ACETYLENIC MICROBIOCIDES

The present invention relates to novel microbiocidally active, in particular fungicidally active, 1 -ynyl-aryl and 1 -ynyl-heteroaryl containing compounds their use in compositions and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.

The incidence of serious microbial infections, particularly fungal infections, either systemic or topical, continues to increase for plants.

Fungicides are compounds, of natural or synthetic origin, which act to protect plants against damage caused by fungi. Current methods of agriculture rely heavily on the use of fungicides. In fact, some crops cannot be grown usefully without the use of fungicides. Using fungicides allows a grower to increase the yield of the crop and consequently, increase the value of the crop. Numerous fungicidal agents have been developed. However, the treatment of fungal infestations continues to be a major problem. Furthermore, fungicide resistance has become a serious problem, rendering these agents ineffective for some agricultural uses. As such, a need exists for the development of new fungicidal compounds.

The present invention accordingly relates to compounds of formula (I)

HetAr is an unsubstituted or substituted 5- membered or 6-membered aromatic monocyclic ring system wherein the substituents are selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl, Ci-C ₄ haloalkyl, Ci-C ₄ alkoxy, Ci-C ₄ alkylthio, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,Cr C ₄ haloalkoxy, Ci-C ₄ alkoximino and CrC ₄ alkylendioxy;

R ¹ and R ² are independly hydrogen, halogen, cyano, unsubstituted or substituted Ci _-6 -alkyl, unsubstituted or substituted Ci _-6 -alkenyl, unsubstituted or substituted Ci _-6 -alkynyl, unsubstituted or substituted CrC ₆ haloalkyl, unsubstituted or substituted CrC ₆ alkoxy, unsubstituted or substituted Ci-C ₆ alkoxy-Ci-C ₆ alkyl, unsubstituted or substituted d- C ₆ haloalkoxy, unsubstituted or substituted CrC ₆ alkylthio, unsubstituted or substituted C C ₆ haloalkylthio, unsubstituted or substituted Ci-C ₆ alkoximino, unsubstituted or substituted CrC ₆ alkylendioxy, unsubstituted or substituted aryl, unsubstituted or substituted aryl-Ci-C ₆ - alkyl, wherein the substituents for the aryl, heteroaryl, cycloalkyl and heterocycloalkyl are independently selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, d- C ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, Ci-C ₆ alkoximino and C C ₆ alkylendioxy and where the wherein the substituents for the alkyl moieties are

independently selected from -OH, CN, F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino, or

R ¹ and R ² form together a unsubstituted or substituted 3 to 6 membered alycyclic ring system wherein the substituents are independently selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, Ci-C ₆ alkoximino and CrC ₆ alkylendioxy;

A' is an unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, wherein the optional substituents are selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, Ci-C ₆ alkoximino and CrC ₆ alkylendioxy;

R ³ is oxygen, =N-0-R ⁵ , N-NR ⁶ R ⁷ or =CR ⁸ R ⁹ ;

R ⁴ is hydrogen, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted aryl-Ci-C ₆ alkyl, unsubstituted or substituted heteroaryl-Cr

C ₆ alkyl, unsubstituted or substituted CrC ₆ alkyl, unsubstituted or substituted CrC ₆ haloalkyl, unsubstituted or substituted CrC ₆ alkoxy, unsubstituted or substituted Ci-C ₆ alkoxy-Cr C ₆ alkyl, unsubstituted or substituted CrC ₆ haloalkoxy, unsubstituted or substituted substituted C ₃ -C ₈ -cycloalkyl, unsubstituted or substituted C ₂ -C ₈ -heterocycloalky,

unsubstituted or substituted C ₃ -C8-cycloalky-Ci-C ₄ alkyl, unsubstituted or substituted C ₂ -C ₈ - heterocycloalky-CrC ₆ alkyl, wherein the substituents for the aryl, heteroaryl, cycloalkyl and heterocycloalkyl are independently selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, C

C ₆ alkoximino and CrC ₆ alkylendioxy and where the wherein the substituents for the alkyl moieties are indepently selected from -OH, CN, F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino,

R ⁵ , R ⁶ , R ⁷ , R ⁸ and R ⁹ are independently or each other hydrogen, unsubstituted or substituted Ci-Ci ₀ alkyl, unsubstituted or substituted Ci-Ciohaloalkyl, unsubstituted or substituted C Ci ₀ alkoxy(CrCio)alkyl, unsubstituted or substituted C ₂ -Ci ₀ alkenyl, unsubstituted or substituted C ₂ -Ci ₀ haloalkenyl, unsubstituted or substituted C ₂ -Ci ₀ alkynyl, unsubstituted or substituted C ₃ -C ₇ cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted C ₃ -C ₇ cycloalkyl-Ci-C ₄ alkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocycloalkyl-CrC ₄ alkyl unsubstituted or substituted aryl, , unsubstituted or substituted aryl-Ci-C ₄ alkyl, unsubstituted or substituted heteroaryl-Ci-C ₄ alkyl wherein the substituents for the aryl, heteroaryl, cycloalkyl and heterocycloalkyl are independently selected from the group consisting of halogen, hydroxy, cyano, CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, Ci-C ₆ alkoximino, CrC ₆ alkylendioxy, pyrimidinyl, phenyl or phenyl substituted by halogen, hydroxy, cyano, Ci-C ₄ alkyl, d- C ₄ haloalkyl, Ci-C ₄ alkoxy, Ci-C ₄ alkoxy-CrC ₄ alkyl, Ci-C ₄ haloalkoxy and where the wherein the substituents for the alkyl moieties are independently selected from -OH, CN, F, CI, Ci_ ₄ alkoxy, Ci _-4 alkylamino;

and agronomically acceptable salts, isomers, structural isomers, stereoisomers,

diastereoisomers, enantiomers, tautomers, atriopisomers and N-oxides of those compounds.

The invention covers all agronomically acceptable salts, isomers, structural isomers, stereoisomers, diastereoisomers, enantiomers, tautomers, atropisomers and N-oxides of those compounds. The compounds of formula (I) may exist in different geometric or optical isomeric forms or in different tautomeric forms. One or more centres of chirality may be present, in which case compounds of the formula (I) may be present as pure enantiomers, mixtures of enantiomers, pure diastereomers or mixtures of diastereomers. There may be double bonds present in the molecule, such as C=C or C=N bonds, in which case

compounds of formula (I) may exist as single isomers or mixtures of isomers. Centres of tautomerisation may be present. This invention covers all such isomers and tautomers and mixtures thereof in all proportions as well as isotopic forms such as deuterated compounds. Also atropisomerism may occur as a result of a restricted rotation about a single bond. Suitable salts of the compounds of formula (I) include acid addition salts such as those with an inorganic acid such as hydrochloric, hydrobromic, sulphuric, nitric or phosphoric acid, or an organic carboxylic acid such as oxalic, tartaric, lactic, butyric, toluic, hexanoic or phthalic acid, or a sulphonic acid such as methane, benzene or toluene sulphonic acid. Other examples of organic carboxylic acids include haloacids such as trifluoroacetic acid.

N-oxides are oxidised forms of tertiary amines or oxidised forms of nitrogen containing heteroaromatic compounds. They are described in many books for example in "Heterocyclic N-oxides" by Angelo Albini and Silvio Pietra, CRC Press, Boca Raton, Florida, 1991. "Halo" or "halogen" means fluoro, chloro, bromo or iodo, preferably chloro or fluoro. "Haloalkyl" means alkyl as defined above substituted with one or more of the same or different halo atoms. Therefore this definition of haloalkyl may also include perhalogenated alkyl groups. Examples of haloalkyl groups include, but are not limited to chloromethyl, fluoromethyl, dichloromethyl, difluoromethyl, trichloromethyl, trifluoromethyl, 2-fluoroethyl, 2- trifluoroethyl, 1 -difluoroethyl, 2-trifluoro-1 -difluoroethyl, 2-chloro-ethyl, 2-trichloro-1 - dichloroethyl 2-iodoethyl, 3-fluoropropyl, 3-chloropropyl, 2-trifluoro-1 -chloroethyl and 1 - difluoro-2-difluoro-3-trifluoropropyl.

The preferred substituents of the substituted alkyl groups are selected from the following substituents -OH, CN, F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino. The alkyl groups are branched or linear. The most preferred alkyl groups are methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl (2-methylpropyl), pentyl, 1 -methylpentyl, 1 -ethyl pentyl, iso-pentyl (3-methylbutyl), hexyl, heptyl, octyl, or nonyl. Preferably the alkyl groups in the compound of formula (I) and/or the alkoxy groups in the compound of formula (I) bear not more than two further substituents, more preferably the alkyl groups in the compound of formula (I) and/or the alkoxy groups in the compound of formula (I) bear not more than one further substituent, most preferred the alkyl groups in the compound of formula (I) and/or the alkoxy groups in the compound of formula (I) are not further substituted.

"Aryl" or "aromatic ring moiety" refers to an aromatic substituent which may be a single ring or multiple rings which are fused together, thus aryl groups derived from arenes by removal of a hydrogen atom from a ring carbon atom, and arenes are monoyclic and polycyclic aromatic hydrocarbons. The term "Aryl" may mean substituted or unsubstituted aryl unless otherwise indicated and hence the aryl moieties may be unsubstituted or substituted with one or more of the same or different substituents. Preferably aryl refers to an aromatic substituent which may be a single ring or multiple rings which are fused together, more preferably to an aromatic substituent which may be a single ring or is formed by two rings which are fused together.

Hetreoaryl signifies heteroaromatic ring system containing at least one heteroatom and consisting either of a single ring or of two or more fused rings are preferably, single rings containing up to four and bicyclic systems up to five heteroatoms which will preferably be chosen from nitrogen, oxygen and sulphur. Examples of such groups include furyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, 1 ,2,3-triazolyl, 1 ,2,4-triazolyl, 1 ,3,4-triazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1 ,2,4-oxadiazolyl, 1 ,3,4-oxadiazolyl, 1 ,2,5-oxadiazolyl, 1 ,2,3-thiadiazolyl, 1 ,2,4-thiadiazolyl, 1 ,3,4-thiadiazolyl, 1 ,2,5-thiadiazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, 1 ,2,3-triazinyl, 1 ,2,4-triazinyl, 1 ,3,5-triazinyl, benzofuryl, benzisofuryl, benzothienyl, benzisothienyl, indolyl, isoindolyl, indazolyl, benzothiazolyl, benzisothiazolyl, benzoxazolyl, benzisoxazolyl, benzimidazolyl, 2,1 ,3-benzoxadiazole, quinolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, naphthyridinyl, benzotriazinyl, purinyl, pteridinyl and indolizinyl, preferably thiazolyl, imidazolyl, pyrrazolyl, pyridyl and pyrimidinyl.

Preferred values of HetAr, A', R ¹ , R ² , R ³ , R ⁴ , R ⁵ , R ⁶ , R ⁷ , R ⁸ and R ⁹ are, in any combination, as set out below.

HetAr is an unsubstituted or substituted 5- membered or 6-membered aromatic monocyclic ring system containing at least one heteroatom selected from N, S or O preferably N consisting of a single ring wherein the optional substituents are selected from the group consisting of halogen, hydroxy, thiol, CrC ₄ alkyl, Ci-C ₄ haloalkyl, Ci-C ₄ alkoxy, CrC ₄ alkoxy- Ci-C ₄ alkyl,CrC ₄ haloalkoxy, Ci-C ₄ alkoximino and Ci-C ₄ alkylendioxy.

Preferably HetAr is an unsubstituted or substituted 5- membered or 6-membered aromatic monocyclic ring system containing one or two heteroatom selected from N, S or O preferably N and consisting of a single ring wherein the optional substituents are selected from the group consisting of halogen, hydroxy, thiol, Ci-C ₄ alkyl, Ci-C ₄ haloalkyl, Ci-C ₄ alkoxy, d- C ₄ alkoxy-Ci-C ₄ alkyl,CrC ₄ haloalkoxy, Ci-C ₄ alkoximino and Ci-C ₄ alkylendioxy.

More preferably HetAr is an imidazolyl, pyrrazolyl, pyridyl, triazoloyl or pyrimidinyl each optionally substituted by substituents selected from the group consisting of halogen, hydroxy, Ci-C ₄ alkyl, Ci-C ₄ haloalkyl, Ci-C ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,CrC ₄ haloalkoxy, C

C ₄ alkoximino and CrC ₄ alkylendioxy;

Most preferably HetAr is an imidazolyl, pyridyl or triazoloyl each optionally substituted by substituents selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl, d- C ₄ haloalkyl, Ci-C ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,CrC ₄ haloalkoxy, Ci-C ₄ alkoximino and C C ₄ alkylendioxy;

In one embodiment HetAr is an imidazolyl optionally substituted by substituents selected from the group consisting of halogen, hydroxy, thiol, CrC ₄ alkyl, Ci-C ₄ haloalkyl, Ci-C ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,CrC ₄ haloalkoxy, Ci-C ₄ alkoximino and CrC ₄ alkylendioxy;

In a further embodiment HetAr is an imidazolyl, pyrrazolyl, pyridyl or pyrimidinyl each optionally substituted by substituents selected from the group consisting of halogen, hydroxy, thiol, Ci-C ₄ alkyl, Ci-C ₄ haloalkyl, Ci-C ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,CrC ₄ haloalkoxy, C C ₄ alkoximino and CrC ₄ alkylendioxy; In a further embodiment HetAr is an pyrrazolyl optionally substituted by substituents selected from the group consisting of halogen, hydroxy, thiol, CrC ₄ alkyl, CrC ₄ haloalkyl, CrC ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,Ci-C ₄ haloalkoxy, Ci-C ₄ alkoximino and CrC ₄ alkylendioxy;

In a further embodiment HetAr is an pyridyl each optionally substituted by substituents selected from the group consisting of halogen, hydroxy, thiol, CrC ₄ alkyl, CrC ₄ haloalkyl, d- C ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,Ci-C ₄ haloalkoxy, Ci-C ₄ alkoximino and CrC ₄ alkylendioxy; In a further embodiment HetAr is a pyrimidinyl optionally substituted by substituents selected from the group consisting of halogen, hydroxy, thiol, CrC ₄ alkyl, CrC ₄ haloalkyl, CrC ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,Ci-C ₄ haloalkoxy, Ci-C ₄ alkoximino and CrC ₄ alkylendioxy;

In a further embodiment HetAr is a triazolyl optionally substituted by substituents selected from the group consisting of halogen, hydroxy, thiol, CrC ₄ alkyl, CrC ₄ haloalkyl, CrC ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,Ci-C ₄ haloalkoxy, Ci-C ₄ alkoximino and CrC ₄ alkylendioxy;

Preferably HetAr is not substituted.

In a further embodiment R ¹ and R ² are independly hydrogen, halogen, unsubstituted or substituted Ci _-4 -alkyl wherein the substituents for Ci _-4 -alkyl are selected from -OH, CN, F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino; or R ¹ and R ² form together a unsubstituted or substituted 3 to 6 membered alycyclic ring system wherein the substituents are independently selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl and the substituents of Ci _-6 -alkyl are selected from -OH, CN, F, CI, Ci _-2 alkoxy, Ci _-2 alkylamino; preferably R ¹ and R ² are independly hydrogen, halogen, unsubstituted or substituted Ci _-2 - alkyl wherein the optional substituents for Ci _-4 -alkyl are selected from -OH, CN, F, CI, Ci_ ₂ alkoxy, Ci _-2 alkylamino or R ¹ and R ² form together a unsubstituted or substituted 3 to 6 membered alycyclic ring system wherein the substituents are independently selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl and the substituents of Ci _-4 -alkyl are selected from -OH, CN, F, CI, Ci _-2 alkoxy, Ci _-2 alkylamino; More preferably R ¹ and R ² are independly hydrogen, halogen or methyl or R ¹ and R ² form together a unsubstituted or substituted 3 membered alycyclic ring system wherein the substituents are independently selected from the group consisting of halogen, hydroxy, C C ₄ alkyl; most preferably R ¹ and R ² are both hydrogen or R ¹ and R ² form together a cyclopropyl ring. In a one embodiment A' is an unsubstituted or substituted aryl which is mono cyclic or bicyclic ring system which is five to ten membered, unsubstituted or substituted heteroaryl which is mono cyclic or bicyclic ring system which is five to ten membered containing at least one heteroatom, wherein the optional substituents are selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, d- C ₆ haloalkoxy, Ci-C ₆ alkoximino and CrC ₆ alkylendioxy;

Preferrably the unsubstituted or substituted heteroaryl which is mono cyclic or bicyclic ring system which is five to ten membered containing at least one heteroatom selected from O, N or S and has not more than 3 heteroatoms.

In a further embodiment A' is an unsubstituted or substituted 5- membered or 6-membered aromatic monocyclic ring system or an unsubstituted or substituted optionally substituted 5- membered or 6-membered aromatic monocyclic ring system containing at least one heteroatom and consisting of a single ring wherein the optional substituents are selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, C C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, Ci-C ₆ alkoximino and CrC ₆ alkylendioxy;

In a further embodiment A' is an optionally substituted phenyl, pyridyl, thiophenyl,thiazolyl wherein the optional substituents are selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, C

C ₆ alkoximino and CrC ₆ alkylendioxy; preferably the optional substituents are selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl, Ci-C ₄ haloalkyl, more preferably the optional substituents are halogen.

