Title:
1H-PYRAZOL-4-AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/042613
Kind Code:
A1
Abstract:
Disclosed are a 1H-pyrazol-4-amide derivative having a structure as represented by formula (I), a preparation method therefor, a pharmaceutical composition containing same, the use thereof as an inhibitor for FGFR and a mutation thereof, the use thereof in the preparation of a drug for treating and/or preventing at least part of FGFR kinase mediated tumors or cancers and a drug for tumor patients having tolerance to FGFR inhibitors, and the use thereof in the preparation of a drug for tumor patients having mutations in V561, V565, N550, N540, V555, E566, K660, and/or V550 of an FGFR signaling pathway.
Inventors:
DENG HAIBING (CN)
SHI YAQIONG (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
SHI YAQIONG (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
Application Number:
PCT/CN2021/114581
Publication Date:
March 03, 2022
Filing Date:
August 25, 2021
Export Citation:
Assignee:
ABBISKO THERAPEUTICS CO LTD (CN)
International Classes:
C07D471/04; A61K31/423; A61K31/428; A61K31/4353; A61K31/437; A61P35/00; C07D401/14; C07D413/14; C07D417/14
Foreign References:
| CN102369186A | 2012-03-07 | |||
| CN101421281A | 2009-04-29 | |||
| CN101622245A | 2010-01-06 |
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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