Title:
ANTI HUMAN Gas6 MONOCLONAL ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2016/063522
Kind Code:
A1
Abstract:
The present invention pertains to a monoclonal antibody, or an antibody fragment thereof, that binds specifically to human growth arrest-specific 6 (hGas6) and binds to at least one amino acid residue among the 314th, 315th, and 316th amino acid residues of human Gas6. The present invention also pertains to: a nucleic acid containing a base sequence that codes for the antibody or the antibody fragment; a transformed cell containing a vector that contains the nucleic acid; a method for producing the antibody or the antibody fragment; reagents for detecting or measuring Gas6 that contain the antibody or the antibody fragment; therapeutic or diagnostic agents for Gas6-related diseases that contain the antibody or the antibody fragment as an active ingredient; and a use of the antibody or the antibody fragment for producing the therapeutic or diagnostic agents for Gas6-related diseases.
Inventors:
UBE YUKO (JP)
YAMADA TSUYOSHI (JP)
YAMAZAKI YUJI (JP)
KIMURA KANAME (JP)
HARIGUCHI AKIKO (JP)
OGAWA SHINYA (JP)
YAMADA TSUYOSHI (JP)
YAMAZAKI YUJI (JP)
KIMURA KANAME (JP)
HARIGUCHI AKIKO (JP)
OGAWA SHINYA (JP)
Application Number:
PCT/JP2015/005291
Publication Date:
April 28, 2016
Filing Date:
October 20, 2015
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
C12N15/09; A61K39/395; A61P13/12; A61P35/00
Foreign References:
| US7547767B2 | 2009-06-16 | |||
| JP2013518055A | 2013-05-20 | |||
| JP2014522639A | 2014-09-08 |
Other References:
MOODY, G.E. ET AL.: "Generation of a fully human Gas6 neutralizing antibody with anti-tumor activity in vivo.", CANCER RES., vol. 73, no. 8, 15 April 2013 (2013-04-15), XP055275151
FISHER, P.W. ET AL.: "A novel site contributing to growth-arrest-specific gene 6 binding to itsreceptors as revealed by a human monoclonal antibody.", BIOCHEM. J., vol. 387, no. 3, 1 May 2005 (2005-05-01), pages 727 - 735, XP055275153
See also references of EP 3211080A4
FISHER, P.W. ET AL.: "A novel site contributing to growth-arrest-specific gene 6 binding to itsreceptors as revealed by a human monoclonal antibody.", BIOCHEM. J., vol. 387, no. 3, 1 May 2005 (2005-05-01), pages 727 - 735, XP055275153
See also references of EP 3211080A4
Attorney, Agent or Firm:
OHNO, Seiji et al. (JP)
Seiji Ono (JP)
Seiji Ono (JP)
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