Title:
ABHD6 ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2022/211060
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a medicine for the prevention and/or treatment of a disease associated with ABHD6, which contains a compound having an ABHD6-inhibiting activity as an active ingredient. A compound represented by general formula (I-A) (wherein all symbols are as defined in the description) or a pharmaceutically acceptable salt thereof has an ABHD6-inhibiting activity, and is therefore useful as a medicinal component having a potent ABHD6-inhibiting activity in the prevention and/or treatment of a diseases associated with ABHD6.
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Inventors:
YOSHIDA ATSUSHI (JP)
HYAKUTAKE RYUICHI (JP)
NAGASHIMA NOZOMU (JP)
MISU RYOSUKE (JP)
MORI SHOHEI (JP)
HYAKUTAKE RYUICHI (JP)
NAGASHIMA NOZOMU (JP)
MISU RYOSUKE (JP)
MORI SHOHEI (JP)
Application Number:
PCT/JP2022/016679
Publication Date:
October 06, 2022
Filing Date:
March 31, 2022
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07D405/14; A61K9/20; A61K31/136; A61K31/4439; A61K31/501; A61K45/00; A61P9/06; A61P19/10; A61P21/02; A61P25/04; A61P25/06; A61P25/08; A61P25/24; A61P29/00; A61P43/00; C07D409/14; C07D417/14; C07D487/04; C07D495/04; C07D495/14; C07D513/04
Domestic Patent References:
| WO2019089676A1 | 2019-05-09 | |||
| WO2010130944A1 | 2010-11-18 | |||
| WO2010062927A2 | 2010-06-03 | |||
| WO2006007448A2 | 2006-01-19 |
Foreign References:
| JP2014524411A | 2014-09-22 | |||
| JP2012508737A | 2012-04-12 | |||
| JP2012509940A | 2012-04-26 | |||
| JP2021500345A | 2021-01-07 | |||
| JP2021503443A | 2021-02-12 | |||
| JP2016525092A | 2016-08-22 |
Other References:
DENG HUI; LI WEIMIN: "Therapeutic potential of targeting α/β-Hydrolase domain-containing 6 (ABHD6)", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 198, 25 April 2020 (2020-04-25), AMSTERDAM, NL , XP086167144, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112353
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 198, no. 112353, 2020
JOURNAL OF NEUROINFLAMMATION, vol. 15, no. 9, 2018
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceuticals", pages: 163 - 198
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 2018, JOHN WILEY & SONS INC
T. W. GREENE: "Protective Groups in Organic Synthesis", 2014, WILEY
"Japanese Pharmaceutical Excipients Directory", 2000, YAKUJI NIPPO LIMITED
CAS , no. 17973-86-3, 6.3
CAS, no. 128625-52-5
See also references of EP 4317153A4
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 198, no. 112353, 2020
JOURNAL OF NEUROINFLAMMATION, vol. 15, no. 9, 2018
"Molecular Design", vol. 7, 1990, HIROKAWA SHOTEN, article "Development of Pharmaceuticals", pages: 163 - 198
RICHARD C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 2018, JOHN WILEY & SONS INC
T. W. GREENE: "Protective Groups in Organic Synthesis", 2014, WILEY
"Japanese Pharmaceutical Excipients Directory", 2000, YAKUJI NIPPO LIMITED
CAS , no. 17973-86-3, 6.3
CAS, no. 128625-52-5
See also references of EP 4317153A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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