In a further embodiment A' is an optionally substituted phenyl, pyridyl, thiophenyl,thiazolyl wherein the optional substituents are selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy.

In one embodiment R ³ is oxygen;

In a further embodiment R ³ is =N-0-R ⁵ ;

In a further embodiment R ³ is N-NR ⁶ R ⁷ ;

In a further embodiment R ³ =CR ⁸ R ⁹ ;

In a preferred embodiment R ³ is =N-0-R ⁵ ;

Preferably R ³ is selected from

=0, =N-OH, =N-NH ₂ , =CHCH ₃ , =CHCH ₂ CH ₃ , =CHCH(CH ₃ ) ₂ , =CHCH ₂ CH(CH ₃ ) ₂ ,

=CHC(CH ₃ ) ₃ , =C(CH ₃ ) ₂ , =C(CH ₂ CH ₃ ) ₂ H, =CHPh, =CH-4-F-Ph, =CH-2,4-F-Ph, =CH-2,5-F-Ph, =CH4-CI-Ph, =CH2,4-CI-Ph, =CH2,5-CI- Ph, =CHCH ₂ Ph, =CHCH ₂ -4-F-Ph, =CHCH ₂ -2,4-F-Ph, =CHCH ₂ -2,5-F-Ph, =CHCH ₂ -4-CI-Ph, =CH CH ₂ -2,4-CI-Ph, =CH CH ₂ -2,5-CI-Ph,

=N-OCH ₃ , =N-OCH ₂ CH ₃ , =N-0(CH ₂ ) ₂ CH ₃ , =N-0(CH ₂ ) ₃ CH _3! =N-0(CH ₂ ) ₄ CH ₃ , =N- 0(CH ₂ ) ₅ CH ₃ , =N-OCH(CH ₃ ) ₂ , =N-OC(CH ₃ ) ₃ , =N-OCH ₂ CH(CH ₃ ) ₂ , =N-OCH ₂ C(CH ₃ ) ₃ , =N-OPh, =N-0-4-F-Ph, =N-0-4-CI-Ph, =N-0-2,4-F-Ph, =N-0-2,4-CI-Ph, =N-OCH ₂ -Ph, =N-OCH ₂ -4-F- Ph, =N-OCH ₂ -4-CI-Ph, =N-OCH ₂ -2,4-F-Ph, =N-OCH ₂ -2,5-F-Ph, =N-OCH ₂ -2,6-F-Ph, =N- OCH ₂ -3,5-F-Ph, =N-OCH ₂ -2,4, 6-F-Ph, =N-OCH ₂ -2,4-CI-Ph, =N-OCH ₂ -2,5-CI-Ph, =N-OCH ₂ - 2,6-CI-Ph, =N-OCH ₂ -3,5-CI-Ph, =N-OCH ₂ -2,4, 6-CI-Ph,

= N

=N-NHCH ₃ , =N-NHCH ₂ CH ₃ , =N-NH(CH ₂ ) ₂ CH ₃ , =N-NH(CH ₂ ) ₃ CH ₃ , =N-NH(CH ₂ ) ₄ CH ₃ , =N- NH(CH ₂ ) ₅ CH ₃ , =N-NHCH(CH ₃ ) ₂ , =N-NHC(CH ₃ ) ₃ , =N-NHCH ₂ CH(CH ₃ ) ₂ , =N-NHCH ₂ C(CH ₃ ) ₃ =N-NHPh, =N-NH-4-F-Ph, =N-NH-4-CI-Ph, =N-NH-2,4-F-Ph, =N-NH-2,4-CI-Ph, =N-NHCH Ph, =N-NHCH ₂ -4-F-Ph, =N-NHCH ₂ -4-CI-Ph, =N-NHCH ₂ -2,4-F-Ph, =N-NHCH ₂ -2,5-F-Ph, = NHCH ₂ -2,6-F-Ph, =N-NHCH ₂ -3,5-F-Ph, =N-NHCH ₂ -2,4, 6-F-Ph, =N-NHCH ₂ -2,4-CI-Ph, =N- NHCH ₂ -2,5-CI-Ph, =N-NHCH ₂ -2,6-CI-Ph, =N-NHCH ₂ -3,5-CI-Ph, =N-NHCH ₂ -2,4, 6-CI-Ph,

=N-N(CH ₃ ) ₂ , =N-N(CH ₃ )CH ₂ CH _3! =N-N(CH ₃ )(CH ₂ ) ₂ CH _3! =N-N(CH ₃ )(CH ₂ ) ₃ CH ₃ , =N- N(CH ₃ )(CH ₂ ) ₄ CH ₃ , =N-N(CH ₃ )(CH ₂ ) ₅ CH ₃ , =N-N(CH ₃ )CH(CH ₃ ) ₂ , =N-N(CH ₃ )C(CH ₃ ) ₃ , =N- N(CH ₃ )CH ₂ CH(CH ₃ ) ₂ , =N-N(CH ₃ )CH ₂ C(CH ₃ ) ₃ , =N-N(CH ₃ )Ph, =N-N(CH ₃ )-4-F-Ph, =N-N(CH ₃ )- 4-CI-Ph, =N-N(CH ₃ )-2,4-F-Ph, =N-N(CH ₃ )-2,4-CI-Ph, =N-N(CH ₃ )CH ₂ -Ph, =N-N(CH ₃ )CH ₂ -4-F- Ph, =N-N(CH ₃ )CH ₂ -4-CI-Ph, =N-N(CH ₃ )CH ₂ -2,4-F-Ph, =N-N(CH ₃ )CH ₂ -2,5-F-Ph, =N- N(CH ₃ )CH ₂ -2,6-F-Ph, =N-N(CH ₃ )CH ₂ -3,5-F-Ph, =N-N(CH ₃ )CH ₂ -2,4, 6-F-Ph, =N-N(CH ₃ )CH ₂ - 2,4-CI-Ph, =N-N(CH ₃ )CH ₂ -2,5-CI-Ph, =N-N(CH ₃ )CH ₂ -2,6-CI-Ph, =N-N(CH ₃ )CH ₂ -3,5-CI-Ph, =N-N(CH ₃ )CH ₂ -2,4, 6-CI-Ph,

R ⁴ is hydrogen, optionally substituted aryl, optionally substituted heteroaryl, optionally, substituted aryl-Ci-C ₆ alkyl, optionally substituted heteroaryl-Ci-C ₆ alkyl, optionally substituted CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, optionally substituted C ₃ -C ₈ -cycloalkyl, optionally substituted C ₃ -C ₈ -heterocycloalky, optionally substituted C ₃ -C8-cycloalky-Ci-C ₄ alkyl, optionally substituted C ₃ -C ₈ -heterocycloalky-Cr C ₆ alkyl, wherein the optional substituents for the aryl, heteroaryl, cycloalkyl and

heterocycloalkyl are selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, d- C ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, Ci-C ₆ alkoximino and C C ₆ alkylendioxy and where the wherein the optional substituents for the alkyl moieties are selected from -OH, CN , F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino.

Preferably R ⁴ is hydrogen, optionally substituted aryl preferably optionally substituted phenyl, optionally substituted CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, d- C ₆ haloalkoxy, optionally substituted C ₃ -C ₈ -cycloalkyl, optionally substituted C ₃ -C ₈ -cycloalky- Ci-C ₄ alkyl, optionally substituted C ₃ -C ₈ -heterocycloalky-CrC ₆ alkyl, wherein the optional substituents for the aryl, cycloalkyl and are selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, CrC ₆ alkoximino and CrC ₆ alkylendioxy preferably the optional substituents for the aryl, cycloalkyl and are selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl, d- C ₄ haloalkyl and where the wherein the optional substituents for the alkyl moieties are selected from -OH, CN, F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino, preferably the optional substituents for the alkyl moieties are selected from -OH, CN, F, CI.

More preferably R ⁴ is hydrogen, methyl, ethyl, propyl, / ^' so-propyl, ie f-butyl, sec-butyl, neo- pentyl, trimethylsilyl, cyclopropyl, 1 -fluoro-cyclopropyl, 1 -chloro-cyclopropyl, 1 -hydroxy- cyclopropyl, 2-methyl-cyclopropyl, 2-/ ^' so-propyl-cyclopropyl, 2-methoxy-cyclopropyl, 2- trifluoromethoxy-cyclopropyl, 2-cyano-cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, phenyl, 4-fluoro-phenyl, 4-chloro-phenyl.

Preferably R ⁵ , R ⁶ , R ⁷ , R ⁸ and R ⁹ are independently or each other hydrogen, unsubstituted or substituted CrC ₈ alkyl, unsubstituted or substituted CrC ₈ haloalkyl, unsubstituted or substituted Ci-C ₄ alkoxy(Ci-C ₄ )alkyl, unsubstituted or substituted C ₂ -C ₄ alkenyl, unsubstituted or substituted C ₂ -C ₄ haloalkenyl, unsubstituted or substituted C ₂ -C ₄ alkynyl, unsubstituted or substituted C ₃ -C ₇ cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted C ₃ -C ₇ cycloalkyl-Ci-C ₄ alkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocycloalkyl-CrC ₄ alkyl unsubstituted or substituted aryl, unsubstituted or substituted aryl-Ci-C ₄ alkyl, unsubstituted or substituted heteroaryl-Ci-C ₄ alkyl wherein the substituents for the aryl, heteroaryl, cycloalkyl and heterocycloalkyl are independently selected from the group consisting of halogen, hydroxy, cyano, CrC ₄ alkyl, CrC ₄ haloalkyl, CrC ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl, CrC ₄ haloalkoxy, pyrimidinyl, phenyl or phenyl substituted by halogen, hydroxy, cyano, CrC ₄ alkyl, CrC ₄ haloalkyl, CrC ₄ alkoxy, C

C ₄ haloalkoxy and where the wherein the substituents for the alkyl moieties are independently selected from -OH, CN, F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino;

More preferably R ⁵ , R ⁶ , R ⁷ , R ⁸ and R ⁹ are independently or each other hydrogen, CrC ₆ alkyl, Ci-C ₆ haloalkyl, Ci-C ₆ alkoxy(Ci-C ₆ )alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₃ - C ₇ cycloalkyl optionally substituted with CrC ₆ alkyl or halogen;

Still more preferably unsubstituted or substituted C ₃ -C ₇ cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted C ₃ -C ₇ cycloalkyl-CrC ₄ alkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocycloalkyl-Ci- C ₄ alkyl unsubstituted or substituted aryl, unsubstituted or substituted aryl-Ci-C ₄ alkyl, unsubstituted or substituted heteroaryl-Ci-C ₄ alkyl wherein the substituents for the aryl, heteroaryl, cycloalkyl and heterocycloalkyl are independently selected from the group consisting of halogen, hydroxy, cyano, CrC ₄ alkyl, Ci-C ₄ haloalkyl, Ci-C ₄ alkoxy, Ci-C ₄ alkoxy- CrC ₄ alkyl, Ci-C ₄ haloalkoxy, pyrimidinyl, phenyl or phenyl substituted by halogen, hydroxy, cyano, CrC ₄ alkyl, Ci-C ₄ haloalkyl, Ci-C ₄ alkoxy, Ci-C ₄ haloalkoxy and where the wherein the substituents for the alkyl moieties are independently selected from -OH, CN, F, CI, Ci_ ₄ alkoxy, Ci _-4 alkylamino;

In a further preferred embodiment

etAr is an imidazolyl, pyrrazolyl, pyridyl or pyrimidinyl each optionally substituted by substituents selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl, d- C ₄ haloalkyl, Ci-C ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,CrC ₄ haloalkoxy, Ci-C ₄ alkoximino and C C ₄ alkylendioxy;

R ¹ and R ² are independly hydrogen, halogen or methyl

R ¹ and R ² are independly hydrogen, halogen or methyl or R ¹ and R ² form together a unsubstituted or substituted 3 membered alycyclic ring system wherein the substituents are independently selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl;

A' is an optionally substituted phenyl, pyridyl, thiophenyl,thiazolyl wherein the optional substituents are selected from the group consisting of halogen, hydroxy, CrC ₆ alkyl, d- C ₆ haloalkyl, CrC ₆ alkoxy;

R ³ is =N-0-R ⁵ or N-NR ⁶ R ⁷ ;

R ⁴ is hydrogen, optionally substituted aryl preferably optionally substituted phenyl, optionally substituted CrC ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, optionally substituted C ₃ -C ₈ -cycloalkyl, optionally substituted C ₃ -C ₈ -cycloalky-Ci-C ₄ alkyl, optionally substituted C ₃ -C8-heterocycloalky-Ci-C ₆ alkyl, wherein the optional substituents for the aryl, cycloalkyl and are selected from the group consisting of halogen, hydroxy, C

C ₆ alkyl, CrC ₆ haloalkyl, CrC ₆ alkoxy, Ci-C ₆ alkoxy-Ci-C ₆ alkyl, CrC ₆ haloalkoxy, C

C ₆ alkoximino and CrC ₆ alkylendioxy preferably the optional substituents for the aryl, cycloalkyl and are selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl, d- C ₄ haloalkyl and where the wherein the optional substituents for the alkyl moieties are selected from -OH, CN, F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino, preferably the optional substituents for the alkyl moieties are selected from -OH, CN, F, CI,

R ⁵ , R ⁶ and R ⁷ are independently or each other hydrogen, unsubstituted or substituted C C ₈ alkyl, unsubstituted or substituted CrC ₈ haloalkyl, unsubstituted or substituted C

C ₄ alkoxy(CrC ₄ )alkyl, unsubstituted or substituted C ₂ -C ₄ alkenyl, unsubstituted or substituted C ₂ -C ₄ haloalkenyl, unsubstituted or substituted C ₂ -C ₄ alkynyl, unsubstituted or substituted C ₃ - C ₇ cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted C ₃ - C ₇ cycloalkyl-CrC ₄ alkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocycloalkyl-Ci-C ₄ alkyl unsubstituted or substituted aryl, unsubstituted or substituted aryl-Ci-C ₄ alkyl, unsubstituted or substituted heteroaryl-Ci-C ₄ alkyl wherein the substituents for the aryl, heteroaryl, cycloalkyl and heterocycloalkyl are independently selected from the group consisting of halogen, hydroxy, cyano, CrC ₄ alkyl, d-C ₄ haloalkyl, CrC ₄ alkoxy, C C ₄ alkoxy-Ci-C ₄ alkyl, CrC ₄ haloalkoxy, pyrimidinyl, phenyl or phenyl substituted by halogen, hydroxy, cyano, CrC ₄ alkyl, CrC ₄ haloalkyl, CrC ₄ alkoxy, CrC ₄ haloalkoxy and where the wherein the substituents for the alkyl moieties are independently selected from -OH, CN, F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino; In a further preferred embodiment

HetAr is an imidazolyl, pyridyl or triazoloyl each optionally substituted by substituents selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl, CrC ₄ haloalkyl, d- C ₄ alkoxy, Ci-C ₄ alkoxy-Ci-C ₄ alkyl,Ci-C ₄ haloalkoxy, Ci-C ₄ alkoximino and CrC ₄ alkylendioxy; R ¹ and R ² are both hydrogen.

R ¹ and R ² are both hydrogen or R ¹ and R ² form together a cyclopropyl ring.

A' is an optionally substituted phenyl, pyridyl, wherein the optional substituents are selected from the group consisting of halogen, hydroxy, CrC ₄ alkyl, CrC ₄ haloalkyl, CrC ₄ alkoxy R ³ is =N-0-R ⁵ ;

R ⁴ is hydrogen, methyl, ethyl, propyl, / ^' so-propyl, ie f-butyl, sec-butyl, neo-pentyl, trimethylsilyl, cyclopropyl, 1 -fluoro-cyclopropyl, 1 -chloro-cyclopropyl, 1 -hydroxy-cyclopropyl, 2-methyl-cyclopropyl, 2-/ ^' so-propyl-cyclopropyl, 2-methoxy-cyclopropyl, 2-trifluoromethoxy- cyclopropyl, 2-cyano-cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, phenyl, 4- fluoro-phenyl, 4-chloro-phenyl.

R ⁵ , R ⁶ and R ⁷ are independently or each other hydrogen, unsubstituted or substituted C C ₈ alkyl, unsubstituted or substituted CrC ₈ haloalkyl, unsubstituted or substituted C

C ₄ alkoxy(Ci-C ₄ )alkyl, unsubstituted or substituted C ₂ -C ₄ alkenyl, unsubstituted or substituted C ₂ -C ₄ haloalkenyl, unsubstituted or substituted C ₂ -C ₄ alkynyl, unsubstituted or substituted C ₃ - C ₇ cycloalkyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted C ₃ - C ₇ cycloalkyl-Ci-C ₄ alkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocycloalkyl-CrC ₄ alkyl unsubstituted or substituted aryl, unsubstituted or substituted aryl-Ci-C ₄ alkyl, unsubstituted or substituted heteroaryl-Ci-C ₄ alkyl wherein the substituents for the aryl, heteroaryl, cycloalkyl and heterocycloalkyl are independently selected from the group consisting of halogen, hydroxy, cyano, CrC ₄ alkyl, CrC ₄ haloalkyl, CrC ₄ alkoxy, C C ₄ alkoxy-Ci-C ₄ alkyl, CrC ₄ haloalkoxy, pyrimidinyl, phenyl or phenyl substituted by halogen, hydroxy, cyano, CrC ₄ alkyl, CrC ₄ haloalkyl, CrC ₄ alkoxy, CrC ₄ haloalkoxy and where the wherein the substituents for the alkyl moieties are independently selected from -OH, CN, F, CI, Ci _-4 alkoxy, Ci _-4 alkylamino;

Further preferred embodiments of the present invention are the embodiments E1 to E24, which are defined as compounds of formula I which are represented by one formula selected from the group consisting of the formulae T-1 to T-24 as described below, wherein in formulae T-1 to T-24 the meanings of the substituents R-i , R ₂ , F¾ and R ₄ have the preferred meanings as mentioned above.

For example, embodiment E1 is represented by the compounds of formula T-1

(T-1 ) and the substituents R-i , R ₂ , R3 and R ₄ have the meanings as defined above. Embodiments E2 to E24 are defined accordingly and the substituents R-i , R ₂ , R3 and R ₄ have the meanings as definded above.

Compounds of formula (I) may be prepared from compounds of formula (I) wherein R ₃ is an oxygen by condensation of compounds of formula (A) or formula (B) optionally in suitable solvent such as ethanol or toluene optionally in the presence of an acid like acetic acid at a temperature between 20 °C and 200 °C and optionally in the presence of a water extraction system like a Dean-Stark apparatus or a chemical water scavenger like magnesium sulphate. For examples of analogous methods see Zampieri D. et al. Arch. Pharm. Chem. Zjfe 2009, 342, 716-722 and DE3608727.

compounds of formula (I) (B)

where (I) Compounds of formula (A) are known, or may be made from known compounds by known methods.

Compounds of formula (B) are known, or may be made from known compounds by known methods.

Compounds of formula (I) wherein R ₃ is =N-OR ₅ may be prepared by treating compounds of formula (I) wherein R ₃ is =N-OH with compounds of formula (C) in the presence of a base like sodium hydride, lithium diisopropyl amide, butyl lithium, sodium hexamethyldisilazide optionally in a suitable solvent like tetrahydrofuran or dimethylformamide and at a

temperature between 20 °C and 100 °C. For examples of analogous methods see Karakurt, A. et al. Arch. Pharm. Chem. Life Sci. 2006, 339, 513 - 520, Emami, S. and Shafiee, A. Heterocycles 2001 , 55{11), 2059-2074 and DE3233145, DE3545085 and DE3608727.

compounds of formula (I) compounds of formula (I) where F¾= N-OH where F¾= N-ORs

Compounds of formula (C) wherein X is a suitable leaving group such as a halogen or alkyl- or aryl-sulfonate are known, or may be made from known compounds by known methods.

In a similar way, compounds of formula (I) wherein R ₃ is =N-NR ₆ R ₇ may be prepared by treating compounds of formula (I) wherein R ₃ is =N-NH ₂ or compounds of formula (I) wherein R ₃ is =N-NR ₇ H with compounds of formula (D) in the presence of a base like sodium hydride, lithium diisopropyl amide, butyl lithium, sodium hexamethyldisilazide optionally in a suitable solvent like tetrahydrofuran or dimethylformamide and at a temperature between 20 °C and 100 °C. For example of an analogous method see Kaur, H. et al. Organic Chemistry: An Indian Journal 2009, 5(4), 367-379.

compounds of formula (I) compounds of formula (I) compounds of formula (I) where ί¾= N-NH2 where ί¾= N-NReRy and R ₇ =H where R3= N-NReRy

Compounds of formula (D) wherein X is a suitable leaving group such as a halogen or an alkyl- or aryl-sulfonate are known, or may be made from known compounds by known methods.

Compounds of formula (I) wherein R ₃ is may be prepared by treating compounds of formula (I) where R ₃ is oxygen (=0) in the presence of a triaryl phosphonium ylide of formula Ar ₃ P=CR ₈ R9 (E) wherein Ar is an aryl group, preferably phenyl (Wittig reaction). The reaction is preferably conducted in a suitable solvent such as tetrahydrofuran at a temperature between -80 °C and 30 °C. For example of an analogous method see Sun, B. et al. Bioorg. Med. Chem. 2010, 18{14), 5352-5366.

compounds of formula (I) compounds of formula (I) where Compounds of formula (E) are known, or may be made from known compounds by known methods.

Additionally, compounds of formula (I), may be prepared from compounds of formula (F), wherein Q is an atom or group suitable for undergoing cross-coupling reactions (for example Q is chlorine, bromine or iodine, or a haloalkylsulfonate such as trifluoromethanesulfonate), with a suitable coupling partner under conditions described in the literature for Sonogashira and related cross-coupling reactions. For examples see Chinchilla, R.; Najera, C. Chem. Soc. Rev. 2011 , 40, 5084-5121 ; Eckhardt, M.; Fu, G. C. J. Am. Chem. Soc, 2003, 125, 13642-13643; Severin, R.; Reimer, J.; Doye, S. J. Org. Chem., 2010, 75, 3518-3521 ;

Compounds of formula (G) are known, or may be made from known compounds by known methods.

Compounds of formula (F) are known, or may be made from known compounds by known methods. See, for examples, Roman, G. et al. Chem. Med. Chem. 2010, 5, 1541 -1555; Hu, Q. et al. J. Med. Chem. 2010, 53, 5049-5053; Belai, I et al. Pestic. Sci. 1995, 44, 225-232; Todoroki, Y. et al. Bioorg. Med. Chem. 2008, 16, 3141 -3152.

In a similar manner, compounds of formula (I), may be prepared from compounds of formula (I), wherein R ₄ is hydrogen or trimethylsilyl with a suitable coupling partner R ₄ -Q of formula (J) wherein Q is an atom or group suitable for undergoing cross-coupling reactions (for example Q is chlorine, bromine or iodine, or a haloalkylsulfonate such as

trifluoromethanesulfonate), under conditions described in the literature for Sonogashira and related cross-coupling reactions. For examples see Chinchilla, R.; Najera, C. Chem. Soc. Rev. 2011 , 40, 5084-5121 ; Eckhardt, M.; Fu, G. C. J. Am. Chem. Soc, 2003, 125, 13642- 13643; Severin, R.; Reimer, J.; Doye, S. J. Org. Chem., 2010, 75, 3518-3521.

(I)

(I)

compounds of formula (I) wherein

R4 is hydrogen or trimethlylsilyl

Compounds of formula (H) are known, or may be made from known compounds by known methods. Additionally, compounds of formula (I) may be prepared by treating compounds of formula (I) wherein Ri and R ₂ are hydrogen sequentially with compounds of formula (J) and compounds of formula (K) wherein LG is an atom or a group known as a leaving group (for example LG is chlorine, bromine or iodine, or a haloalkylsulfonate as trifluoromethanesulfonate, or a alkylarylsulfonate as tosylsulfonate) ) in the presence of a base like sodium hydride, lithium diisopropyl amide, butyl lithium, sodium hexamethyldisilazide, sodium methoxide, triethly amine optionally in a suitable solvent like tetrahydrofuran or dimethylformamide and at a temperature between -78 °C and 100 °C. For examples of analogous methods see

Santamaria, A. et al. ARKIVOC 2007, 4, 234-250, DE3525221 and DE34401 14.

(I) (I)

compounds of formula (I) compounds of formula (I)

wherein Ri and R ₂ are hydrogen wherein R ₂ is hydrogen

The reactions to give compounds of formula (I) are advantageously carried out in aprotic inert organic solvents. Such solvents are hydrocarbons such as benzene, toluene, xylene or cyclohexane, chlorinated hydrocarbons such as dichloromethane, trichloromethane, tetrachloromethane or chlorobenzene, ethers such as diethyl ether, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, tetrahydrofuran or dioxane, nitriles such as acetonitrile or propionitrile, amides such as Ν,Ν-dimethylformamide, diethylformamide or N-methylpyrrolidinone. The reaction temperatures are advantageously between -20°C and +120°C. In general, the reactions are slightly exothermic and, as a rule, they can be carried out at ambient temperature. To shorten the reaction time, or else to start the reaction, the mixture may be heated briefly to the boiling point of the reaction mixture. The reaction times can also be shortened by adding a few drops of base as reaction catalyst. Suitable bases are, in particular, tertiary amines such as trimethylamine, triethylamine, quinuclidine, 1 ,4-diazabicyclo[2.2.2]octane, 1 ,5-diazabicyclo[4.3.0]non-5-ene or 1 ,5-diazabicyclo- [5.4.0]undec-7-ene. However, inorganic bases such as hydrides, e.g. sodium hydride or calcium hydride, hydroxides, e.g. sodium hydroxide or potassium hydroxide, carbonates such as sodium carbonate and potassium carbonate, or hydrogen carbonates such as potassium hydrogen carbonate and sodium hydrogen carbonate may also be used as bases. The bases can be used as such or else with catalytic amounts of a phase-transfer catalyst, for example a crown ether, in particular 18-crown-6, or a tetraalkylammonium salt.

The compounds of formula (I) and, where appropriate, the tautomers thereof, can, if appropriate, also be obtained in the form of hydrates and/or include other solvents, for example those which may have been used for the crystallization of compounds which are present in solid form.

It has now been found that the compounds of formula (I) according to the invention have, for practical purposes, a very advantageous spectrum of activities for protecting useful plants against diseases that are caused by phytopathogenic microorganisams, such as fungi, bacteria or viruses.

The invention therefore also relates to a method of controlling or preventing infestation of useful plants by phytopathogenic microorganisms, wherein a compound of formula (I) is applied as active ingredient to the plants, to parts thereof or the locus thereof. The compounds of formula (I) according to the invention are distinguished by excellent activity at low rates of application, by being well tolerated by plants and by being environmentally safe. They have very useful curative, preventive and systemic properties and are used for protecting numerous useful plants. The compounds of formula (I) can be used to inhibit or destroy the diseases that occur on plants or parts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops of useful plants, while at the same time protecting also those parts of the plants that grow later e.g. from phytopathogenic microorganisms.

It is also possible to use compounds of formula (I) as dressing agents for the treatment of plant propagation material, in particular of seeds (fruit, tubers, grains) and plant cuttings (e.g. rice), for the protection against fungal infections as well as against phytopathogenic fungi occurring in the soil. Furthermore, the compounds of formula (I) according to the invention may be used for controlling fungi in related areas, for example in the protection of technical materials, including wood and wood related technical products, in food storage or in hygiene management.

The compounds of formula (I) are, for example, effective against the phytopathogenic fungi of the following classes: Fungi imperfecti (e.g. Botrytis, Pyricularia, Helminthosporium, Fusarium, Septoria, Cercospora and Alternaria) and Basidiomycetes (e.g. Rhizoctonia, Hemileia, Puccinia). Additionally, they are also effective against the Ascomycetes classes (e.g. Venturia and Erysiphe, Podosphaera, Monilinia, Uncinula) and of the Oomycetes classes (e.g. Phytophthora, Pythium, Plasmopara). Furthermore, the novel compounds of formula (I) are effective against phytopathogenic bacteria and viruses (e.g. against

Xanthomonas spp, Pseudomonas spp, Erwinia amylovora as well as against the tobacco mosaic virus). The compounds of formula (I) are also effective against Asian soybean rust (Phakopsora pachyrhizi).

Within the scope of the invention, useful plants to be protected typically comprise the following species of plants: cereal (wheat, barley, rye, oat, rice, maize, sorghum and related species); beet (sugar beet and fodder beet); pomes, drupes and soft fruit (apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries and blackberries); leguminous plants (beans, lentils, peas, soybeans); oil plants (rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, groundnuts); cucumber plants (pumpkins, cucumbers, melons); fibre plants (cotton, flax, hemp, jute); citrus fruit (oranges, lemons, grapefruit, mandarins); vegetables (spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, paprika); lauraceae (avocado, cinnamomum, camphor) or plants such as tobacco, nuts, coffee, eggplants, sugar cane, tea, pepper, vines, hops, bananas and natural rubber plants, as well as ornamentals.

The term "useful plants" is to be understood as including also useful plants that have been rendered tolerant to herbicides like bromoxynil or classes of herbicides (such as, for example, HPPD inhibitors, ALS inhibitors, for example primisulfuron, prosulfuron and trifloxysulfuron, EPSPS (5-enol-pyrovyl-shikimate-3-phosphate-synthase) inhibitors, GS (glutamine synthetase) inhibitors or PPO (protoporphyrinogen-oxidase) inhibitors) as a result of conventional methods of breeding or genetic engineering. An example of a crop that has been rendered tolerant to imidazolinones, e.g. imazamox, by conventional methods of breeding (mutagenesis) is Clearfield® summer rape (Canola). Examples of crops that have been rendered tolerant to herbicides or classes of herbicides by genetic engineering methods include glyphosate- and glufosinate-resistant maize varieties commercially available under the trade names RoundupReady® , Herculex I® and LibertyLink®. The term "useful plants" is to be understood as including also useful plants which have been so transformed by the use of recombinant DNA techniques that they are capable of synthesising one or more selectively acting toxins, such as are known, for example, from toxin-producing bacteria, especially those of the genus Bacillus. Examples of such plants are: YieldGard® (maize variety that expresses a CrylA(b) toxin); YieldGard Rootworm® (maize variety that expresses a Cryl 11 B(b1 ) toxin); YieldGard Plus® (maize variety that expresses a CrylA(b) and a CrylllB(bl ) toxin); Starlink® (maize variety that expresses a Cry9(c) toxin); Herculex I® (maize variety that expresses a CrylF(a2) toxin and the enzyme phosphinothricine N-acetyltransferase (PAT) to achieve tolerance to the herbicide glufosinate ammonium); NuCOTN 33B® (cotton variety that expresses a CrylA(c) toxin); Bollgard I® (cotton variety that expresses a CrylA(c) toxin); Bollgard II® (cotton variety that expresses a CrylA(c) and a CryllA(b) toxin); VIPCOT® (cotton variety that expresses a VIP toxin); NewLeaf® (potato variety that expresses a CrylllA toxin); NatureGard® Agrisure® GT Advantage (GA21 glyphosate-tolerant trait), Agrisure® CB Advantage (Bt1 1 corn borer (CB) trait), Agrisure® RW (corn rootworm trait) and Protecta®.

The term "crops" is to be understood as including also crop plants which have been so transformed by the use of recombinant DNA techniques that they are capable of synthesising one or more selectively acting toxins, such as are known, for example, from toxin-producing bacteria, especially those of the genus Bacillus.

Toxins that can be expressed by such transgenic plants include, for example, insecticidal proteins from Bacillus cereus or Bacillus popilliae; or insecticidal proteins from Bacillus thuringiensis, such as δ-endotoxins, e.g. CrylAb, CrylAc, Cry1 F, Cry1 Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or vegetative insecticidal proteins (Vip), e.g. Vip1 , Vip2, Vip3 or Vip3A; or insecticidal proteins of bacteria colonising nematodes, for example Photorhabdus spp. or Xenorhabdus spp., such as Photorhabdus luminescens, Xenorhabdus nematophilus; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins and other insect- specific neurotoxins; toxins produced by fungi, such as Streptomycetes toxins, plant lectins, such as pea lectins, barley lectins or snowdrop lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin, papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroidoxidase, ecdysteroid-UDP- glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors, HMG-COA-reductase, ion channel blockers, such as blockers of sodium or calcium channels, juvenile hormone esterase, diuretic hormone receptors, stilbene synthase, bibenzyl synthase, chitinases and glucanases.

In the context of the present invention there are to be understood by δ-endotoxins, for example CrylAb, CrylAc, Cry1 F, Cry1 Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or vegetative insecticidal proteins (Vip), for example Vip1 , Vip2, Vip3 or Vip3A, expressly also hybrid toxins, truncated toxins and modified toxins. Hybrid toxins are produced recombinantly by a new combination of different domains of those proteins (see, for example, WO 02/15701 ). Truncated toxins, for example a truncated CrylAb, are known. In the case of modified toxins, one or more amino acids of the naturally occurring toxin are replaced. In such amino acid replacements, preferably non-naturally present protease recognition sequences are inserted into the toxin, such as, for example, in the case of Cry3A055, a cathepsin-G-recognition sequence is inserted into a Cry3A toxin (see WO 03/018810).

Examples of such toxins or transgenic plants capable of synthesising such toxins are disclosed, for example, in EP-A-0 374 753, WO 93/07278, WO 95/34656, EP-A-0 427 529, EP-A-451 878 and WO 03/052073.

The processes for the preparation of such transgenic plants are generally known to the person skilled in the art and are described, for example, in the publications mentioned above. Cryl-type deoxyribonucleic acids and their preparation are known, for example, from WO 95/34656, EP-A-0 367 474, EP-A-0 401 979 and WO 90/13651.

The toxin contained in the transgenic plants imparts to the plants tolerance to harmful insects. Such insects can occur in any taxonomic group of insects, but are especially commonly found in the beetles (Coleoptera), two-winged insects (Diptera) and butterflies (Lepidoptera).

Transgenic plants containing one or more genes that code for an insecticidal resistance and express one or more toxins are known and some of them are commercially available.

