2-AMINOPYRIDINE DERIVATIVE - ASTELLAS PHARMA INC

Title:

2-AMINOPYRIDINE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2005/100341

Kind Code:

A1

Abstract:

A compound useful a remedy or a preventive for inflammatory diseases or autoimmune diseases in which IKK2 participate. Namely, a 2-aminopyridine derivative characterized by having a 2-hydroxyphenyl group at the 6-position and a saturated cyclic group containing a nitrogen atom such as piperidine at the 4-position. Because of having an excellent antiinflammatory effect based on an IKK2 inhibitory effect, the above compound or a medicinal composition thereof is useful as a remedy or a preventive for inflammatory diseases or autoimmune diseases, in particular, rheumatoid arthritis.

Inventors:

OKAMOTO YOSHINORI (JP)
KUBOTA HIROKAZU (JP)
SATO IPPEI (JP)
HATTORI KAZUYUKI (JP)
KANAYAMA TAKATOSHI (JP)
YOKOYAMA KAZUHIRO (JP)
TERAI YOSHIYA (JP)
TAKEUCHI MASAHIRO (JP)

Application Number:

PCT/JP2005/007178

Publication Date:

October 27, 2005

Filing Date:

April 13, 2005

Export Citation:

Click for automatic bibliography generation Help

Assignee:

ASTELLAS PHARMA INC (JP)
OKAMOTO YOSHINORI (JP)
KUBOTA HIROKAZU (JP)
SATO IPPEI (JP)
HATTORI KAZUYUKI (JP)
KANAYAMA TAKATOSHI (JP)
YOKOYAMA KAZUHIRO (JP)
TERAI YOSHIYA (JP)
TAKEUCHI MASAHIRO (JP)

International Classes:

A61K31/506; A61K31/55; A61P29/00; A61P35/00; A61P37/06; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D413/04; C07D413/14; (IPC1-7): C07D401/04; A61K31/506; A61K31/55; A61P29/00; A61P35/00; A61P37/06; C07D401/14; C07D403/04; C07D413/14

Domestic Patent References:

WO2002002539A1	2002-01-10
WO1996032384A1	1996-10-17
WO2002096867A2	2002-12-05
WO1994026733A1	1994-11-24
WO2002044153A1	2002-06-06
WO2002024679A1	2002-03-28
WO2005014556A1	2005-02-17
WO2004080979A1	2004-09-23

Foreign References:

JP2003095951A	2003-04-03
JP2001139560A	2001-05-22

Other References: