5,6-DIHYDRO-1,2,4-TRIAZINE COMPOUND AND PHARMACEUTICAL USE THEREOF AS GLP-1 RECEPTOR AGONIST

Title:

5,6-DIHYDRO-1,2,4-TRIAZINE COMPOUND AND PHARMACEUTICAL USE THEREOF AS GLP-1 RECEPTOR AGONIST

Document Type and Number:

WIPO Patent Application WO/2023/222124

Kind Code:

A1

Abstract:

Disclosed in the present invention are a 5,6-dihydro-1,2,4-triazine compound and the pharmaceutical use thereof as a GLP-1 receptor agonist. A structure of the 5,6-dihydro-1,2,4-triazine compound is represented by formula (I), and in the formula, the definition of each substituent is as described in the description and the claims. The compound of the present invention can be used for treating diabetes, metabolic syndrome and the like when being used as a GLP-1 receptor agonist.

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Inventors:

WANG KAI (CN)
XIE XIN (CN)
CHEN LILI (CN)
YUN YING (CN)
SHEN JIANHUA (CN)
GUO SHIMENG (CN)
XU TIFEI (CN)

Application Number:

PCT/CN2023/095368

Publication Date:

November 23, 2023

Filing Date:

May 19, 2023

Export Citation:

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Assignee:

SHANGHAI INST MATERIA MEDICA CAS (CN)

International Classes:

C07D405/14; A61K31/53; A61P1/16; A61P3/00; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P25/16; A61P25/28; C07D401/14; C07D403/06; C07D403/14

Foreign References:

CN114716423A	2022-07-08
CN115521297A	2022-12-27
CN113480534A	2021-10-08
CN114478497A	2022-05-13
CN113831337A	2021-12-24
CN114591296A	2022-06-07
CN114763352A	2022-07-19

Attorney, Agent or Firm:

XU & PARTNERS, LLC. (CN)

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