Title:
32624 A NOVEL HUMAN UDP-GLUCURONOSYL AND GLYCOSYL TRANSFERASE FAMILY MEMBER AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002026834
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acids molecules, designated 32624 nucleic acid molecules, which encode novel UDP-glucuronosyl and plycosyl transferase members. The invention also provides antisense nucleic acids molecules, recombinant expression vectors containing 32624 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 32624 gene has been introduced or disrupted. The invention still further provides isolated 32624 proteins, fusion proteins, antigenic peptides and anti-32624 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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Inventors:
LEIBY KEVIN R (US)
Application Number:
PCT/US2001/029963
Publication Date:
January 23, 2003
Filing Date:
September 25, 2001
Export Citation:
Assignee:
MILLENNIUM PHARM INC (US)
LEIBY KEVIN R (US)
LEIBY KEVIN R (US)
International Classes:
C12N9/10; C12N15/12; C12Q1/68; C12Q1/6883; (IPC1-7): C12N9/10; A61K38/45; C07K16/18; C12N5/10; C12N15/12; C12N15/63; G01N33/48; G01N33/50
Domestic Patent References:
| WO2001068848A2 | 2001-09-20 | |||
| WO2001079468A2 | 2001-10-25 | |||
| WO2002018554A2 | 2002-03-07 |
Other References:
DATABASE EMBL [online] 16 January 2000 (2000-01-16), SULSTON J.E. AND WATERSTON R.: "Toward a complete human genome sequence", XP002209401, Database accession no. AC021146
DATABASE EMBL [online] 1 March 2002 (2002-03-01), BAKER K.P. ET AL.: "Secreted and transmembrane polypeptides and nucleic acids encoding the same.", XP002209402, Database accession no. AX376455
DATABASE EMBL [online] 18 December 2001 (2001-12-18), BAKER K.P. ET AL.: "Novel nucleic acids encoding PRO polypeptides.", XP002209404, Database accession no. AAU29284
DATABASE EMBL [online] 7 January 2002 (2002-01-07), POLICKY J.L. ET AL.: "Drug metabolizing enzymes", XP002209405, Database accession no. AX327326
DATABASE EMBL [online] 18 May 2002 (2002-05-18), WEI M.H. ET AL.: "Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof.", XP002209408, Database accession no. AX395164
DATABASE EMBL [online] 7 March 2002 (2002-03-07), WEI M. ET AL.: "Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof.", XP002209410, Database accession no. AX395165
DATABASE EMBL [online] 17 May 2002 (2002-05-17), WEI M. ET AL.: "Isolated drug-metabolizing proteins, nucleic acid molecules encoding human derug-metabolizing proteins, and uses thereof.", XP002209412, Database accession no. AX395167
AMADO M ET AL: "A Family of human beta3-Galactosyltransferases (subtitle: characterization of four members of a udp-galactose:BETA-n-acetyl-glu cosamine/BETA-nacetyl-galactosamine BETA-1,3- galactosyltransferase family", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 21, 22 May 1998 (1998-05-22), pages 12770 - 12778, XP002109786, ISSN: 0021-9258
KAPITONOV D ET AL: "CONSERVED DOMAINS OF GLYCOSYLTRANSFERASES", GLYCOBIOLOGY, IRL PRESS,, GB, vol. 9, no. 10, October 1999 (1999-10-01), pages 961 - 978, XP001026525, ISSN: 0959-6658
TUKEY R.H. AND STRASSBURG C.P.: "Genetic multiplicity of the human UDP-Glucuronosyltransferases and regulation in the gastrointestinal tract.", MOLEC. PHARMACOL., vol. 59, no. 3, March 2001 (2001-03-01), pages 405 - 414, XP002209400
DATABASE EMBL [online] 1 March 2002 (2002-03-01), BAKER K.P. ET AL.: "Secreted and transmembrane polypeptides and nucleic acids encoding the same.", XP002209402, Database accession no. AX376455
DATABASE EMBL [online] 18 December 2001 (2001-12-18), BAKER K.P. ET AL.: "Novel nucleic acids encoding PRO polypeptides.", XP002209404, Database accession no. AAU29284
DATABASE EMBL [online] 7 January 2002 (2002-01-07), POLICKY J.L. ET AL.: "Drug metabolizing enzymes", XP002209405, Database accession no. AX327326
DATABASE EMBL [online] 18 May 2002 (2002-05-18), WEI M.H. ET AL.: "Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof.", XP002209408, Database accession no. AX395164
DATABASE EMBL [online] 7 March 2002 (2002-03-07), WEI M. ET AL.: "Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof.", XP002209410, Database accession no. AX395165
DATABASE EMBL [online] 17 May 2002 (2002-05-17), WEI M. ET AL.: "Isolated drug-metabolizing proteins, nucleic acid molecules encoding human derug-metabolizing proteins, and uses thereof.", XP002209412, Database accession no. AX395167
AMADO M ET AL: "A Family of human beta3-Galactosyltransferases (subtitle: characterization of four members of a udp-galactose:BETA-n-acetyl-glu cosamine/BETA-nacetyl-galactosamine BETA-1,3- galactosyltransferase family", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 21, 22 May 1998 (1998-05-22), pages 12770 - 12778, XP002109786, ISSN: 0021-9258
KAPITONOV D ET AL: "CONSERVED DOMAINS OF GLYCOSYLTRANSFERASES", GLYCOBIOLOGY, IRL PRESS,, GB, vol. 9, no. 10, October 1999 (1999-10-01), pages 961 - 978, XP001026525, ISSN: 0959-6658
TUKEY R.H. AND STRASSBURG C.P.: "Genetic multiplicity of the human UDP-Glucuronosyltransferases and regulation in the gastrointestinal tract.", MOLEC. PHARMACOL., vol. 59, no. 3, March 2001 (2001-03-01), pages 405 - 414, XP002209400
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