Title:
9,10-DIHYDROPHENANTHRENE COMPOUNDS AND USE THEREOF IN TREATMENT OF LIVER INJURY
Document Type and Number:
WIPO Patent Application WO/2021/160139
Kind Code:
A1
Abstract:
A 9,10-dihydrophenanthrene compound and use thereof in the treatment of liver injury. Specifically, a compound of formula (I) or a compound of formula (II) is provided, which exhibits anti-inflammatory and antioxidant activities in liver tissues, and therefore can be used in the treatment or prevention of liver injury diseases, especially liver injury diseases pathologically based on inflammation and lipid peroxidation.
More Like This:
Inventors:
YE YANG (CN)
PAN GUOYU (CN)
YAO SHENG (CN)
XUE YARU (CN)
DENG QIANGQIANG (CN)
TANG CHUNPING (CN)
PENG ZHAOLIANG (CN)
KE CHANGQIANG (CN)
PAN GUOYU (CN)
YAO SHENG (CN)
XUE YARU (CN)
DENG QIANGQIANG (CN)
TANG CHUNPING (CN)
PENG ZHAOLIANG (CN)
KE CHANGQIANG (CN)
Application Number:
PCT/CN2021/076395
Publication Date:
August 19, 2021
Filing Date:
February 09, 2021
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K31/085; A61K31/05; A61K31/09; A61K31/11; A61K31/122; A61K31/192; A61K31/343; A61K31/366; A61K31/40; A61P1/16; C07C39/19; C07C39/225; C07C39/23; C07C39/40; C07C43/23; C07C43/295; C07C47/46; C07C49/747; C07C65/19; C07C205/25; C07D207/333; C07D307/77; C07D311/78
Foreign References:
| CN109516903A | 2019-03-26 | |||
| CN104069365A | 2014-10-01 | |||
| CN110075094A | 2019-08-02 | |||
| TW201828968A | 2018-08-16 | |||
| TW201828968A | 2018-08-16 |
Other References:
XUE YA-RU; YAO SHENG; LIU QIAN; PENG ZHAO-LIANG; DENG QIANG-QIANG; LIU BO; MA ZHENG-HUA; WANG LE; ZHOU HU; YE YANG; PAN GUO-YU: "Dihydro-stilbene gigantol relieves CCl-induced hepatic oxidative stress and inflammation in mice via inhibiting C5b-9 formation in the liver", ACTA PHARMACOLOGICA SINICA, NATURE PUBLISHING GROUP, GB, vol. 41, no. 11, 13 May 2020 (2020-05-13), GB, pages 1433 - 1445, XP037286159, ISSN: 1671-4083, DOI: 10.1038/s41401-020-0406-6
XUE YARU, DENG QIANGQIANG, ZHANG QINGLI, MA ZHENGHUA, CHEN BINFAN, YU XIAOLU, PENG HUIGE, YAO SHENG, LIU JIA, YE YANG, PAN GUOYU: "Gigantol Ameliorates CCl4-induced Liver Injury via Preventing Activation of JNK/cPLA2/12-LOX Inflammatory Pathway.", SCIENTIFIC REPORTS, vol. 10, no. 1, 1 December 2020 (2020-12-01), XP055835830, DOI: 10.1038/s41598-020-79400-0
ABDEL-RAZIK AYMAN F, ELSHAMY ABDEL-SAMID I, NASSAR MAHMOUD I, EL-KOUSY SALAH M, HAMDY HANAA: "CHEMICAL CONSTITUENTS AND HEPATOPROTECTIVE ACTIVITY OF Juncus subulatus", REV. LATINOAMER. QUÍM., vol. 37, no. 1, 1 May 2015 (2015-05-01), pages 70 - 84, XP055835833, DOI: 10.13140/RG.2.1.2939.7926
LIN CHE-WEI, HWANG TSONG-LONG, CHEN FU-AN, HUANG CHIA-HSIN, HUNG HSIN-YI, WU TIAN-SHUNG: "Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 8, 26 August 2016 (2016-08-26), US, pages 1911 - 1921, XP055835835, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.6b00118
LIN CHE-WEI, HWANG TSONG-LONG, CHEN FU-AN, HUANG CHIA-HSIN, HUNG HSIN-YI, WU TIAN-SHUNG: "Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 8, 26 August 2016 (2016-08-26), US, pages 1911 - 1921, XP055835835, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.6b00118
MA WEI, LIU FENG, DING YUN-YUN, ZHANG YUE, LI NING: "Four new phenanthrenoid dimers from Juncus effusus L. with cytotoxic and anti-inflammatory activities", FITOTERAPIA, IDB HOLDING, MILAN., IT, vol. 105, 10 June 2015 (2015-06-10), IT, pages 83 - 88, XP055835839, ISSN: 0367-326X, DOI: 10.1016/j.fitote.2015.06.006
MA WEI, LIU FENG, DING YUN-YUN, ZHANG YUE, LI NING: "Four new phenanthrenoid dimers from Juncus effusus L. with cytotoxic and anti-inflammatory activities", FITOTERAPIA, IDB HOLDING, MILAN., IT, vol. 105, 10 June 2015 (2015-06-10), IT, pages 83 - 88, XP055835839, ISSN: 0367-326X, DOI: 10.1016/j.fitote.2015.06.006
