Title:
2H-BENZOTRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2024/060912
Kind Code:
A1
Abstract:
The present invention provides a 2H-benzotriazole derivative, a preparation method therefor, and a pharmaceutical composition containing same, belongs to the technical field of medicines, and particularly relates to a 2H-benzotriazole derivative represented by formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing same, and use thereof in the preparation of a medicament for treating and/or preventing premature ejaculation. By means of in-vivo activity test research, the 2H-benzotriazole derivative of the present invention has a remarkable anti-premature ejaculation effect; and compared with an existing clinical medicament dapoxetine which is uniquely approved to be sold in the market, the effect of the 2H-benzotriazole derivative is significantly higher than that of the medicament dapoxetine which is sold, and the 2H-benzotriazole derivative has remarkable treatment characteristics and substantive technical progress. The 2H-benzotriazole derivative of the present invention or the pharmaceutically acceptable salt thereof has a wide research and application prospect in the aspect of serving as a medicament for treating premature ejaculation.
Inventors:
WANG PENG (CN)
ZHAO YUQING (CN)
ZHOU YAN (CN)
ZHANG LIRONG (CN)
ZHOU JIE (CN)
ZHOU XIN (CN)
ZHAO YUQING (CN)
ZHOU YAN (CN)
ZHANG LIRONG (CN)
ZHOU JIE (CN)
ZHOU XIN (CN)
Application Number:
PCT/CN2023/114340
Publication Date:
March 28, 2024
Filing Date:
August 23, 2023
Export Citation:
Assignee:
ORXES THERAPEUTICS CO LTD (CN)
International Classes:
C07D417/12; A61K31/496; A61P15/10; C07D413/12
Foreign References:
| CN115304590A | 2022-11-08 | |||
| CN115304593A | 2022-11-08 | |||
| CN115381827A | 2022-11-25 | |||
| CN1177297A | 1998-03-25 | |||
| CN105859606A | 2016-08-17 | |||
| JPH0733744A | 1995-02-03 | |||
| GB2435827A | 2007-09-12 |
Other References:
WANG, GUAN; ZHANG, GUI-SEN; GUO, LIN; YU, LEI-PING; LI, JIAN-QI: "Synthesis and Biological Activities of N-Indolalkyl Piperidine Derivatives and their Analogues", CHINESE JOURNAL OF MEDICINAL CHEMISTRY, GAI-KAI BIANJIBU, CN, vol. 19, no. 3, 30 June 2009 (2009-06-30), CN , pages 161 - 169, XP009553914, ISSN: 1005-0108
Attorney, Agent or Firm:
SHENYANG DONGDA INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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