Title:
2,7-SUBSTITUTED PYRROLO[2,1-F][1,2,4]TRIAZINE COMPOUND HAVING PROTEIN KINASE INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2023/140629
Kind Code:
A1
Abstract:
The present invention relates to a 2,7-substituted pyrrolo[2,1-f][1,2,4]triazine compound having protein kinase inhibitory activity, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing, alleviating or treating diseases caused by abnormal cell growth, containing the compound as an active ingredient. The novel 2,7-substituted pyrrolo[2,1-f][1,2,4]triazine cyclic compound of the present invention exhibits excellent inhibitory activity against various protein kinases involved in growth factor signal transduction, and thus is useful as an agent for preventing, alleviating or treating abnormal cell growth diseases caused by these protein kinases.
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Inventors:
SONG YOUNG KYU (KR)
SHIM YOUNG KEY (KR)
LEE TAE HEON (KR)
SONG HYEON HO (KR)
KIM HYE JEONG (KR)
KIM SEONG U (KR)
SHIM YOUNG KEY (KR)
LEE TAE HEON (KR)
SONG HYEON HO (KR)
KIM HYE JEONG (KR)
KIM SEONG U (KR)
Application Number:
PCT/KR2023/000902
Publication Date:
July 27, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
DR I&B CO LTD (KR)
International Classes:
A61K49/00; A61K9/51; A61K41/00; A61K49/18; A61K49/22
Domestic Patent References:
| WO2019074962A1 | 2019-04-18 | |||
| WO2020083404A1 | 2020-04-30 |
Foreign References:
| CN105130992A | 2015-12-09 |
Other References:
GREGORY R. OTT, WELLS GREGORY J., THIEU THO V., QUAIL MATTHEW R., LISKO JOSEPH G., MESAROS EUGEN F., GINGRICH DIANE E., GHOSE ARUP: "2,7-Disubstituted-pyrrolo[2,1- f ][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 54, no. 18, 22 September 2011 (2011-09-22), US , pages 6328 - 6341, XP055251510, ISSN: 0022-2623, DOI: 10.1021/jm200758k
KE ZHIPENG; LU TAO; LIU HAICHUN; YUAN HAOLIANG; RAN TING; ZHANG YANMIN; YAO SIHUI; XIONG XIAO; XU JINXING; XU ANYANG; CHEN YADONG: "3D-QSAR and molecular fragment replacement study on diaminopyrimidine and pyrrolotriazine ALK inhibitors", JOURNAL OF MOLECULAR STRUCTURE, ELSEVIER AMSTERDAM, NL, vol. 1067, 1 January 1900 (1900-01-01), NL , pages 127 - 137, XP028647307, ISSN: 0022-2860, DOI: 10.1016/j.molstruc.2014.03.036
KE ZHIPENG; LU TAO; LIU HAICHUN; YUAN HAOLIANG; RAN TING; ZHANG YANMIN; YAO SIHUI; XIONG XIAO; XU JINXING; XU ANYANG; CHEN YADONG: "3D-QSAR and molecular fragment replacement study on diaminopyrimidine and pyrrolotriazine ALK inhibitors", JOURNAL OF MOLECULAR STRUCTURE, ELSEVIER AMSTERDAM, NL, vol. 1067, 1 January 1900 (1900-01-01), NL , pages 127 - 137, XP028647307, ISSN: 0022-2860, DOI: 10.1016/j.molstruc.2014.03.036
Attorney, Agent or Firm:
HALLA PATENT & LAW FIRM (KR)
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