Title:
カスパーゼ-3阻害剤を含む新規な造影剤
Document Type and Number:
Japanese Patent JP2007512302
Kind Code:
A
Abstract:
The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 inhibitor labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising the imaging agents, together with kits for the preparation of the radiopharmaceuticals. Also described are chelator conjugates of the caspase-3 inhibitor, which are suitable for the preparation of imaging agents comprising a radioactive or paramagnetic metal ion. The imaging agents are useful for the diagnostic imaging and or therapy monitoring in vivo of various disease states where caspase-3 is involved.
Inventors:
Hiscock, Duncan
Ben, Newton
Gilbert, Benedicte
Ben, Newton
Gilbert, Benedicte
Application Number:
JP2006540617A
Publication Date:
May 17, 2007
Filing Date:
November 26, 2004
Export Citation:
Assignee:
GE HEALTHCARE LIMITED
International Classes:
A61K49/00; A61K47/16; A61K47/22; A61K49/06; A61K49/08; A61K49/10; A61K49/14; A61K51/00; A61K51/04; A61K51/06; A61K51/08; A61P1/16; A61P3/10; A61P9/10; A61P13/08; A61P13/10; A61P19/02; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P31/04; A61P31/18; A61P35/00; A61P35/02; A61P37/04; A61P37/06; A61P43/00; C07F7/22; C07D403/12; C07D497/20
Domestic Patent References:
| JP2003534297A | 2003-11-18 | |||
| JP2003531871A | 2003-10-28 | |||
| JP2006519777A | 2006-08-31 | |||
| JP2003534297A | 2003-11-18 | |||
| JP2003531871A | 2003-10-28 |
Other References:
JPN5006019024; ＨＡＢＥＲＫＯＲＮ，Ｕ． ｅｔ ａｌ: ＮＵＣＬＥＡＲ ＭＥＤＩＣＩＮＥ ＡＮＤ ＢＩＯＬＯＧＹ Ｖｏｌ．２８， Ｎｏ．７, 200110, ｐ．７９３-７９８
JPN5006019026; Ｌａｘｍａｎ，Ｂ． ｅｔ ａｌ: ＰＮＡＳ Ｖｏｌ．９９， Ｎｏ．２６, 20021224, ｐ．１６５５１-１６５５５
JPN5006019024; ＨＡＢＥＲＫＯＲＮ，Ｕ． ｅｔ ａｌ: ＮＵＣＬＥＡＲ ＭＥＤＩＣＩＮＥ ＡＮＤ ＢＩＯＬＯＧＹ Ｖｏｌ．２８， Ｎｏ．７, 200110, ｐ．７９３-７９８
JPN5006019026; Ｌａｘｍａｎ，Ｂ． ｅｔ ａｌ: ＰＮＡＳ Ｖｏｌ．９９， Ｎｏ．２６, 20021224, ｐ．１６５５１-１６５５５
JPN6012006274; Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｉｃａｌ Ｍｅｔｈｏｄｓ Ｖｏｌ．２６５, 2002, ｐ．１１１-１２１
JPN5006019026; Ｌａｘｍａｎ，Ｂ． ｅｔ ａｌ: ＰＮＡＳ Ｖｏｌ．９９， Ｎｏ．２６, 20021224, ｐ．１６５５１-１６５５５
JPN5006019024; ＨＡＢＥＲＫＯＲＮ，Ｕ． ｅｔ ａｌ: ＮＵＣＬＥＡＲ ＭＥＤＩＣＩＮＥ ＡＮＤ ＢＩＯＬＯＧＹ Ｖｏｌ．２８， Ｎｏ．７, 200110, ｐ．７９３-７９８
JPN5006019026; Ｌａｘｍａｎ，Ｂ． ｅｔ ａｌ: ＰＮＡＳ Ｖｏｌ．９９， Ｎｏ．２６, 20021224, ｐ．１６５５１-１６５５５
JPN6012006274; Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｉｃａｌ Ｍｅｔｈｏｄｓ Ｖｏｌ．２６５, 2002, ｐ．１１１-１２１
Attorney, Agent or Firm:
Kenichi Matsumoto
Hirokazu Ogura
Toshihisa Kurokawa
Hirokazu Ogura
Toshihisa Kurokawa