Title:
抗ヒスタミン性の4-ジフェニルメチル/ジフェニルメトキシピペリジン誘導体類を製造する新規な中間体
Document Type and Number:
Japanese Patent JP3712208
Kind Code:
B2
Abstract:
The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R 1 represents hydrogen or hydroxy; R 2 represents hydrogen; R 1 and R 2 taken together form a second bond between the carbon atoms bearing R 1 and R 2 ; n is an integer of from 1 to 5; m is an integer 0 or 1; R 3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R 1 and R 2 are taken together to form a second bond between the carbon atoms bearing R 1 and R 2 or where R 1 represented hydroxy, m is an integer 0.
Inventors:
Klaus, Richard C.
Strom, Robert M.
Sukhotini, Carrie L.
Krupper, William J.
Wolf, Richard A.
Kerr, Albert A.
Ludigil, Duane Yi.
Panzone, Jean Battista
Hey, David A.
Woo W C W
Strom, Robert M.
Sukhotini, Carrie L.
Krupper, William J.
Wolf, Richard A.
Kerr, Albert A.
Ludigil, Duane Yi.
Panzone, Jean Battista
Hey, David A.
Woo W C W
Application Number:
JP50283195A
Publication Date:
November 02, 2005
Filing Date:
May 26, 1994
Export Citation:
Assignee:
Merrell Pharmaceuticals, Inc.
International Classes:
A61K31/445; A61P11/08; A61P37/00; A61P37/08; A61P43/00; C07C33/46; C07C39/24; C07C45/46; C07C45/63; C07C45/65; C07C45/67; C07C47/273; C07C49/792; C07C49/798; C07C49/80; C07C49/813; C07C49/82; C07C49/825; C07C49/83; C07C49/835; C07C49/86; C07C59/86; C07C59/88; C07D295/18; C07C59/90; C07C69/007; C07C69/16; C07C69/612; C07C69/65; C07C69/738; C07C69/78; C07C235/34; C07C235/78; C07C235/84; C07C255/16; C07C255/36; C07C255/40; C07C257/06; C07C259/06; C07D211/08; C07D211/14; C07D211/16; C07D211/22; C07D211/34; C07D211/44; C07D211/46; C07D295/16; C07D295/185; C07D401/06; C07D401/10; C07D491/107; A61K; C07D; (IPC1-7): C07C69/738; C07C235/78
Domestic Patent References:
| JP58008081A | ||||
| JP52087193A | ||||
| JP64047758A | ||||
| JP60094962A | ||||
| JP55141469A |
Foreign References:
| US3839431 |
Other References:
Sulfur Letters, 1992年,Vol.15, No.3, p.127-133
Suomen Kemistilehti, 1970年,Vol.43, p.91-97
Synthesis, 1981年,No.10, p.828-829
Physiol.Chem.&Physics, 1981年,Vol.13, p.145-152
Bull.Chem.Soc.Jpn., 1992年,Vol.65, p.1731-1733
Heterocycles, 1992年,Vol.34, No.7, p.1311-1315
J.Chem.Soc.,Chem.Commun., 1987年,p.1028-1029
J.Heterocyclic Chem., 1988年,Vol.25,p.1471-1474
Suomen Kemistilehti, 1970年,Vol.43, p.91-97
Synthesis, 1981年,No.10, p.828-829
Physiol.Chem.&Physics, 1981年,Vol.13, p.145-152
Bull.Chem.Soc.Jpn., 1992年,Vol.65, p.1731-1733
Heterocycles, 1992年,Vol.34, No.7, p.1311-1315
J.Chem.Soc.,Chem.Commun., 1987年,p.1028-1029
J.Heterocyclic Chem., 1988年,Vol.25,p.1471-1474
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Katsuro Sasai
Junji Yuda
Shoji Miwa
Katsuro Sasai