MA WEI; ZHANG YUE; DING YUN-YUN; LIU FENG; LI NING: "Cytotoxic and anti-inflammatory activities of phenanthrenes from the medullae ofJuncus effususL.", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 39, no. 2, 19 November 2015 (2015-11-19), KR, pages 154 - 160, XP035958522, ISSN: 0253-6269, DOI: 10.1007/s12272-015-0680-x
MA WEI; ZHANG YUE; DING YUN-YUN; LIU FENG; LI NING: "Cytotoxic and anti-inflammatory activities of phenanthrenes from the medullae ofJuncus effususL.", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 39, no. 2, 19 November 2015 (2015-11-19), KR, pages 154 - 160, XP035958522, ISSN: 0253-6269, DOI: 10.1007/s12272-015-0680-x
YAO, CHUNSUO ET AL.: "Synthesis of the Active Stilbenoids by Photooxidation Reaction of Trans-ε-Viniferin.", CHINESE JOURNAL OF CHEMISTRY, vol. 22, no. 11, 31 December 2004 (2004-12-31)
XUE YARU, DENG QIANGQIANG, ZHANG QINGLI, MA ZHENGHUA, CHEN BINFAN, YU XIAOLU, PENG HUIGE, YAO SHENG, LIU JIA, YE YANG, PAN GUOYU: "Gigantol Ameliorates CCl4-induced Liver Injury via Preventing Activation of JNK/cPLA2/12-LOX Inflammatory Pathway.", SCIENTIFIC REPORTS, vol. 10, no. 1, 1 December 2020 (2020-12-01), XP055835830, DOI: 10.1038/s41598-020-79400-0
ABDEL-RAZIK AYMAN F, ELSHAMY ABDEL-SAMID I, NASSAR MAHMOUD I, EL-KOUSY SALAH M, HAMDY HANAA: "CHEMICAL CONSTITUENTS AND HEPATOPROTECTIVE ACTIVITY OF Juncus subulatus", REV. LATINOAMER. QUÍM., vol. 37, no. 1, 1 May 2015 (2015-05-01), pages 70 - 84, XP055835833, DOI: 10.13140/RG.2.1.2939.7926
LIN CHE-WEI, HWANG TSONG-LONG, CHEN FU-AN, HUANG CHIA-HSIN, HUNG HSIN-YI, WU TIAN-SHUNG: "Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 8, 26 August 2016 (2016-08-26), US, pages 1911 - 1921, XP055835835, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.6b00118
LIN CHE-WEI, HWANG TSONG-LONG, CHEN FU-AN, HUANG CHIA-HSIN, HUNG HSIN-YI, WU TIAN-SHUNG: "Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 8, 26 August 2016 (2016-08-26), US, pages 1911 - 1921, XP055835835, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.6b00118
MA WEI, LIU FENG, DING YUN-YUN, ZHANG YUE, LI NING: "Four new phenanthrenoid dimers from Juncus effusus L. with cytotoxic and anti-inflammatory activities", FITOTERAPIA, IDB HOLDING, MILAN., IT, vol. 105, 10 June 2015 (2015-06-10), IT, pages 83 - 88, XP055835839, ISSN: 0367-326X, DOI: 10.1016/j.fitote.2015.06.006
MA WEI, LIU FENG, DING YUN-YUN, ZHANG YUE, LI NING: "Four new phenanthrenoid dimers from Juncus effusus L. with cytotoxic and anti-inflammatory activities", FITOTERAPIA, IDB HOLDING, MILAN., IT, vol. 105, 10 June 2015 (2015-06-10), IT, pages 83 - 88, XP055835839, ISSN: 0367-326X, DOI: 10.1016/j.fitote.2015.06.006
MA WEI; ZHANG YUE; DING YUN-YUN; LIU FENG; LI NING: "Cytotoxic and anti-inflammatory activities of phenanthrenes from the medullae ofJuncus effususL.", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 39, no. 2, 19 November 2015 (2015-11-19), KR, pages 154 - 160, XP035958522, ISSN: 0253-6269, DOI: 10.1007/s12272-015-0680-x
MA WEI; ZHANG YUE; DING YUN-YUN; LIU FENG; LI NING: "Cytotoxic and anti-inflammatory activities of phenanthrenes from the medullae ofJuncus effususL.", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 39, no. 2, 19 November 2015 (2015-11-19), KR, pages 154 - 160, XP035958522, ISSN: 0253-6269, DOI: 10.1007/s12272-015-0680-x
YAO, CHUNSUO ET AL.: "Synthesis of the Active Stilbenoids by Photooxidation Reaction of Trans-ε-Viniferin.", CHINESE JOURNAL OF CHEMISTRY, vol. 22, no. 11, 31 December 2004 (2004-12-31)
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF: