Title:
DIHYDROPYRROLO[2,3-D]PYRIDAZIN-7-ONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/042612
Kind Code:
A1
Abstract:
A dihydropyrrolo[2,3-d]pyridazin-7-one derivative having the structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, as well as a use thereof as an FGFR and mutation inhibitor, and a use thereof in the preparation of a drug for treating and/or preventing a tumor or cancer at least partly mediated by an FGFR kinase and a tumor in a patient having resistance to an FGFR inhibitor, and especially in the preparation of a drug for treating and/or preventing a tumor in a patient having a mutation in V561, V565, N550, N540, V555, E566, K660, and/or V550 on an FGFR signaling pathway. The substituents in formula (I) have the same definitions as those in the description.
Inventors:
DENG HAIBING (CN)
XIN WENQUN (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
XIN WENQUN (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
Application Number:
PCT/CN2021/114580
Publication Date:
March 03, 2022
Filing Date:
August 25, 2021
Export Citation:
Assignee:
ABBISKO THERAPEUTICS CO LTD (CN)
International Classes:
C07D487/04; A61K31/50; A61K31/519; A61P35/00
Domestic Patent References:
| WO2015178955A1 | 2015-11-26 |
Foreign References:
| CN106573001A | 2017-04-19 | |||
| CN109476666A | 2019-03-15 |
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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