What is claimed is:

1.

A compound of formula (I): wherein: q is an integer from 1 to 4; R1 and R2 are independently selected from the group consisting of hydrogen and hydrocarbyl, wherein said hydrocarbyl may be optionally substituted with one or more groups comprising one or more heteroatoms, and wherein said hydrocarbyl optionally may have one or more carbon atoms replaced by one or more heteroatoms independently selected from the group consisting of oxygen, nitrogen, sulfur and phosphorus; R3 and R4 are independently selected from the group consisting of hydrogen; (O) R9 ;S02R9; and S03R9; or R3 and R4 together form =O; =NOR9; or =CR11R12; wherein R9 and R10 are independently selected from the group consisting of hydrogen; hydrocarbyl; amino; and hydrocarbylamino; wherein said hydrocarbyl moeities may be optionally substituted with one or more groups comprising one or more heteroatoms, and wherein said hydrocarbyl moieties optionally may have one or more carbon atoms replaced by one or more heteroatoms independently selected from the group consisting of oxygen, nitrogen, sulfur and phosphorus; and wherein R11 andR12 are independently selected from the group consisting of hydrogen; CN; halogen; oxo; hydrocarbyl; NR9R10; SR9;S (O) R9 ;S02R9; andSO3R9; wherein said hydrocarbyl moeities may be optionally substituted with one or more groups comprising one or more heteroatoms, and wherein said hydrocarbyl moieties optionally may have one or more carbon atoms replaced by one or more heteroatoms independently selected from the group consisting of oxygen, nitrogen, sulfur and phosphorus; or R11 and R12 together with the carbon atom to which they are attached form a cyclic ring; and R5 and R6 are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl;OR9;SR9;S (O) R9 ;S02R9; andS03R9; wherein the R5 and R6 radicals optionally may be substituted with one or more radicals independently selected from the group consisting of halogen; N02;CN; oxo; hydrocarbyl ; OR13; NR13R14; SR13; S(O)R13; NR13OR14;NR13NR14R15;CO2R13;OM;SO2R13;SO3R13; SO2OM;C(O)OM;COR13; C(O)NR13R14; NR13CO2R14;OC(O)R13;OC(O)NR13R14;NR13C(O)R14;NR13C(O)NR14R15; NR13SONR14R15;NR13SO2NR14R15;PR13R14; NR13SOR14;NR13SO2R14; P(OR13)OR14;S+R13R14A;andP(O)R13R14;P+R13R14R15A; N R R R A' ; wherein said hydrocarbyl may be optionally substituted with one or more groups comprising one or more heteroatoms, and wherein said hydrocarbyl optionally may have one or more carbon atoms replaced by one or more heteroatoms independently selected from the group consisting of oxygen, nitrogen, sulfur and phosphorus; wherein Rl3, R, and R15 are independently selected from the group consisting of hydrogen or hydrocarbyl, wherein said hydrocarbyl may be optionally substituted with one or more groups comprising one or more heteroatoms, and wherein said hydrocarbyl optionally may have one or more carbon atoms replaced by one or more heteroatoms independently selected from the group consisting of oxygen, nitrogen, sulfur and phosphorus; or wherein R13 and R'4 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R14 and R15 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein Ais a pharmaceutically acceptable anion, and M is a pharmaceutically acceptable cation; and wherein R9 is as defined above; or R4 and R6 together represent a bond; and RN is selected from the group consisting of hydrogen and hydrocarbyl, wherein said hydrocarbyl may be optionally substituted with one or more groups comprising one or more heteroatoms, and wherein said hydrocarbyl optionally may have one or more carbon atoms replaced by one or more heteroatoms independently selected from the group consisting of oxygen, nitrogen, sulfur and phosphorus; one or more Rx radicals are independently selected from the group consisting of hydrogen; hydrocarbyl;OR ; S(O)R13;S(O)2R13;SO3R13;S+R13R14A;NR13R14;SR13; NR130R14; NR13NR14R15 CO2R13; ;OM;S020M;S02NR R ; C(O)OM;COR13;S(O)nNR13R14;NR14C(O)R13;C(O)NR13R14; P(O)R13R14;P+R13R14R15A;aminoacidN+R13R14R15A;PR13R14; residue; peptide residue; polypeptide residue; and carbohydrate residue, wherein said hydrocarbyl may be optionally substituted with one or more groups comprising one or more heteroatoms, and wherein said hydrocarbyl optionally may have one or more carbon atoms replaced by one or more heteroatoms independently selected from the group consisting of oxygen, nitrogen, sulfur and phosphorus; and wherein n is 0,1 or 2; and wherein Rl3, Rl4, Rl5, A, and M are as defined above; or a pharmaceutically acceptable salt, solvate, or prodrug thereof ; and provided that at least one of R1, R2, R3, R4, R5, and R6 is a radical other than hydrogen or alkyl; and provided that when R5 or R6 is aryl, the other of R5 and R6 is a radical other than heterocycylalkyl.

2.

A compound of claim 1 wherein: q is an integer from 1 to 4; R1 and R2 are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl) aryl; or R1 and R2 taken together with the carbon to which they are attached form orC3C10cycloalkenyl;cycloalkyl wherein the R1 and R2 alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl) aryl radicals optionally may be substituted with one or more radicals selected from the group consisting ofCN; halogen; oxo; OR9; NR9R10; S+R9R10A;PR9R10; SR9; SO2R9;SO3R9;CO2R9;P+R9R10RwA;S(O)R9; CONR9R10; and wherein the R1 and R2 alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl) aryl radicals optionally may have one or more carbons replaced byO ;NR9 ;N+R9R1A ;S ;SO ;S02 ;S+R9A ; PR9;P (O) R9;P R9R10A ; orphenylene; and wherein R9, R, and Rw are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; alkylammoniumalkyl; arylalkyl; heterocyclylalkyl; carboxyalkyl; alkoxyalkyl; carboalkoxyalkyl; carboxyaryl; carboxyheterocyclyl; amino; alkylamino; carboxyalkylamino; alkoxyalkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and R3 and R4 are independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aryl; S (O) R9 ; SO2R9 ; andSO3R9; or R3 and R4 together form =0; =NNR9R10 ; =NR9 ; or =CR11R12; wherein R11 andR12 are independently selected from the group consisting of hydrogen;CN; halogen; oxo; alkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; carboxyalkyl; alkoxyalkyl; carboalkoxyalkyl; cycloalkyl; cycloalkenyl; haloalkyl; hydroxyalkyl; cyanoalkyl; OR9; S(O)R9;SO2R9;SO3R9;CO2R9;SR9; andCONR9R10; or R12R11and together with the carbon atom to which they are attached form a cyclic ring; and wherein R9 and R'° are as defined above; and R5 and R6 are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl;OR9;SR9;S (O) R9 ;S02R9; and SO3R9 ; wherein the R5 and R6 alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; and quaternary heterocyclyl radicals optionally may be substituted with one or more radicals independently selected from the group consisting of oxo; alkyl; polyalkyl; haloalkyl; hydroxyalkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; polyether ; OR13 ;NR R ; SR13;SO3R13;NR13OR14;NR13NR14R15; SO2R13; C02R13;OM;S020M;S02NR13R14;C (O) NR13R14 ;C (O) OM ; NR13C(O)NR14R15;NR13CO2R14;OC(O)R13;COR13;NR13C(O)R14; NR13SO2R14;NR13SONR14R15;OC(O)NR13R14;NR13SOR14; P(O)R13R14;P+R13R14R15A;NR13SO2NR14R15;PR13R14; andN+R13R14R15A;andP(OR13)OR14;S+R13R14A; wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the R5 and R6 radicals optionally may be further substituted with one or more radicals selected from the group consisting ofCN; halogen; hydroxy; oxo; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclyl;OR ; NR7R8 ;SR7;S (o) R7 ;So2R7 ;S03R7 ;CO2R7 ; P(O)R7R8;PR7R8;P+R7R8R9A;andCONR7R8;N+R7R8R9A; PCOXOROR8; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the R6radicalsand optionally may have one or more carbons replaced NR7;N+R7R8A O; ;S;SO;SO2;S+R7A ;PR7;P (o) R7;P+R7R8A ; or phenylene; and wherein R7 and R8 are independently selected from the group consisting of hydrogen; alkyl, alkenyl; alkynyl; aryl; and heterocyclyl; and wherein R13, R14, and R15 are independently selected from the group consisting of hydrogen; alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminoalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether; or wherein R13 and R14 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R14 and R15 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein the R13, R14, and R15 alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminoalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; sulfo; oxo; alkyl; haloalkyl; hydroxyalkyl; sulfoalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclylalkyl; carboxy; carboxyalkyl; N+R9R1;SR16;S (O) R9;S02R9;S03R16 ;C02R16 ; _ PO(OR16)OR17;P9R10;P+R9R10R11A;CONR9R10;SO2NR9R10; S R R A ; and carbohydrate residue; and wherein the R13, R14, and R15 alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminoalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may have one or more carbons replaced by O; NR9; N+R9R10A ; S; SO; SO2; S+R9A ; PR9; P+R9R10A ; P(O)R9; phenylene; carbohydrate residue; amino acid residue; peptide residue; or polypeptide residue; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation; and wherein R9, R10, R", R 12, Rw, and Aare as defined above; and RN is selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aralkyl; and heterocyclylalkyl; and one or more Rx radicals are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; acyloxy; OR13; S(O)R13;S(O)2R13;SO3R13;S+R13R14A;NR13R14;SR13; NR13OR14; ;NRNRR15 ;C02R13 ;OM;S020M; ~S02NR13R14 ; ~ C(O)OM;COR13;OR18;NR14C(O)R13;C(O)NR13R14; NR18OR14;N+R13R14R15A;PR13R14;S(O)nNR13R14;NR13R18; P (o) R13Rl4 ;P+R13Rl4Rl5A; amino acid residue; peptide residue; polypeptide residue; and carbohydrate residue; wherein the Rx alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; acyloxy radicals optionally may be further substituted with one or more radicals selected from the group consisting of halogen;CN; oxo;OR16 ; SR16;S(O)R9;SO2R9;SO3R16;CO2R16;NR9R10;N+R9R10RwA; PO(OR16)OR17;P9R10;P+R9R11R12A;CONR9R10;SO2NR9R10; S+R9R1A ; and carbohydrate residue; and wherein the R'quaternary heterocyclyl radical optionally may be substituted with one or more radicals selected from the group consisting of oxo; alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether;OR13 ; NR13R14; SR13; S(O)R13; SO2R13; S03R13 ; NR13OR14; NR13NR14R15; CO2R13; OM ;S020M; C(O)OM;COR13;P(O)R13R14;SO2NR13R14;C(O)NR13R14; P(OR13)OR14;S+R13R14A;P13R14;P+R13R14R15A; N+R13R14R15A;N+R13R14R15A;and carbohydrate residue; and wherein the Rx radicals comprising carbon optionally may have one or more carbons replaced NR13;N+R13R14A ;S;SO;SO2; O; P(O)R13;PR13R14;P+R13R14A ;S+R13A ;PR13; phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; polyether; or polyalkyl; wherein said phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; and polyalkyl optionally may have one or more carbons replaced NR9;N+R9R10A ;S; O; S+R9A ;PR9;P+R9R10A ;orP(O)R9;andSO;SO2; wherein R18 is selected from the group consisting alkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl; and wherein the R18 alkyi; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; NO2; oxo;OR9 ; NR9R10; N+R9R11R12A; SR9; S (O) R9 ;S02R9 ;S03R9 ;C02R9 ;CONR9R10 ;S020M ;S02NR9R1 ; PR9R10 ;P (OR13) ORl4 ;PO (OR16) OR17; andC (O) OM; and wherein R9, Rl°, R", R12, R R'4, R'5, R, R17, RW, A, and M are as defined above; or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

3.

A compound of claim 1 wherein: q is an integer from 1 to 4; R1 and R2 are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; alkynyl; arylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; alkylaryl; and (polyalkyl) aryl; or R1 and R2 taken together with the carbon to which they are attached form orC3C10cycloalkenyl;cycloalkyl wherein the R1 and R2 alkyl; cycloalkyl; alkenyl; alkynyl; arylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; alkylaryl; and (polyalkyl) aryl radicals optionally may be substituted with one or more radicals selected from the group consisting ofCN; halogen; oxo;OR9;NR9R10 ; N+R9R10RwA ;;SR9; P+R9R10RwA;S(O)R9;SO2R9;SO3R9; PR9R10; CO2R9; CONR9R10; and wherein the R1 and R2 alkyl; cycloalkyl; alkenyl; alkynyl; arylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; alkylaryl; and (polyalkyl)aryl radicals optionally may have one or more carbons replaced NR9; O; N+R9R10A ,S;SO;SO2;S+R9A ,PR9;P (O) R9;P+R9R10A , or phenylene; and wherein R9, R, and Rw are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; alkylammoniumalkyl; arylalkyl; heterocyclylalkyl; carboxyalkyl; carboalkoxyalkyl; carboxyheterocyclyl; carboxyalkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and R3 and R4 are independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aryl; heterocyclyl; OR9; SR9; S (O) and SO3R9 ; or R3 and R4 together form =O; =NOR9; =S; =NNR9R10; =NR9; or =CR11R12; wherein R11 and R12 are independently selected from the group consisting of hydrogen;CN; halogen; oxo; alkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; carboxyalkyl; carboalkoxyalkyl; cycloalkyl; cyanoalkyl;OR9;NR9R10;SR9;S (O) R9 ;S02R9 ;S03R9 ;C02R9; andCONR9R10; or R11 and R12 together with the carbon atom to which they are attached form a cyclic ring; and wherein R9 and R'° are as defined above; and R5 and R6 are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl;OR9;SR9;S (O) R9 ;S02R9; and SO3R9 ; wherein the R5 and R6 alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; and quaternary heterocyclyl radicals optionally may be substituted with one or more radicals independently selected from the group consisting of oxo; alkyl; polyalkyl; haloalkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; NR13OR14;NR13NR14R15;CO2R13;OM; SO2R13;SO3R13; C(O)NR13R14;C(O)OM;COR13;SO2OM;SO2NR13R14; NR13CO2R14;OC(O)R13;OC(O)NR13R14;NR13C(O)R14;NR13C(O)NR14R15; NR13SONR14R15;NR13SO2NR14R15;PR13R14; NR13SOR14;NR13SO2R14; P(O)R13R14; S+R13R14A;and P(OR13)OR14; N+R13Rl4Rl5A ; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the RI and R6 radicals optionally may be further substituted with one or more radicals selected from the group consisting ofCN; halogen; hydroxy; oxo; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary (o) R7 ;So2R7 ;S03R7 ;CO2R7 ; CONR7R8; PR7R8;P+R7R8R9A;and P(O)R7R8; PCOXOROR8; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the R6radicalsand optionally may have one or more carbons replaced NR7;N+R7R8A O; SO;SO2;S+R7A ;PR7;P(O)R7;P+R7R8A ;orphenylene;;S; and wherein R7 and R8 are independently selected from the group consisting of hydrogen and alkyl; and wherein R13, R14, and R15 are independently selected from the group consisting of hydrogen; alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; carboxyalkylaminocarbonylalkyl; and polyether; or wherein R'3 and R'4 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R14 and R15 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein the R13, R14, and R15 alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; sulfo; oxo; alkyl; sulfoalkyl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclylalkyl; carboxy; carboxyalkyl; guanidinyl;OR16;NR9R10 ;N+R9R10RwA;SR16 ; S (O) R9;S02R 9 ;S03R 16 ;C02R 16 ;CONR9R 10 ;S02NR9Rlo P+R9R10R11A;S+R9R10A;andPO(OR16)OR17;PR9R10; carbohydrate residue; and wherein the R13, R14, and R15 alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may have one or more carbons replaced byO;NR9; SO;SO2;S+R9A ;PR9;P+R9R10A ;P(O)R9;N+R9R10A ;S; phenylene; carbohydrate residue; amino acid residue; peptide residue; or polypeptide residue; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation; and wherein R9, R°, R", R'2, RW, and Aare as defined above; and RN is selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; and aralkyl; and one or more RX radicals are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; polyalkyl; haloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; polyether; S+R13R14A;NR13OR14;NR13NR14R15;S(O)2R13;SO3R13; C02R13;OM;S020M ; SO2NR13R14; NR14C(O)R13; C(O)NR13R14; C (O) OM ; COR13; OR18; S(O)nNR13R14; NR13R18; NR18OR14; P(O)R13R14;P+R13R14R15A;aminoacidN+R13R14R15A;PR13R14; residue; peptide acid residue; polypeptide acid residue; and carbohydrate acid residue; wherein the R'alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; and acyloxy radicals optionally may be further substituted with one or more radicals selected from the group consisting of halogen;CN; oxo ; OR16; NR9R10; S(O)R9;SO2R9;SO3R16;CO2R16; SR16; CONR9R10 ;S02NR9R10 ;PO (OR'6) OR" ;PR9R10 ;P+R9R11R12A ;<BR> <BR> <BR> <BR> <BR> S+R9R1A ; and carbohydrate residue; and wherein the Rx quaternary heterocyclyl radical optionally may be substituted with one or more radicals selected from the group consisting of oxo; alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether;OR13;NRR14 ;SR13 ;S (0)R13 ;S02R13 ; NR13NR14R15;CO2R13;OM;SO2OM; SO3R13;NR13OR14; C(O)OM;COR13;P(O)R13R14;SO2NR13R14;C(O)NR13R14; P(OR13)OR14;S+R13R14A;andPR13R14;P+R13R14R15A; N+R13Rl 4Rl 5A; and carbohydrate residue; and wherein the Rx radicals comprising carbon optionally may have one or more carbons replaced byO ;NR13 ;N+R13R14A__ _S ;SO ;S02 ; S+R13A ;PR13 ;P (O) R13 ;PR13 ;P+R13R14A ; phenylene; amino acid; peptide; polypeptide; carbohydrate; polyether; or polyalkyl; wherein said phenylene; amino acid; peptide; polypeptide; carbohydrate; and polyalkyl optionally may have one or more carbons replaced by O; NR9; SO;SO2;S+R9A ;PR9;P+R9R10A ;orP(O)R9;N+R9R10A ;S; and wherein R18is selected from the group consisting of alkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl; and wherein the R18 alkyi; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; oxo;OR9;NR9R10 ;N+R9R11R12A ;SR9 ;S (O) R9 ; CO2R9;CONR9R10;SO2OM;SO2NR9R10;SO2R9;SO3R9; PR9R10; P(OR13)OR14; PO(OR16)OR17; andC (O) OM; and wherein R9, R'°, R", R12,R13,R14,R15,R16,R17,RA",andMareas defined above; or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

