4-SUBSTITUTED BENZOIC ACID DERIVATIVES AND CARCINOSTATICS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

WIPO Patent Application WO/1999/012884

A1

Novel compounds represented by general formula (I) which do not act on normal cells but detransform specifically cells transformed by various oncogenes, salts thereof, or hydrates of the same, wherein G¿1? represents OR?1¿ or NR?2¿R?3¿ (wherein R?2¿ and R?3¿ are the same or different and each represents hydrogen, lower alkyl or hydroxy, or R?2¿ and R?3¿ may form together with the nitrogen atom adjacent thereto a nitrogen-containing heterocycle); G¿2? represents hydrogen or halogeno; when G¿3? is hydrogen, hydroxy or lower alkylcarbonyloxy, then G¿4? represents lower alkyl, or G¿3? and G¿4? may form together -O-CH¿2?-; and G¿5? represents OR?4¿ or NR?5¿R?6¿ (wherein R?5¿ represents hydroxy or an optionally substituted cyclic group; and R?6¿ represents hydrogen or lower alkyl).

JPH10182551	SUBSTITUTED BENZOIC ACID DERIVATIVES, THEIR PRODUCTION AND USE OF THE COMPOUNDS ON THERAPY OF DISEASE
JPH023622	POLYOXYALKYLENEETHER DERIVATIVE HAVING ORGANIC TERMINAL GROUP, ITS ALKYL ETHER AND ALKALI METAL AND ALKALINE EARTH METAL SALT
JP4937435	New compounds and their pharmaceutical uses

HAGA NOBUHIRO (JP)
SUGITA KENJI (JP)
KAMATA SUSUMU (JP)

PCT/JP1998/003992

March 18, 1999

September 07, 1998

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SHIONOGI & CO (JP)
HAGA NOBUHIRO (JP)
SUGITA KENJI (JP)
KAMATA SUSUMU (JP)

C07C65/40; C07C69/94; C07C229/52; C07C237/40; C07C259/10; (IPC1-7): C07C65/40; A61K31/165; A61K31/19; A61K31/235; C07C69/94; C07C225/22; C07C237/20; C07C259/10

JPS6110528A

1986-01-18

Yamauchi, Hideaki (Ltd. Patent Dept. 12-4 Sagisu 5-chome Fukushima-ku, Osaka-shi Osaka, JP)

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