Title:
2-AMINOARYLOXAZOLE COMPOUNDS AS TYROSINE KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005040139
Kind Code:
A3
Abstract:
The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors.
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Inventors:
MOUSSY ALAIN (FR)
WERMUTH CAMILLE (FR)
GRIERSON DAVID (FR)
BENJAHAD ABDELLAH (FR)
CROISY MARTINE (FR)
CIUFOLINI MARCO (FR)
GIETHLEN BRUNO (FR)
WERMUTH CAMILLE (FR)
GRIERSON DAVID (FR)
BENJAHAD ABDELLAH (FR)
CROISY MARTINE (FR)
CIUFOLINI MARCO (FR)
GIETHLEN BRUNO (FR)
Application Number:
PCT/IB2004/003698
Publication Date:
October 13, 2005
Filing Date:
October 22, 2004
Export Citation:
Assignee:
AB SCIENCE (FR)
CENTRE NAT RECH SCIENT (FR)
INST CURIE (FR)
MOUSSY ALAIN (FR)
WERMUTH CAMILLE (FR)
GRIERSON DAVID (FR)
BENJAHAD ABDELLAH (FR)
CROISY MARTINE (FR)
CIUFOLINI MARCO (FR)
GIETHLEN BRUNO (FR)
CENTRE NAT RECH SCIENT (FR)
INST CURIE (FR)
MOUSSY ALAIN (FR)
WERMUTH CAMILLE (FR)
GRIERSON DAVID (FR)
BENJAHAD ABDELLAH (FR)
CROISY MARTINE (FR)
CIUFOLINI MARCO (FR)
GIETHLEN BRUNO (FR)
International Classes:
C07D413/04; C07D413/14; C07D263/48; (IPC1-7): A61K31/422; A61K31/42; C07D263/48; C07D413/04; C07D413/14; A61P37/00; A61P35/00; A61P29/00
Domestic Patent References:
| WO2005000298A2 | 2005-01-06 | |||
| WO2004032882A2 | 2004-04-22 | |||
| WO2004001059A2 | 2003-12-31 | |||
| WO2002045652A2 | 2002-06-13 |
Foreign References:
| EP0949242A1 | 1999-10-13 | |||
| US5000775A | 1991-03-19 | |||
| EP0254259A2 | 1988-01-27 |
Other References:
MURALI DHAR T. G. ET AL.: "A modified approach to 2-(N-Aryl)-1,3-oxazoles", ORGANIC LETTERS, vol. 4, no. 12, 2002, pages 2091 - 2093, XP002333344
NATH ET AL.: "Synthesis and mercuration of some new 2-arylamino-4,5-disubstituted oxazoles as pesticides", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 20(B), no. 9, 1981, pages 827 - 829, XP009049725
RAO ET AL.: "Synthesis and fungitoxicity of substituted pyrazolyloxazole", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 58, no. 9, 1981, pages 925 - 926, XP009049726
NATH ET AL.: "Synthesis and mercuration of some new 2-arylamino-4,5-disubstituted oxazoles as pesticides", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, vol. 20(B), no. 9, 1981, pages 827 - 829, XP009049725
RAO ET AL.: "Synthesis and fungitoxicity of substituted pyrazolyloxazole", JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 58, no. 9, 1981, pages 925 - 926, XP009049726
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