Examples of such plants are: YieldGard® (maize variety that expresses a CrylAb toxin); YieldGard Rootworm® (maize variety that expresses a Cry3Bb1 toxin); YieldGard Plus® (maize variety that expresses a CrylAb and a Cry3Bb1 toxin); Starlink® (maize variety that expresses a Cry9C toxin); Herculex I® (maize variety that expresses a Cry1 Fa2 toxin and the enzyme phosphinothricine N-acetyltransferase (PAT) to achieve tolerance to the herbicide glufosinate ammonium); NuCOTN 33B® (cotton variety that expresses a CrylAc toxin); Bollgard I® (cotton variety that expresses a CrylAc toxin); Bollgard II® (cotton variety that expresses a CrylAc and a Cry2Ab toxin); VipCot® (cotton variety that expresses a

Vip3A and a Cry1 Ab toxin); NewLeaf® (potato variety that expresses a Cry3A toxin); Nature- Gard®, Agrisure® GT Advantage (GA21 glyphosate-tolerant trait), Agrisure® CB Advantage (Bt1 1 corn borer (CB) trait) and Protecta®. Further examples of such transgenic crops are:

1 . Bt11 Maize from Syngenta Seeds SAS, Chemin de I'Hobit 27, F-31 790 St. Sauveur, France, registration number C/FR/96/05/10. Genetically modified Zea mays which has been rendered resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenic expression of a truncated CrylAb toxin. Bt1 1 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium.

2. Bt176 Maize from Syngenta Seeds SAS, Chemin de I'Hobit 27, F-31 790 St. Sauveur, France, registration number C/FR/96/05/10. Genetically modified Zea mays which has been rendered resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenic expression of a CrylAb toxin. Bt176 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium. 3. MIR604 Maize from Syngenta Seeds SAS, Chemin de I'Hobit 27, F-31 790 St. Sauveur, France, registration number C/FR/96/05/10. Maize which has been rendered insect-resistant by transgenic expression of a modified Cry3A toxin. This toxin is Cry3A055 modified by insertion of a cathepsin-G-protease recognition sequence. The preparation of such transgenic maize plants is described in WO 03/018810.

4. MON 863 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1 150 Brussels, Belgium, registration number C/DE/02/9. MON 863 expresses a Cry3Bb1 toxin and has resistance to certain Coleoptera insects. 5. IPC 531 Cotton from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1 150 Brussels, Belgium, registration number C/ES/96/02. 6. 1507 Maize from Pioneer Overseas Corporation, Avenue Tedesco, 7 B-1 160 Brussels, Belgium, registration number C/NL/00/10. Genetically modified maize for the expression of the protein Cry1 F for achieving resistance to certain Lepidoptera insects and of the PAT protein for achieving tolerance to the herbicide glufosinate ammonium.

7. NK603 x MON 810 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1 150 Brussels, Belgium, registration number C/GB/02/M3/03. Consists of conventionally bred hybrid maize varieties by crossing the genetically modified varieties NK603 and MON 810. NK603 MON 810 Maize transgenically expresses the protein CP4 EPSPS, obtained from Agrobacterium sp. strain CP4, which imparts tolerance to the herbicide Roundup® (contains glyphosate), and also a CrylAb toxin obtained from Bacillus thuringiensis subsp. kurstaki which brings about tolerance to certain Lepidoptera, include the European corn borer.

The term "locus" of a useful plant as used herein is intended to embrace the place on which the useful plants are growing, where the plant propagation materials of the useful plants are sown or where the plant propagation materials of the useful plants will be placed into the soil. An example for such a locus is a field, on which crop plants are growing.

The term "plant propagation material" is understood to denote generative parts of the plant, such as seeds, which can be used for the multiplication of the latter, and vegetative material, such as cuttings or tubers, for example potatoes. There may be mentioned for example seeds (in the strict sense), roots, fruits, tubers, bulbs, rhizomes and parts of plants.

Germinated plants and young plants which are to be transplanted after germination or after emergence from the soil, may also be mentioned. These young plants may be protected before transplantation by a total or partial treatment by immersion. Preferably "plant propagation material" is understood to denote seeds. The compounds of formula (I) can be used in unmodified form or, preferably, together with carriers and adjuvants conventionally employed in the art of formulation.

Therefore the invention also relates to compositions for controlling and protecting against phytopathogenic microorganisms, comprising a compound of formula (I) and an inert carrier, and to a method of controlling or preventing infestation of useful plants by phytopathogenic microorganisms, wherein a composition, comprising a compound of formula (I) as acitve ingredient and an inert carrier, is applied to the plants, to parts thereof or the locus thereof.

To this end compounds of formula (I) and inert carriers are conveniently formulated in known manner to emulsifiable concentrates, coatable pastes, directly sprayable or dilutable solutions, dilute emulsions, wettable powders, soluble powders, dusts, granulates, and also encapsulations e.g. in polymeric substances. As with the type of the compositions, the methods of application, such as spraying, atomising, dusting, scattering, coating or pouring, are chosen in accordance with the intended objectives and the prevailing circumstances. The compositions may also contain further adjuvants such as stabilizers, antifoams, viscosity regulators, binders or tackifiers as well as fertilizers, micronutrient donors or other formulations for obtaining special effects.

Suitable carriers and adjuvants (auxiliaries) can be solid or liquid and are substances useful in formulation technology, e.g. natural or regenerated mineral substances, solvents, dispersants, wetting agents, tackifiers, thickeners, binders or fertilizers. Such carriers are for example described in WO 97/33890.

The compounds of formula (I) or compositions, comprising a compound of formula (I) as acitve ingredient and an inert carrier, can be applied to the locus of the plant or plant to be treated, simultaneously or in succession with further compounds. These further compounds can be e.g. fertilizers or micronutrient donors or other preparations which influence the growth of plants. They can also be selective herbicides as well as insecticides, fungicides, bactericides, nematicides, molluscicides or mixtures of several of these preparations, if desired together with further carriers, surfactants or application promoting adjuvants customarily employed in the art of formulation.

A preferred method of applying a compound of formula (I), or a composition, comprising a compound of formula (I) as acitve ingredient and an inert carrier, is foliar application. The frequency of application and the rate of application will depend on the risk of infestation by the corresponding pathogen. However, the compounds of formula (I) can also penetrate the plant through the roots via the soil (systemic action) by drenching the locus of the plant with a liquid formulation, or by applying the compounds in solid form to the soil, e.g. in granular form (soil application). In crops of water rice such granulates can be applied to the flooded rice field. The compounds of formula (I) may also be applied to seeds (coating) by impregnating the seeds or tubers either with a liquid formulation of the fungicide or coating them with a solid formulation.

A formulation, i.e. a composition comprising the compound of formula (I) and, if desired, a solid or liquid adjuvant or, if desired as well, a further, other biocidally active ingredient, is prepared in a known manner, typically by intimately mixing and/or grinding the compound with extenders, for example solvents, solid carriers and, optionally, surface-active

compounds (surfactants). The activity of the compositions according to the invention can be broadened considerably, and adapted to prevailing circumstances, by adding other insecticidally, acaricidally and/or fungicidally active ingredients. The mixtures of the compounds of formula (I) with other insecticidally, acaricidally and/or fungicidally active ingredients may also have further surprising advantages which can also be described, in a wider sense, as synergistic activity. For example, better tolerance by plants, reduced phytotoxicity, insects can be controlled in their different development stages or better behaviour during their production, for example during grinding or mixing, during their storage or during their use.

Suitable additions to active ingredients here are, for example, representatives of the following classes of active ingredients: organophosphorus compounds, nitrophenol derivatives, thioureas, juvenile hormones, formamidines, benzophenone derivatives, ureas, pyrrole derivatives, carbamates, pyrethroids, chlorinated hydrocarbons, acylureas, pyridyl- methyleneamino derivatives, macrolides, neonicotinoids and Bacillus thuringiensis preparations. The compositions can also comprise further solid or liquid auxiliaries, such as stabilizers, for example unepoxidized or epoxidized vegetable oils (for example epoxidized coconut oil, rapeseed oil or soya oil), antifoams, for example silicone oil, preservatives, viscosity regulators, binders and/or tackifiers, fertilizers or other active ingredients for achieving specific effects, for example bactericides, fungicides, nematocides, plant activators, molluscicides or herbicides.

The compositions according to the invention are prepared in a manner known per se, in the absence of auxiliaries for example by grinding, screening and/or compressing a solid active ingredient and in the presence of at least one auxiliary for example by intimately mixing and/or grinding the active ingredient with the auxiliary (auxiliaries). These processes for the preparation of the compositions and the use of the compounds I for the preparation of these compositions are also a subject of the invention.

The application methods for the compositions, that is the methods of controlling pests of the abovementioned type, such as spraying, atomizing, dusting, brushing on, dressing, scattering or pouring - which are to be selected to suit the intended aims of the prevailing circumstances - and the use of the compositions for controlling pests of the abovementioned type are other subjects of the invention. Typical rates of concentration are between 0.1 and 1000 ppm, preferably between 0.1 and 500 ppm, of active ingredient. The rate of application per hectare is generally 1 to 2000 g of active ingredient per hectare, in particular 10 to 1000 g/ha, preferably 10 to 600 g/ha.

A preferred method of application in the field of crop protection is application to the foliage of the plants (foliar application), it being possible to select frequency and rate of application to match the danger of infestation with the pest in question. Alternatively, the active ingredient can reach the plants via the root system (systemic action), by drenching the locus of the plants with a liquid composition or by incorporating the active ingredient in solid form into the locus of the plants, for example into the soil, for example in the form of granules (soil application). In the case of paddy rice crops, such granules can be metered into the flooded paddy-field.

The compositions according to the invention are also suitable for the protection of plant propagation material, for example seeds, such as fruit, tubers or kernels, or nursery plants, against pests of the abovementioned type. The propagation material can be treated with the compositions prior to planting, for example seed can be treated prior to sowing. Alternatively, the compositions can be applied to seed kernels (coating), either by soaking the kernels in a liquid composition or by applying a layer of a solid composition. It is also possible to apply the compositions when the propagation material is planted to the site of application, for example into the seed furrow during drilling. These treatment methods for plant propagation material and the plant propagation material thus treated are further subjects of the invention.

The following non-limiting examples illustrate the above-described invention in greater detail without limiting it. Example 1 : Synthesis of /V-te f-butoxy-1 -[4-(2-cvclopropylethvnyl)phenyll-2-(1 ,2,4-triazol-1 - vDethanimine.

Step 1 : Synthesis of 1 -(4-bromophenyl)-2-(1 ,2,4-triazol-1 -yl)ethanone

To a cold (0-5 °C) solution of 4H-1 ,2,4-triazole (33.7g, 488 mmol) in dimethylformamide (90 ml) was added 2-bromo-1 -(4-bromophenyl)ethanone (27,8 g, 100 mmol; Aldrich D38308) in several portions. The suspension was stirred at 0-5 °C for an hour and was allowed to warm to room temperature. The reaction mixture was poured into water (200 ml) and extracted with ethyl acetate (3 x 100 ml). The combined organic layers were washed with water (100 ml), brine (100 ml), dried over magnesium sulphate, filtered and evaporated under reduced pressure to give 7.6 g of 1 -(4-bromophenyl)-2-(1 ,2,4-triazol-1 -yl)ethanone as a white powder.

Step 2: Synthesis of 1 -[4-(2-cvclopropylethvnyl)phenyll-2-(1 ,2,4-triazol-1 -yl)ethanone

A solution of 1 -(4-bromophenyl)-2-(1 ,2,4-triazol-1 -yl)ethanone (7.5 g, 28 mmol),

ethynylcyclopropane (7.5 g, 1 10 mmol; Aldrich 663018), triethylamine (80 ml, 560 mmol), cuprous iodide (0,27 g, 1 .4 mmol), bis(triphenylphosphine)palladium(ll)dichloride (2.0 g, 2.8 mmol) in dimethylformamide (40 ml) was stirred overnight at room temperature under an inert atmosphere. The reaction mixture was diluted with water (150 ml) and extracted with ethyl acetate (3 x 100 ml). The combined organic layers were washed with water (3 x 50 ml), dried over magnesium sulphate, filtered and evaporated under reduced pressure. The crude brown solid obtained was purified by flash chromatography to give 3.83 g of 1 -[4-(2- cyclopropylethynyl)phenyl]-2-(1 ,2,4-triazol-1 -yl)ethanone as a yellow solid.

Step 3: Synthesis of /V-te f-butoxy-1 -[4-(2-cvclopropylethvnyl)phenyll-2-(1 ,2,4-triazol-1 - vDethanimine.

1 -[4-(2-cyclopropylethynyl)phenyl]-2-(1 ,2,4-triazol-1 -yl)ethanone (201 mg, 0.8 mmol) was mixed with O-ie f-butylhydroxylaminehydrochloride (251 mg, 2 mmol; Aldrich 20023) and sodium acetate (164 mg, 2 mmol) in ethanol (10 ml). The reaction mixture was reflux overnight. The solvent was removed under reduced pressure and the residue was diluted with ethyl acetate (50 ml). The organic phase was washed with water (1 x 20 ml), dried over magnesium sulphate, filtered and evaporated under reduced pressure. The crude residue was purified by flash chromatography to give /V-ie f-butoxy-1 -[4-(2- cyclopropylethynyl)phenyl]-2-(1 ,2,4-triazol-1 -yl)ethanimine as an mixture of E/Z-isomers.

Example 2: Synthesis of 1 -[4-(2-cvclopropylethvnyl)phenyll-/V-(cvclopropylmethoxy)-2- imidazol-1 -yl-ethanimine

Step 1 : Synthesis of 1 -(4-bromophenyl)-2-imidazol-1 -yl-ethanone

To a cold (0-5 °C) solution of imidazole (33.2 g, 488 mmol) in dimethylformamide (90 ml) was added 2-bromo-1 -(4-bromophenyl)ethanone (27,8 g, 100 mmol; Aldrich D38308) in several portions. The suspension was stirred at 0-5 °C for 0.25 hour and the reaction mixture was poured into water (100 ml), diluted with ethyl acetate (200 ml), filtered and the solid residue was washed with ethyl acetate (50 ml). The water layer was extracted with ethyl acetate (3 x 50 ml). The combined organic layers were washed with water (100 ml), brine (100 ml), dried over magnesium sulphate, filtered and evaporated under reduced pressure to give 23 g of 1 - (4-bromophenyl)-2-imidazol-1 -yl-ethanone.

Step 2: Synthesis of 1 -[4-(2-cvclopropylethvnyl)phenyll-2-imidazol-1 -yl-ethanone

A solution of 1 -(4-bromophenyl)-2-imidazol-1 -yl-ethanone (5.3 g, 20 mmol)

ethynylcyclopropane (5.3 g, 80 mmol; Aldrich 663018), triethylamine (56 ml, 400 mmol), cuprous iodide (0,19 g, 1 mmol), bis(triphenylphosphine)palladium(ll)dichloride (1.4 g, 2.0 mmol) in dimethylformamide (40 ml) was stirred overnight at room temperature under an inert atmosphere. The reaction mixture was diluted with water (150 ml) and a saturated aqueous solution of sodium bicarbonate (50 ml) and extracted with ethyl acetate (3 x 100 ml). The combined organic layers were washed with water (3 x 50 ml), dried over magnesium sulphate, filtered and evaporated under reduced pressure. The crude brown solid obtained was purified by flashchromatography to give 2.25 g of 1 -[4-(2-cyclopropylethynyl)phenyl]-2- (1 ,2,4-triazol-1 -yl)ethanone.

Step 3: Synthesis of 1 -[4-(2-cvclopropylethvnyl)phenyll-2-imidazol-1 -yl-ethanone oxime

1 -[4-(2-cyclopropylethynyl)phenyl]-2-imidazol-1 -yl-ethanone (0.50 g, 2 mmol) was mixed with hydroxylamine hydrochloride (278 mg, 4 mmol) and sodium acetate (328 mg, 4 mmol) in ethanol (20 ml). The reaction mixture was reflux for 3 hours. The solvent was removed under reduced pressure and the residue was diluted with ethyl acetate (50 ml). The organic phase was washed with water (1 x 20 ml), dried over magnesium sulphate, filtered and evaporated under reduced pressure. The crude residue was purified by flash chromatography to give 1 - [4-(2-cyclopropylethynyl)phenyl]-2-imidazol-1 -yl-ethanone oxime as a mixture of E/Z-isomers.

