Title:
The screening method of an AMPK protein activation agent, and an AMPK protein activation agent
Document Type and Number:
Japanese Patent JP6174018
Kind Code:
B2
Abstract:
A method for screening an AMPK activator, wherein inhibition of an interaction between prohibitin and AMPK is used as an index is provided. Besides, an AMPK activator comprising, as an active ingredient, a compound inhibiting an interaction between prohibitin and AMPK, and a prohibitin-AMPK complex are also provided.
Inventors:
Tomohiro Ide
Naoki Kobayashi
Akasaka Yunike
Takashi Komine
Koji Murakami
Naoki Kobayashi
Akasaka Yunike
Takashi Komine
Koji Murakami
Application Number:
JP2014515674A
Publication Date:
August 02, 2017
Filing Date:
May 16, 2013
Export Citation:
Assignee:
Kyorin Pharmaceutical Co., Ltd.
International Classes:
G01N33/50; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P35/00; C07K14/47; C12N9/12; G01N33/15
Domestic Patent References:
| JP2007077028A |
Other References:
Iryna O. ZUBOVYCH et al.,Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans,Molecular Biology of the Cell,2010年 3月,Vol.21,No.6,P.956-969
J. CHOI et al.,Sanguinarine is an allosteric activator of AMP-activated protein kinase,Biochem. Biophys. Res. Commun.,2011年 9月23日,Vol.413,no.2,P.259-263
J. CHOI et al.,Sanguinarine is an allosteric activator of AMP-activated protein kinase,Biochem. Biophys. Res. Commun.,2011年 9月23日,Vol.413,no.2,P.259-263
Attorney, Agent or Firm:
Yoshiki Hasegawa
Yoshinori Shimizu
Kimoto
Yoshinori Shimizu
Kimoto
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