Title:
3-FURYL-2-CYANO-2-ACRYLAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/081822
Kind Code:
A1
Abstract:
Disclosed are a 3-furyl-2-cyano-2-acrylamide derivative with epidermal growth factor receptor (EGFR) inhibitory activity and pharmaceutical acceptable salt thereof, together with preparation method therefor, pharmaceutical composition comprising the compound, and application of the compound in treating senile dementia (AD). The new compound is shown as formula Ⅰ, wherein R1 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl and C3-C6 cycloalkyl; R2 is selected from the group consisting of alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, alkaryl, aralkyl and heteroaralkyl; X is selected from the group consisting of CH2、NH、O and S; m and n are all integers greater than or equal to zero.
Inventors:
FENG ZEWANG (CN)
JIA JIANHUAN (CN)
LIU YAN (CN)
WANG ZHENGUO (CN)
ZHAO XUAN (CN)
JIA JIANHUAN (CN)
LIU YAN (CN)
WANG ZHENGUO (CN)
ZHAO XUAN (CN)
Application Number:
PCT/CN2014/092647
Publication Date:
June 11, 2015
Filing Date:
December 01, 2014
Export Citation:
Assignee:
JENKEM TECHNOLOGY CO LTD BEIJING (CN)
International Classes:
C07D307/54; A61K31/341; A61K31/4045; A61P25/28; C07D307/46; C07D405/12
Domestic Patent References:
| WO2012103282A2 | 2012-08-02 | |||
| WO2012103282A2 | 2012-08-02 | |||
| WO2012103282A2 | 2012-08-02 |
Other References:
TARLETON MARK ET AL.: "Focused Library Development of 2-phenylacrylamides as Broad Spectrum Cytotoxic Agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 23 October 2013 (2013-10-23), pages 333 - 347, XP028961401
Attorney, Agent or Firm:
SBZL IP LAW OFFICE (CN)
北京商专永信知识产权代理事务所（普通合伙） (CN)
北京商专永信知识产权代理事务所（普通合伙） (CN)
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