1-AMINO TRIAZOLO CENT 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV

Title:

1-AMINO TRIAZOLO CENT 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV

Document Type and Number:

WIPO Patent Application WO2000066584

Kind Code:

B1

Abstract:

The invention relates to triazolo[4,3-a]quinazoline-5-ones and/or 5-thiones of formula (I) or (II), whereby (I) and (II) are position isomers of group R on nitrogen 3 or 4. Optionally, the invention also relates to the racemic forms, isomers and pharmaceutically acceptable salts thereof. The invention further relates to a method for the production thereof and to compositions containing said derivatives. The compounds act as inhibitors of phosphodiesterase IV (PDE-4).

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Inventors:

GAUDILLIERE BERNARD (FR)
LAVALETTE REMI (FR)
ANDRIANJARA CHARLES (FR)
BREUZARD FRANCINE (FR)

Application Number:

PCT/FR2000/001174

Publication Date:

February 15, 2001

Filing Date:

April 28, 2000

Export Citation:

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Assignee:

WARNER LAMBERT CO (US)
GAUDILLIERE BERNARD (FR)
LAVALETTE REMI (FR)
ANDRIANJARA CHARLES (FR)
BREUZARD FRANCINE (FR)

International Classes:

A61K31/4985; A61K31/505; A61K31/519; A61K31/5377; A61K31/541; A61K31/55; A61P1/00; A61P1/18; A61P3/10; A61P9/00; A61P9/04; A61P9/12; A61P11/00; A61P11/06; A61P13/08; A61P15/06; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/24; A61P25/28; A61P25/36; A61P35/00; A61P43/00; C07D239/22; C07D487/04; A61K; C07D; (IPC1-7): C07D487/04; A61K31/505

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