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Title:
2-PYRIDONE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/143574
Kind Code:
A1
Abstract:
The present invention provides a 2-pyridone derivative having a structure represented by formula I, or a stereoisomer or pharmaceutically acceptable salt thereof. Activity experiment results show that the 2-pyridone derivative provided in the present invention has higher activity and selectivity, and can be used to treat thyroid hormone receptor-related diseases.

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Inventors:
LV HEJUN (CN)
WANG PENG (CN)
GUO FEI (CN)
CHEN SHAOQING (CN)
LIU JUNFENG (CN)
Application Number:
PCT/CN2021/141829
Publication Date:
July 07, 2022
Filing Date:
December 28, 2021
Export Citation:
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Assignee:
KPC PHARMACEUTICALS INC (CN)
SHANGHAI KUNHENG PHARMA TECH CO LTD (CN)
International Classes:
C07D401/12; A61K31/53; A61P3/04; A61P5/14; A61P9/06; C07D213/69; C07D401/10
Domestic Patent References:
WO2021057791A12021-04-01
WO2021143706A12021-07-22
WO2021121210A12021-06-24
WO2020169069A12020-08-27
WO2007009913A12007-01-25
WO2010122980A12010-10-28
WO2009037172A12009-03-26
WO2020073974A12020-04-16
WO2019240938A12019-12-19
WO2020169069A12020-08-27
Foreign References:
CN113698388A2021-11-26
CN101228135A2008-07-23
CN101801960A2010-08-11
CN110938094A2020-03-31
CN111320609A2020-06-23
Other References:
PHYSIOLOGICAL REVIEWS, vol. 81, no. 3, 2001, pages 1097 - 1126
ENDOCRINE REVIEWS, vol. 14, 1993, pages 348 - 399
DRUGS, vol. 77, 2017, pages 1613 - 1621
AGRICULTURAL AND BIOL. CHEM., vol. 38, no. 6, 1974, pages 1169
J. MED. CHEM., vol. 32, 1989, pages 320
J. MED. CHEM., vol. 57, no. 10, 2014, pages 3912
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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