Title:
新規チオ尿素化合物及びこれを含有する薬学的組成物
Document Type and Number:
Japanese Patent JP2004506714
Kind Code:
A
Abstract:
The present invention relates to thiourea compounds and the pharmaceutical compositions containing the same, and particularly, to novel thiourea compounds as an antagonist against vanilloid receptor (VR) and the pharmaceutical compositions thereof. As diseases associated with the activity of vanilloid receptor, pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.
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Inventors:
Sue Yangor
Otaku
Kim Hee Do
Lee J War
Park Hyun Jun
Park Yang Ho
E Jun Bung
Otaku
Kim Hee Do
Lee J War
Park Hyun Jun
Park Yang Ho
E Jun Bung
Application Number:
JP2002521195A
Publication Date:
March 04, 2004
Filing Date:
August 20, 2001
Export Citation:
Assignee:
Pacific Corporation
International Classes:
A61P1/04; A61K31/18; A61K31/222; A61K31/235; A61P3/10; A61P9/00; A61P11/00; A61P11/06; A61P13/10; A61P17/00; A61P25/00; A61P25/06; A61P25/18; A61P27/02; A61P29/00; C07C311/08; C07C311/47; C07C333/20; C07C335/12; C07C335/14; C07C335/16; C07C335/20; C07C335/26; C07D207/323; C07D207/416; C07D207/42; C07D209/08; C07D209/14; C07D213/40; C07D213/61; C07D213/76; C07D217/06; C07D231/14; C07D231/56; C07D233/54; C07D235/14; C07D239/42; C07D241/12; C07D241/24; C07D277/28; C07D295/13; C07D295/215; C07D295/28; C07D307/52; C07D311/58; C07D317/58; C07D333/20; C07D333/42; C07D207/32; C07D207/40; C07D235/10; (IPC1-7): C07C335/12; A61K31/18; A61K31/222; A61K31/235; A61P1/04; A61P3/10; A61P9/00; A61P11/00; A61P11/06; A61P13/10; A61P17/00; A61P25/00; A61P25/06; A61P25/18; A61P27/02; A61P29/00
Domestic Patent References:
| JPS62228056A | 1987-10-06 | |||
| JPH03215420A | 1991-09-20 | |||
| JPS5855417A | 1983-04-01 | |||
| JP2002537373A | 2002-11-05 | |||
| JP2002503451A | 2002-02-05 | |||
| JP2002509131A | 2002-03-26 |
Foreign References:
| US3823148A | 1974-07-09 | |||
| US6057451A | 2000-05-02 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto