2,3-DIHYDRO-1H-QUINOLIN-4-ONE OXIME DERIVATIVE AND INHIBITORS OF THE INDUCTION OF HEAT SHOCK PROTEIN EXPRESSION

Title:

2,3-DIHYDRO-1H-QUINOLIN-4-ONE OXIME DERIVATIVE AND INHIBITORS OF THE INDUCTION OF HEAT SHOCK PROTEIN EXPRESSION

Document Type and Number:

WIPO Patent Application WO/2003/051844

Kind Code:

A1

Abstract:

It is intended to provide a 2,3-dihydro-1H-quinolin-4-one oxime derivative, which is useful because of having an activity of inhibiting the induction of the expression of heat shock proteins (in particular, HSP70), and its salt, and inhibitors of the induction of heat shock protein expression and preventives/remedies for cancer or inflammatory diseases containing the same.

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Inventors:

MATSUMOTO SHUJI (JP)
KATO YUTAKA (JP)
HAZE KYOSUKE (JP)

Application Number:

PCT/JP2002/013076

Publication Date:

June 26, 2003

Filing Date:

December 13, 2002

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Assignee:

HSP RES INST INC (JP)
MOCHIDA PHARM CO LTD (JP)
MATSUMOTO SHUJI (JP)
KATO YUTAKA (JP)
HAZE KYOSUKE (JP)

International Classes:

A61K31/47; A61K31/4741; A61P29/00; A61P35/00; A61P43/00; C07D215/42; C07D491/056; (IPC1-7): C07D215/42; A61K31/47; A61K31/4741; A61P29/00; A61P35/00; A61P43/00; C07D491/056

Foreign References:

JPS55122719A

1980-09-20

Other References:

HATASHI EISAKU ET AL.: "Antitumor activity of eighty-four synthesized N-heteroaromatic compounds", YAKUGAKU ZASSHI, vol. 97, no. 9, 1977, pages 1022 - 1033, XP002966370

Attorney, Agent or Firm:

Watanabe, Mochitoshi (12-5 Iwamoto-cho 2-chom, Chiyoda-ku Tokyo, JP)

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