4.

A compound of claim 1 wherein: q is an integer from 1 to 4; R1 and R2 are independently selected from the group consisting of hydrogen; (C2C10)alkenyl;(C2C10)alkynyl;(C3C10)cycloalkyl; aryl (CiCio) alkyl; (CiCio) alkoxy (CiCio) alkyl; (C1C10)alkoxy(C2C10) alkenyl; and(polyalkyl)aryl;or(C1C10)alkoxy(C2C10)alkynyl;(C1C10)alkylaryl; R1 and R2 taken together with the carbon to which they are attached form (C3C, o) cycloalkyl; wherein the R1 and R2 (C,C, o) alkyl; (C3C10) cycloalkyl; (C2 C10) alkenyl; (C2C10)alkynyl ; aryl (CiCio) alkyl; (C,C, o) alkoxy (C,CIo) alkyl; (C1C10) alkoxy (C2Clo) alkenyl; (C1C10) alkoxy (C2Clo) alkynyl; (Cl C10) alkylaryl; and (polyalkyl) aryl radicals optionally may be substituted with one or more radicals selected from the group consisting ofCN; halogen; oxo; OR9; NR9R10; S+R9R10A;PR9R10; SR9; SO2R9;SO3R9;CO2R9;andCONR9R10;andP+R9R10RwA;S(O)R9; wherein the R1 and R2 (C1C10) alkyl; (C3Clo) cycloalkyl; (C2 C10) alkenyl; (C2C10) alkynyl; aryl (CiCio) alkyl; (CiCio) alkoxy (C,C, o) alkyl; (CiCio) alkoxy (C2C10) alkenyl; (C1C10)alkoxy(C2C10) alkynyl; (C C10) alkylaryl; and (polyalkyl) aryl radicals optionally may have one or more carbons replaced NR9;N+R9R10A ;S;SO;SO2;S+R9A ; O; PR9;P (O) R9;P+R9R10A ; orphenylene; and wherein R9, R, and Rw are independently selected from the group consisting of hydrogen; (C,C, o) alkyl; (C3C, o) cycloalkyl; (C2C10) alkenyl; (C2C10) alkynyl; aryl; heterocyclyl; ammonium (C,C, o) alkyl; (C heterocyclyl(C1C10)alkylammonium(C1C10)alkyl;aryl(C1C10)alkyl; C10) alkyl; carboxy (CiCio) alkyl; carbo (CiCio) alkoxy (CiCio) alkyl; carboxyheterocyclyl; carboxy (CIClo) alkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and R3 and R4 are independently selected from the group consisting of hydrogen; (C2C10)alkynyl;aryl;heterocyclyl;(C2C10)alkenyl; OR9; NR9R10; SR9; S(O)R9;SO2R9; orSO3R9; R3 and R4 together form =O; =NOR9; =S; =NR9; or =CR11R12; wherein Ri 1 and R12 are independently selected from the group consisting of hydrogen;CN; halogen; oxo; (C1C10) alkyl; (C2Clo) alkenyl; (C2C10) alkynyl; aryl; heterocyclyl; aryl (CICl0) alkyl; carboxy (CICl0) alkyl; carbo(C1C10)alkoxy(C1C10)alkyl;cyano(C1C10)alkyl; OR9; NR9R10; SR9; SO3R9;CO2R9;SO2R9; CONR9R10; or R12R11and together with the carbon atom to which they are attached form a cyclic ring; and wherein R9 and R'° are as defined above; and R5 and R6 are independently selected from the group consisting of hydrogen; (C2C10)alkenyl;(C2C10)alkynyl;(C3C10)cycloalkyl; aryl; heterocyclyl; quaternary heterocyclyl; OR9; SR9; SO2R9; andSO3R9; wherein the R5 and R6 (CiCio) alkyl; (C3C, o) cycloalkyl; (C2 C10) alkenyl; (C2C10) alkynyl; aryl; heterocyclyl; and quaternary heterocyclyl radicals optionally may be substituted with one or more radicals independently selected from the group consisting of oxo; (C1 halo(C1C10)alkyl;(C3C10)cycloalkyl;(C2C10)alkenyl;C10)alkyl;polyalkyl; (C2C10) alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; OR13;NR13R14;SR13;S(O)R13;heterocyclyl(C1C10)alkyl;polyether; SO2R13;NR13NR14R15;CO2R13;OM; NR13OR14; SO2OM;C(O)OM;COR13; C(O)NR13R14; NR13CO2R14;OC(O)R13;OC(O)NR13R14;NR13C(O)R14;NR13C(O)NR14R15; NR13SONR14R15;NR13SO2NR14R15; NR13SOR14;NR13SO2R14; P+R13R14R15A;P(OR13)OR14;S+R13R14AP(O)R13R14;PR13R14; ; andN+R13R14R15A; wherein the halo(C1C10)alkyl,hydroxy(C1polyalkyl, C10) alkyl, (C3C, o) cycloalkyl, (C2C10) alkenyl, (C2C, o) alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, aryl (CiCio) alkyl, heterocyclyl (C1 <BR> <BR> <BR> Cl0) alkyl, and polyether substituents of the R5 and R6 radicals optionally may be further substituted with one or more radicals selected from the group consisting ofCN; halogen; hydroxy; oxo; (C1C10) alkyl; (C3C10) cycloalkyl; (C2C10) alkenyl; (C2C10) alkynyl; aryl; heterocyclyl; aryl (CiCio) alkyl; heterocyclyl (CICl0) alkyl; quaternary heterocyclyl ; OR7 ; NR7R8; SR7; S(O)R7;CO2R7;CONR7R8;N+R7R8R9A; SO3R7; P (O) R7R8; PR7R8; P+R7R8R9A; and P(O)(OR7)OR8 ; and wherein the (CiCio) alkyl, polyalkyl, halo (CiCio) alkyl, hydroxy (C1 C, o) alkyl, (C3C, o) cycloalkyl, (C2C10) alkenyl, (C2C10) alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, aryl (CIClo) alkyl, heterocyclyl (Cl C10)alkyl, and polyether substituents of the R6and radicals optionally may have one or more carbons replaced NR7;N+R7R8A ;S;SO; O; PR7;P(O)R7;P+R7R8A ;orphenylene;andSO2;S+R7A ; wherein R7 and R8 are independently selected from the group consisting of hydrogen and (C1C10) alkyl; and wherein R13, R14, and R15 are independently selected from the group consisting of hydrogen; (CiCio) alkyl; halo (C,C, o) alkyl; (C3CIO) cycloalkyl; polyalkyl; (C2C10) alkenyl; (C2C10) alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; aryl (C,C, o) alkyl; heterocyclyl (C,C, o) alkyl; quaternary heterocyclyl (CiCio) alkyl; (C1C10) alkylaryl (CiCio) alkyl; (C1 Cio) alkylheterocyclyl (CiCio) alkyl; (C,C, o) alkylammonium (CiCio) alkyl; carboxy (C1C10) alkylaminocarbonyl (CiCio) alkyl; and polyether; or wherein R'3 and R'4 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R 14 and R1 5 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein the R13, R14, and R15 (CiCio) alkyl; halo (CICl0) alkyl; (C3 C10) cycloalkyl; polyalkyl; (C2C10) alkenyl; (C2C10) alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; aryl (C,C, o) alkyl; heterocyclyl (C,C, o) alkyl; quaternary heterocyclyl(C1C10)alkyl; (C1(C1C10)alkyl; C10) alkylheterocyclyl (C,C, o) alkyl; (C1C10) alkylammonium (C,C, o) alkyl; aminocarbonyl (CiCio) alkyl; (CiCio) alkylaminocarbonyl (CiCio) alkyl; carboxy (C1C10) alkylaminocarbonyl (CiCio) alkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; sulfo; oxo; (C1C10) alkyl; sulfo (C1 C10) alkyl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclyl (C1 C10) alkyl; carboxy; carboxy (CICl0) alkyl; guanidinyl;OR16 ; NR9R10; ; S(O)R9;SO2R9;SO3R16;CO2R16;N+R9R10RwA;SR16; CONR9R10; PO(OR16)OR17;PR9R10;P+R9R10R11A SO2NR9R10; ;S+R9R10A; and carbohydrate residue; and wherein the R13, R14, and R15 (C1C10) alkyl; halo (CiCio) alkyl; (C3 C10) cycloalkyl; polyalkyl; (C2C10) alkenyl; (C2C10) alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; aryl (CICl0) alkyl; heterocyclyl (CICl0) alkyl; quaternary heterocyclyl (CICl0) alkyl; (C,Clo) alkylaryl (CCI0) alkyl; (C1 C10) alkylheterocyclyl (CiCio) alkyl; (C1C10)alkylammonium(C1C10) alkyl; aminocarbonyl (CiCio) alkyl; (CIC, o) alkylaminocarbonyl (CiCio) alkyl; carboxy (CiCio) alkylaminocarbonyl (C1C10) alkyl; and polyether radicals optionally may have one or more carbons replaced by O; NR9; SO;SO2;S+R9A ;PR9;P+R9R10A ;P(O)R9;N+R9R10A ;S; phenylene; carbohydrate residue; amino acid residue; peptide residue; or polypeptide residue; and wherein R17areindependentlyselectedfromthegroupand consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation; and wherein R9, R'°, R", R12, RW, and Aare as defined above; and RN is selected from the group consisting of hydrogen; (C1C10) alkyl; (C2Clo) alkenyl; (C2C10) alkynyl; and aryl (CiCio) alkyl; and one or more Rx radicals are independently selected from the group consisting of hydrogen; (C1C10) alkyl; (C3 Cl0) cycloalkyl; polyalkyl; halo (C1C10) alkyl; (C2C10) alkenyl; (C2Clo) alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; aryl (C1C10) alkyl; polyether; acyloxy; OR13; S(O)R13;S(O)2R13;SO3R13; SR13; NR13NR14R15;CO2R13;OM;SO2OM;S+R13R14A;NR13OR14; C(O)NR13R14;C(O)OM;COR13;OR18;SO2NR13R14;NR14C(O)R13; NR18OR14;N+R13R14R15A;PR13R14; S(O)nNR13R14;NR13R18; P (O) R13Rl4 P+R13R14R15A; amino acid residue; peptide acid residue; polypeptide acid residue; and carbohydrate acid residue; wherein the Rx (C1C10) alkyl; (C3C, o) cycloalkyl; polyalkyl; halo (C1 Ciao) alkyl; hydroxy (CiCio) alkyl; (C2C10)alkenyl ; (C2C10)alkynyl ; aryl; heterocyclyl; aryl (C,C, o) alkyl; heterocyclyl (C,C, o) alkyl; polyether; and acyloxy radicals optionally may be further substituted with halogen;CN; oxo; N+R9R11R12A;SR16;S(O)R9;SO2R9;SO3R16; OR16;NR9R10; SO2NR9R10;PO(OR16)OR17;PR9R10;CO2R16;CONR9R10; P+R9RllR12A ; orS+R9RloA ; and wherein the Rx quaternary heterocyclyl radical optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN;N02; oxo; (CiCio) alkyl; (C3C, o) cycloalkyl; polyalkyl; halo (CiCio) alkyl; hydroxy (CiCio) alkyl; (C2C10)alkenyl ; (C2Clo) alkynyl; aryl; heterocyclyl; aryl (C1C10) alkyl; heterocyclyl (CClO) alkyl; polyether; OR13;S(O)R13;SO2R13;SO3R13;NR13OR14; SR13; OM;SO2OM;SO2NR13R14;C(O)NR13R14;NR13NR14R15;CO2R13; C (O) (O)R13R14; PR13R14; P+R13R14R15A; andN+R13R14R15A;andP(OR13)OR14;S+R13R14A; wherein the Rx radicals comprising carbon optionally may have one or more carbons replaced by O; NR13; N+R13R14A ; S; SO; SO2; +;PR13 ;P (0)R13 ;PR13 ;P+R13R14A ; phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; polyether; or polyalkyl; wherein said phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; and polyalkyl optionally may have one or more carbons replaced NR9;N+R9R10A ;S; O; S+R9A ;PR9;P+R9R10A ;orP(O)R9;andSO;SO2; wherein R18 is selected from the group consisting of (C1C10)alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; acyl; and aryl (C, C10) alkoxycarbonyl; and wherein the R'8 (CiCio) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (C,C, o) alkyl; acyl; and aryl (C,CIO) alkoxycarbonyl radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; S (O) R9 ;S02R9;S03R9;C02R9 ;CONR9R1 ° ;S020M ;So2NR9Rl ° ; PR9R10; P(OR13)OR14; PO(OR16)OR17 ; andC (O) OM; and wherein R9, R'°, R", R, R, R, R, R, R, RW, A, and M are as defined above; or a pharmaceutically acceptable salt, solvate, or prodrug thereof; and provided that aryl is selected from the group consisting of optionally substituted phenyl, biphenyl and naphthyl; and provided that heterocyclyl is selected from the group consisting of optionally substituted heterocyclyl comprising a 5 to 10 membered ring and comprising one or more ring atoms that are heteroatoms selected from the group consisting of oxygen, nitrogen, sulfur and phosphorus.

5.

