Title:
2-(2,2-DIARYLETHYL)-CYCLIC AMINE DERIVATIVE OR SALT, SYNTHESIS THEREOF, AND APPLICATION AND COMPOSITION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/196898
Kind Code:
A1
Abstract:
Provided in the present invention are a 2-(2,2-diarylethyl)-cyclic amine derivative or salt, the synthesis thereof, and an application and composition thereof. Biological activity tests show that the 2-(2,2-diarylethyl)-cyclic amine derivative has a good M receptor antagonistic activity; the derivative may be used as a pharmaceutically active ingredient for the treatment of diseases mediated or regulated by muscarinic receptors, comprising asthma, chronic obstructive pulmonary disease (COPD), overactive bladder (OAB), bronchial spasms associated with COPD, visceral fistula, irritable bowel syndrome, Parkinson's disease, depression or anxiety, schizophrenia, related mental illness and so on.
Inventors:
LIANG XINMIAO (CN)
ZHAO YAOPENG (CN)
LIU YANFANG (CN)
WANG JIXIA (CN)
WANG CHANGJIAN (CN)
WANG ZHIWEI (CN)
DU NANA (CN)
ZHANG XIULI (CN)
GUO ZHIMOU (CN)
WANG CHAORAN (CN)
ZHAO YAOPENG (CN)
LIU YANFANG (CN)
WANG JIXIA (CN)
WANG CHANGJIAN (CN)
WANG ZHIWEI (CN)
DU NANA (CN)
ZHANG XIULI (CN)
GUO ZHIMOU (CN)
WANG CHAORAN (CN)
Application Number:
PCT/CN2019/082224
Publication Date:
October 17, 2019
Filing Date:
April 11, 2019
Export Citation:
Assignee:
DALIAN INST CHEM & PHYSICS CAS (CN)
International Classes:
C07D211/14; A61K31/40; A61K31/445; A61K31/4535; A61P11/06; A61P13/10; A61P25/16; A61P25/18; A61P25/22; A61P25/24; C07D207/08; C07D307/52
Domestic Patent References:
| WO2004091607A1 | 2004-10-28 | |||
| WO2003035599A1 | 2003-05-01 | |||
| WO1993016044A1 | 1993-08-19 | |||
| WO1997045423A1 | 1997-12-04 |
Foreign References:
| US2769812A | 1956-11-06 | |||
| US3252982A | 1966-05-24 | |||
| CN107129453A | 2017-09-05 |
Attorney, Agent or Firm:
SHENYANG PATENT & TRADEMARK AGENCY ACADEMIA SINICA (CN)
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