
| WO1997001760A1 |
Other References:
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HOSAIN, F., et al.,THE JOURNAL OF NUCLEAR MEDICINE,1996年 1月,Vol.37, No.1,p.105-107
KULTYSHEV, R.G., et al.,J. AM. CHEM. SOC.,2002年,Vol.124, No.11,p.2614-2624
MASSART, R. et al.,JOURNAL DE CHIMIE PHYSIQUE,1987年,Vol.84, No.7-8,p.967-973
SAHOO, Y., et al.,Alkyl Phosphonate/Phosphate Coating on Magnetite Nanoparticles: A Comparison with Fatty Acids,LANGMUIR,2001年,Vol.17,p.7907-7911
FAUCONNIER, N., et al.,Synthesis of aqueous magnetic liquids by surface complexation of maghemite nanoparticles,JOURNAL OF MOLECULAR LIQUIDS,1999年,Vol.83,p.233-242
TRONC, E., et al.,HEPERFINE INTERACTIONS,1995年,Vol.95,p.129-148
VAYSSIERES. L., et al.,Size Tailoring of Magnetite Particles Formed by Aqueous Precipitation: An Example of Thermodynamic Stability of Nanometric Oxide Particles,JOURNAL OF COLLOID AND INTERFACE SCIENCE,1998年,Vol.205,p.205-212
MASSART, R.,IEEE TRANSACTIONS ON MAGNETICS,米国,IEEE INC.,1981年 3月,Vol.17, No.2,p.1247-1248
FAUCONNIER, F., et al.,Adsorption of gluconic and citric acids on maghemite particles in aqueous medium,PROGR. COLLOID POLYM SCI,1996年,Vol.100,p.212-216
TRONC, E.,HYPERFINE INTERACTIONS,1986年,Vol.28,p.525-528
HOSAIN, F., et al.,THE JOURNAL OF NUCLEAR MEDICINE,1996年 1月,Vol.37, No.1,p.105-107
KULTYSHEV, R.G., et al.,J. AM. CHEM. SOC.,2002年,Vol.124, No.11,p.2614-2624
MASSART, R. et al.,JOURNAL DE CHIMIE PHYSIQUE,1987年,Vol.84, No.7-8,p.967-973
SAHOO, Y., et al.,Alkyl Phosphonate/Phosphate Coating on Magnetite Nanoparticles: A Comparison with Fatty Acids,LANGMUIR,2001年,Vol.17,p.7907-7911
FAUCONNIER, N., et al.,Synthesis of aqueous magnetic liquids by surface complexation of maghemite nanoparticles,JOURNAL OF MOLECULAR LIQUIDS,1999年,Vol.83,p.233-242
TRONC, E., et al.,HEPERFINE INTERACTIONS,1995年,Vol.95,p.129-148
VAYSSIERES. L., et al.,Size Tailoring of Magnetite Particles Formed by Aqueous Precipitation: An Example of Thermodynamic Stability of Nanometric Oxide Particles,JOURNAL OF COLLOID AND INTERFACE SCIENCE,1998年,Vol.205,p.205-212
MASSART, R.,IEEE TRANSACTIONS ON MAGNETICS,米国,IEEE INC.,1981年 3月,Vol.17, No.2,p.1247-1248
FAUCONNIER, F., et al.,Adsorption of gluconic and citric acids on maghemite particles in aqueous medium,PROGR. COLLOID POLYM SCI,1996年,Vol.100,p.212-216
TRONC, E.,HYPERFINE INTERACTIONS,1986年,Vol.28,p.525-528
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Mitsutaka Iwasaki
Shoji Nakajima