A compound of claim 1 wherein: q is an integer from 1 to 4; R1 and R2 are independently selected from the group consisting of hydrogen, methyl, ethyl, npropyl, isopropyl, nbutyl, isobutyl, secbutyl, tert butyl, pentyl, hexyl, phenoxymethylene, phenoxyethylene, phenoxypropylene, pyridinyloxymethylene, pyridinyloxyethylene; methylpyridinyloxymethylene, methylpyridinyloxyethylene, pyrimidinyloxymethylene, and pyrimidinyloxyethylene; or R1 and R2 taken together with the carbon to which they are attached form cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl; and R3 and R4 are independently selected from the group consisting of hydrogen, hydroxy, methyl, ethyl, phenyl, pyridinyl, amino, methylamino, dimethylamino, ethylamino and diethylamino; and R5 and R6 are independently selected from the group consisting of hydrogen, phenyl, chlorophenyl, fluorophenyl, bromophenyl, iodophenyl, hydroxyphenyl, methoxyphenyl, ethoxyphenyl, methoxy (chlorophenyl), methoxy (fluorophenyl), methoxy (bromophenyl), methoxy (iodophenyl), ethoxy (chlorophenyl), ethoxy (fluorophenyl), ethoxy (bromophenyl), ethoxy (iodophenyl), nitrophenyl, aminophenyl, methylaminophenyl, dimethylaminophenyl, ethylaminophenyl, diethylaminophenyl, trimethylammoniumphenyl, triethylammoniumphenyl, trimethylammoniummethylcarbonylaminophenyl, triethylammoniummethylcarbonylaminophenyl, trimethylammoniumethylcarbonylaminophenyl, triethylammoniumethylcarbonylaminophenyl, trimethylammoniumpropylcarbonylaminophenyl, triethylammoniumpropylcarbonylaminophenyl, trimethylammoniumbutylcarbonylaminophenyl, triethylammoniumbutylcarbonylaminophenyl, methylcarbonylaminophenyl, chloromethylcarbonylaminophenyl, fluoromethylcarbonylaminophenyl, bromomethylcarbonylaminophenyl, iodomethylcarbonylaminophenyl, ethylcarbonylaminophenyl, chloroethylcarbonylaminophenyl, fluoroethylcarbonylaminophenyl, bromoethylcarbonylaminophenyl, iodoethylcarbonylaminophenyl, propylcarbonylaminophenyl, chloropropylcarbonylaminophenyl, fluoropropylcarbonylaminophenyl, bromopropylcarbonylaminophenyl, iodopropylcarbonylaminophenyl, butylcarbonylaminophenyl, chlorobutylcarbonylaminophenyl, fluorobutylcarbonylaminophenyl, bromobutylcarbonylaminophenyl, iodobutylcarbonylaminophenyl, 3,4dioxymethylenephenyl, pyridinyl, methylpyridinyl, pyridinium, methylpyridinium, thienyl, chlorothienyl, fluorothienyl, bromothienyl, iodothienyl; methoxycarbonylphenyl, ethoxycarbonylphenyl, trimethylammoniumethoxyethoxyethoxyphenyl, triethylammoniumethoxyethoxyethoxyphenyl, chloroethoxyethoxyethoxyphenyl, fluoroethoxyethoxyethoxyphenyl, bromoethoxyethoxyethoxyphenyl, iodoethoxyethoxyethoxyphenyl, pyridiniumethoxyethoxyethoxyphenyl, piperazinyloxymethoxyethoxyethoxyphenyl, methylpiperazinyloxymethoxyethoxyethoxyphenyl, dimethylpiperazinyloxymethoxyethoxyethoxyphenyl, piperidinyloxymethoxyethoxyethoxyphenyl, methylpiperidinyloxymethoxyethoxyethoxyphenyl, and dimethylpiperidinyloxymethoxyethoxyethoxyphenyl; and RN is selected from the group consisting of hydrogen, methyl, ethyl, n propyl, nbutyl, npentyl, nhexyl and benzyl; and one or more Rx radicals are independently selected from the group consisting of hydroxy, methyl, ethyl, npropyl, isopropyl, nbutyl, isobutyl, tertbutyl, secbutyl, methoxy, ethoxy, npropoxy, isopropoxy, methylthio, methylsulfinyl, methylsulfonyl, ethylthio, ethylsulfinyl, ethylsulfonyl, amino, hydroxyamino, methylamino, dimethylamino, ethylamino, diethylamino, trimethylammonium, triethylammonium, NmethylNcarboxymethylamino, N, NdimethylNcarboxymethylammonium, methylcarbonylamino, chloromethylcarbonylamino, fluoromethylcarbonylamino, bromomethylcarbonylamino, iodomethylcarbonylamino, ethylcarbonylamino, npropylcarbonylamino, nbutylcarbonylamino, npentylcarbonylamino, n hexylcarbonylamino, benzyloxycarbonylamino, aminoimidocarbonylamino, morpholinyl, Nmethylmorpholinium, azetidinyl, Nmethylazetidinium, pyrrolidine, Nmethylpyrrolidinium, piperazinyl, Nmethylpiperazinyl, N, N' dimethylpiperazinium, piperidinyl, methylpiperidinyl, Nmethyl piperidinium, and thienyl; or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

6.

A compound of claim 1 wherein: q is an integer from 1 to 4; R1 and R2 are independently selected from the group consisting of hydrogen and (C1C10)alkyl; or R1 and R2 taken together with the carbon to which they are attached form (C3C, o) cycloalkyl; and R3 and R4 are independently selected from the group consisting of hydrogen and hydroxy; and R5 is phenyl, wherein said phenyl is optionally substituted with one or more radicals independently selected from the group consisting of halogen; (CiCio) alkyl; halo (C,C, o) alkyl; aryl (CiCio) alkyl; heterocyclyl(C1C10)alkyl; polyether; OR13; NR13R14; NR13C(O)R14; and wherein R13, R14, and R15 are independently selected from the group consisting of hydrogen; (CiCio) alkyl; halo (CCl0) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; heterocyclyl (CiCio) alkyl; quaternary heterocyclyl (C,Clo) alkyl; (C,C, o) alkylheterocyclyl (C,C, o) alkyl; (C1C10)alkylammonium(C1C10) alkyl; and polyether; or wherein the R13, R14, and R15 (C1C10)alkyl ; halo (C,C, o) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CIC, 0) alkyl; heterocyclyl (Ci C10) alkyl; quaternary heterocyclyl (CiCio) alkyl; (C,CIO) alkylheterocyclyl (C1 Cl0) alkyl; (C1C10) alkylammonium (C1C10) alkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen; (C1C10) alkyl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclyl (C1C10) alkyl; carboxy; carboxy (C1 NR9R10;N+R9R10RwA;andCONR9R10;andC10)alkyl;OR16; wherein R9 and R10 are independently selected from the group consisting of hydrogen; (CIC, o) alkyl; heterocyclyl; ammonium (C,C, o) alkyl; (CiCio) alkylammonium (C,C, o) alkyl; aryl (CiCio) alkyl; heterocyclyl (C1 CIO) alkyl; carboxy (C,C, o) alkyl; carbo (CiCio) alkoxy (CiCio) alkyl; carboxyheterocyclyl; carboxy (C,C, o) alkylamino; and acyl; and wherein Ais a pharmacecutically acceptable anion; and wherein R12and are independently selected from the group consisting of hydrogen; (C,C, o) alkyl; heterocyclyl; aryl (CiCio) alkyl; carboxy(C1C10)alkyl; and or R11 andR12 together with the carbon atom to which they are attached form a cyclic ring; and wherein R* and R16 are as defined in claim 2; and R6 is hydrogen; and RN is selected from the group consisting of hydrogen; (C1C10) alkyl; and aryl (C,C, o) alkyl; and one or more Rx radicals are independently selected from the group consisting of (C1C10) alkyl; halo (C,C, o) alkyl;OR13 ; NR13Rl4 ; wherein R'3 and R'4 are as defined above; or a pharmaceutically acceptable salt, solvate, or prodrug thereof ; and provided that aryl is selected from the group consisting of optionally substituted phenyl, biphenyl and naphthyl; and provided that heterocyclyl is selected from the group consisting of optionally substituted heterocyclyl comprising a 5 to 10 membered ring and comprising one or more ring atoms that are heteroatoms selected from the group consisting of oxygen, nitrogen, sulfur and phosphorus.

7.

A compound of claim 1 wherein: q is an integer from 1 to 4; Ri and R2 are independently selected from the group consisting of ethyl and nbutyl; or R1 and R2 taken together with the carbon to which they are attached form cyclopentyl; and one of R3 and R4 is hydrogen and the other of R3 and R4 is hydroxy; and R5 is selected from the group consisting of phenyl, hydroxyphenyl, methoxyphenyl, ethoxyphenyl, nitrophenyl, aminophenyl, methylaminophenyl, dimethylaminophenyl, ethylaminophenyl, diethylaminophenyl, trimethylammoniumphenyl, triethylammoniumphenyl, trimethylammoniummethylcarbonylaminophenyl, triethylammoniummethylcarbonylaminophenyl, trimethylammoniumethylcarbonylaminophenyl, triethylammoniumethylcarbonylaminophenyl, trimethylammoniumpropylcarbonylaminophenyl, triethylammoniumpropylcarbonylaminophenyl, trimethylammoniumbutylcarbonylaminophenyl, triethylammoniumbutylcarbonylaminophenyl, methylcarbonylaminophenyl, chloromethylcarbonylaminophenyl, fluoromethylcarbonylaminophenyl, bromomethylcarbonylaminophenyl, iodomethylcarbonylaminophenyl, ethylcarbonylaminophenyl, chloroethylcarbonylaminophenyl, fluoroethylcarbonylaminophenyl, bromoethylcarbonylaminophenyl, iodoethylcarbonylaminophenyl, propylcarbonylaminophenyl, chloropropylcarbonylaminophenyl, fluoropropylcarbonylaminophenyl, bromopropylcarbonylaminophenyl, iodopropylcarbonylaminophenyl, butylcarbonylaminophenyl, chlorobutylcarbonylaminophenyl, fluorobutylcarbonylaminophenyl, bromobutylcarbonylaminophenyl, iodobutylcarbonylaminophenyl, trimethylammoniumethoxyethoxyethoxyphenyl, triethylammoniumethoxyethoxyethoxyphenyl, chloroethoxyethoxyethoxyphenyl, fluoroethoxyethoxyethoxyphenyl, bromoethoxyethoxyethoxyphenyl, iodoethoxyethoxyethoxyphenyl, and pyridiniumethoxyethoxyethoxyphenyl; and R6 is hydrogen; RN is selected from the group consisting of hydrogen, methyl, ethyl, and benzyl; and one or more RX radicals are independently selected from the group consisting of hydroxy, methyl, ethyl, methoxy, ethoxy, amino, hydroxyamino, methylamino, dimethylamino, ethylamino, diethylamino, trimethylammonium, triethylammonium, NmethylNcarboxymethylamino, N, NdimethylNcarboxymethylammonium, methylcarbonylamino, chloromethylcarbonylamino, fluoromethylcarbonylamino, bromomethylcarbonylamino, iodomethylcarbonylamino, ethylcarbonylamino, benzyloxycarbonylamino, and aminoimidocarbonylamino; or. a pharmaceutically acceptable salt, solvate, or prodrug thereof.

8.

A compound of claim 1 selected from the compounds of the group consisting of : (4R,5R)3,3dibutyl7(dimethylamino)2, 3,4,5tetrahydro2methyl5 (3 nitrophenyl)1,2benzothiazepin4ol 1,1dioxide; (4R,5R)5(3aminophenyl)3,3dibutyl7(dimethylamino)2, 3,4,5tetrahydro 2methyl1,2benzothiazepin4ol 1,1dioxide; <BR> <BR> <BR> <BR> <BR> <BR> 5chloroN[3[(4R, 5R)3, 3dibutyl7(dimethylamino)2,[3[(4R, 5R)3, 3dibutyl7(dimethylamino)2, 3,4,5tetrahydro4<BR> <BR> <BR> <BR> hydroxy2methyl1,1dioxido1, 2benzothiazepin5yl] phenyl] pentanamide;<BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> 5 [ [3 [ (4R, 5R)3, 3dibutyl7 (dimethylamino)2,3,4,5tetrahydro4hydroxy2 methyl1,1dioxido1, 2benzothiazepin5yl] phenyl] amino]N, N, Ntriethyl5 oxopentanaminium trifluoroacetate; <BR> <BR> <BR> <BR> <BR> <BR> 2chloroN [3 [ (4R, SR)3, 3dibutyl7 (dimethylamino)2,3,4,5tetrahydro4<BR> <BR> <BR> <BR> hydroxy2methyl1, 1dioxido1, 2benzothiazepin5yl] phenyl] acetamide; 2[[3[(4R,5R)3,3dibutyl7(dimethylamino]2, 3,4,5tetrahydro4hydroxy2 methyl1, 1dioxido1, 2benzothiazepin5yl] phenyl] amino]N, N, Ntriethyl2 oxoethanaminium chloride; (4R,5R)3,3dibutyl7(dimethylamino)2, 3,4,5tetrahydro5 (4 methoxyphenyl)2methyl1,2benzothiazepin4ol 1,1dioxide; (4R, SR)3, 3dibutyl7 (dimethylamino)2,3,4,5tetrahydro5 (4 hydroxyphenyl)2methyl1,2benzothiazepin4ol 1,1dioxide; (4R, 5R)3,3dibutyl7(dimethylamino)2, 3,4,5tetrahydro5 (4 ( ( (2 iodoethyoxy) ethoxy) ethoxy) phenyl)2methyl1,2benzothiazepin4ol 1,1 dioxide; <BR> <BR> <BR> <BR> <BR> <BR> 1 [2 [2 [2 [4 [ (4R, 5R)3, 3dibutyl7 (dimethylamino)2,3,4,5tetrahydro4 hydroxy2methyl1,1dioxido1,2benzothiazepin5 yl] phenoxy] ethoxy] ethoxy] ethyl] pyridinium; 2 [2 [2 [4 [ (4R, 5R)3, 3dibutyl7 (dimethylamino)2,3,4,5tetrahydro4 hydroxy2methyl1,1dioxido1,2benzothiazepin5 yl] phenoxy] ethoxy] ethoxy]N, N, Ntriethylethanaminiumiodide; (4R,5R)3,3dibutyl7(dimethylamino)2, 3,4,5tetrahydro5 (3 methoxyphenyl)2methyl1,2benzothiazepin4ol 1,1dioxide; (4R,5R)3,3dibutyl7(dimethylamino)2, 3,4,5tetrahydro5 (3nitrophenyl) 1,2benzothiazepin4ol 1,1dioxide and (4S, 5R)3, 3dibutyl7 (dimethylamino)2,3,4,5tetrahydro5 (3nitrophenyl)l, 2benzothiazepin4ol 1,1dioxide; (4R, 5R)5(3aminophenyl)3,3dibutyl7(dimethylamino)2, 3,4,5tetrahydro <BR> <BR> <BR> 1,2benzothiazepin4ol 1,1dioxide;<BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> <BR> 5bromoN [3 [ (4R, SR)3, 3dibutyl7 (dimethylamino)2,3,4,5tetrahydro4 hydroxy1,1dioxido1,2benzothiazepin5yl) phenyl] pentanamide; <BR> <BR> <BR> <BR> <BR> <BR> 5 [ [3 [ (4R, 5R)3, 3dibutyl7 (dimethylamino)2,3,4,5tetrahydro4hydroxy 1,1dioxido1, 2benzothiazepin5yl] phenyl] amino]N, N, Ntriethyl5oxo1 pentanaminium trifluoroacetate; (4R, SR)3, 3dibutyl7 (dimethylamino)2,3,4,5tetrahydro5phenyl1,2 benzothiazepin4ol 1,1dioxide; (4R,SR)3,3dibutyl7 (dimethylamino)2,3,4,5tetrahydro5 (4 methoxyphenyl)1,2benzothiazepin4ol 1,1dioxide; (4R,SR)3,3dibutyl7 (dimethylamino)2,3,4,5tetrahydro5 (4 hydroxyphenyl)1,2benzothiazepin4ol 1,1dioxide; 2 [2 [2 [4 [ (4R, 5R)3,3dibutyl7(dimethylamino)2,3,4,5tetrahydro4 hydroxy1, 1dioxido1,2benzothiazepin5yl] phenoxy] ethoxy] ethoxy]N, N, N triethylethanaminium iodide; <BR> <BR> <BR> <BR> (4R,SR)3,3dibutyl7 (dimethylamino)2,3,4,5tetrahydro5 (3nitrophenyl)2 (phenylmethyl)1,2benzothiazepin4ol 1,1dioxide; <BR> <BR> <BR> <BR> (4R, SR)3, 3dibutyl7 (dimethylamino)5 [3 (ethylamino) phenyl]2,3,4,5<BR> <BR> <BR> tetrahydro2 (phenylmethyl)1, 2benzothiazepin4ol 1, 1dioxide;<BR> <BR> <BR> <BR> <BR> <BR> (4R, SR)3, 3dibutyl7(dimethylamino)2,3,4,5tetrahydro5 (4<BR> <BR> <BR> methoxyphenyl)2 (phenylmethyl)1, 2benzothiazepin4ol 1, 1dioxide; and (4R, SR)7dimethylamino)2ethyl4, 5dihydro5 (4methoxyphenyl) spiro [1, 2benzothiazepine3 (2H), l'cyclopentan]4ol 1, 1dioxide; and their pharmaceutically acceptable salts. <BR> <BR> <BR> <BR> <P>.

9.

A compound of claim 2 wherein R 5 and R6 are independently<BR> <BR> <BR> <BR> selected from the group consisting of H; aryl; heterocyclyl; and quaternary heterocyclyl; wherein the RS and R6 aryl; heterocyclyl; and quaternary heterocyclyl radicals optionally may be substituted with one or more radicals independently selected from the group consisting of halogen;CN;N02; oxo; alkyl; polyalkyl; haloalkyl; hydroxyalkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; OR13;S(O)R13;SO2R13;SO3R13;NR13OR14; SR13; OM;NR13NR14R15;CO2R13; SO2OM; C(O)NR13R14; NR13C(O)R14;NR13C(O)NR14R15;NR13CO2R14; C(O)OM;COR13; NR13SOR14;NR13SO2R14;NR13SONR14R15;OC(O)R13;OC(O)NR13R14; P(O)R13R14;PR13R14;P+R13R14R15A;NR13SO2NR14R15;PR13R14; P(OR) OR ;S R13Rl4A; and N+R13R14Rl5A ; a d wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the R5 and R6 radicals optionally may be further substituted with one or more radicals selected from the group consisting ofCN; halogen; hydroxy; oxo; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclyl;SR7;S(O)R7;SO2R7;SO3R7;CO2R7; NR7R8; P(O)R7R8;PR7R8;P+R7R8R9A;andCONR7R8;N+R7R8R9A; P (O) (OR7) OR8; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the R5 and R6 radicals optionally may have one or more carbons replaced NR7;N+R7R8A O; SO;SO2;S+R7A ;PR7;P(O)R7;P+R7R8A ;orphenylene;;S; and wherein R7 and R8 are independently selected from the group consisting of hydrogen; alkyl, alkenyl; alkynyl; aryl; and heterocyclyl; and wherein R, R, and R are independently selected from the group consisting of hydrogen; alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether; or wherein R'3 and R14 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R14 and R15 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein the R, R, and R alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; sulfo; oxo; alkyl; haloalkyl; hydroxyalkyl; sulfoalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclylalkyl; carboxy; carboxyalkyl; guanidinyl; OR16; SR16;S(O)R9;SO2R9;SO3R16; N+R9R10RwA; C02R16 ;CONR10 ;S02NR9R10 ;PO (OR16)OR17 ;PR10 ; P+R9R10R11A; S+R9R10A; and carbohydrate residue; and wherein the R13, R14, and R alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may have one or more carbons replaced byO;NR9; SO;SO2;S+R9A ;PR9;P+R9R10A ;P(O)R9;N+R9R10A ;S; phenylene; carbohydrate residue; amino acid residue; peptide residue; or polypeptide residue; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation; and wherein R9, R'°, R", R'2, R"", and Aare as defined in claim 2.

10.

A compound of claim 2 wherein R5 or R6 has the formula Ar(Ry), wherein: t is an integer from 0 to 5; Ar is selected from the group consisting of phenyl; thiophenyl; pyridyl; piperazinyl; piperonyl; pyrrolyl; naphthyl; furanyl; anthracenyl; quinolinyl; isoquinolinyl; quinoxalinyl; imidazolyl; pyrazolyl; oxazolyl; isoxazolyl; pyrimidinyl; thiazolyl; triazolyl; isothiazolyl; indolyl; benzoimidazolyl; benzoxazolyl; benzothiazolyl; and benzoisothiazolyl; and one or more Ry are independently selected from the group consisting of oxo; alkyl; polyalkyl; haloalkyl; hydroxyalkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; polyether;OR13;NR13R14 ;SR13 ;S (O) R13 ; NR13OR14;NR13NR14R15;CO2R13;OM; SO2R13;SO3R13; SO2OM; C(O)OM;COR13; C(O)NR13R14; NR13CO2R14;OC(O)R13;OC(O)NR13R14;NR13C(O)R14;NR13C(O)NR14R15; NR13SONR14R15;NR13SO2NR14R15; NR13SOR14;NR13SO2R14; P+R13R14R15A;P(OR13)OR14;S+R13R14A;P(O)R13R14;PR13R14; andN+R13R14R15A; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ry radicals optionally may be further substituted with one or more radicals selected from the group consisting ofCN; halogen; hydroxy; oxo; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclyl; OR7; NR7R8;SR7;S (O)R7; SO2R7; SO3R7; CO2R7; CONR7R8 ; N+R7R8R9A;P (o) R7R8 ;PR7R8 ;P+R7R8R9A; andP (O) (OR7) OR8 ; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ryradicals optionally may have one or more carbons replaced NR7;N+R7R8A ;S;S;SO; O; PR7;P(O)R7;P+R7R8A ;orphenylene;andSO2;S+R7A ; wherein R7 and R8 are independently selected from the group consisting of hydrogen; alkyl, alkenyl; alkynyl; aryl; and heterocyclyl; and wherein R, R, and R are independently selected from the group consisting of hydrogen; alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether; or wherein R13 and R14 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R14 and R15 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein the R13, R14, and R alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; sulfo; oxo; alkyl; haloalkyl; hydroxyalkyl; sulfoalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclylalkyl; carboxy; carboxyalkyl; guanidinyl; OR16; SR16;S(O)R9;SO2R9;SO3R16; N+R9R10RwA; C02R16;CONR9R1;S02NR9R10; PO(OR16)OR17; PR9R10; P+R9R10R11A; S+R9R10A; and carbohydrate residue; and wherein the R, R, and R alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may have one or more carbons replaced by0 ;NR9 ; N+R9R10A ;N+R9R10A ;S; S+R9A ;PR9;P+R9R10A ;P(O)R9;SO2; phenylene; carbohydrate residue; amino acid residue; peptide residue; or polypeptide residue; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation; and wherein R9, R'°, Roll, R12, R", and Aare as defined in claim 2.

11.	A compound of claim 2 wherein at least one of R5 and R6 has the formula wherein Ry and t are defined as in claim 10.

12.	A compound of claim 11 wherein RNis selected from the group consisting of hydrogen, alkyl and aralkyl.

13.	A compound of claim 11 wherein RN is selected from the group consisting of hydrogen, aryl(C1C10)alkyl.and.

14.	A compound of claim 11 wherein RN is selected from the group consisting of hydrogen, methyl, ethyl and benzyl.

15.	A compound of claim 11 wherein R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, and (C3C10)cycloalkyl.

16.	A compound of claim 11 wherein R1 areR2 independently selected from the group consisting of hydrogen and (C1C10)alkyl.

17.	A compound of claim 11 wherein R1 andR2 are independently selected from the group consisting of (C1C10)alkyl.

18.	A compound of claim 11 wherein R1 andR2 are independently selected from the group (C1C7)alkyl.of.

19.	A compound of claim 11 wherein R2and are independently selected from the group (C2C4)alkyl.of.

20.	A compound of claim 11 wherein R2areand the same (C1 C10)alkyl.

21.	A compound of claim 11 wherein R1 and R2 are independently selected from the group consisting ethyl; npropyl; nbutyl; and isobutyl.

22.	A compound of claim 11 wherein R1and R2 are each nbutyl.

23.	A compound of claim 11 wherein one ofR1 and R2 is ethyl and the other andR2R1 is nbutyl.

24.	A compound of claim 11 wherein q is 1,2, or 3.

25.	A compound of claim 11 wherein q is 1 or 2.

26.	A compound of claim 11 wherein q is 1.

27.	A compound of claim 11 wherein R3 and R4 are independently selected from the group consisting of hydrogen OR9.

28.	A compound of claim 27 wherein R9 is hydrogen.

29.	A compound of claim 28 wherein said hydroxy group is in a syn relationship to said structure of formula (II).

30.	A compound of claim 11 wherein Rx radicals are present at the 7, 8and 9positions of the benzo ring of the structure of formula (I).

31.	A compound of claim 11 wherein an RX radical is present at one or more of the 7, 8, or 9positions of the benzo ring of the structure of formula (I).

32.	A compound of claim 11 wherein Rx radicals are present at the 7and 9positions of the benzo ring of the structure of formula (I).

33.	A compound of claim 11 wherein an Rx radical is present at the 7position of the benzo ring of the structure of formula (I).

34.

A compound of claim 32 wherein said one or more are independently selected from the group consisting of alkyl; aryl; cycloalkyl; heterocyclyl; polyalkyl; acyloxy; polyether; halogen;OR13 ; NR13R14; SR13;S+R13R14A;CO2R13;andNR13NR14R15;N+R9R11R12A; NR C (O) R ; wherein alkyl; aryl; cycloalkyl; heterocyclyl; polyalkyl; acyloxy; and polyether; can be further substituted withOR16 ; NR9R10; N+R9R10RwA; SR16;S (O) R9;S02R9;S03R16; oxo;C02R16;CN; halogen; PO(OR16)OR17;PR9R10;P+R9R11R12A;orCONR9R10;SO2NR9R10; S+R9R10A;and wherein in RX, one or more carbons are optionally replaced by O; S;SO;SO2;S+R13A ;PR13;P(O)R13;NR13;N+R13R14A ; P+R13R14A ; phenylene ; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; polyether; or polyalkyl; and wherein in said polyalkyl; phenylene; amino acid residue; peptide residue; polypeptide residue; and carbohydrate residue; one or more carbons are optionally replaced NR9;N+R9R10A ;S;SO;SO2; O; P+R9R10A ;orP(O)R9.S+R9A ;PR9;.

35.

A compound of claim 33 wherein said one or more are independently selected from the group consisting of alkyl; aryl; cycloalkyl; heterocyclyl; polyalkyl; acyloxy; polyether; halogen;OR13 ; NR13R14; SR13;S+R13R14A;CO2R13;andNR13NR14R15;N+R9R11R12A; NRtR13 ; wherein alkyl; aryl; cycloalkyl; heterocyclyl; polyalkyl; acyloxy; and polyether; can be further substituted withOR16 ; NR9R10; N+R9R10RwA; SR16;S (O) R9;S02R9;S03R16; oxo;C02R16;CN; halogen; PO(OR16)OR17;PR9R10;P+R9R11R12A;orCONR9R10;SO2NR9R10; S+R9R10A; and wherein in RX, one or more carbons are optionally replaced by O; S;SO;SO2;S+R13A ;PR13;P(O)R13;NR13;N+R13R14A ; aminoP+R13R14A ;phenylene; acid residue; peptide residue; polypeptide residue; carbohydrate residue; polyether; or polyalkyl; and wherein in said polyalkyl; phenylene; amino acid residue; peptide residue; polypeptide residue; and carbohydrate residue; one or more carbons are optionally replaced NR9;N+R9R10A ;S;SO;SO2; O; + 9 9+ 9 109.

36.	A compound of claim 34 wherein said one or more are independently selected from the group consisting of polyether; 13R14; andN+R9R11R12A.

37.	A compound of the claim 35 wherein said R is selected from the group consisting of polyether;OR13 ; NR13R14; and N+R9R11R12A.

38.	A compound of claim 36 wherein said one or more RI are independently selected from the group consisting ofOR13 and NR13R14.

39.	A compound of claim 37 wherein said Rx is independently selected from the group consisting ofOR13 and NR13R14.

40.	A compound of claim 38 wherein R13 and R14 are each methyl.

41.	A compound of the claim 39 wherein R13 and R14 are each methyl.

42.	A compound of claim 11 wherein an Ry substituent is attached at the 3or the 4position of the phenyl ring of the structure of formula (II).

43.	A compound of claim 11 wherein t is 1 or 2.

44.	A compound of claim 42 wherein t is 1 or 2.

45.

A compound of claim 11 wherein said one or more Ry are independently selected from the group consisting of hydrogen; halogen; (CiCio) alkyl; halo (ClCl0) alkyl; aryl (C,C, o) alkyl; heterocyclyl (CiCio) alkyl; polyether;OR13 ; NR13R14 ; and NR13C(O)R14; and wherein R, R, and R are independently selected from the group consisting of hydrogen; (CiCio) alkyl; halo (ClCl0) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; heterocyclyl (C1C10) alkyl; quaternary heterocyclyl (ClCl0) alkyl; (CiCio) alkylheterocyclyl (CiCio) alkyl; (CIClo) alkylammonium (ClCl0) alkyl; and polyether; or wherein the R13, R14, and R15 (C1C10) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; halo (CiCio) alkyl; heterocyclyl (C1C10) alkyl; quaternary (C1C10)alkylheterocyclyl(C1C10)alkyl; (C1C10) alkylammonium (C1C10) alkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen; (ClClo) alkyl; heterocyclyl; quaternary heterocyclyl; quaternary carboxy(C1C10)alkyl;OR16;NR9R10;heterocyclyl(C1C10)alkyl;carboxy; CONR9R10;andN+R9R10RwA;and wherein R9, R, and Ru are independently selected from the group consisting of hydrogen; (C1C10) alkyl; heterocyclyl; ammonium (C1C10) alkyl; (CiCio) alkylammonium (CiCio) alkyl; aryl (C1C10) alkyl; heterocyclyl (C1 C10) alkyl; carboxy (ClCl0) alkyl; carbo (C,C, o) alkoxy (C,C, o) alkyl; carboxyheterocyclyl; carboxy (C1C10) alkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and wherein R12and are independently selected from the group consisting of hydrogen; (CiCio) alkyl; heterocyclyl; aryl (CiCio) alkyl; carbo(C1C10)alkoxy(C1C10)alkyl;orcarboxy(C1C10)alkyl;and R12R11and together with the carbon atom to which they are attached form a cyclic ring; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation.

46.

A compound of claim 11 wherein said Ry is independently selected from the group consisting of hydrogen, chloro, fluoro, bromo, iodo, hydroxy, methoxy, ethoxy, nitro, amino, methylamino, dimethylamino, ethylamino, diethylamino, trimethylammonium, triethylammonium, trimethylammoniummethylcarbonylamino, triethylammoniummethylcarbonylamino, trimethylammoniumethylcarbonylamino, triethylammoniumethylcarbonylamino, trimethylammoniumpropylcarbonylamino, triethylammoniumpropylcarbonylamino, trimethylammoniumbutylcarbonylamino, triethylammoniumbutylcarbonylamino, methylcarbonylamino, chloromethylcarbonylamino, fluoromethylcarbonylamino, bromomethylcarbonylamino, iodomethylcarbonylamino, ethylcarbonylamino, chloroethylcarbonylamino, fluoroethylcarbonylamino, bromoethylcarbonylamino, iodoethylcarbonylamino, propylcarbonylamino, chloropropylcarbonylamino, fluoropropylcarbonylamino, bromopropylcarbonylamino, iodopropylcarbonylamino, butylcarbonylamino, chlorobutylcarbonylamino, fluorobutylcarbonylamino, bromobutylcarbonylamino, iodobutylcarbonylamino, methoxycarbonyl, ethoxycarbonyl, trimethylammoniumethoxyethoxyethoxy, triethylammoniumethoxyethoxyethoxy, chloroethoxyethoxyethoxy, fluoroethoxyethoxyethoxy, bromoethoxyethoxyethoxy, iodoethoxyethoxyethoxy, pyridiniumethoxyethoxyethoxy, piperazinyloxymethoxyethoxyethoxy, methylpiperazinyloxymethoxyethoxyethoxy, dimethylpiperazinyloxymethoxyethoxyethoxy, piperidinyloxymethoxyethoxyethoxy, methylpiperidinyloxymethoxyethoxyethoxy, and dimethylpiperidinyloxymethoxyethoxyethoxyphenyl.

47.

A compound of claim 11 wherein said one or more Ry are independently selected from the group consisting of hydroxy, methoxy, ethoxy, nitro, amino, methylamino, dimethylamino, ethylamino, diethylamino, trimethylammonium, triethylammonium, trimethylammoniummethylcarbonylamino, triethylammoniummethylcarbonylamino, trimethylammoniumethylcarbonylamino, triethylammoniumethylcarbonylamino, trimethylammoniumpropylcarbonylamino, triethylammoniumpropylcarbonylamino, trimethylammoniumbutylcarbonylamino, triethylammoniumbutylcarbonylamino, methylcarbonylamino, chloromethylcarbonylamino, fluoromethylcarbonylamino, bromomethylcarbonylamino, iodomethylcarbonylamino, ethylcarbonylamino, chloroethylcarbonylamino, fluoroethylcarbonylamino, bromoethylcarbonylamino, iodoethylcarbonylamino, propylcarbonylamino, chloropropylcarbonylamino, fluoropropylcarbonylamino, bromopropylcarbonylamino, iodopropylcarbonylamino, butylcarbonylamino, chlorobutylcarbonylamino, fluorobutylcarbonylamino, bromobutylcarbonylamino, iodobutylcarbonylamino, trimethylammoniumethoxyethoxyethoxy, triethylammoniumethoxyethoxyethoxy, chloroethoxyethoxyethoxy, fluoroethoxyethoxyethoxy, bromoethoxyethoxyethoxy, iodoethoxyethoxyethoxy, and pyridiniumethoxyethoxyethoxy.

48.

A compound of claim 11 wherein said one or more Ry are independently selected from the group consisting of trimethylammonium, triethylammonium, trimethylammoniummethylcarbonylamino, triethylammoniummethylcarbonylamino, trimethylammoniumethylcarbonylamino, triethylammoniumethylcarbonylamino, trimethylammoniumpropylcarbonylamino, triethylammoniumpropylcarbonylamino, trimethylammoniumbutylcarbonylamino, triethylammoniumbutylcarbonylamino, trimethylammoniumethoxyethoxyethoxy, and triethylammoniumethoxyethoxyethoxy.

49.	A compound of claim 11 wherein: RN is selected from the group consisting of hydrogen, alkyl and aralkyl; and R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, and (C3C, o) cycloalkyl.

50.	A compound of claim 11 wherein: RN is selected from the group consisting of hydrogen, alkyl and aralkyl; and R3 and R4 are independently selected from the group consisting of hydrogen and hydroxy.

51.	A compound of claim 50 wherein said hydroxy group is in a syn relationship to said structure of formula (II).

52.	A compound of claim 11 wherein: RN is selected from the group consisting of hydrogen, alkyl and aralkyl; and selectedfromthegroupconsistingofpolyether;OR13;Rxis NRl3Rl4; and N+R9R1lR12A ; wherein R9, R", R12, R'3 and R'4 are as defined in claim 2.

53.	A compound of claim 11 wherein: R1 and independentlyselectedfromthegroupconsistingofare hydrogen, alkyl, and (C3Clo) cycloalkyl; and R3 and R4 are independently selected from the group consisting of hydrogen and hydroxy.

54.	A compound of claim 11 wherein: R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, and (C3CIO) cycloalkyl; and RX is selected from the group consisting of polyether; OR13; NR13R14; and N+R9R1 lR12A; wherein R9, R", R'2, R13 and R14 are as defined in claim 2.

55.	A compound of claim 11 wherein: R3 and R4 are independently selected from the group consisting of hydrogen and hydroxy; and selectedfromthegroupconsistingofpolyether;OR13;Rxis 13R14; andN+R9R1 1R12A; wherein R9, R", R12, R13 and R14 are as defined in claim 2.

56.

A compound of claim 11 wherein: RN is selected from the group consisting of hydrogen, alkyl and aralkyl; R1 and R2 are independently selected from the group consisting of <BR> <BR> <BR> hydrogen, alkyl, and (C3Clo) cycloalkyl; and R3 and R4 are independently selected from the group consisting of hydrogen and hydroxy.

57.

A compound of claim 11 wherein: RN is selected from the group consisting of hydrogen, alkyl and aralkyl; R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, and (C3C10)cycloalkyl; and Rx is selected from the group consisting of polyether ;OR13 ;NR13R14; and N+R9R11R12A; wherein R9, R", R'z, R'3 and R'4 are as defined in claim 2.

58.

A compound of claim 11 wherein: RN is selected from the group consisting of hydrogen, alkyl and aralkyl; R3 and R4 are independently selected from the group consisting of hydrogen and hydroxy; and selectedfromthegroupconsistingofpolyether;OR13;Rxis NR13RI4; wherein R9, R11, R12, R. and R'4 are as defined in claim 2.

59.

A compound of claim 11 wherein: R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, and (C3C, o) cycloalkyl; R3 and R4 are independently selected from the group consisting of hydrogen and hydroxy; and Rx is selected from the group consisting OR13;polyether; N+R9R11R12A;NR13R14;and wherein R9, R", R'2, R'3 and R14 are as defined in claim 2.

60.

A compound of claim 11 wherein: RNRNis selected from the group consisting of hydrogen, alkyl and aralkyl; R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, and (C3C10)cycloalkyl; R3 and R4 are independently selected from the group consisting of hydrogen and hydroxy; and Rx is selected from the group consisting OR13;polyether; N+R9R11R12A;NR13R14;and wherein R9, r11, andR14R13 are as defined in claim 2.

61.	A compound of claim 60 wherein RN is selected from the group consisting of hydrogen, (C1C10)alkyl and aryl(C1C10)alkyl.

62.	A compound of claim 60 wherein RNis selected from the group consisting of hydrogen, methyl, ethyl and benzyl.

63.	A compound of claim 60 wherein R2and are independently selected from the group consisting of hydrogen and (C1C10)alkyl.

64.	A compound of claim 60 wherein R1 andR2 are independently selected from the group consisting of (C1C10)alkyl.

65.	A compound of claim 60 wherein R1 andR2 are independently selected from the group consisting of (C2C4)alkyl.

66.	A compound of claim 60 wherein R2and are independently selected from the group consisting ethyl; npropyl; nbutyl; and isobutyl.

67.	A compound of claim 60 wherein R2and are each nbutyl.

68.	A compound of claim 60 wherein one of R1 andR2 is ethyl and the other andR2isnbutyl.R1.

69.	A compound of claim 60 wherein q is 1, 2, or 3.

70.	A compound of claim 60 wherein q is 1 or 2.

71.	A compound of claim 60 wherein q is 1.

72.	A compound of claim 60 wherein R radicals are present at the 7, 8and 9positions of the benzo ring of the structure of formula (I).

73.	A compound of claim 60 wherein an Rx radical is present at one or more of the 7, 8, or 9positions of the benzo ring of the structure of formula (I).

74.	A compound of claim 60 wherein Rx radicals are present at the 7and 9positions of the benzo ring of the structure of formula (I).

75.	A compound of claim 60 wherein an RX radical is present at the 7position of the benzo ring of the structure of formula (I).

76.	A compound of claim 60 wherein said one or more RX are independently selected from the group consisting ofOR andNR R wherein R13 and R14 are as defined in claim 2..

77.	A compound of claim 76 wherein R13 and R14 are each methyl.

78.	A compound of claim 60 wherein an Ry substituent is independently attached at the 3or the 4position of the phenyl ring of formula (II).

79.	A compound of claim 60 wherein t is 1 or 2.

80.	A compound of claim 60 wherein t is 1.

81.

A compound of claim 60 wherein said one or more Ry are independently selected from the group consisting of hydrogen; halogen; hydroxy;N02; (ClC1O) alkyl; halo (CiCio) alkyl; aryl (CiCio) alkyl; heterocyclyl (CIClO) alkyl; polyether;OR13 ; NR13R14; and NR13C(O) R'; and wherein R, R, and R are independently selected from the group consisting of hydrogen; (C1C10) alkyl; halo (C1C10) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (ClCl0) alkyl; heterocyclyl (C,C, o) alkyl; quaternary heterocyclyl (CiCio) alkyl; (C1C10) alkylheterocyclyl (CIC, o) alkyl; (C1C10) alkylammonium (C,C, o) alkyl; and polyether; or wherein the R13, R14, and R15 (C1C10)alkyl ; halo (CiCio) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; heterocyclyl (C1 heterocyclyl(C1C10)alkyl;(C1C10)alkylheterocyclyl(C1C10)alkyl;quaternary Cl0) alkyl; (C1C10) alkylammonium (ClCl0) alkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen; (C1C10)alkyl ; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclyl (C1C10) alkyl; carboxy; carboxy (C1 NR9R10;N+R9R10RwA;andCONR9R10;andC10)alkyl;OR16; wherein R9, R, and Rw are independently selected from the group consisting of hydrogen; (CiCio) alkyl; heterocyclyl; ammonium (CiCio) alkyl; heterocyclyl(C1(C1C10)alkylammonium(C1C10)alkyl;aryl(C1C10)alkyl; C10) alkyl; carboxy (CiCio) alkyl; carbo (ClCl0) alkoxy (C,C, o) alkyl; carboxyheterocyclyl; carboxy (CiCio) alkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and wherein R12and are independently selected from the group consisting of hydrogen; (C,C, o) alkyl; heterocyclyl; aryl (C,C, o) alkyl; carboxy(C1C10)alkyl; and carbo(C1C10)alkoxy(C1C10)alkyl; or R11 and R12 together with the carbon atom to which they are attached form a cyclic ring; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation.

82.

A compound of claim 60 wherein said Ry is independently selected from the group consisting of hydrogen, chloro, fluoro, bromo, iodo, hydroxy, methoxy, ethoxy, nitro, amino, methylamino, dimethylamino, ethylamino, diethylamino, trimethylammonium, triethylammonium, trimethylammoniummethylcarbonylamino, triethylammoniummethylcarbonylamino, trimethylammoniumethylcarbonylamino, triethylammoniumethylcarbonylamino, trimethylammoniumpropylcarbonylamino, triethylammoniumpropylcarbonylamino, trimethylammoniumbutylcarbonylamino, triethylammoniumbutylcarbonylamino, methylcarbonylamino, chloromethylcarbonylamino, fluoromethylcarbonylamino, bromomethylcarbonylamino, iodomethylcarbonylamino, ethylcarbonylamino, chloroethylcarbonylamino, fluoroethylcarbonylamino, bromoethylcarbonylamino, iodoethylcarbonylamino, propylcarbonylamino, chloropropylcarbonylamino, fluoropropylcarbonylamino, bromopropylcarbonylamino, iodopropylcarbonylamino, butylcarbonylamino, chlorobutylcarbonylamino, fluorobutylcarbonylamino, bromobutylcarbonylamino, iodobutylcarbonylamino, methoxycarbonyl, ethoxycarbonyl, trimethylammoniumethoxyethoxyethoxy, triethylammoniumethoxyethoxyethoxy, chloroethoxyethoxyethoxy, fluoroethoxyethoxyethoxy, bromoethoxyethoxyethoxy, iodoethoxyethoxyethoxy, pyridiniumethoxyethoxyethoxy, piperazinyloxymethoxyethoxyethoxy, methylpiperazinyloxymethoxyethoxyethoxy, dimethylpiperazinyloxymethoxyethoxyethoxy, piperidinyloxymethoxyethoxyethoxy, methylpiperidinyloxymethoxyethoxyethoxy, and dimethylpiperidinyloxymethoxyethoxyethoxyphenyl.

83.

A compound of claim 60 wherein said one or more Ry are independently selected from the group consisting of hydroxy, methoxy, ethoxy, nitro, amino, methylamino, dimethylamino, ethylamino, diethylamino, trimethylammonium, triethylammonium, trimethylammoniummethylcarbonylamino, triethylammoniummethylcarbonylamino, trimethylammoniumethylcarbonylamino, triethylammoniumethylcarbonylamino, trimethylammoniumpropylcarbonylamino, triethylammoniumpropylcarbonylamino, trimethylammoniumbutylcarbonylamino, triethylammoniumbutylcarbonylamino, methylcarbonylamino, chloromethylcarbonylamino, fluoromethylcarbonylamino, bromomethylcarbonylamino, iodomethylcarbonylamino, ethylcarbonylamino, chloroethylcarbonylamino, fluoroethylcarbonylamino, bromoethylcarbonylamino, iodoethylcarbonylamino, propylcarbonylamino, chloropropylcarbonylamino, fluoropropylcarbonylamino, bromopropylcarbonylamino, iodopropylcarbonylamino, butylcarbonylamino, chlorobutylcarbonylamino, fluorobutylcarbonylamino, bromobutylcarbonylamino, iodobutylcarbonylamino, trimethylammoniumethoxyethoxyethoxy, triethylammoniumethoxyethoxyethoxy, chloroethoxyethoxyethoxy, fluoroethoxyethoxyethoxy, bromoethoxyethoxyethoxy, iodoethoxyethoxyethoxy, and pyridiniumethoxyethoxyethoxy.

84.

A compound of claim 60 wherein said one or more Ry are independently selected from the group consisting of trimethylammonium, triethylammonium, trimethylammoniummethylcarbonylamino, triethylammoniummethylcarbonylamino, trimethylammoniumethylcarbonylamino, triethylammoniumethylcarbonylamino, trimethylammoniumpropylcarbonylamino, triethylammoniumpropylcarbonylamino, trimethylammoniumbutylcarbonylamino, triethylammoniumbutylcarbonylamino, trimethylammoniumethoxyethoxyethoxy, and triethylammoniumethoxyethoxyethoxy.

85.	A compound of claim 60 wherein said hydroxy group is in a syn relationship to said structure of formula (II).

86.

A compound of formula (I): wherein: qqis 1 2; R1 and R2 are each independently alkyl; R3 is hydroxy; R4 and R6 are hydrogen; R5 has the formula (II): wherein t is an integer from 0 to 5; one or more Ry are independently selected from the group consisting of hydrogen; oxo; alkyl; polyalkyl; haloalkyl; hydroxyalkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; OR13; SO2R13;SO3R13;NR13OR14;NR13NR14R15;SR13;S(O)R13; CO2R13; OM; SO2OM; C(O)OM; C(O)NR13R14; NR13C(O)NR14R15;NR13CO2R14;OC(O)R13;COR13;NR13C(O)R14; NR13SO2R14;NR13SONR14R15;OC(O)NR13R14;NR13SOR14; PR13R14;P+R13R14R15A;NR13SO2NR14R15;P(O)R13R14; P (OR) OR 4 ;S R13Rl4A; and N+R13R14R15A; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ry radicals optionally may be further substituted with one or more radicals selected from the group consisting ofCN; halogen; hydroxy; oxo; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclyl; OR7; NR7R8 ;SR7;S (O)R7; SO2R7; SO3R7; CO2R7; CONR7R8 ; N+R7R8R9A;P (o) R7R8 ;PR7R8 ;P+R7R8R9A; andP (o) (oR7) OR8 ; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ry radicals optionally may have one or more carbons replaced NR7;N+R7R8A ;S;SO; O; PR7;P(O)R7;P+R7R8A ;orphenylene;andSO2;S+R7A ; wherein R7 and R8 are independently selected from the group consisting of hydrogen; alkyl, alkenyl; alkynyl; aryl; and heterocyclyl; and wherein R, R, and R are independently selected from the group consisting of hydrogen; alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether; or wherein R'3 and R'4 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R14 and R15 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein the R13, R14, and R15 alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; sulfo; oxo; alkyl; haloalkyl; hydroxyalkyl; sulfoalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclylalkyl; carboxy; carboxyalkyl; guanidinyl; N+R9R10RwA;SR16;S(O)R9;SO2R9;SO3R16; OR16;NR9R10; C02R 16 ;CONR9R" ;S02NR9R'O ;PO (OR 16) OR 17 ;PR9R10<BR> <BR> <BR> <BR> <BR> P R9R10Rl lA;S R9R10A; and carbohydrate residue; and wherein the R13, R14, and R15 alkyl ; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may have one or more carbons replaced byO ;NR9 ; SO;SO2;S+R9A ;PR9;P+R9R10A ;P(O)R9;N+R9R10A ;S; phenylene; carbohydrate residue; amino acid residue; peptide residue; or polypeptide residue; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation; and wherein R9, R'°, R", R'2, RW, and Aare as defined in claim 2; and RN is selected from the group consisting of hydrogen; alkyl; and aralkyl; and one or more Rx radicals are independently selected from the group consisting of alkoxy, alkylamino and dialkylamino; or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

87.	A compound of claim 86 wherein R'and R2 are each the same (Ci C, 0) alkyl.

88.	A compound of claim 86 wherein R'and R2 are each nbutyl.

89.	A compound of claim 86 wherein one or more Rx are independently selected from the group consisting of methoxy and dimethylamino.

90.	A compound of claim 86 wherein q is 1.

91.	A compound of claim 86 wherein q is 1, and Rx is selected from the group consisting of methoxy and dimethylamino.

92.	A compound of claim 86 wherein RN is selected from thegroup consisting of hydrogen; methyl, ethyl and benzyl.

93.	A compound of claim 86 wherein said hydroxy group is in a syn relationship to said structure of formula (II).

94.	A compound of claim 86 wherein t is 1.

95.	A compound of claim 86 wherein t is 1 and RY is in the para position.

96.	A compound of claim 86 wherein t is 1 and RY is in the meta position.

97.

A compound of claim 86 wherein one or more Ry are independently selected from selected from the group consisting of halogen; hydroxy;N02; (C1C10) alkyl; halo (CiCio) alkyl; aryl (CiCio) alkyl; heterocyclyl (CiCio) alkyl; polyether; OR13; NR13C(O)R14;andand wherein R13, R14, and R15 are independently selected from the group consisting of hydrogen; (C,C, o) alkyl; halo (CiCio) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (C,CIO) alkyl; heterocyclyl (CiCio) alkyl; quaternary heterocyclyl (C1C10) alkyl; (C1C10) alkylheterocyclyl (C,C, o) alkyl; (C1C10) alkylammonium (CiCio) alkyl; and polyether; or wherein the R13, R14, and R15 (C1C10) alkyl; halo (C,C, o) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (C,C, o) alkyl; heterocyclyl (C, Ciao) alkyl; quaternary heterocyclyl (CiCio) alkyl; (CiCio) alkylheterocyclyl (Ci C10) alkyl; (C1C10) alkylammonium (C,C, o) alkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen; (C,C, o) alkyl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclyl (CiCio) alkyl; carboxy; carboxy (C, NR9R10;N+R9R10RwA;andCONR9R10;andC10)alkyl;OR16; wherein R9, R, and Rw are independently selected from the group consisting of hydrogen; (C1C10) alkyl; heterocyclyl; ammonium (C,C, o) alkyl; (C1C10) alkylammonium (CCl0) alkyl; aryl (CCl0) alkyl; heterocyclyl (C1 C10) alkyl; carboxy (C,C, o) alkyl; carbo (C,C, o) alkoxy (CiCio) alkyl; carboxyheterocyclyl; carboxy (CiCio) alkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and wherein R11 andR12 are independently selected from the group consisting of hydrogen; (C,C, o) alkyl; heterocyclyl; aryl (C,C, o) alkyl; carboxy(C1C10)alkyl; and or R11 andR12 together with the carbon atom to which they are attached form a cyclic ring; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation.

98.	A compound of claim 97 wherein: R'and R2 are each the same (CiCio) alkyl; one or more Rx are independently selected from the group consisting of methoxy and dimethylamino; said hydroxy group is in a syn relationship to said structure of formula (II); t is 1; and Ry is in the meta or para position.

99.	A compound of claim 97 wherein R'and R2 are each nbutyl.

100.	A compound of claim 97 wherein q is 1.

101.	A compound of claim 97 wherein RN is selected from the group consisting of hydrogen; methyl, ethyl and benzyl.

102.	A compound of claim 97 wherein Ry is in the para position.

103.	A compound of claim 97 wherein Ry is in the meta position.

104.

A compound of the formula (III): wherein: q and r are independently integers from 0 to 4; t and u are independently integers from 0 to 4; R1, R2, R1A, and R2A are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl)aryl; or R1 and R2 taken together with the carbon to which they are attached form C3Clo cycloalkyl or C3Clo cycloalkenyl; or R1A and R taken together with the carbon to which they are attached form C3C, o cycloalkyl or C3CIO cycloalkenyl; whereintheR1 R2 R1A andR2A alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl) aryl radicals optionally may be substituted with one or more radicals selected from the group consisting of CN; halogen; S(O)R9;SO2R9;SO3R9;CO2R9;andPR9R10;P+R9R10RwA; CONR9R10 ; and wherein the R1, R2, R1A, and R2A alkyl ; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl)aryl radicals optionally may have one or more carbons replaced NR9;N+R9R10A ;S;SO; O; S02 R9A ;PR9;P (O) R9;P R9R10A ; orphenylene; and wherein R9, R, and Rw are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; alkylammoniumalkyl; arylalkyl; heterocyclylalkyl; carboxyalkyl; alkoxyalkyl; carboalkoxyalkyl; carboxyaryl; carboxyheterocyclyl; amino; alkylamino; carboxyalkylamino; alkoxyalkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and R, R, R, and R are independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aryl; heterocyclyl;OR9 ; NR9R10;SR9;S (O) R9 ;S02R9; and SO3R9 ; or R3 and R4 together form =O; =NOR9; =S; =NNR9R10; =NR9; or <BR> <BR> =cRl IR12 ; or<BR> <BR> <BR> <BR> <BR> <BR> <BR> R3A and R4A together form =O; =NOR9; =S; =NNR9R10; =NR9; or =CR11R12; wherein R12and are independentyl selected from the group consisting of hydrogen;CN; halogen; oxo; alkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; carboxyalkyl; alkoxyalkyl; carboalkoxyalkyl; cycloalkyl; cycloalkenyl; haloalkyl; hydroxyalkyl; cyanoalkyl;OR9;NR9R10;SR9;S (O) R9 ;S02R9 ;S03R9 ;C02R9; and CONR9R10;or R12R11and together with the carbon atom to which they are attached form a cyclic ring; and wherein R9 and R'° are as defined above; and one or more Ry and RYA are independently selected from the group consisting of oxo; alkyl; polyalkyl; haloalkyl; hydroxyalkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; SR13;S (O) R13; SO2R13; SO3R13; NR13OR14; NR13NR14R15; C02R13;OM;S020M ; SO2NR13R14; C(O)NR13R14; C(O)OM; NR13C(O)NR14R15;NR13CO2R14;OC(O)R13;COR13;NR13C(O)R14; NR13SO2R14;NR13SONR14R15;OC(C)NR13R14;NR13SOR14; PR13R14;P+R13R14R15A;NR13SO2NR14R15;P(O)R13R14; andN+R13R14R15A;andP(OR13)OR14;S+R13R14A; wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ry and RYA radicals optionally may be further substituted with one or more radicals selected from the group consisting ofCN; halogen; hydroxy; oxo; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclyl;SR7;S(O)R7;SO2R7;SO3R7;CO2R7; NR7R8; CONR ; N+R7R8R9A; P(O)R7R8; PR7R8; P+R7R8R9A ; and P(O)(OR7)OR8;and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ry and radicals optionally may have one or more carbons replaced NR7;N+R7R8A O; SO;SO2;S+R7A ;PR7;P(O)R7;P+R7R8A ;orphenylene;;S; and wherein R7 and R8 are independently selected from the group consisting of hydrogen; alkyl, alkenyl; alkynyl; aryl; and heterocyclyl; and wherein R13, R14, and R15 are independently selected from the group consisting of hydrogen; alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether; or wherein R'3 and R'4 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R14 and R15 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein the R13, R14, and R15 alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; sulfo; oxo; alkyl; haloalkyl; hydroxyalkyl; sulfoalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclylalkyl; carboxy; carboxyalkyl; guanidinyl; N+R9R10RwA;SR16;S(O)R9;SO2R9;SO3R16; OR16;NR9R10; CO2R16; PO(OR16)OR17;PR9R10; SO2NR9R10; P+R9R10R11A; S+R9R10A; and carbohydrate residue; and wherein the R13, R14, and R15 alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl ; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may have one or more carbons replaced byO;NR9; SO;SO2;S+R9A ;PR9;P+R9R10A ;P(O)R9;N+R9R10A ;S; phenylene; carbohydrate residue; amino acid residue; peptide residue; or polypeptide residue; and wherein R16 and independentlyselectedfromthegroupare consisting ofR9 and M; and wherein n is 0,1 or 2; and wherein M is a pharmaceutically acceptable cation; and wherein R9, R'°, R", R'2, R"', and Aare as defined above; and RN and RNA are independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aralkyl; and heterocyclylalkyl; and one or more Rx and RXA radicals are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; uaternary heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; acyloxy; OR13; NR13R14; S(O)2R13;SO3R13;S+R13R14A; S(O)R13; NR13OR14; OM;SO2OM;SO2NR13R14; CO2R13; C(O)OM;COR13;OR18;SOnNR13R18;NR14C(O)R13;C(O)NR13R14; PR13R14;P(O)R13R14;NR18OR14;N+R13R14R15A; P+R13Rl4Rl5A; amino acid residue; peptide residue; polypeptide residue; and carbohydrate residue; wherein the Rx and RXA alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; acyloxy radicals optionally may be further substituted with one or more radicals selected from the group consisting of halogen;CN; SR16;S(O)R9;SO2R9;SO3R16;CO2R16; NR9R10;N+R9R10RwA; <BR> <BR> CONR9RIO ° ;So2NR9Rl;PO (OR16)OR17; PR9R10; P+R9R11R12A; <BR> <BR> <BR> <BR> <BR> S+R9R1A ; and carbohydrate residue; and wherein the Rx and RXA quaternary heterocyclyl radical optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN;N02; oxo; alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether;SR13;S(O)R13;SO2R13;SO3R13; NR13R14; NR13OR14; OM;SO2OM;SO2NR13R14; CO2R13; COR13;P(O)R13R14;PR13R14;C(O)NR13R14;C(O)OM; S+R13R14A;N+R13R14R15A;andP+R13R14R15A;P(OR13)OR14; carbohydrate residue; and wherein the Rx and RXA radicals comprising carbon optionally may have one or more carbons replaced by O; NR13; N+R13R14A ; S; SO; S02;S+R13A ;PR13 ;P (O) R13 ;P+R13R14A ; phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; polyether; or polyalkyl; wherein said phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; and polyalkyl optionally may have one or more carbons replaced NR9;N+R9R10A ;S;SO;SO2;O; P+R9R10A ;orP(O)R9;andS+R9A ;PR9; wherein R18 is selected from the group consisting of alkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl; and heterocyclylalkoxycarbonyl; and wherein the R18 alkyi; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; NO2; oxo;OR9;NR9R10; N+R9R1 lR12A;SR9 ;S (O) R9; S02R9 ;S03R9 ;C02R9 ;CONR9R10 ;S020M ;S02NR9R10 ;PR9R1 ;<BR> <BR> <BR> <BR> P (OR16) OR17 ;PO (OR16) ORl7; andC (O) OM; and wherein R9, R10, R11, R12, R15,R16,R17,Rw,A,andMareasR14, defined above; and R19 is selected from the group consisting of alkane diyl; alkene diyl; alkyne diyl; polyalkane diyl; alkoxy diyl; polyether diyl; polyalkoxy diyl; carbohydrate; amino acid; and peptide; polypeptide; wherein alkane diyl; alkene diyl; alkyne diyl; polyalkane diyl; alkoxy diyl; polyether diyl; polyalkoxy diyl; carbohydrate residue; amino acid residue; peptide residue; and polypeptide residue; can optionally have one or more carbons replaced by0 ; NR7;NR8;S;SO;SOz.;SVA';PR7;PR8; phenylene; heterocyclyl; quaternary heterocyclyl; or aryl; wherein alkane diyl; alkene diyl; alkyne diyl; polyalkane diyl; alkoxy diyl; polyether diyl; polyalkoxy diyl; carbohydrate residue; amino acid residue; peptide residue; and polypeptide residue can be substituted with one or more substituent groups independently selected from the group consisting of alkyl; alkenyl; alkynyl; polyalkyl; polyether; aryl; haloalkyl; cycloalkyl; heterocyclyl; arylalkyl; halogen; SO3R13; NR13OR14; NR13NR14R15; NO2; CO2R13 SO2OM;C(O)OM;COR13; C(O)NR13R14; P+R13R14R15A;P(OR13)OR14;S+R13R14A;andP(O)R13R14;PR13R14; N+R13R14R15A; wherein R7, R8, R", R'2, R3, R4 R, and Aare as defined above; or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

105.	A compound of claim 104 wherein R', R'A, R2, and R2A are independently selected from the group consisting of hydrogen and alkyl.

106.	A compound of claim 104 wherein R', R1A, R2, and R2A are independently selected from the group consisting of hydrogen and CiCio alkyl.

107.	A compound of claim 104 wherein R', R1A, R2, and R2A are independently selected from the group consisting of C2C7 alkyl.

108.	A compound of claim 104 wherein R', R1A, R2, and R2A are independently selected from the group consisting of C2C4 alkyl.

109.	A compound of claim 104 wherein R', R, R2, and R2A are independently selected from the group consisting of ethyl; npropyl; nbutyl; and isobutyl.

110.	A compound of claim 104 wherein R3, R3A, R4, and R4A are independently selected from the group consisting of hydrogen andOR9, wherein R9 is as defined in claim 104.

111.	A compound of claim 110 wherein R9 is hydrogen.

112.	A compound of claim 104 wherein RN and RNA are independently selected from the group consisting of hydrogen, alkyl and aralkyl.

113.	A compound of claim 104 wherein RN and RNA are independently selected from the group consisting of hydrogen, (CiCio) alkyl and aryl (CiCio) alkyl.

114.	A compound of claim 104 wherein RN and RNA are independently selected from the group consisting of hydrogen, methyl, ethyl and benzyl.

115.	A compound of claim 104 wherein one or more RX and RXA are independently selected from the group consisting of methoxy and dimethylamino.

116.	A compound of claim 104 wherein q and r are each 1.

117.

A compound of claim 104 wherein one or more Ry are independently selected from selected from the group consisting of halogen; hydroxy;N02; (C1C10) alkyl; halo (CiCio) alkyl; aryl (CiCio) alkyl; heterocyclyl (ClCl0) alkyl; polyether ; OR13; NR13R14; and NR13C(O)R14; and wherein R, R, and R15 are independently selected from the group consisting of hydrogen; (C1C10) alkyl; halo (C1C10) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; heterocyclyl (C,C, o) alkyl; quaternary heterocyclyl (CiCio) alkyl; (CiCio) alkylheterocyclyl (C,C, o) alkyl; (C1C10) alkylammonium (C1C10) alkyl; and polyether; or wherein the R13, R14, and R15 (CiCio) alkyl; halo (CIC, o) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; heterocyclyl (C1 heterocyclyl(C1C10)alkyl;(C1C10)alkylheterocyclyl(C1C10)alkyl;quaternary Cl0) alkyl; (C1C10) alkylammonium (ClCl0) alkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen; (C1C10) alkyl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclyl (C1C10) alkyl; carboxy; carboxy (C1 NR9R10;N+R9R10RwA;andCONR9R10;andC10)alkyl;OR16; wherein R9, R, and Rw are independently selected from the group consisting of hydrogen; (C1C10) alkyl; heterocyclyl; ammonium (CiCio) alkyl; (C1C10)alkylammonium(C1C10) alkyl; aryl (C,C, o) alkyl; heterocyclyl (C1 C10) alkyl; carboxy (CIC, o) alkyl; carbo (C,Clo) alkoxy (CiCio) alkyl; carboxyheterocyclyl; carboxy (ClCl0) alkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and wherein R12and are independently selected from the group consisting of hydrogen; (C1C10) alkyl; heterocyclyl; aryl (CiCio) alkyl; carbo(C1C10)alkoxy(C1C10)alkyl;orcarboxy(C1C10)alkyl;and R12togetherwiththecarbonatomtowhichtheyareattachedR11and form a cyclic ring wherein R17areindependentlyselectedfromthegroupand consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation.

