3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES

Title:

3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES

Document Type and Number:

WIPO Patent Application WO2006004589

Kind Code:

A3

Abstract:

The present invention provides compounds of Formula (I) or (II) salt form or prodrug thereof, wherein variables are defined herein, that are modulators of metalloproteases such as matrix metalloproteases (MMPs) and ADAMs. The compounds or compositions described herein can be used to treat diseases associated with metalloprotease activity including, for example, arthritis, cancer, cardiovascular disorders, skin disorders, inflammation or allergic conditions.

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Inventors:

YOON TAEYOUNG (US)
YUAN JUN (US)
LEE KYUNGAE (US)
MAYNARD GEORGE D (US)
LIU NIAN (US)

Application Number:

PCT/US2005/016139

Publication Date:

April 06, 2006

Filing Date:

May 06, 2005

Export Citation:

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Assignee:

NEUROGEN CORP (US)
YOON TAEYOUNG (US)
YUAN JUN (US)
LEE KYUNGAE (US)
MAYNARD GEORGE D (US)
LIU NIAN (US)

International Classes:

(IPC1-7): C07D403/04; C07D403/14; C07D405/04; C07D405/14; A61K31/501; A61K31/502; A61K31/5377; A61K31/55

Foreign References:

US3753988A

1973-08-21

Other References:

GUERY S. ET AL: "Synthesis of 4-aryl-1-(4-methylpiperazin-1-yl)phtahalazines by Suzuki-type cross-coupling reaction", SYNTHESIS, vol. 5, 2001, pages 699 - 701, XP002995529

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