Title:
ANTI-TGF-beta3 ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/204277
Kind Code:
A1
Abstract:
The present invention provides an anti-TGF-beta3 antibody and a method of using the antibody. The anti-TGF-beta3 antibody according to the present invention has a binding activity to TGF-beta3 but does not have a neutralizing activity to TGF-beta3, and is useful as an inhibitor for the activation of B-cells and as a therapeutic agent for autoimmune diseases.
Inventors:
FUJIO KEISHI (JP)
OKAMURA TOMOHISA (JP)
YAMAMOTO KAZUHIKO (JP)
INOUE MARIKO (JP)
KOMAI TOSHIHIKO (JP)
BAN NOBUHIRO (JP)
NONAKA TATSUYA (JP)
ISHII SHINYA (JP)
MURATA HIROKO (JP)
OKAMURA TOMOHISA (JP)
YAMAMOTO KAZUHIKO (JP)
INOUE MARIKO (JP)
KOMAI TOSHIHIKO (JP)
BAN NOBUHIRO (JP)
NONAKA TATSUYA (JP)
ISHII SHINYA (JP)
MURATA HIROKO (JP)
Application Number:
PCT/JP2017/019457
Publication Date:
November 30, 2017
Filing Date:
May 25, 2017
Export Citation:
Assignee:
UNIV TOKYO (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K16/22; A61K39/395; A61P5/14; A61P19/02; A61P21/04; A61P25/00; A61P29/00; A61P31/00; A61P37/02; A61P37/06; C12N15/09
Foreign References:
| EP0536275B1 | 1998-04-22 | |||
| US5055289A | 1991-10-08 |
Other References:
HAWORTH R.S. ET AL.: "Differential changes in transforming growth factor-beta isoform expression during postnatal cardiac growth", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 245, no. 3, 1998, pages 923 - 927, XP055442130
FUJIO K. ET AL.: "Therapeutic potential of regulatory cytokines that target B cells", INT. IMMUNOL., vol. 28, no. 4, 2015, pages 189 - 195, XP055442133
HOFFMANN E. ET AL.: "PK modulation of haptenylated peptides via non-covalent antibody complexation", J. CONTROL. RELEASE, vol. 171, no. 1, 2013, pages 48 - 56, XP055114266
METZ S. ET AL.: "Bispecific digoxigenin-binding antibodies for targeted payload delivery", PROC. NATL. ACAD. SCI. U.S.A., vol. 108, no. 20, 2011, pages 8194 - 8199, XP055345937
FUJIO K. ET AL.: "Therapeutic potential of regulatory cytokines that target B cells", INT. IMMUNOL., vol. 28, no. 4, 2015, pages 189 - 195, XP055442133
HOFFMANN E. ET AL.: "PK modulation of haptenylated peptides via non-covalent antibody complexation", J. CONTROL. RELEASE, vol. 171, no. 1, 2013, pages 48 - 56, XP055114266
METZ S. ET AL.: "Bispecific digoxigenin-binding antibodies for targeted payload delivery", PROC. NATL. ACAD. SCI. U.S.A., vol. 108, no. 20, 2011, pages 8194 - 8199, XP055345937
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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