Title:
COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE
Document Type and Number:
WIPO Patent Application WO2003051842
Kind Code:
A3
Abstract:
Carbamates and related compounds of formula R1R2NCO-Y or R1R2NCS-Y wherein R1 and R2 may form a ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasma level of free fatty acids, glycerol, LDL-cholesterol, HDL-cholesterol, insulin and/or glucose; and or modulate intracellular triacylglycerol and cholesterol stores, intracellular level of fatty acids, fatty acid esters such as diacylglycerols, phosphatidic acids, long chain acyl-CoA's as well as citrate or malonyl-CoA; and or increase insulin sensitivity; and or modulate insulin secretion from pancreatic beta cells. More particularly said disorders are selected from the group consisting of insulin resistance, diabetes type 1, hyperglycemia, dislipidemia, obesity, abnormalities of lipoprotein metabolism and any combinations thereof.
Inventors:
EBDRUP SOEREN
HANSEN HOLGER CLAUS
VEDSOE PER
CORNELIS DE JONG JOHANNES
JACOBSEN POUL
HANSEN HOLGER CLAUS
VEDSOE PER
CORNELIS DE JONG JOHANNES
JACOBSEN POUL
Application Number:
PCT/DK2002/000853
Publication Date:
June 03, 2004
Filing Date:
December 13, 2002
Export Citation:
Assignee:
NOVO NORDISK AS (DK)
International Classes:
A61K31/16; A61K31/27; A61K31/275; A61K31/341; A61K31/343; A61K31/352; A61K31/37; A61K31/381; A61K31/40; A61K31/401; A61K31/4015; A61K31/4035; A61K31/4045; A61K31/407; A61K31/41; C07D249/08; A61K31/415; A61K31/4155; A61K31/4164; A61K31/4184; A61K31/4192; A61K31/4196; A61K31/423; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/444; A61K31/445; A61K31/451; A61K31/4545; A61K31/455; A61K31/465; A61K31/47; A61K31/4709; A61K31/472; A61K31/4725; A61K31/473; A61K31/495; A61K31/496; A61K31/498; A61K31/4995; A61K31/50; A61K31/505; A61K31/5375; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61K31/63; A61K45/00; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P17/06; A61P21/04; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P43/00; C07C39/367; C07C233/25; C07C233/26; C07C233/60; C07C269/00; C07C271/58; C07C275/34; C07C303/34; C07C303/38; C07C307/06; C07C311/04; C07C311/17; C07C311/21; C07C311/29; C07C311/40; C07C317/22; C07C323/20; C07D207/325; C07D207/36; C07D207/40; C07D207/404; C07D209/08; C07D209/32; C07D209/48; C07D211/40; C07D211/88; C07D213/61; C07D213/63; C07D213/64; C07D213/643; C07D213/65; C07D213/68; C07D213/69; C07D213/70; C07D213/74; C07D213/75; C07D213/82; C07D213/84; C07D215/14; C07D215/20; C07D215/22; C07D217/06; C07D217/24; C07D221/14; C07D231/12; C07D231/14; C07D231/16; C07D231/18; C07D233/54; C07D233/60; C07D233/70; C07D233/84; C07D235/18; C07D235/26; C07D237/14; C07D239/22; C07D239/34; C07D239/38; C07D241/18; C07D241/44; C07D249/04; C07D249/12; C07D249/18; C07D253/04; C07D257/04; C07D261/12; C07D261/20; C07D263/52; C07D277/20; C07D277/24; C07D277/34; C07D277/68; C07D285/00; C07D285/01; C07D295/18; C07D295/20; C07D295/205; C07D295/26; C07D307/16; C07D307/28; C07D307/52; C07D307/89; C07D311/16; C07D311/18; C07D333/16; C07D333/32; C07D333/34; C07D333/40; C07D401/04; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D413/12; C07D417/12; C07D471/04; C07D471/06; C07D487/08; C07D487/18; C07D491/10; C07D513/04; C07D521/00; (IPC1-7): A61K31/325; A61K31/4196; A61K31/4192; A61K31/415; A61K31/352; A61K31/4035; A61K31/40; A61K31/404; A61K31/423; A61K31/42; A61K31/428; A61K31/44; A61K31/495; A61K31/505; A61K31/41
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SCHMIDT F ET AL: "Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (adept): a phenol nitrogen mustard carbamate", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 8, 22 April 1997 (1997-04-22), pages 1071 - 1076, XP004136187, ISSN: 0960-894X
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