Step 4: Synthesis of 1 -[4-(2-cvclopropylethvnyl)phenyll-/V-(cvclopropylmethoxy)-2- imidazol-1 - yl-ethanimine

To a solution of 1 -[4-(2-cyclopropylethynyl)phenyl]-2-imidazol-1 -yl-ethanone (160 mg, 0.6 mmol) in dimethylformamide (10 ml) was added sodium hydride (60% dispersion in mineral oil, 29 mg, 0.72 mmol) and the reaction mixture was stirred at room temperature for 0.5 hour. Cycloproplymethyl bromide (92 mg, 66 mmol) was added and the reaction mixture was stirred at room temperature overnight. The reaction mixture was poured into water (50 ml) and extracted with ethyl acetate (3 x 50 ml). The combined organic layers were washed three times with water (3 x 20 ml), once with brine (20 ml), dried over magnesium sulphate, filtered and evaporated under reduced pressure. The crude residue was purified by flash chromatography to give 1 -[4-(2-cyclopropylethynyl)phenyl]-/V-(cyclopropylmethoxy)-2- imidazol-1 -yl-ethanimine as a mixture of E/Z-isomers. Example 3: Synthesis of 1 -[3-chloro-4-(2-cvclopropylethvnyl)phenyll-2-imidazol-1 -yl-N- methoxy-ethanimine

Step 1 : Synthesis of 4-bromo-3-chloro-N-methoxy-N-methyl-benzamide

To a stirred solution of 4-bromo-3-chloro-benzoic acid (5.0 g, 21 .2 mmol) in dichloromethane (50 ml) was added /V-methoxymethylamine (1 .43 g, 23.34 mmol), 1 -ethyl-3-(3- dimethylaminopropyl)carbodiimide (4.16 g, 25.48 mmol), 7-aza-1 -hydroxybenzotriazole (590 mg, 4.25 mmol)and /V-ethyldiisopropylamine (7.42 ml, 42.5 mmol). The mixture was then allowed to react overnight at room temperature. 100 ml of ethyl acetate as well as 100 ml of water were added. The organic phase was washed once with a saturated solution of sodium bicarbonate (50 ml). The organic phase was then concentrated under reduced pressure. The crude product was purified by flash chromatography to provide 5.91 g of 4-bromo-3-chloro-/V- methoxy-/V-methyl-benzamide

Step 2: Synthesis of 2-bromo-1 -(4-bromo-3-chloro-phenyl)ethanone

To a stirred solution of 4-bromo-3-chloro-/V-methoxy-/V-methyl-benzamide (4.6 g, 17 mmol) in tetrahydrofuran was added 3.0 M solution of methyl magnesium bromide (6.6 ml, 20 mmol) slowly at 5 °C. The resultant reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture was poured into 20% aqueous HCI (300 ml.) and then extracted with EtOAc (3 x 150 mL). The combined organic layers were washed with brine (1 x 100 ml), dried over magnesium sulphate, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography to give 3.0 g the 2-bromo-1 -(4-bromo-3-chloro- phenyl)ethanone .

Step 3: Synthesis of 2-bromo-1 -(4-bromo-3-chloro-phenyl)ethanone

To a stirred solution of 1 -(4-bromo-3-chloro-phenyl)ethanone (3.00 g, 12.85 mmol) in tetrahydrofuran (40 ml) and methanol (30 ml) was added tetrabutylammonium tribromide (6.32 g, 12.85 mmol) in tetrahydrofuran (20 ml) at room temperature. The reaction mixture was stirred for 24 hours at room temperature. The reaction mixture was evaporated under reduced pressure. The residue was dissolved in ethyl acetate (100 ml) and washed with water (2 x 50 ml). The organic phase was dried over magnesium sulfate, filtered and concentrated to afford 2-bromo-1 -(4-bromo-3-chloro-phenyl)ethanone (4.01 g) as a yellow oil. The product was used in the next step without further purification.

Step 4: Synthesis of 1 -(4-bromo-3-chloro-phenyl)-2-imidazol-1 -yl-ethanone

To a stirred solution of 2-bromo-1 -(4-bromo-3-chloro-phenyl)ethanone (4.0 g, 12.8 mmol) in tetrahydrofuran (50 ml) at 0 °C was added imidazole (1.76 g, 25.6 mmol). The reaction mixture was then stirred at room temperature for 3 hours. The solvent was removed under reduced pressure. The residue was diluted with ethyl acetate (100 ml) and washed with water (2 x 50 ml). The organic extract was dried over magnesium sulfate and concentrated under reduced pressure to give 4.0 g of 1 -(4-bromo-3-chloro-phenyl)-2-imidazol-1 -yl- ethanone. Step 5: Synthesis of 1 -(4-bromo-3-chloro-phenyl)-2-imidazol-1 -yl-N-methoxy-ethanimine

1 -(4-bromo-3-chloro-phenyl)-2-imidazol-1 -yl-ethanone (0.50 g, 1.7 mmol) was mixed with methoxyamine hydrochloride (284 mg, 3.4 mmol) and sodium carbonate (360 mg, 3.4 mmol) in ethanol (10 ml). The reaction mixture was reflux for 4 hours. The reaction mixture was poured into ice and water and the resulting mixture was extracted with ethyl acetate (50 ml). The organic phase was was washed with water (1 x 20 ml), dried over magnesium sulphate, filtered and evaporated under reduced pressure. The crude residue was purified by flash chromatography to give 1 -(4-bromo-3-chloro-phenyl)-2-imidazol-1 -yl-/V-methoxy-ethanimine as an mixture of E/Z-isomers.

Step 6: Synthesis of 1 -[3-chloro-4-(2-cvclopropylethvnyl)phenyll-2-imidazol-1 -yl-N-methoxy- ethanimine

A solution of 1 -(4-bromo-3-chloro-phenyl)-2-imidazol-1 -yl-N-methoxy-ethanimine (100 mg, 0.3 mmol), ethynylcyclopropane (80 mg, 1 .2 mmol; Aldrich 663018), triethylamine (0.010 ml, 0.08 mmol)), cuprous iodide (2.9 mg, 0.015 mmol), bis(triphenylphosphine)palladium(ll)dichloride (22 mg, 0.03 mmol) in dimethylformamide (5 ml) was stirred at 130 °C for an hour. The reaction mixture was diluted with water (10 ml) and ethyl acetate (10 ml) and then the organic layer was separated. The organic phase was washed with brine (10 ml), dried over magnesium sulphate, filtered, and the filtrate concentrated under reduced pressure to give the crude product. The crude product was purified by flash chromatography and then by reverse phase preparative HPLC to give 1 -[3- chloro-4-(2-cyclopropylethynyl)phenyl]-2-imidazol-1 -yl-N-methoxy-ethanimine. Example 4: Synthesis of 1 -[4-(2-cvclopropylethvnyl)phenyll-N-ethoxy-2-(1 ,2,4-triazol-1 - vDethanimine

Step 1 : Synthesis of 1 -(4-bromophenyl)-N-ethoxy-2-(1 ,2,4-triazol-1 -yl)ethanimine

A mixture of 1 -(4-bromophenyl)-2-(1 H-1 ,2,4-triazol-1 -yl)ethanone (532 mg, 2.0 mmol), O- ethylhydroxylamine hydrochloride (390 mg, 4.00 mmol) and sodium acetate (492 mg, 6.00 mmol) in ethanol (5 ml) was heated in a sealed tube at 95 °C overnight. The reaction mixture was allowed to cool to room temperature, poured into water (30 ml) and stirred for 30 min. The precipitated solid was filtered off, washed twice with water and dried to provide 498 mg of as a cream coloured solid as a mixture of E/Z-isomers.

Step 2: Synthesis of 1 -[4-(2-cvclopropylethvnyl)phenyll-N-ethoxy-2-(1 ,2,4-triazol-1 - vDethanimine

In a microwave vial, 1 -(4-bromophenyl)-2-(1 H-1 ,2,4-triazol-1 -yl)ethanone O-ethyl oxime (480 mg, 1 .55 mmol) was dissolved in dry dimethylformamide (10 ml) and degassed with argon. To this was added triethylamine (1 .082 ml, 7.76 mmol) and degassing was continued for 1 min. Ethynylcyclopropane (0.526 ml, 6.21 mmol), tetrakis(triphenylphosphine)palladium(0) (71 .8 mg, 0.062 mmol) and copper iodide (cat) were added, the vial was closed and the reaction mixture was heated in the microwave at 120 °C for 1 h. The reaction mixture was partitioned between ethyl acetate (50 ml) and water/brine (1/1 , 50 ml). After washing, the layers were separated, the organic layer was washed two more times with water/brine (1/1 , 2 x 25 ml), dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography to give 1 -[4-(2- cyclopropylethynyl)phenyl]-N-ethoxy-2-(1 ,2,4-triazol-1 -yl)ethanimine as a mixture of E/Z- isomers.

Example 5: Synthesis of 1 -[5-[2-(4-fluorophenyl)ethvnyll-2-pyridyll-2-imidazol-1 -yl-N- methoxy-ethanimine.

Step 1 : Synthesis of 1 -(5-bromo-2-pyridyl)ethanol

Under inert atmosphere, 5-bromo-2-iodopyridine (14.19 g, 50 mmol) was dissolved in dry tetrahydrofuran (150 ml) and the reaction vessel was placed in a cooled ice/NaCI bath (under N ₂ ). To this was added dropwise isopropylmagnesium bromide (25.00 ml, 50.0 mmol). After complete addition, stirring was continued at the same temperature for 0.5 hour. A solution of acetaldehyde (4 ml, 70.8 mmol) in dry tetrahydrofuran (25 ml) was added dropwise. After complete addition, the cooling bath was removed and stirring was continued at room temperature for 0.5 hour. The reaction mixture was quenched with water (150 ml) and brine (100 ml). EtOAc (100 ml) was added and the mixture was transferred into a separation funnel. The layers were separated. The organic layer was washed with brine (50 ml), dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude product was purified over by flash chromatography to give 8.09 g of 1 -(5-bromo-2-pyridyl)ethanol as a yellow oil.

Step 2: Synthesis of 1 -(5-bromo-2-pyridyl)ethanone

To a solution of 1 -(5-bromopyridin-2-yl)ethanol (7.66 g, 37.9 mmol) in dichloromethane (100 ml) was added manganese dioxide (19.78 g, 227 mmol) and the mixture was heated at 40 °C overnight. The reaction mixture was filtered over Celite and the Celite was thouroughly flushed with dichloromethane. The yellow filtrate was concentrated to afford 7.39 g of 1 -(5- bromo-2-pyridyl)ethanone as a pale yellow solid. Step 3: Synthesis of 2-bromo-1 -(5-bromo-2-pyridyl)ethanone hydrobromide

HBr

1 -(5-bromopyridin-2-yl)ethanone (7.05 g, 35.2 mmol) was dissolved in a mixture of methanol (60 ml) and acetic acid (90 ml) and hydrobromic acid (33 wt% in acetic acid, 10 ml, 60.8 mmol) were added. The suspension was cooled at 0 °C and to this was added dropwise a solution of bromine (1 .816 ml, 35.2 mmol) in acetic acid (12.5 ml). The suspension was heated at 70 °C for 1 h. After 1 hour, a yellow solution was obtained. The reaction mixture was concentrated under reduced pressure. The green solid residue was crystallised from 2- propanol (-250 ml) to give 5.36 g of 2-bromo-1 -(5-bromo-2-pyridyl)ethanone hydrobromide as a pale green solid (85% pure). Used without further purification in the next step.

Step 4: Synthesis of 1 -(5-bromo-2-pyridyl)-2-imidazol-1 -yl-ethanone

A suspension of 2-bromo-1 -(5-bromopyridin-2-yl)ethanone hydrobromide (5.1 g, 14.17 mmol) in dry tetrahydrofuran (100 ml) was cooled in an ice bath and to the organic solution was added imidazole (5.0 g, 73.4 mmol). The reaction mixture was stirred vigorously at 0 °C for 2 hours. The reaction mixture was concentrated under reduced pressure and the residue was partitioned between ethyl acetate (100 ml) and water (100 ml). After separation, the water- layer was extracted two more times with ethyl acetate (2 x 100 ml). The combined organic layers were dried over sodium sulphate, filtered and evaporated under reduced pressure. The crude product was purified by column chromatography. The residual solid therefore obtained was triturated with ether, filtered off, washed with ether and dried to give 2.40 g of 1 -(5-bromo-2-pyridyl)-2-imidazol-1 -yl-ethanone as a pale brown solid.

Step 5: Synthesis of 1 -(5-bromo-2-pyridyl)-2-imidazol-1 -yl-N-methoxy-ethanimine

A mixture of 1 -(5-bromopyridin-2-yl)-2-(1 H-imidazol-1 -yl)ethanone (2.25 g, 8.46 mmol), O- methylhydroxylamine hydrochloride (1.059 g, 12.68 mmol) and sodium acetate (1.73 g, 21 .1 mmol) in ethanol (30 ml) was heated at 90 °C overnight. The reaction mixture was concentrated and the residue was partitioned between ethyl acetate (50 ml) and water (50 ml). After separation, the aqueous layer was extracted two more times with EtOAc (2 x 50 ml). The combined organic layers were dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography to give 2.1 g of 1 -(5-bromo-2-pyridyl)-2-imidazol-1 -yl-N-methoxy-ethanimine as a yellow solid and a mixture of E/Z-isomers.

Step 6: Synthesis of 1 -[5-[2-(4-fluorophenyl)ethvnyll-2-pyridyll-2-imidazol-1 -yl-N-methoxy- ethanimine.

In a microwave vial, a mixture of 1 -(5-bromopyridin-2-yl)-2-(1 H-imidazol-1 -yl)ethanone O- methyl oxime (590 mg, 2.0 mmol), 1 -ethynyl-4-fluorobenzene (480 mg, 4.00 mmol) and triethylamine (1.39 ml, 10.0 mmol) was dissolved in dry dimethylformamide (10 ml) and degassed with argon. To this were added tetrakis(triphenylphosphine)palladium(0) (92 mg, 0.080 mmol) and copper iodide (cat) and degassing was continued for 1 minute. The vial was closed and the reaction mixture was heated in the microwave at 120 °C for 1 h. The reaction mixture was partitioned between ethyl acetate (50 ml) and water/brine (1/1 , 50 ml). After washing, the layers were separated, the organic layer was washed two more times with water/brine (1/1 , 2 x 25 ml), dried over sodium sulphate and concentrated under reduced pressure. The crude product was purified by flash column chromathography to give a yellow/pale brown solid. The solid was triturated with ether and the ether was removed with a pipette. This was repeated three more times to give 1 -[5-[2-(4-fluorophenyl)ethynyl]-2- pyridyl]-2-imidazol-1 -yl-N-methoxy-ethanimine.

Example 6: Synthesis of 1 -[5-[2-(4-fluorophenyl)ethvnyll-2-pyridyll-2-imidazol-1 -yl-N- methoxy-ethanimine. Step 1 : Synthesis of 2-bromo-1 -(6-chloro-3-pyridyl)ethanone

1 -(6-chloropyridin-3-yl)ethanone (3.890 g, 25.00 mmol) was dissolved in dry tetrahydrofuran (50 ml), 1 ,3-dibromo-5,5-dimethylimidazolidine-2,4-dione (7.15 g, 25.00 mmol) was added and the mixture was heated at 55 °C for 2 h. 1 ,3-dibromo-5,5-dimethylimidazolidine-2,4- dione (1 .787 g, 6.25 mmol) was added and heating was continued at 55 °C for 2 more hours. The reaction mixture was concentrated and the residue was partitioned between ethyl acetate (100 ml) and water/brine (1/1 , 100 ml). After washing, the layers were separated, the organic layer were dried over sodium sulphate and concentrated under reduced pressure. The crude product was purified by flash chromatography to yield 3.63 g of 2-bromo-1 -(6- chloro-3-pyridyl)ethanone as a white fluffy crystalline solid . (During this step a partial substitution of the chlorine atom with bromine was observed. Since the final Sonogashira reaction for both the 2-chloro and the 2-bromo compounds will give the same product the impurity was carried out throughout the synthesis. This fact will not be mentioned in the following steps). Step 2: Synthesis of 1 -(6-chloro-3-pyridyl)-2-imidazol-1 -yl-ethanone

Under nitrogen, imidazole (5.26 g, 77 mmol) was dissolved in dry dimethylformamide (15 ml) and cooled to 0 °C in ice. To this was added portion-wise 2-bromo-1 -(6-chloro-3- pyridyl)ethanone (3.62 g, 15.4 mmol). The mixture was stirred in an ice bath for 2 hours, followed by room temperature overnight. The reaction mixture diluted with EtOAc (150 ml), washed three times with brine/water (1/1 , 3 x 100 ml), dried over sodium sulphate, filtered, and concentrated under reduced pressure. The crude product was purified by flash chromatography to give 1 -(6-chloro-3-pyridyl)-2-imidazol-1 -yl-ethanone.

Step 3: Synthesis of 1 -(6-chloro-3-pyridyl)-2-imidazol-1 -yl-N-methoxy-ethanimine

1 -(6-chloro-3-pyridyl)-2-imidazol-1 -yl-ethanone (800 mg) was dissolved in ethanol (10 ml) and to this were added methoxylamine hydrochloride (452 mg, 5.41 mmol) and sodium acetate (740 mg, 9.02 mmol). The mixture was heated at 90 °C overnight. The reaction mixture was diluted with ethyl acetate (100 ml), washed with water (50 ml), a saturated solution of sodium bicarbonate (50 ml), brine (50 ml), dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude product was purified by flash

chromatography to give 1 -(6-chloro-3-pyridyl)-2-imidazol-1 -yl-N-methoxy-ethanimine as a mixture of E/Z-isomers.

