1-N-AMINOBENZIMIDAZOLE DERIVATIVES

WIPO Patent Application WO/2003/082854

A1

It is intended to provide 1-N-aminobenzimidazole derivatives represented by the following general formula (I) or salts thereof and drugs containing the same: wherein R¹ and R² represent each optionally substituted alkyl, etc.; R³, R⁵ and R⁶ represent each alkyl, alkoxy, hydrogen, etc.; R⁴ represents optionally substituted alkyl, etc.; A represents a benzene ring, etc.; B represents oxygen, etc.; and n is an integer of from 0 to 2. Because of showing little individual differences in the therapeutic effect based on individual differences in the CYP2C19 activity, the compounds (I) can exert an appropriate therapeutic effect on any patients in a single administration dose. Moreover, these compounds carry little risk of the interaction or carcinogenesis induced by CYP1A family members. Thus, they are useful as remedies for digestive ulcer capable of surely and safely exerting the therapeutic effect.

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NAGASAWA MASAAKI (JP)
NISHIOKA HIROYASU (JP)
ASAMI KAZUYASU (JP)
MIURA NAOYOSHI (JP)
NAKAMURA HIDEKI (JP)
MORITA HITOSHI (JP)

PCT/JP2003/003996

October 09, 2003

March 28, 2003

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ZERIA PHARM CO LTD (JP)
NAGASAWA MASAAKI (JP)
NISHIOKA HIROYASU (JP)
ASAMI KAZUYASU (JP)
MIURA NAOYOSHI (JP)
NAKAMURA HIDEKI (JP)
MORITA HITOSHI (JP)

A61P1/04; A61P43/00; C07D401/12; (IPC1-7): C07D401/12; A61K31/4439; A61K31/444; A61P1/04; A61P43/00; C07D471/04; C07D495/04

WO2001083473A1	2001-11-08
WO2001014366A1	2001-03-01
WO2000050037A1	2000-08-31
WO1999018959A1	1999-04-22

The, Patent Corporate Body Aruga Patent Office (3-6 NIHONBASHININGYOCHO 1-CHOM, CHUO-KU Tokyo, JP)

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