1-HETEROINDENE DERIVATIVES AND MEDICINAL COMPOSITION CONTAINING THE SAME

WIPO Patent Application WO/1999/054325

A1

Compounds represented by formula (I) or salts thereof; and a medicinal composition containing any of the compounds, especially an estrogen receptor controlling agent and an osteoporosis remedy, wherein R?1¿ represents an optionally substituted aromatic group, hydroxyl, or alkoxy; X represents sulfur or oxygen (in this case, R?2¿ represents hydrogen) or X in cooperation with R?2¿ forms a group represented by the formula (A): N-R?8¿-R?2¿' (wherein R?8¿ represents methylene or carbonyl and R?2¿' represent a direct bond of methylene); R?3¿ represents hydrogen, halogeno, hydroxy, alkoxy, acyloxy, an optionally substituted aromatic group, etc.; R?4¿ represents carbonyl or hydroxymethylene; R?5¿ represents alkylene; and R?6¿ and R?7¿ each represents alkyl or in cooperation represent alkylene.

OGAWA MASASHI (JP)
MORITA TADASHI (JP)
IIBUCHI NORIHIRO (JP)
SUZUKI HIDEAKI (JP)
TSUTSUI HIDEYUKI (JP)
KANO ATSUYUKI (JP)
KATO SATORU (JP)

PCT/JP1999/002037

October 28, 1999

April 16, 1999

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SENGA PHARMACEUTICAL LAB INC (JP)
OGAWA MASASHI (JP)
MORITA TADASHI (JP)
IIBUCHI NORIHIRO (JP)
SUZUKI HIDEAKI (JP)
TSUTSUI HIDEYUKI (JP)
KANO ATSUYUKI (JP)
KATO SATORU (JP)

C07D307/80; C07D333/56; (IPC1-7): C07D307/80; A61K31/34; A61K31/445; A61K31/47; C07D333/56; C07D471/04

JPH09507071A	1997-07-15
JPH08333366A	1996-12-17
JPH08511273A	1996-11-26
JPH07267858A	1995-10-17
JPS57181081A	1982-11-08

Hiraki, Yusuke (Toranomon 1-chome Minato-ku Tokyo, JP)

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