Step 4: Synthesis of 1 -[6-(2-cvclopropylethvnyl)-3-pyridyll-2-imidazol-1 -yl-N-methoxy- ethanimine

In a microwave vial, 1 -(6-chloro-3-pyridyl)-2-imidazol-1 -yl-N-methoxy-ethanimine (420 mg) was dissolved in dry dimethylformamide (10 ml) and degassed with argon. To this was added triethylamine (1 .17 ml, 8.38 mmol) and degassing was continued for 1 minute. Ethynylcyclopropane (0.568 ml, 6.70 mmol), tetrakis(triphenylphosphine)palladium(0) (77 mg, 0.067 mmol) and copper iodide (cat) were added to the reaction mixture. The vial was closed and the reaction mixture was heated in the microwave at 120 °C for 1 h. The reaction mixture was partitioned between EtOAc (50 ml) and water/brine (1/1 , 50 ml). After washing, the layers were separated, the organic layer was washed two more times with water/brine (1/1 , 2 x 25 ml), dried over sodium sulphate, filtered, and concentrated under reduced pressure. The crude product was purified by flash chromathography and by C-18 reversed phase silica to give 1 -[6-(2-cyclopropylethynyl)-3-pyridyl]-2-imidazol-1 -yl-N-methoxy- ethanimine as a mixture of E/Z-isomers. Example 7: Synthesis of Compound N-[1 -[4-(2-cvclopropylethvnyl)phenyll-2-imidazol-1 -yl- ethylidenelaminol-4-(4-methoxyphenyl)thiazol-2-amine )

Step 1 : Synthesis of 1 -[4-(2-cvclopropylethvnyl) phenyll-2-imidazol-1 -yl-ethylidenel aminolthiourea

To a stirred solution of l-[4-(2-cyclopropylethynyl)phenyl]-2-imidazol-l-yl-ethanone (Example 2, step 2, 0.4 g, 2 mmol) in acetic acid (1 mL, 17.4 mmol) was added thiosemicarbazide (1 equiv., 2 mmol) and the reaction ixture was heated to 80-85 °C overnight. When the TLC confirmed the completion of the reaction, the reaction mixture was concentrated to get crude mass, which was diluted with DCM (50 mL) and washed with water (1* 30 mL) followed by a brine wash (1 * 30 mL). The organic layer was dried over anhydrous Na2S04, filtered before the solvent was removed under reduced pressure. The resulting crude mass was purified by column chromatography using Combiflash and product was eluted with 5% MeOH in DCM to get 240 mg of l-[4-(2-cyclopropylethynyl) phenyl]-2-imidazol-l-yl- ethylidene]amino] thiourea as a mixture of E/Z isomers. Step 2: Synthesis of Compound N-[1 -[4-(2-cvclopropylethvnyl)phenyll-2-imidazol-1 -yl- ethylidenelaminol-4-(4-methoxyphenyl)thiazol-2-amine )

To a stirred solution of l-[4-(2-cyclopropylethynyl)phenyl]-2-imidazol-l-yl- ethylidene]amino]thiourea (0.12 g, 0.37 mmol) in ethanol (4 mL), 2-bromo-l-(4- methoxyphenyl)ethanone (1 equiv., 0.37 mmol) was added and heated to 80-85 °C for 30 mins. When the TLC confirmed the completion of the reaction, the reaction mixture was concentrated to get crude mass which was diluted with DCM and washed with water followed by brine wash and dried over anhydrous Na ₂ S0 ₄ before evaporation of solvent. The resulting crude product was purified by flash column chromatography using with 5% MeOH in DCM to give N-[l-[4-(2- cyclopropylethynyl)phenyl]-2-imidazol-l-yl-ethylidene]amino] -4-(4-methoxyphenyl)thiazol-2-amine as a gum.

Table 1 : This table discloses 177 rmula (T-1 )

(T-1 )

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined below in the table

No. R ₃

1 .001 =0

1 .002 =N-OH

1 .003 =N-NH ₂

No. R ₃

CI

1.031

1.032

CI

1.033

1.034 =N-OCH ₃

1.035 =N-OCH ₂ CH ₃

1.036 =N-0(CH ₂ ) ₂ CH ₃

1.037 =N-0(CH ₂ ) ₃ CH ₃

1.038 =N-0(CH ₂ ) ₄ CH ₃

1.039 =N-0(CH ₂ ) ₅ CH ₃

1.040 =N-OCH(CH ₃ ) ₂

1.041 =N-OC(CH ₃ ) ₃

1.042 =N-OCH ₂ CH(CH ₃ ) ₂

1.043 =N-OCH ₂ C(CH ₃ ) ₃

1.044 =N-OPh

1.045 =N-0-4-F-Ph

1.046 =N-0-4-CI-Ph

1.047 =N-0-2,4-F-Ph

1.048 =N-0-2,4-CI-Ph

1.049 =N-OCH ₂ -Ph

1.050 =N-OCH ₂ -4-F-Ph

1.051 =N-OCH ₂ -4-CI-Ph

1.052 =N-OCH ₂ -2,4-F-Ph

1.053 =N-OCH ₂ -2,5-F-Ph

1.054 =N-OCH ₂ -2,6-F-Ph

1.055 =N-OCH ₂ -3,5-F-Ph

1.056 =N-OCH ₂ -2,4, 6-F-Ph

1.057 =N-OCH ₂ -2,4-CI-Ph

1.058 =N-OCH ₂ -2,5-CI-Ph

1.059 =N-OCH ₂ -2,6-CI-Ph R ₃

OCH ₂ -3,5-CI-Ph CH ₂ -2,4, 6-CI-Ph

= N

^' °-<l

= N

^' °-<l

= N

= N

= N

= N

= N R ₃

= N

= N

= N

= N

= N

NT

= N

= N

= N

^° ! R ₃

= N

=N-NHCH ₃

=N-NHCH ₂ CH ₃ N-NH(CH ₂ ) ₂ CH ₃ N-NH(CH ₂ ) ₃ CH ₃ N-NH(CH ₂ ) ₄ CH ₃ N-NH(CH ₂ ) ₅ CH ₃

=N-NHCH(CH ₃ ) ₂

=N-NHC(CH ₃ ) ₃ -NHCH ₂ CH(CH ₃ ) ₂ N-NHCH ₂ C(CH ₃ ) ₃

=N-NHPh

=N-NH-4-F-Ph

=N-NH-4-CI-Ph

=N-NH-2,4-F-Ph N-NH-2,4-CI-Ph

=N-NHCH ₂ -PhN-NHCH ₂ -4-F-PhN-NHCH ₂ -4-CI-Ph -NHCH ₂ -2,4-F-Ph -NHCH ₂ -2,5-F-Ph -NHCH ₂ -2,6-F-Ph -NHCH ₂ -3,5-F-PhNHCH ₂ -2,4, 6-F-Ph-NHCH ₂ -2,4-CI-Ph-NHCH ₂ -2,5-CI-Ph-NHCH ₂ -2,6-CI-Ph-NHCH ₂ -3,5-CI-PhNHCH ₂ -2,4, 6-CI-Ph

= N

H ^ R ₃

= N

H ^

= N

= N

= N

= N

= N

= N

= N R ₃

= N

= N

= N

= N

NT

= N

= N

NT CI

= N

= N

= N R ₃

N-N(CH ₃ ) ₂ (CH ₃ )CH ₂ CH ₃ (CH ₃ )(CH ₂ ) ₂ CH ₃ (CH ₃ )(CH ₂ ) ₃ CH ₃ (CH ₃ )(CH ₂ ) ₄ CH ₃ (CH ₃ )(CH ₂ ) ₅ CH ₃ (CH ₃ )CH(CH ₃ ) ₂ (CH ₃ )C(CH ₃ ) ₃ H ₃ )CH ₂ CH(CH ₃ ) ₂ CH ₃ )CH ₂ C(CH ₃ ) ₃ N-N(CH ₃ )PhN(CH ₃ )-4-F-Ph (CH ₃ )-4-CI-Ph (CH ₃ )-2,4-F-Ph(CH ₃ )-2,4-CI-PhN(CH ₃ )CH ₂ -PhCH ₃ )CH ₂ -4-F-PhCH ₃ )CH ₂ -4-CI-Ph H ₃ )CH ₂ -2,4-F-Ph H ₃ )CH ₂ -2,5-F-Ph H ₃ )CH ₂ -2,6-F-Ph H ₃ )CH ₂ -3,5-F-Ph 3)CH ₂ -2,4 _! 6-F-Ph H ₃ )CH ₂ -2,4-CI-Ph H ₃ )CH ₂ -2,5-CI-Ph H ₃ )CH ₂ -2,6-CI-Ph H ₃ )CH ₂ -3,5-CI-Ph 3)CH ₂ -2,4 _! 6-CI-Ph

= N

H ₃ C

= N

H ₃ C R ₃

= N

= N

= N H ₃ C

= N

H ₃ C

= N

= N

= N

Table 2: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1 . Table 3: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 4: This table discloses 1 7 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 5: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 6: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and

R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 7: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 8: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 9: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 10: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 1 : This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 12: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 13: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 14: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 15: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 16: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 17: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 18: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 19: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 20: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 . Table 21 : This table discloses 177 specific compounds of the formula (T-1 ), wherein R R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 22: This table discloses 1 7 specific compounds of the formula (T-1 ), wherein R R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 23: This table discloses 177 specific compounds of the formula (T-1 ), wherein R R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 24: This table discloses 177 specific compounds of the formula (T-1 ), wherein R R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 25: This table discloses 177 specific compounds of the formula (T-1 ), wherein R R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 26: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 27: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 28: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 29: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 30: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 31 : This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 32: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 33: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 34: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 35: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 36: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 37: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1. Table 38: This table discloses 177 specific compounds of the formula (T-1 ), wherein R methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 39: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 40: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 . Table 41 : This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 42: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 43: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 44: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 45: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 46: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 47: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 48: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 49: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 50: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 51 : This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 52: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 53: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 54: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 55: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 . Table 56: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 57: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 58: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 59: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 60: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 61 : This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 62: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 63: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 64: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 65: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 66: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 67: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 68: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 69: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and

R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 70: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 71 : This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 72: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 73: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1 . Table 74: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 75: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 76: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 77: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 78: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 79: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 80: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 81 : This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 82: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 83: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 84: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 85: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 86: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 87: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 88: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 89: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 90: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 91 : This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 92: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and

R ₂ are fluoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 93: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and

R ₂ are fluoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1

Table 94: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and

R ₂ are fluoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 95: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and

R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 96: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and

R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 97: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and

R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 98: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and

R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 99: This table discloses 177 specific compounds of the formula (T-1 ), wherein Ri and

R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 100: This table discloses 177 specific compounds of the formula (T-1 ), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 101 : This table discloses 177 specific compounds of formula (T-2)

(T-2)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1 .

Table 102: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 103: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 104: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 105: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 . Table 106: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 107: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 108: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 109: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and

R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 1 10: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 1 1 : This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 12: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 13: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 14: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 15: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 16: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 17: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 1 18: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 19: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 120: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 121 : This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 122: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 123: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 . Table 124: This table discloses 177 specific compounds of the formula (T-2), wherein R R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 125: This table discloses 177 specific compounds of the formula (T-2), wherein R R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 126: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 127: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 128: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 129: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 130: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 131 : This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 132: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 133: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 134: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 135: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 136: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 137: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1. Table 138: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 139: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 140: This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 Table 141 : This table discloses 177 specific compounds of the formula (T-2), wherein R methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 142: This table discloses 177 specific compounds of the formula (T-2), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 143: This table discloses 177 specific compounds of the formula (T-2), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 144: This table discloses 177 specific compounds of the formula (T-2), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 145: This table discloses 177 specific compounds of the formula (T-2), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 146: This table discloses 177 specific compounds of the formula (T-2), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 147: This table discloses 177 specific compounds of the formula (T-2), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 148: This table discloses 177 specific compounds of the formula (T-2), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 149: This table discloses 177 specific compounds of the formula (T-2), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 150: This table discloses 177 specific compounds of the formula (T-2), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 151 : This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 152: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 153: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 154: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 155: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 156: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 157: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 158: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 . Table 159: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 160: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 161 : This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 162: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and

R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 163: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 164: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 165: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 166: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 167: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 168: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 169: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 170: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 171 : This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 172: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 173: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 174: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 175: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 176: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1 . Table 77: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and

R ₂ are luoride, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 78: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and

R ₂ are luoride, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 79: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and

R ₂ are luoride, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 80: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 81 : This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 82: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and

R ₂ are luoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 83: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and

R ₂ are luoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 84: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 85: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 86: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 87: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 88: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 89: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 90: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 91 : This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 92: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 93: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 94: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and

R ₂ are luoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 . Table 195: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 196: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 197: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 198: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 199: This table discloses 177 specific compounds of the formula (T-2), wherein Ri and R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 200: This table discloses 177 specific compounds of the formula (T-2), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 201 : This table discloses 177 specific compounds of formula (T-3)

(T-3)

wherein R-i , R ₂ and R ₄ are all hydrogen, andand R ₃ is as defined in the Table 1 .

Table 202: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 203: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 204: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 205: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 206: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 207: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 208: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 209: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 . Table 210: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 21 1 : This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 212: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 213: This table discloses 177 specific compounds of the formula (T-3), wherein Ri and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 214: This table discloses 177 specific compounds of the formula (T-3), wherein Ri and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 215: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 216: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 217: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 218: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 219: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 220: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 221 : This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 222: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 223: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 224: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 225: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 226: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 227: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1 . Table 228: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 229: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 230: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 231 : This table discloses 177 specific compounds of the formula (T-3), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 232: This table discloses 177 specific compounds of the formula (T-3), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 233: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 234: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 235: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 236: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 237: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 238: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 239: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 240: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 . Table 241 : This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 242: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 243: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 244: This table discloses 177 specific compounds of the formula (T-3), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 . Table 245: This table discloses 177 specific compounds of the formula (T-3), wherein R methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 246: This table discloses 177 specific compounds of the formula (T-3), wherein R methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 247: This table discloses 177 specific compounds of the formula (T-3), wherein R methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 248: This table discloses 177 specific compounds of the formula (T-3), wherein R methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 249: This table discloses 177 specific compounds of the formula (T-3), wherein R methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 250: This table discloses 177 specific compounds of the formula (T-3), wherein R methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 251 : This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 252: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 253: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 254: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 255: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 256: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 257: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 258: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 259: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 260: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 261 : This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 262: This table discloses 177 specific compounds of the formula (T-3), wherein R R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1. Table 263: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 264: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 265: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 266: This table discloses 177 specific compounds of the formula (T-3), wherein Ri and

R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 267: This table discloses 177 specific compounds of the formula (T-3), wherein Ri and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 268: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 269: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 270: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 271 : This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 272: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 273: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 274: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 275: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 276: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 277: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 278: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 279: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 280: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 . Table 281 : This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 282: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 283: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 284: This table discloses 177 specific compounds of the formula (T-3), wherein Ri and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 285: This table discloses 177 specific compounds of the formula (T-3), wherein Ri and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 286: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 287: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 288: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 289: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are fluoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 290: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 291 : This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are fluoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 292: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are fluoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 293: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are fluoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 294: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and

R ₂ are fluoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 295: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 296: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 297: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 298: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1 . Table 299: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 300: This table discloses 177 specific compounds of the formula (T-3), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 301 : This table discloses 177 specific compounds of formula (T-4)

(T-4)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 302: This table discloses 177 specific compounds of the formula (T-4 wherein R R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 303: This table discloses 177 specific compounds of the formula (T-4 wherein R R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 304: This table discloses 177 specific compounds of the formula (T-4 wherein R R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 305: This table discloses 177 specific compounds of the formula (T-4 wherein R R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 306: This table discloses 177 specific compounds of the formula (T-4 wherein R R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 307: This table discloses 177 specific compounds of the formula (T-4 wherein R R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 308: This table discloses 177 specific compounds of the formula (T-4 wherein R R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 309: This table discloses 177 specific compounds of the formula (T-4 wherein R R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 310: This table discloses 177 specific compounds of the formula (T-4 wherein R R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 31 1 : This table discloses 177 specific compounds of the formula (T-4 , wherein R R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 312: This table discloses 177 specific compounds of the formula (T-4 , wherein R R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 313: This table discloses 177 specific compounds of the formula (T-4 , wherein R

R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 314: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 315: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 316: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 317: This table discloses 177 specific compounds of the formula (T-4), wherein Ri and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 318: This table discloses 177 specific compounds of the formula (T-4), wherein Ri and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 319: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 320: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 321 : This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 322: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 323: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 324: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 325: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 326: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 327: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1 .

Table 328: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 329: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 330: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 331 : This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 . Table 332: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 333: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 334: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 335: This table discloses 177 specific compounds of the formula (T-4), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 336: This table discloses 177 specific compounds of the formula (T-4), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 337: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 338: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 339: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 340: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 . Table 341 : This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 342: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 343: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 344: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 345: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 346: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 347: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 348: This table discloses 177 specific compounds of the formula (T-4), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 . Table 349: This table discloses 177 specific compounds of the formula (T-4), wherein R methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 350: This table discloses 177 specific compounds of the formula (T-4), wherein R methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 351 : This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 352: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 353: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 354: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 355: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 356: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 357: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 358: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 359: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 360: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 361 : This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 362: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 363: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 364: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 365: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 366: This table discloses 177 specific compounds of the formula (T-4), wherein R R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 367: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 368: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 369: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 370: This table discloses 177 specific compounds of the formula (T-4), wherein Ri and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 371 : This table discloses 177 specific compounds of the formula (T-4), wherein Ri and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 372: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 373: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 374: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 375: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 376: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 377: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 378: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 379: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 380: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 381 : This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 382: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 383: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 384: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 . Table 385: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 386: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 387: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 388: This table discloses 177 specific compounds of the formula (T-4), wherein Ri and

R ₂ are fluoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 389: This table discloses 177 specific compounds of the formula (T-4), wherein Ri and R ₂ are fluoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 390: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are fluoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 391 : This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are fluoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 392: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are fluoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 393: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are fluoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 394: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 395: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and

R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 396: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 397: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 398: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 399: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 400: This table discloses 177 specific compounds of the formula (T-4), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 401 : This table discloses 177 specific compounds of formula (T-5)

wherein R-ι, R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 402: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 403: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 404: This table discloses 177 specific compounds of the formula (T-5), wherein R

R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 405: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 406: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 407: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 408: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 409: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 410: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 41 1 : This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 412: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 413: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 414: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 415: This table discloses 177 specific compounds of the formula (T-5), wherein R R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 416: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 417: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 418: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 419: This table discloses 177 specific compounds of the formula (T-5), wherein Ri and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 420: This table discloses 177 specific compounds of the formula (T-5), wherein Ri and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 421 : This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 422: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 423: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 424: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and

R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 425: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 426: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 427: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1 .

Table 428: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 429: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 430: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 431 : This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 432: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 433: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 . Table 434: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 435: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 436: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 437: This table discloses 177 specific compounds of the formula (T-5), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 438: This table discloses 177 specific compounds of the formula (T-5), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 439: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 440: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 . Table 441 : This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 442: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 443: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 444: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 445: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 446: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 447: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 448: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 449: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 450: This table discloses 177 specific compounds of the formula (T-5), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 . Table 451 : This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 452: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 453: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 454: This table discloses 177 specific compounds of the formula (T-5), wherein Ri and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 455: This table discloses 177 specific compounds of the formula (T-5), wherein Ri and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 456: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 457: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 458: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 459: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 460: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 461 : This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 462: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 463: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 464: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 465: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 466: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 467: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 468: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 . Table 469: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 470: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 471 : This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 472: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 473: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 474: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 475: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 476: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 477: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 478: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 479: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 480: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 481 : This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 482: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 483: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 484: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 485: This table discloses 177 specific compounds of the formula T-5 wherein R and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 486: This table discloses 177 specific compounds of the formula T-5 wherein R and

R ₂ are fluoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 487: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 488: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 489: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 490: This table discloses 177 specific compounds of the formula (T-5), wherein Ri and R ₂ are fluoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 491 : This table discloses 177 specific compounds of the formula (T-5), wherein Ri and R ₂ are fluoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 492: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 493: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 494: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 495: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 496: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 497: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 498: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 499: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 500: This table discloses 177 specific compounds of the formula (T-5), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 501 : This table discloses 177 specific compounds of formula (T-6)

(T-6)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1 Table 502: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 503: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 504: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 505: This table discloses 177 specific compounds of the formula (T-6), wherein Ri and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 506: This table discloses 177 specific compounds of the formula (T-6), wherein Ri and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 507: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 508: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 509: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 510: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 51 1 : This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 512: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 513: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 514: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 515: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 516: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 517: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 518: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 519: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 . Table 520: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 521 : This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 522: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 523: This table discloses 177 specific compounds of the formula (T-6), wherein Ri and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 524: This table discloses 177 specific compounds of the formula (T-6), wherein Ri and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 525: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 526: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 527: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1 .

Table 528: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 529: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 530: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 531 : This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 532: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 533: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 534: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 535: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 536: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 537: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 . Table 538: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 539: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 540: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 . Table 541 : This table discloses 177 specific compounds of the formula (T-6), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 542: This table discloses 177 specific compounds of the formula (T-6), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 543: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 544: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 545: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 546: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 547: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 548: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 549: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 550: This table discloses 177 specific compounds of the formula (T-6), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 551 : This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 552: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 553: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 554: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1 . Table 555: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 556: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 557: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 558: This table discloses 177 specific compounds of the formula (T-6), wherein Ri and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 559: This table discloses 177 specific compounds of the formula (T-6), wherein Ri and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 560: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 561 : This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 562: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 563: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 564: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 565: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 566: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 567: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 568: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 569: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 570: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and

R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 571 : This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 572: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 . Table 573: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 574: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 575: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 576: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 577: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 578: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 579: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 580: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 581 : This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 582: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 583: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 584: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 585: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 586: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1

Table 587: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1

Table 588: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 589: This table discloses 177 specific compounds of the formula (T-6 wherein R and R ₂ are fluoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table

Table 590: This table discloses 177 specific compounds of the formula (T-6 wherein R and

R ₂ are fluoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 591 : This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are fluoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 592: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are fluoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 593: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are fluoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 594: This table discloses 177 specific compounds of the formula (T-6), wherein Ri and R ₂ are fluoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 595: This table discloses 177 specific compounds of the formula (T-6), wherein Ri and R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 596: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 597: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 598: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 599: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 600: This table discloses 177 specific compounds of the formula (T-6), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 601 : This table discloses 177 specific compounds of formula (T-7)

(T-7)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1 .

Table 602: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 603: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 604: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 605: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 . Table 606: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 607: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 608: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 609: This table discloses 177 specific compounds of the formula (T-7), wherein Ri and

R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 610: This table discloses 177 specific compounds of the formula (T-7), wherein Ri and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 61 1 : This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 612: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 613: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 614: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 615: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 616: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 617: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 618: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 619: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 620: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 621 : This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 622: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 623: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 . Table 624: This table discloses 177 specific compounds of the formula (T-7), wherein R R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 625: This table discloses 177 specific compounds of the formula (T-7), wherein R R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 626: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 627: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 628: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 629: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 630: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 631 : This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 632: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 633: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 634: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 635: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 636: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 637: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1. Table 638: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 639: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 640: This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 Table 641 : This table discloses 177 specific compounds of the formula (T-7), wherein R methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 642: This table discloses 177 specific compounds of the formula (T-7), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 643: This table discloses 177 specific compounds of the formula (T-7), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 644: This table discloses 177 specific compounds of the formula (T-7), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 645: This table discloses 177 specific compounds of the formula (T-7), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 646: This table discloses 177 specific compounds of the formula (T-7), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 647: This table discloses 177 specific compounds of the formula (T-7), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 648: This table discloses 177 specific compounds of the formula (T-7), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 649: This table discloses 177 specific compounds of the formula (T-7), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 650: This table discloses 177 specific compounds of the formula (T-7), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 651 : This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 652: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 653: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 654: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 655: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 656: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 657: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 658: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 . Table 659: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 660: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and

R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 661 : This table discloses 177 specific compounds of the formula (T-7), wherein R-i and

R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 662: This table discloses 177 specific compounds of the formula (T-7), wherein Ri and

R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 663: This table discloses 177 specific compounds of the formula (T-7), wherein Ri and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 664: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and

R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 665: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and

R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 666: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and

R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 667: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and

R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 668: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 669: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and

R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 670: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 671 : This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 672: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 673: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 674: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 675: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 676: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1 . Table 677: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 678: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 679: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 680: This table discloses 177 specific compounds of the formula (T-7), wherein Ri and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 681 : This table discloses 177 specific compounds of the formula (T-7), wherein Ri and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 682: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 683: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 684: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 685: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 686: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 687: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 688: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 689: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 690: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 691 : This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 692: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 693: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 694: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 . Table 695: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 696: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 697: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 698: This table discloses 177 specific compounds of the formula (T-7), wherein Ri and R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 699: This table discloses 177 specific compounds of the formula (T-7), wherein Ri and R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 700: This table discloses 177 specific compounds of the formula (T-7), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 701 : This table discloses 177 specific compounds of formula (T-8)

(T-8)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1 .

Table 702: This table discloses 177 specific compounds of the formula (T-8 wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 703: This table discloses 177 specific compounds of the formula (T-8 wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 704: This table discloses 177 specific compounds of the formula (T-8 wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 705: This table discloses 177 specific compounds of the formula (T-8 wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 706: This table discloses 177 specific compounds of the formula (T-8 wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 707: This table discloses 177 specific compounds of the formula (T-8 wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 708: This table discloses 177 specific compounds of the formula (T-8 wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 709: This table discloses 177 specific compounds of the formula (T-8 wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 . Table 710: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 71 1 : This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 712: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 713: This table discloses 177 specific compounds of the formula (T-8), wherein Ri and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 714: This table discloses 177 specific compounds of the formula (T-8), wherein Ri and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 715: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 716: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 717: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 718: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 719: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 720: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 721 : This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 722: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 723: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 724: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 725: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 726: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 727: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1 . Table 728: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 729: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 730: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 731 : This table discloses 177 specific compounds of the formula (T-8), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 732: This table discloses 177 specific compounds of the formula (T-8), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 733: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 734: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 735: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 736: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 737: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 738: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 739: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 740: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 . Table 741 : This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 742: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 743: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 744: This table discloses 177 specific compounds of the formula (T-8), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 . Table 745: This table discloses 177 specific compounds of the formula (T-8), wherein R methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 746: This table discloses 177 specific compounds of the formula (T-8), wherein R methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 747: This table discloses 177 specific compounds of the formula (T-8), wherein R methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 748: This table discloses 177 specific compounds of the formula (T-8), wherein R methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 749: This table discloses 177 specific compounds of the formula (T-8), wherein R methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 750: This table discloses 177 specific compounds of the formula (T-8), wherein R methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 751 : This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 752: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 753: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 754: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 755: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 756: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 757: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 758: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 759: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 760: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 761 : This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 762: This table discloses 177 specific compounds of the formula (T-8), wherein R R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1. Table 763: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 764: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 765: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 766: This table discloses 177 specific compounds of the formula (T-8), wherein Ri and

R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 767: This table discloses 177 specific compounds of the formula (T-8), wherein Ri and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 768: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 769: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 770: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 771 : This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 772: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 773: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 774: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 775: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 776: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 777: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 778: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 779: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 780: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 . Table 781 : This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 782: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 783: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 784: This table discloses 177 specific compounds of the formula (T-8), wherein Ri and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 785: This table discloses 177 specific compounds of the formula (T-8), wherein Ri and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 786: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 787: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 788: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 789: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are fluoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 790: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 791 : This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are fluoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 792: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are fluoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 793: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are fluoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 794: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and

R ₂ are fluoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 795: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 796: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 797: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 798: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1 . Table 799: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 800: This table discloses 177 specific compounds of the formula (T-8), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 801 : This table discloses 177 specific compounds of formula (T-9)

(T-9)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 802: This table discloses 177 specific compounds of the formula (T-9 wherein R R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 803: This table discloses 177 specific compounds of the formula (T-9 wherein R R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 804: This table discloses 177 specific compounds of the formula (T-9 wherein R R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 805: This table discloses 177 specific compounds of the formula (T-9 wherein R R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 806: This table discloses 177 specific compounds of the formula (T-9 wherein R R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 807: This table discloses 177 specific compounds of the formula (T-9 wherein R R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 808: This table discloses 177 specific compounds of the formula (T-9 wherein R R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 809: This table discloses 177 specific compounds of the formula (T-9 wherein R R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 810: This table discloses 177 specific compounds of the formula (T-9 wherein R R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 81 1 : This table discloses 177 specific compounds of the formula (T-9 , wherein R R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 812: This table discloses 177 specific compounds of the formula (T-9 , wherein R R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 813: This table discloses 177 specific compounds of the formula (T-9 , wherein R

R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 814: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 815: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 816: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 817: This table discloses 177 specific compounds of the formula (T-9), wherein Ri and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 818: This table discloses 177 specific compounds of the formula (T-9), wherein Ri and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 819: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 820: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 821 : This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 822: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 823: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 824: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 825: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 826: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 827: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1 .

Table 828: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 829: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 830: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 831 : This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 . Table 832: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 833: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 834: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 835: This table discloses 177 specific compounds of the formula (T-9), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 836: This table discloses 177 specific compounds of the formula (T-9), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 837: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 838: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 839: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 840: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 . Table 841 : This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 842: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 843: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 844: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 845: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 846: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 847: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 848: This table discloses 177 specific compounds of the formula (T-9), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 . Table 849: This table discloses 177 specific compounds of the formula (T-9), wherein R methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 850: This table discloses 177 specific compounds of the formula (T-9), wherein R methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 851 : This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 852: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 853: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 854: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 855: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 856: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 857: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 858: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 859: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 860: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 861 : This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 862: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 863: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 864: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 865: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 866: This table discloses 177 specific compounds of the formula (T-9), wherein R R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 867: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 868: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 869: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 870: This table discloses 177 specific compounds of the formula (T-9), wherein Ri and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 871 : This table discloses 177 specific compounds of the formula (T-9), wherein Ri and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 872: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 873: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 874: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 875: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 876: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 877: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1 .

Table 878: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 879: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 880: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 881 : This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 882: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 .

Table 883: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 884: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 . Table 885: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 886: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 887: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are fluoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 888: This table discloses 177 specific compounds of the formula (T-9), wherein Ri and

R ₂ are fluoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 889: This table discloses 177 specific compounds of the formula (T-9), wherein Ri and R ₂ are fluoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 890: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are fluoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 891 : This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are fluoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 892: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are fluoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 893: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are fluoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 894: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 895: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and

R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 896: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 897: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 898: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 899: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 900: This table discloses 177 specific compounds of the formula (T-9), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 901 : This table discloses 177 specific compounds of formula (T-10)

(T-10)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 902: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 903: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 904: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 905: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 906: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 907: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 908: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 909: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 910: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 91 1 : This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 912: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 913: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 914: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 915: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 916: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 917: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 918: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 919: This table discloses 177 specific compounds of the formula (T-10), wherein Ri and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 920: This table discloses 177 specific compounds of the formula (T-10), wherein Ri and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 921 : This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 922: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 923: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 924: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 .

Table 925: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1 .

Table 926: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1 .

Table 927: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1 .

Table 928: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1 .

Table 929: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1 .

Table 930: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1 .

Table 931 : This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1 .

Table 932: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1 . Table 933: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1 .

Table 934: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1 .

Table 935: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1 .

Table 936: This table discloses 177 specific compounds of the formula (T-10), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 937: This table discloses 177 specific compounds of the formula (T-10), wherein Ri is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 938: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 939: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 940: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1 . Table 941 : This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1 . Table 942: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 943: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 944: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1 .

Table 945: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1 .

Table 946: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1 .

Table 947: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1 .

Table 948: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1 .

Table 949: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1 . Table 950: This table discloses 177 specific compounds of the formula (T-10), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 951 : This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 952: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 953: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 954: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 955: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 956: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 957: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 958: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 959: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 960: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 961 : This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 962: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 963: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 964: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 965: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 966: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 967: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 968: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 969: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 970: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 971 : This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 972: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 973: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 974: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 975: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 976: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 977: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 978: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 979: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 980: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 981 : This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 982: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 983: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 984: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 985: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 986: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 987: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 988: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 989: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 990: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 991 : This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 992: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 993: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 994: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 995: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 996: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 997: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 998: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 999: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1000: This table discloses 177 specific compounds of the formula (T-10), wherein R-i and R ₂ are fluoride, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1001 : This table discloses 177 specific compounds of formula (T-1 1 )

(T-1 1 )

wherein R-ι , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1002: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1003: This table discloses 1 7 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1004: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1005: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1006: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1007: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1008: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1009: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1010: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 101 1 : This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1012: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1013: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1014: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1015: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1016: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1017: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1018: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1019: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1020: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1021 : This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1022: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1023: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1024: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1025: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1026: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1027: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1028: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1029: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1030: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1031 : This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1032: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1033: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1034: This table discloses 1 7 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1035: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1036: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1037: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1038: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1039: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1040: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1041 : This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1042: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1043: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1044: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1045: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1046: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1047: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1048: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1049: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1050: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1051 : This table discloses 1 7 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1052: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1053: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1054: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1055: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1056: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1057: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1058: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1059: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1060: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1061 : This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1062: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1063: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1064: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1065: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1066: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1067: This table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1068: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1069: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1070: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1071 : This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1072: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1073: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1074: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1075: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1076: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1077: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1078: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1079: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1080: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1081 : This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1082: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1083: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1084: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1085: This table discloses 177 specific compounds of the formula (T-1 1 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1086: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1087: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1088: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1089: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1090: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1091 : Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1092: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1093: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1094: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1095: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1096: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1097: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1098: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1099: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1 100: Th s table discloses 177 specific compounds of the formula (T-1 1 ), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1 101 : Th s table discloses 177 specific compounds of formula (T-12)

(T-12)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1 102: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1 103: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1 104: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1 105: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1 106: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1 107: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1 108: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1 109: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1 1 10: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 1 1 1 : This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 1 12: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 1 13: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 1 14: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 1 15: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1 1 16: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 1 17: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1 1 18: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 1 19: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1 120: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1 121 : This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1 122: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1 123: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1 124: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1 125: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1 126: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1 127: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1 128: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1 129: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1 130: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1 131 : This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1 132: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1 133: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1 134: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1 135: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 136: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1 137: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 138: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1 139: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1 140: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1 141 : This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1 142: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 143: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1 144: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1 145: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1 146: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1 147: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1 148: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1 149: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1 150: This table discloses 177 specific compounds of the formula (T-12), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1 151 : This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1 152: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1 153: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1 154: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1 155: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1 156: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1 157: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1 158: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1 159: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1 160: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 161 : This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 162: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 163: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 164: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 165: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 166: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 167: This table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1 168: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1 169: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1 170: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1 171 : This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1 172: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1 173: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1 174: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1 175: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1 176: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1 177: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1 178: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1 179: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1 180: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1 181 : This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1 182: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1 183: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1 184: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1 185: This table discloses 177 specific compounds of the formula (T-12 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1 186: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 187: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 188: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 189: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 190: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 191 : Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 192: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1 193: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1 194: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1 195: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1 196: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1 197: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1 198: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1 199: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1200: Th s table discloses 177 specific compounds of the formula (T-12), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1201 : Th s table discloses 177 specific compounds of formula (T-13)