118.

A compound of claim 104 wherein R'9 is selected from the group consisting of alkane diyl; polyalkane diyl; alkoxy diyl; and polyalkoxy diyl; wherein alkane diyl and polyalkane diyl can optionally have one or more byO;NR7;N+R7R8A ;S;SO;SO2;S+R7A ;carbonsreplaced PR7; P(O)R7; P+R7R8A ; or phenylene, wherein R7 and R8 are defined as in claim 104.

119.

A compound of claim 104 wherein R'9 is selected from the group consisting of alkoxy diyl and polyalkoxydiyl wherein one or more carbons are optionally replaced byO;NR7;N+R7R8A ;S;SO;SO2; S+R7A ; PR7; P(O)R7; P+R7R8A ; phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; or polyalkyl, wherein R9 and R'° are defined as in claim 104.

120.	A compound of claim 104 having the formula:.

121.

A compound of the formula (IV): wherein: q and r are independently integers from 0 to 3; t and u are independently integers from 0 to 5; R, R2, R, and R2A are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl)aryl; or R1 and R2 taken together with the carbon to which they are attached from C3C10cycloalkyl or C3C10 cycloalkenyl; or R1A and R2A taken together with the carbon to which they are attached form C3Clo cycloalkyl or C3Clo cycloalkenyl; wherein the R1, R2, R1A, and R2A alkyl ; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl) aryl radicals optionally may be substituted with one or more radicals selected from the group consisting of CN; halogen; S(O)R9;SO2R9;SO3R9;CO2R9;andPR9R10;P+R9R10RwA; CONR9R10 ; and wherein the R', R2, R, and R alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl)aryl radicals optionally may have one or more carbons replaced NR9;N+R9R10A ;S;SO; O; SO2;P(O)R9;P+R9R10A ;orphenylene;andPR9; wherein R9, R, and Rw are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; alkylammoniumalkyl; arylalkyl; heterocyclylalkyl; carboxyalkyl; alkoxyalkyl; carboalkoxyalkyl; carboxyaryl; carboxyheterocyclyl; amino; alkylamino; carboxyalkylamino; alkoxyalkylamino ; and acyl; and wherein Ais a pharmaceutically acceptable anion; and R3, R4, R, and R are independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aryl; heterocyclyl;OR9 ; NR9R10;SR9;S (O) R9 ;S02R9; and SO3R9 ; or R3 and R4 together form =O; =NNR9R10 ; =NR9; or =CR11R12 ; R3A and R4A together form =O; =NOR9; or =CR11R12; wherein R11 and R12 are independently selected from the group consisting of hydrogen;CN; halogen; oxo; alkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; carboxyalkyl; alkoxyalkyl; carboalkoxyalkyl; cycloalkyl; cycloalkenyl; haloalkyl; hydroxyalkyl; cyanoalkyl;OR9;NR9R10;SR9;S (O) R9 ;S02R9 ;S03R9 ;C02R9; and CONR9R10; or R11 and R12 together with the carbon atom to which they are attached form a cyclic ring; and wherein R9 and R10 are as defined above; and one or more Ry and RYA are independently selected from the group consisting of hydrogen; halogen;CN ; NO2 ; oxo; alkyl; polyalkyl; haloalkyl; hydroxyalkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; polyether;OR13 ; NR13R14; SO2R13;SO3R13;NR13OR14;NR13NR14R15;SR13;S(O)R13, C02R13;OM;S020M;S02NR13R14 ;CNRR14 ;C (0)OM ; COR13;NR13CO2R14;OC(O)R13; NR13C(O)NR14R15; NR13SO2R14;NR13SONR14R15;OC(O)NR13R14;NR13SOR14; PR13R14;P+R13R14R15A;NR13SO2NR14R15;P(O)R13R14; P (OR) OR ;S+R13Rl4A; andN+R13Rl4Rl5A~ ; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ry and RyA radicals optionally may be further substituted with one or more radicals selected from the group consisting ofCN; halogen; hydroxy; oxo; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary (O) R ;S02R ;S03R ;C02R P(O)R7R8;PR7R8;P+R7R8R9A;andCONR7R8;N+R7R8R9A; PXOROR8; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ry and radicals optionally may have one or more carbons replaced NR7;N+R7R8A?O; ;S;SO;SO2;S+R7A ;PR7;P (o) R7;P+R7R8A ; or phenylene; and wherein R7 and R8 are independently selected from the group consisting of hydrogen; alkyl, alkenyl; alkynyl; aryl; and heterocyclyl; and wherein R, R, and R are independently selected from the group consisting of hydrogen; alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether; or wherein R'3 and R'4 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R14 and R15 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein the R13, R14, and R15 alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; sulfo; oxo; alkyl; haloalkyl; hydroxyalkyl; sulfoalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclylalkyl; carboxy; carboxyalkyl; guanidinyl; N+R9R11R12A;SR16;S(O)R9;SO2R9;SO3R16; OR16;NR9R10; C02R16;CoNR9Rl0;S02NR9R10 ; PO(OR16)OR17; PR9R10; P+R9R10R11A; S+R9R10A; and carbohydrate residue; and wherein the R13, R14, and R15 alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may have one or more carbons replaced by O; NR9; SO;SO2;S+R9A ;PR9;P+R9R10A ;P(O)R9;N+R9R10A ;S; phenylene; carbohydrate residue; amino acid residue; peptide residue; or polypeptide residue; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation; and wherein n is 0,1 or 2; and wherein R9, R'°, R'1, R12, Rw, and Aare as defined above; and RN and RNA are independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aralkyl; and heterocyclylalkyl; and one or more Rx and RXA radicals are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; acyloxy; OR13;S(O)R13;S(O)2R13;SO3R13;S+R13R14A; SR13; CO2R13;OM;SO2OM;SO2NR13R14;NR13OR14;NR13NR14R15; C(O)OM;COR13;OR18;SOnNR13R14;NR14C(O)R13;C(O)NR13R14; NR18OR14; PR13R14;P(O)R13R14;A; P+R13Rl4Rl5A; amino acid residue; peptide residue; polypeptide residue; and carbohydrate residue; wherein the Rx and RXA alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; acyloxy radicals optionally may be further substituted with one or more radicals selected from the group consisting of halogen;CN; oxo ; OR16; NR9R10; S(O)R9;SO2R9;SO3R16;CO2R16; SR16; CONR9R10; PR9R10;P+R9R11R12A: PO(OR16)OR17; S R R A' ; and carbohydrate residue; and wherein the Rx and RXA quaternary heterocyclyl radical optionally may be substituted with one or more radicals selected from the group consisting of oxo; alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; OR13; S(O)R13;SO2R13;SO3R13; SR13; CO2R13;OM;SO2OM;SO2NR13R14;NR13OR14;NR13NR14R15; COR13;P(O)R13R14;PR13R14;C(O)NR13R14;C(O)OM; S+R13R14A;N+R13R14R15;andP+R13R14R15A;P(OR13)OR14; carbohydrate residue; and wherein the Rx and Rxl radicals comprising carbon optionally may have one or more carbons replaced by O; NR13; N+R13R14A ; S; SO; PR13;P(O)R13;P+R13R14A ;phenylene;aminoSO2;S+R13A ; acid; peptide; polypeptide; carbohydrate; polyether; or polyalkyl; wherein said phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; and polyalkyl optionally may have one or more carbons replaced NR9;N+R9R10A ;S;SO;SO2;S+R9A ;PR9; O; P+R9R10A ;P+R9R10A ;or P(O)R9; and wherein R18is selected from the group consisting of alkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl; and heterocyclylalkoxycarbonyl; and wherein the R18 alkyi; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; NO2; oxo;OR9;NR9R1 ° ;N+R9R11 R12A;SR9 ;S (O) R9 ; CO2R9;CONR9R10;SO2OM;SO2NR9R10;PR9R10;SO2R9;SO3R9; P (OR16) ORl7 ;PO (OR16) ORl7; andC (O) OM; and wherein R9, R°, R", R'2, R13, R14, R, R, R, R A, and M are as defined above; and R19 is selected from the group consisting of alkane diyl; alkene diyl; alkyne diyl; polyalkane diyl; alkoxy diyl; polyether diyl; polyalkoxy diyl; carbohydrate; amino acid; and peptide; polypeptide; wherein alkane diyl; alkene diyl; alkyne diyl; polyalkane diyl; alkoxy diyl; polyether diyl; polyalkoxy diyl; carbohydrate residue; amino acid residue; peptide residue; and polypeptide residue; can optionally have one or more carbons replaced by O; S;SO;SO2;S+R7A ;PR7;P(O)R7; NR7;N+R7R8A ; heterocyclyl;quaternaryhetercyclyl;oraryl;P+R7R8A ;phenylene; wherein alkane diyl; alkene diyl; alkyne diyl; polyalkane diyl; alkoxy diyl; polyether diyl; polyalkoxy diyl; carbohydrate residue; amino acid residue; peptide residue; and polypeptide residue can be substituted with one or more substituent groups independently selected from the group consisting of alkyl; alkenyl; alkynyl; polyalkyl; polyether; aryl; haloalkyl; cycloalkyl; heterocyclyl; arylalkyl; halogen; oxo ; OR13; NR13R14; SR13; S(O)R13; SO2R13; S03R13 ;NROR14 ;NRNRR15 ;N02 ;C02R13;CN;OM; SO2OM;C(O)OM;COR13; C(O)NR13R14; P+R13R14R15A;P(OR13)OR14;S+R13R14A;andP(O)R13R14;PR13R14; N+R9R1 lR12A; wherein R7, R8, R11, R12, R13, R14 R15, and A are as defined above; or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

122.	A compound of claim 121 wherein R', R'A, R2, and R2A are independently selected from the group consisting of hydrogen and alkyl.

123.	A compound of claim 121 wherein R', R, R2, and R2A are independently selected from the group consisting of hydrogen and CiCio alkyl.

124.	A compound of claim 121 wherein R', R1A R2, and R2A are independently selected from the group consisting of C2C7 alkyl.

125.	A compound of claim 121 wherein R', R1A, R2, and R2A are independently selected from the group consisting of C2C4 alkyl.

126.	A compound of claim 121 wherein R', R, R2, and R are independently selected from the group consisting of ethyl; npropyl; nbutyl; and isobutyl.

127.	A compound of claim 121 wherein R3, R, R4, and R4A are independently selected from the group consisting of hydrogen andOR9, wherein R9 is as defined in claim 121.

128.	A compound of claim 126 wherein R9 is hydrogen.

129.	A compound of claim 121 wherein RN and RNA are independently selected from the group consisting of hydrogen, alkyl and aralkyl.

130.	A compound of claim 121 wherein RI and RNA are independently selected from the group consisting of hydrogen, (C1C10) alkyl and aryl (CiCio) alkyl.

131.	A compound of claim 121 wherein RN and RNA are independently selected from the group consisting of hydrogen, methyl, ethyl and benzyl.

132.	A compound of claim 121 wherein one or more Rx and RXA are independently selected from the group consisting of methoxy and dimethylamino.

133.	A compound of claim 121 wherein q and r are each 1.

134.

A compound of claim 121 wherein one or more Ry are independently selected from selected from the group consisting of halogen; hydroxy;N02; (CiCio) alkyl; halo (CiCio) alkyl; aryl (C1C10) alkyl; heterocyclyl (ClCl0) alkyl; ; and wherein R, R, and R are independently selected from the group consisting of hydrogen; (C1C10) alkyl; haloCiCio) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; heterocyclyl (C,C, o) alkyl; quaternary heterocyclyl (CiCio) alkyl; (CIC, o) alkylheterocyclyl (C,C, o) alkyl; (CiCio) alkylammonium (C1C10) alkyl; and polyether; or wherein the R13, R14, and R15 (C,C, o) alkyl; halo (C1C10) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; heterocyclyl (C1 heterocyclyl(C1C10)alkyl;(C1C10)alkylheterocyclyl(C1C10)alkyl;quaternary C10) alkyl; (C,C, o) alkylammonium (C,C, o) alkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen; (C1C10) alkyl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclyl (CiCio) alkyl; carboxy; carboxy C1 NR9R10;N+R9R10RWA;andCONR9R10;andC10)alkyl;OR16; wherein R9, R and ru are independently selected from the group consisting of hydrogen; (C1C10) alkyl; heterocyclyl; ammonium (C,C, o) alkyl; (C1C10) alkylammonium (CCl0) alkyl; aryl (CiCio) alkyl; heterocyclyl (C1 Ciao) alkyl; carboxy (CiCio) alkyl; carbo (CIC, o) alkoxy (C,C, o) alkyl; carboxyheterocyclyl; carboxy (C1C10) alkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and wherein R11 areindependentlyselectedfromthegroupR12 consisting of hydrogen; (CiCio) alkyl; heterocyclyl; aryl (C,C, o) alkyl; carbo(C1C10)alkoxy(C1C10)alkyl;orcarboxy(C1C10)alkyl;and R11 and R12 together with the carbon atom to which they are attached form a cyclic ring; wherein R17areindependentlyselectedfromthegroupand consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation.

135.

A compound of claim 121 wherein R19 is selected from the group consisting of alkane diyl; polyalkane diyl; alkoxy diyl; and polyalkoxy diyl; wherein alkane diyl and polyalkane diyl can optionally have one or more carbons replaced NR7;N+R7R8A ;S;SO;SO2;S+R7A ; O; PR7 ;P (O) R7 ;P+RRgA ; or phenylene, wherein R7 and R8 are defined as in claim 121.

136.

A compound of claim 121 wherein R'9 is selected from the group consisting of alkoxy diyl and polyalkoxydiyl wherein one or more carbons are optionally replaced by O; NR7; N+R7R8A ; S; SO; SO2; S+R7A ; PR7; P(O)R7; P+R7R8A ; phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; or polyalkyl, wherein R9 and R° are defined as in claim 121.

137.	A compound of claim 121 having the structural formula:.

138.

A compound of formula (V): wherein: q is an integer from 0 to 4; r is an integer from 0 to 3; t is an integer from 0 to 4; u is an integer from 0 to 5; R1, R2, R, and R2A are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl)aryl; or R1 and R2 taken together with the carbon to which they are attached form C3Clo cycloalkyl or C3Clo cycloalkenyl; or R and R taken together with the carbon to which they are attached form C3Clo cycloalkyl or C3Clo cycloalkenyl; wherein the R1, R2, R1A, and R2A alkyl ; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polyalkyl) aryl radicals optionally may be substituted with one or more radicals selected from the group consisting of CN; halogen; P+R9R10RwA; PR9R10; S(O)R9; SO2R9; SO3R9; CO2R9; and CONR9R10; and whereintheR1 R2 R1A andR2A alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; alkoxyalkyl; alkoxyalkenyl; alkoxyalkynyl; aryloxyalkyl; aryloxyalkenyl; aryloxyalkynyl; heterocylcyloxyalkyl; heterocycloxyalkenyl; heterocyclyloxyalkynyl; alkylaryl; and (polalkyl)aryl radicals optionally may have one or more carbons replaced NR9;N+R9R10A ;S;SO; O; S02 ; S+R9A ; PR9; P(O)R9; P+R9R10A ; or phenylene ; and wherein R9, R, and RI are independently selected from the group consisting of hydrogen; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; alkylammoniumalkyl; arylalkyl; heterocyclylalkyl; carboxyalkyl; alkoxyalkyl; carboalkoxyalkyl; carboxyaryl; carboxyheterocyclyl; amino; alkylamino; carboxyalkylamino; alkoxyalkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and R3, R4, R, and R4A are independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aryl; heterocyclyl;OR9 ; NR9R10;SR9;S (O) R9 ;S02R9; and SO3R9 ; or R3 and R4 together form =O; =NOR9; or =CR1 lR12 ; R4Atogetherform=O;=NOR9;=S;=NNR9R10;=NR9;orR3Aand =CR11R12; wherein Ri 1 and R12 are independently selected from the group consisting of hydrogen;CN; halogen; oxo; alkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; carboxyalkyl; alkoxyalkyl; carboalkoxyalkyl; cycloalkyl; cycloalkenyl; haloalkyl; hydroxyalkyl; cyanoalkyl;OR9;NR9R10;SR9;S (O) R9 ;S02R9 ;S03R9 ;C02R9; and CONR9R10; or R12R11and together with the carbon atom to which they are attached form a cyclic ring; and wherein R9 and R'° are as defined above; and one or more Ry and RYA are independently selected from the group consisting of oxo; alkyl; polyalkyl; haloalkyl; hydroxyalkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; SO2R13;SO3R13;NR13OR14;NR13NR14R15;SR13;S(O)R13; C02R13;OM;S020M;S02NR1 3R1 4 ;C (o) NR13Rl 4 ;C (O) OM ; NR13C(O)NR14R15;NR13CO2R14;OC(O)R13;COR13;NR13C(O)R14; NR13SO2R14;NR13SONR14R15;OC(O)NR13R14;NR13SOR14; PR13R14;P+R13R14R15A;NR13SO2NR14R15;P(O)R13R14; andN+R13R14R15A;andP(OR13)OR14;S+R13R14A; wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ry and RyA radicals optionally may be further substituted with one or more radicals selected from the group consisting ofCN; halogen; hydroxy; oxo; alkyl; cycloalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary (o) R7 ;So2R7 ;S03R7 ;C02R7 ; P(O)R7R8;PR7R8;P+R7R8R9A;andCONR7R8;N+R7R8R9A; PCOXOROR8; and wherein the alkyl, polyalkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heterocyclyl, quaternary heterocyclyl, arylalkyl, heterocyclylalkyl, and polyether substituents of the Ry and RyA radicals optionally may have one or more carbons replaced NR7;N+R7R8A O; SO;SO2;S+R7A ;PR7;P(O)R7;P+R7R8A ;orphenylene;;S; and wherein R7 and R8 and independently selected from the group consisting of hydrogen; alkyl, alkenyl; alkynyl; aryl; and heterocyclyl; and wherein R13, R14, and R15 are independently selected from the group consisting of hydrogen; alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether; or wherein R'3 and R14 together with the nitrogen atom to which they are attached form a monoor polycyclic heterocyclyl that is optionally substituted with one or more radicals selected from the group consisting of oxo, carboxy, and quaternary salts; or wherein R14 and R15 together with the nitrogen atom to which they are attached form a cyclic ring; and wherein the R, R, and R alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; sulfo; oxo; alkyl; haloalkyl; hydroxyalkyl; sulfoalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclylalkyl; carboxy; carboxyalkyl; guanidinyl; N+R9R11R12A;SR16;S(O)R9;SO2R9;SO3R16; OR16;NR9R10; SO2NR9R10;PO(OR16)OR17;PR9R10;CO2R16;CONR9R10; P+R9R10R11A; S+R9R10 A; and carbohydrate residue; and wherein the R, R, and R alkyl; haloalkyl; cycloalkyl; polyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; quaternary heterocyclylalkyl; alkylarylalkyl; alkylheterocyclylalkyl; alkylammoniumalkyl; aminocarbonylalkyl; alkylaminocarbonylalkyl; carboxyalkylaminocarbonylalkyl; and polyether radicals optionally may have one or more carbons replaced by O; NR9; NRA ;S ;SO ;S02 ;SA ;PR9 ;PRA ;P (0)R9 ; phenylene; carbohydrate residue; amino acid residue; peptide residue; or polypeptide residue; and wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation; and wherein n is 0,1 or 2; and wherein R9, R'°, R", Rl2, Rw and Aare as defined above; and RN and RNA are independently selected from the group consisting of hydrogen; alkyl; alkenyl; alkynyl; aralkyl; and heterocyclylalkyl; and one or more Rx and RI radicals are independently selected from the group consisting of hydrogen; halogen;CN;N02; alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; acyloxy; SR13;S(O)R13;S(O)2R13;SO3R13;S+R13R14A;OR13;NR13R14; CO2R13;OM;SO2OM;SO2NR13R14;RN13OR14;NR13NR14R15; C(O)OM;COR13;OR18;S(O)nNR13R14;NR14C(O)R13;C(O)NR13R14; NR13R18; NR18OR14; P(O)R13R14; PR13R14; P+R13R14R15A; amino acid residue; peptide residue; polypeptide residue; and carbohydrate residue; wherein the Rx and RXA alkyl ; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; acyloxy radicals optionally may be further substituted with one or more radicals selected from the group consisting of halogen;CN; oxo ; OR16; NR9R10;N+R9R10RwA;SR16 ;S (O) R9 ;SO2R9 ;SO3R16 ;CO2R16 ;<BR> <BR> <BR> <BR> <BR> CONR9R1 ° ;So2NR9Rl;PO (OR'6) OR" ;PR9R10; P+R9R11R12A; S+R9R10A ; and carbohydrate residue; and wherein the Rx and RXA quaternary heterocyclyl radical optionally may be substituted with one or more radicals selected from the group consisting of oxo; alkyl; cycloalkyl; polyalkyl; haloalkyl; hydroxyalkyl; alkenyl; alkynyl; aryl; heterocyclyl; arylalkyl; heterocyclylalkyl; polyether; OR13; S(O)R13;SO2R13;SO3R13; SR13; NR13OR14; OM;SO2OM;SO2NR13R14; CO2R13; COR13;P(O)R13R14;PR13R14;C(O)NR13R14;C(O)OM; P(OR13)OR14;S+R13R14A;N+R13R14R15A;andP+R13R14R15A; carbohydrate residue; and wherein the Rx and R'radicals comprising carbon optionally may have one or more carbons replaced NR13;N+R13R14A ;S;SO;O; SO2; S+R13 P(O)R13;P+R13R14A ;phenylene;PR13; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; polyether; or polyalkyl; wherein said phenylene; amino acid residue; peptide residue; polypeptide residue; carbohydrate residue; and polyalkyl optionally may have one or more carbons replaced NR9;N+R9R10A ;S;SO;O; SO2; P+R9R10A ;orP(O)R9;andS+R9A ;PR9; wherein selectedfromthegroupconsistingofalkyl;alkenyl;is alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl; and wherein the R18 alkyi; alkenyl; alkynyl; aryl; heterocyclyl; quaternary heterocyclyl; arylalkyl; heterocyclylalkyl; acyl; alkoxycarbonyl; arylalkoxycarbonyl; and heterocyclylalkoxycarbonyl radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen;CN; NO2; oxo;OR9;NR9R1 ; N+R9R11R12A; SR9 ;S (O) R9; S02R9 ;S03R9 ;C02R9 ;CONR9R10 ;S020M ;S02NR9R10 ;PR9R10 ; P (OR16)OR17; PO(OR16)OR17 ; andC (O) OM; and wherein R9, R'°, R", R'2, R'3, R'4, R'5, R'6, R", Rw, A, and M are as defined above; and R'9 is selected from the group consisting of alkane diyl; alkene diyl; alkyne diyl; polyalkane diyl; alkoxy diyl; polyether diyl; polyalkoxy diyl; carbohydrate residue; amino acid residue; peptide residue; and polypeptide residue; wherein alkane diyl; alkene diyl; alkyne diyl; polyalkane diyl; alkoxy diyl; polyether diyl; polyalkoxy diyl; carbohydrate residue; amino acid residue; peptide residue; and polypeptide residue; can optionally have one or more byO;NR7;N+R7R8A ;S;SO;SO2;S+R7A ;carbonsreplaced PR7; P(O)R7; P+R7R8A ; phenylene; heterocyclyl; quaternary heterocyclyl; or aryl; wherein alkane diyl; alkene diyl; alkyne diyl; polyalkane diyl; alkoxy diyl; polyether diyl; polyalkoxy diyl; carbohydrate residue; amino acid residue; peptide; and polypeptide residue can be substituted with one or more substituent groups independently selected from the group consisting of alkyl; alkenyl; alkynyl; polyalkyl; polyether; aryl; haloalkyl; cycloalkyl; heterocyclyl; arylalkyl; halogen; oxo;OR13 ;NR13R14;SR13; S(O)R13; SO2R13; SO3R13; NR13OR14; NR13NR14R15; NO2; CO2R13 ;CN;OM; SO2OM;C(O)OM;COR13; C(O)NR13R14; P+R13R14R15A;P(OR13)OR14;S+R13R14A;andP(O)R13R14;PR13R14; N+R13R14R15A; wherein R7, R8, R", R'2, R'3, R'a R'5, and Aare as defined above; or a pharmaceutically acceptable salt, solvate, or prodrug thereof.

139.	A compound of claim 138 wherein R', R'A, R2, and R2A are independently selected from the group consisting of hydrogen and alkyl.

140.	A compound of claim 138 wherein R', R'A, R2, and R are independently selected from the group consisting of hydrogen and ClC,, alkyl.

141.	A compound of claim 138 wherein R', R'A, R2, and R2A are independently selected from the group consisting of C2C7 alkyl.

142.	A compound of claim 138 wherein R', R R, andR2A are independently selected from the group consisting of C2C4 alkyl.

143.	A compound of claim 138 wherein R', R'A, R2, and R2A are independently selected from the group consisting of ethyl; npropyl; nbutyl; and isobutyl.

144.	A compound of claim 138 wherein R3, R R4, and R4^ are independently selected from the group consisting of hydrogen andOR9, wherein R9 is as defined in claim 138.

145.	A compound of claim 144 wherein R9 is hydrogen.

146.	A compound of claim 138 wherein RN and RNA are independently selected from the group consisting of hydrogen, alkyl and aralkyl.

147.	A compound of claim 138 wherein RN and RNA are independently selected from the group consisting of hydrogen, (CiCio) alkyl and aryl (CiCio) alkyl.

148.	A compound of claim 138 wherein RN and Rua are independently selected from the group consisting of hydrogen, methyl, ethyl and benzyl.

149.	A compound of claim 138 wherein one or more RX and RXA are independently selected from the group consisting of methoxy and dimethylamino.

150.	A compound of claim 138 wherein q and r are each 1.

151.

A compound of claim 138 wherein one or more Ry are independently selected from selected from the group consisting of halogen; hydroxy;N02; (C,C, O) alkyl; halo (C,C, o) alkyl; aryl (C,C, o) alkyl; OR13;NR13R14;andNR13C(O)R14;heterocyclyl(C1C10)alkyl;polyether; and wherein R, R, and R are independently selected from the group consisting of hydrogen; (CiC, o) alkyl; halo (CiCio) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (CiCio) alkyl; heterocyclyl (C,C, o) alkyl; quaternary heterocyclyl (C,C, o) alkyl; (C,C, o) alkylheterocyclyl (C1C10)alkyl ; (C1C10)alkylammonium(C1C10) alkyl; and polyether; or wherein the R13, R14, and R15 (C,C, o) alkyl; halo (C,C, o) alkyl; heterocyclyl; quaternary heterocyclyl; aryl (C,CIO) alkyl; heterocyclyl (C1 heterocyclyl(C1C10)alkyl;(C1C10)alkylheterocyclyl(C1C10)alkyl;quaternary C10) alkyl; (CiCio) alkylammonium (CiCio) alkyl; and polyether radicals optionally may be substituted with one or more radicals selected from the group consisting of halogen; (CiCio) alkyl; heterocyclyl; quaternary heterocyclyl; quaternary heterocyclyl (C1C10) alkyl; carboxy; carboxy (C1 NR9R10;N+R9R10RwA;andCONR9R10;andC10)alkyl;OR16; wherein R10and are independently selected from the group consisting of hydrogen; (CiCio) alkyl; heterocyclyl; ammonium (CiCio) alkyl; heterocyclyl(C1(C1C10)alkylammonium(C1C10)alkyl;aryl(C1C10)alkyl; C10) alkyl; carboxy (C,C, o) alkyl; carbo (C,C, o) alkoxy (CIC, o) alkyl; carboxyheterocyclyl; carboxy (CiCio) alkylamino; and acyl; and wherein Ais a pharmaceutically acceptable anion; and wherein R12areindependentlyselectedfromthegroupand consisting of hydrogen; (CiCio) alkyl; heterocyclyl; aryl (CiCio) alkyl; carbo(C1C10)alkoxy(C1C10)alkyl;orcarboxy(C1C10)alkyl;and R11togetherwiththecarbonatomtowhichtheyareattachedR12 form a cyclic ring; wherein R16 and R17 are independently selected from the group consisting ofR9 and M; and wherein M is a pharmaceutically acceptable cation.

152.

A compound of claim 138 wherein R'9 is selected from the group consisting of alkane diyl; polyalkane diyl; alkoxy diyl; and polyalkoxy diyl; wherein alkane diyl and polyalkane diyl can optionally have one or more carbons replaced NR7;N+R7R8A ;S;SO;SO2;S+R7A ; O; PR7; P(O)R7; P+R7R8A ; or phenylene, wherein R7 and R8 are defined as in claim 138.

153.

A compound of claim 138 wherein R'9 is selected from the group consisting of alkoxy diyl and polyalkoxydiyl wherein one or more carbons are optionally replaced byO;NR7;N R7R8A ;S;SO;SO2; S+R7A ; PR7; P(O)R7; P+R7R8A ; phenylene; amino acid; peptide; polypeptide; carbohydrate; or polyalkyl, wherein R9 and R10 are defined as in claim 138.

154.	A compound of claim 138 having the formula:.

155.	A pharmaceutical composition comprising an anti hyperlipidemic effective amount of a compound of formula (I) of claim 1; and a pharmaceutically acceptable carrier.

156.	A pharmaceutical composition comprising an anti atherosclerotic effective amount of a compound of formula (I) of claim 1; and a pharmaceutically acceptable carrier.

157.	A pharmaceutical composition comprising an anti hypercholesterolemia effective amount of a compound of formula (I) of claim 1; and a pharmaceutically acceptable carrier.

158.	A pharmaceutical composition comprising an anti hyperlipidemic effective amount of a compound of formula (I) of claim 2; and a pharmaceutically acceptable carrier.

159.	A pharmaceutical composition comprising an anti atherosclerotic effective amount of a compound of formula (I) of claim 2; and a pharmaceutically acceptable carrier.

160.	A pharmaceutical composition comprising an anti hypercholesterolemia effective amount of a compound of formula (I) of claim 2; and a pharmaceutically acceptable carrier.

161.	A method for the prophylaxis or treatment of a hyperlipidemic condition comprising administering to a patient in need thereof a composition of claim 155 in unit dosage form.

162.	A method for the prophylaxis or treatment of an atherosclerotic condition comprising administering to a patient in need thereof a composition of claim 156 in unit dosage form.

163.	A method for the prophylaxis or treatment of hypercholesterolemia comprising administering to a patient in need thereof a composition of claim 157 in unit dosage form.

164.	A method for the prophylaxis or treatment of a hyperlipidemic condition comprising administering to a patient in need thereof a composition of claim 158 in unit dosage form.

165.	A method for the prophylaxis or treatment of an atherosclerotic condition comprising administering to a patient in need thereof a composition of claim 159 in unit dosage form.

166.	A method for the prophylaxis or treatment of hypercholesterolemia comprising administering to a patient in need thereof a composition of claim 160 in unit dosage form.