PORPHYRIN COMPOUND AND USE THEREOF

Title:

PORPHYRIN COMPOUND AND USE THEREOF

Document Type and Number:

Japanese Patent JP2016166160

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a porphyrin compound useful as an anti-oxidant that can exhibit high anti-oxidation capability only to the location of high reactive oxygen species (ROS) in a living body, and that is useful as a drug delivery composition.SOLUTION: The porphyrin compound A in figure 1 has a high lipid solubility, and therefore can permeate through blood-brain barrier and cell membrane. Since there are abundance of reactive oxygen species in cell, a sulfide group is oxidized and becomes sulfoxide B having a high antioxidation power. Because the sulfoxide B has a lowered lipid solubility, and stays within the cell, and as a result, the porphyrin compound as an antioxidant stays at the location where there are abundance of ROS and an antioxidation power is needed.SELECTED DRAWING: Figure 1

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Inventors:

MASUI DAI

Application Number:

JP2015047653A

Publication Date:

September 15, 2016

Filing Date:

March 10, 2015

Export Citation:

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Assignee:

UNIV TOKYO MEDICAL

International Classes:

C07D487/22; A61K31/409; A61K47/22; A61P9/00; A61P9/10; A61P25/28; A61P35/00; A61P39/02

Attorney, Agent or Firm:

Koichiro Tsujimaru
Yumi Nakayama
Isaji So

Previous Patent: JP2016166159

Next Patent: A manufacturing method of organic acid