Title:
46980, A NOVEL HUMAN NEUROLIGIN FAMILY MEMBER AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2001094563
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acids molecules, designated 46980 nucleic acid molecules, which encode novel neuroligin members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 46980 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 46980 gene has been introduced or disrupted. The invention still further provides isolated 46980 proteins, fusion proteins, antigenic peptides and anti-46980 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Inventors:
CURTIS RORY A J (US)
Application Number:
PCT/US2001/018335
Publication Date:
May 10, 2002
Filing Date:
June 06, 2001
Export Citation:
Assignee:
MILLENNIUM PHARM INC (US)
CURTIS RORY A J (US)
CURTIS RORY A J (US)
International Classes:
C07K14/705; (IPC1-7): C12N15/00; C07K14/705; C07K16/28; C12Q1/68; A61K38/17; G01N33/53; C12N15/11; G01N33/50; G01N33/68; C12N15/62; C12N5/10
Domestic Patent References:
| WO1999055915A2 | 1999-11-04 | |||
| WO1999046281A2 | 1999-09-16 | |||
| WO1998039486A1 | 1998-09-11 |
Other References:
PHILIBERT R.A. ET AL: "The structure and expression of the human neuroligin-3 gene", GENE, vol. 246, no. 1-2, April 2000 (2000-04-01), pages 303 - 310, XP004195505, ISSN: 0378-1119
ICHTCHENKO KONSTANTIN ET AL: "Structures, alterative splicing, and neurexin binding of multiple neuroligins.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 5, 2 February 1996 (1996-02-02), pages 2676 - 2682, XP002189904, ISSN: 0021-9258
IRIE M. ET AL: "Binding of neuroligins to PSD-95.", SCIENCE, vol. 277, no. 5331, 5 September 1997 (1997-09-05), pages 1511 - 1515, XP002189905, ISSN: 0036-8075
GRIFMAN MIRTA ET AL: "FUNCTIONAL REDUNDANCY OF ACETYLCHOLINESTERASE AND NEUROLIGIN IN MAMMALIAN NEURITOGENESIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 95, November 1998 (1998-11-01), pages 13935 - 13940, XP002189906
SONG JI-YING ET AL: "Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 96, no. 3, 2 February 1999 (1999-02-02), pages 1100 - 1105, XP002189907, ISSN: 0027-8424
ICHTCHENKO K ET AL: "NEUROLIGIN 1: A SPLICE SITE-SPECIFIC LIGAND FOR BETA-NEUREXINS", CELL, vol. 81, no. 3, 5 May 1995 (1995-05-05), pages 435 - 443, XP002942769, ISSN: 0092-8674
MISSLER M. ET AL: "Neurexins: three genes and 1001 products", TRENDS IN GENETICS, vol. 14, no. 1, January 1998 (1998-01-01), pages 20 - 26, XP004101480, ISSN: 0168-9525
ICHTCHENKO KONSTANTIN ET AL: "Structures, alterative splicing, and neurexin binding of multiple neuroligins.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 5, 2 February 1996 (1996-02-02), pages 2676 - 2682, XP002189904, ISSN: 0021-9258
IRIE M. ET AL: "Binding of neuroligins to PSD-95.", SCIENCE, vol. 277, no. 5331, 5 September 1997 (1997-09-05), pages 1511 - 1515, XP002189905, ISSN: 0036-8075
GRIFMAN MIRTA ET AL: "FUNCTIONAL REDUNDANCY OF ACETYLCHOLINESTERASE AND NEUROLIGIN IN MAMMALIAN NEURITOGENESIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 95, November 1998 (1998-11-01), pages 13935 - 13940, XP002189906
SONG JI-YING ET AL: "Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 96, no. 3, 2 February 1999 (1999-02-02), pages 1100 - 1105, XP002189907, ISSN: 0027-8424
ICHTCHENKO K ET AL: "NEUROLIGIN 1: A SPLICE SITE-SPECIFIC LIGAND FOR BETA-NEUREXINS", CELL, vol. 81, no. 3, 5 May 1995 (1995-05-05), pages 435 - 443, XP002942769, ISSN: 0092-8674
MISSLER M. ET AL: "Neurexins: three genes and 1001 products", TRENDS IN GENETICS, vol. 14, no. 1, January 1998 (1998-01-01), pages 20 - 26, XP004101480, ISSN: 0168-9525
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