Title:
4-(N-METHYL)AMINOPIPERIDINE MYRICETIN DERIVATIVE CONTAINING DITHIOCARBAMATE, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/253140
Kind Code:
A1
Abstract:
The present invention discloses a 4-(N-methyl)aminopiperidine myricetin derivative containing dithiocarbamate, having a structural formula (I): wherein R is a substituted phenyl, a substituted aromatic heterocyclyl; n is carbon number in a carbon chain and may be 2, 3, 4 or 5; the substituent on the substituted phenyl may be C1-6 alkyl, C1-6 alkoxy, nitro, halogen atom or hydrogen atom at ortho-, meta- or para-position on the benzene ring; the aromatic heterocyclyl may be thienyl, furyl, pyrryl or pyridyl; the substituent on the substituted aromatic heterocyclyl may be C1-6 alkyl, C1-6 alkoxy, halogen atom or hydrogen atom at ortho-, meta- or para-position, and preparation method and use thereof. The derivative of the present invention has good inhibitory activity on cancer cells.
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Inventors:
XUE WEI (CN)
JIANG SHICHUN (CN)
HUAI ZIYOU (CN)
TANG XU (CN)
HUANG YINJIU (CN)
LIU LIWEI (CN)
CHEN MEI (CN)
HE JUN (CN)
SU SHIJUN (CN)
JIANG SHICHUN (CN)
HUAI ZIYOU (CN)
TANG XU (CN)
HUANG YINJIU (CN)
LIU LIWEI (CN)
CHEN MEI (CN)
HE JUN (CN)
SU SHIJUN (CN)
Application Number:
PCT/CN2019/123150
Publication Date:
December 24, 2020
Filing Date:
December 05, 2019
Export Citation:
Assignee:
UNIV GUIZHOU (CN)
International Classes:
C07D405/12; A61P35/00; C07D405/14
Foreign References:
| CN110183429A | 2019-08-30 | |||
| CN103804335A | 2014-05-21 | |||
| CN107021945A | 2017-08-08 |
Other References:
HUANG, WEI ET AL.: "Synthesis and Antitumor Activity of Novel Dithiocarbamate Substituted Chromones", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 9, 9 April 2009 (2009-04-09), XP026322199, ISSN: 0223-5234, DOI: 20200215201405A
Attorney, Agent or Firm:
BEIJING HUI & XIN IP LAW OFFICE (CN)
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