(T-13)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1202: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1203: This table discloses 1 7 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1204: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1205: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1206: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1207: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1208: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1209: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1210: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 121 1 : This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1212: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1213: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1214: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1215: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1216: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1217: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1218: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1219: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1220: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1221 : This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1222: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1223: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1224: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1225: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1226: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1227: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1228: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1229: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1230: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1231 : This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1232: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1233: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1234: This table discloses 1 7 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1235: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1236: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1237: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1238: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1239: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1240: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1241 : This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1242: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1243: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1244: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1245: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1246: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1247: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1248: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1249: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1250: This table discloses 177 specific compounds of the formula (T-13), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1251 : This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1252: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1253: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1254: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1255: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1256: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1257: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1258: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1259: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1260: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1261 : This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1262: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1263: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1264: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1265: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1266: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1267: This table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1268: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1269: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1270: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1271 : This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1272: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1273: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1274: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1275: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1276: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1277: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1278: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1279: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1280: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1281 : This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1282: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1283: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1284: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1285: This table discloses 177 specific compounds of the formula (T-13 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1286: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1287: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1288: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1289: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1290: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1291 : Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1292: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1293: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1294: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1295: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1296: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1297: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1298: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1299: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1300: Th s table discloses 177 specific compounds of the formula (T-13), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1301 : Th s table discloses 177 specific compounds of formula (T-14)

(T-14)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1302: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1303: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1304: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1305: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1306: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1307: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1308: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1309: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1310: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 131 1 : This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1312: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1313: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1314: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1315: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1316: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1317: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1318: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1319: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1320: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1321 : This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1322: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1323: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1324: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1325: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1326: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1327: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1328: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1329: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1330: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1331 : This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1332: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1333: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1334: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1335: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1336: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1337: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1338: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1339: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1340: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1341 : This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1342: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1343: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1344: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1345: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1346: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1347: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1348: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1349: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1350: This table discloses 177 specific compounds of the formula (T-14), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1351 : This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1352: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1353: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1354: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1355: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1356: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1357: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1358: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1359: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1360: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1361 : This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1362: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1363: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1364: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1365: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1366: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1367: This table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1368: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1369: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1370: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1371 : This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1372: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1373: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1374: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1375: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1376: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1377: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1378: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1379: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1380: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1381 : This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1382: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1383: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1384: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1385: This table discloses 177 specific compounds of the formula (T-14 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1386: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1387: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1388: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1389: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1390: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1391 : Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1392: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1393: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1394: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1395: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1396: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1397: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1398: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1399: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1400: Th s table discloses 177 specific compounds of the formula (T-14), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1401 : Th s table discloses 177 specific compounds of formula (T-15)

(T-15)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1402: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1403: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1404: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1405: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1406: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1407: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1408: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1409: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1410: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 141 1 : This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1412: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1413: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1414: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1415: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1416: This table discloses 1 7 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1417: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1418: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1419: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1420: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1421 : This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1422: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1423: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1424: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1425: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1426: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1427: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1428: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1429: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1430: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1431 : This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1432: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1433: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1434: This table discloses 1 7 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1435: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1436: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1437: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1438: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1439: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1440: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1441 : This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1442: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1443: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1444: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1445: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1446: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1447: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1448: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1449: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1450: This table discloses 177 specific compounds of the formula (T-15), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1451 : This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1452: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1453: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1454: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1455: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1456: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1457: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1458: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1459: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1460: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1461 : This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1462: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1463: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1464: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1465: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1466: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1467: This table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1468: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1469: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1470: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1471 : This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1472: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1473: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1474: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1475: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1476: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1477: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1478: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1479: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1480: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1481 : This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1482: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1483: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1484: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1485: This table discloses 177 specific compounds of the formula (T-15 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1486: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1487: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1488: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1489: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1490: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1491 : Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1492: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1493: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1494: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1495: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1496: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1497: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1498: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1499: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1500: Th s table discloses 177 specific compounds of the formula (T-15), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1501 : Th s table discloses 177 specific compounds of formula (T-16)

(T-16)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1502: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1503: This table discloses 1 7 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1504: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1505: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1506: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1507: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1508: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1509: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1510: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 151 1 : This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1512: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1513: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1514: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1515: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1516: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1517: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1518: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1519: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1520: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1521 : This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1522: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1523: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1524: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1525: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1526: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1527: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1528: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1529: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1530: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1531 : This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1532: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1533: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1534: This table discloses 1 7 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1535: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1536: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1537: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1538: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1539: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1540: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1541 : This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1542: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1543: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1544: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1545: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1546: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1547: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1548: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1549: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1550: This table discloses 177 specific compounds of the formula (T-16), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1551 : This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1552: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1553: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1554: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1555: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1556: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1557: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1558: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1559: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1560: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1561 : This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1562: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1563: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1564: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1565: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1566: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1567: This table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1568: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1569: This table discloses 1 7 specific compounds of the formula (T-16 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1570: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1571 : This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1572: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1573: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1574: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1575: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1576: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1577: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1578: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1579: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1580: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1581 : This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1582: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1583: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1584: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1585: This table discloses 177 specific compounds of the formula (T-16 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1586: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1587: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1588: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1589: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1590: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1591 : Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1592: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1593: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1594: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1595: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1596: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1597: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1598: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1599: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1600: Th s table discloses 177 specific compounds of the formula (T-16), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1601 : Th s table discloses 177 specific compounds of formula (T-17)

(T-17)

wherein R _{1 ;} R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1602: This table discloses 177 specific compounds of the formula (T-17), wherein R and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1603: This table discloses 177 specific compounds of the formula (T-17), wherein R and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1604: This table discloses 177 specific compounds of the formula (T-17), wherein R^ and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1605: This table discloses 177 specific compounds of the formula (T-17), wherein R^ and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1606: This table discloses 177 specific compounds of the formula (T-17), wherein R and R ₂ are hydrogen, R ₄ is ferf-butyl and R ₃ is as defined in the Table 1.

Table 1607: This table discloses 177 specific compounds of the formula (T-17), wherein R^ and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1608: This table discloses 177 specific compounds of the formula (T-17), wherein R^ and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1609: This table discloses 177 specific compounds of the formula (T-17), wherein R and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1610: This table discloses 177 specific compounds of the formula (T-17), wherein R and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 161 1 : This table discloses 177 specific compounds of the formula (T-17), wherein R^ and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1612: This table discloses 177 specific compounds of the formula (T-17), wherein R^ and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1613: This table discloses 177 specific compounds of the formula (T-17), wherein R and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1614: This table discloses 177 specific compounds of the formula (T-17), wherein R and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1615: This table discloses 177 specific compounds of the formula (T-17), wherein R^ and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1616: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1617: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1618: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1619: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1620: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1621 : This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1622: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1623: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1624: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1625: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1626: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1627: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1628: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1629: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1630: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1631 : This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1632: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1633: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1634: This table discloses 1 7 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1635: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1636: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1637: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1638: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1639: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1640: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1641 : This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1642: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1643: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1644: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1645: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1646: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1647: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1648: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1649: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1650: This table discloses 177 specific compounds of the formula (T-17), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1651 : This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1652: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1653: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1654: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1655: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1656: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1657: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1658: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1659: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1660: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1661 : This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1662: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1663: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1664: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1665: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1666: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1667: This table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1668: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1669: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1670: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1671 : This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1672: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1673: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1674: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1675: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1676: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1677: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1678: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1679: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1680: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1681 : This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1682: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1683: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1684: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1685: This table discloses 177 specific compounds of the formula (T-17 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1686: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1687: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1688: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1689: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1690: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1691 : Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1692: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1693: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1694: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1695: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1696: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1697: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1698: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1699: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1700: Th s table discloses 177 specific compounds of the formula (T-17), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1701 : Th s table discloses 177 specific compounds of formula (T-18)

(T-18)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1702: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1703: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1704: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1705: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1706: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1707: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1708: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1709: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1710: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 171 1 : This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1712: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1713: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1714: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1715: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1716: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1717: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1718: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1719: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1720: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1721 : This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1722: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1723: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1724: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1725: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1726: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1727: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1728: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1729: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1730: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1731 : This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1732: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1733: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1734: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1735: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1736: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1737: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1738: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1739: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1740: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1741 : This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1742: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1743: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1744: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1745: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1746: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1747: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1748: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1749: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1750: This table discloses 177 specific compounds of the formula (T-18), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1751 : This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1752: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1753: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1754: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1755: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1756: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1757: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1758: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1759: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1760: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1761 : This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1762: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1763: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1764: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1765: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1766: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1767: This table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1768: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1769: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1770: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1771 : This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1772: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1773: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1774: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1775: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1776: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1777: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1778: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1779: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1780: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1781 : This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1782: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1783: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1784: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1785: This table discloses 177 specific compounds of the formula (T-18 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1786: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1787: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1788: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1789: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1790: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1791 : Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1792: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1793: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1794: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1795: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1796: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1797: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1798: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1799: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1800: Th s table discloses 177 specific compounds of the formula (T-18), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1801 : Th s table discloses 177 specific compounds of formula (T-19)

(T-19)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1802: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1803: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1804: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1805: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1806: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1807: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1808: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1809: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1810: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 181 1 : This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1812: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1813: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1814: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1815: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1816: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1817: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1818: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1819: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1820: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1821 : This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1822: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1823: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1824: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1825: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1826: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1827: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1828: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1829: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1830: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1831 : This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1832: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1833: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1834: This table discloses 1 7 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1835: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1836: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1837: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1838: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1839: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1840: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1841 : This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1842: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1843: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1844: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1845: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1846: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1847: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1848: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1849: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1850: This table discloses 177 specific compounds of the formula (T-19), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1851 : This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1852: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1853: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1854: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1855: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1856: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1857: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1858: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1859: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1860: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1861 : This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1862: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1863: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1864: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1865: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1866: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1867: This table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1868: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1869: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1870: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1871 : This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1872: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1873: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1874: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1875: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1876: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1877: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1878: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1879: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1880: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1881 : This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1882: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1883: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1884: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1885: This table discloses 177 specific compounds of the formula (T-19 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1886: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1887: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1888: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1889: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1890: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1891 : Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1892: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1893: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1894: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1895: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1896: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1897: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1898: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1899: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1900: Th s table discloses 177 specific compounds of the formula (T-19), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1901 : Th s table discloses 177 specific compounds of formula (T-20)

(T-20)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 1902: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1903: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1904: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1905: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1906: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1907: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1908: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1909: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1910: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 191 1 : This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1912: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1913: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1914: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1915: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1916: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1917: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 1918: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1919: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1920: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1921 : This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1922: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1923: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1924: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1925: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1926: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1927: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 1928: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1929: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1930: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1931 : This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1932: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 1933: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1934: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1935: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1936: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 1937: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1938: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1939: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1940: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 1941 : This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1942: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1943: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 1944: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1945: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1946: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1947: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1948: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1949: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 1950: This table discloses 177 specific compounds of the formula (T-20), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1951 : This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1952: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1953: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1954: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1955: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1956: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1957: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1958: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1959: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1960: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 1961 : This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1962: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1963: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1964: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1965: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1966: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1967: This table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1968: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 1969: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1970: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1971 : This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1972: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1973: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1974: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 1975: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 1976: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 1977: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 1978: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 1979: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 1980: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 1981 : This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 1982: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 1983: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 1984: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 1985: This table discloses 177 specific compounds of the formula (T-20 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 1986: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1987: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1988: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1989: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1990: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1991 : Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1992: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 1993: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 1994: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 1995: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 1996: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 1997: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 1998: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 1999: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2000: Th s table discloses 177 specific compounds of the formula (T-20), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2001 : Th s table discloses 177 specific compounds of formula (T-21 )

(T-21 )

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 2002: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2003: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2004: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2005: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2006: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2007: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2008: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2009: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2010: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 201 1 : This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2012: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2013: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2014: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2015: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2016: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2017: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 2018: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2019: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2020: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2021 : This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2022: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2023: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2024: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2025: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2026: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2027: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 2028: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2029: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2030: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2031 : This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2032: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 2033: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2034: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2035: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 2036: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 2037: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2038: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2039: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2040: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2041 : This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2042: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2043: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 2044: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2045: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2046: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2047: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2048: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2049: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 2050: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2051 : This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2052: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2053: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2054: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2055: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2056: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2057: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2058: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2059: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2060: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 2061 : This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2062: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2063: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2064: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2065: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2066: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2067: This table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2068: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 2069: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2070: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2071 : This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2072: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2073: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2074: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2075: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2076: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2077: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2078: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2079: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2080: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2081 : This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2082: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2083: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2084: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2085: This table discloses 177 specific compounds of the formula (T-21 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 2086: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2087: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2088: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2089: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2090: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2091 : Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2092: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2093: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2094: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2095: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2096: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2097: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2098: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2099: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2100: Th s table discloses 177 specific compounds of the formula (T-21 ), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2101 : Th s table discloses 177 specific compounds of formula (T-22)

(T-22)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 2102: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2103: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2104: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2105: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2106: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2107: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2108: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2109: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 21 10: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 21 1 1 : This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 21 12: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 21 13: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 21 14: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 21 15: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 21 16: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 21 17: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 21 18: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 21 19: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2120: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2121 : This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2122: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2123: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2124: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2125: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2126: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2127: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 2128: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2129: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2130: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2131 : This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2132: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 2133: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2134: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2135: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 2136: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 2137: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2138: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2139: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2140: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2141 : This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2142: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2143: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 2144: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2145: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2146: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2147: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2148: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2149: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 2150: This table discloses 177 specific compounds of the formula (T-22), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2151 : This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2152: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2153: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2154: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2155: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2156: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2157: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2158: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2159: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2160: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 2161 : This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2162: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2163: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2164: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2165: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2166: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2167: This table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2168: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 2169: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2170: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2171 : This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2172: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2173: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2174: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2175: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2176: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2177: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2178: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2179: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2180: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2181 : This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2182: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2183: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2184: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2185: This table discloses 177 specific compounds of the formula (T-22 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 2186: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2187: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2188: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2189: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2190: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2191 : Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2192: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2193: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2194: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2195: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2196: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2197: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2198: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2199: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2200: Th s table discloses 177 specific compounds of the formula (T-22), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2201 : Th s table discloses 177 specific compounds of formula (T-23)

(T-23)

wherein R _{1 ;} R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 2202: This table discloses 177 specific compounds of the formula (T-23), wherein R and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2203: This table discloses 177 specific compounds of the formula (T-23), wherein R and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2204: This table discloses 177 specific compounds of the formula (T-23), wherein R^ and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2205: This table discloses 177 specific compounds of the formula (T-23), wherein R^ and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2206: This table discloses 177 specific compounds of the formula (T-23), wherein R and R ₂ are hydrogen, R ₄ is ferf-butyl and R ₃ is as defined in the Table 1.

Table 2207: This table discloses 177 specific compounds of the formula (T-23), wherein R^ and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2208: This table discloses 177 specific compounds of the formula (T-23), wherein R^ and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2209: This table discloses 177 specific compounds of the formula (T-23), wherein R and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2210: This table discloses 177 specific compounds of the formula (T-23), wherein R and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 221 1 : This table discloses 177 specific compounds of the formula (T-23), wherein R^ and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2212: This table discloses 177 specific compounds of the formula (T-23), wherein R^ and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2213: This table discloses 177 specific compounds of the formula (T-23), wherein R and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2214: This table discloses 177 specific compounds of the formula (T-23), wherein R and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2215: This table discloses 177 specific compounds of the formula (T-23), wherein R^ and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2216: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2217: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 2218: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2219: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2220: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2221 : This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2222: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2223: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2224: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2225: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2226: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2227: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 2228: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2229: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2230: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2231 : This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2232: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 2233: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2234: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2235: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 2236: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 2237: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2238: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2239: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2240: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2241 : This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2242: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2243: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 2244: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2245: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2246: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2247: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2248: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2249: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 2250: This table discloses 177 specific compounds of the formula (T-23), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2251 : This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2252: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2253: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2254: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2255: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2256: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2257: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2258: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2259: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2260: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 2261 : This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2262: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2263: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2264: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2265: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2266: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2267: This table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2268: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 2269: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2270: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2271 : This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2272: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2273: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2274: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2275: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2276: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2277: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2278: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2279: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2280: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2281 : This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2282: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2283: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2284: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2285: This table discloses 177 specific compounds of the formula (T-23 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 2286: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2287: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2288: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2289: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2290: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2291 : Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2292: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2293: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2294: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2295: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2296: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2297: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2298: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2299: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2300: Th s table discloses 177 specific compounds of the formula (T-23), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2301 : Th s table discloses 177 specific compounds of formula (T-24)

(T-24)

wherein R-i , R ₂ and R ₄ are all hydrogen, and R ₃ is as defined in the Table 1.

Table 2302: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2303: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2304: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2305: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2306: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2307: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2308: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2309: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2310: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 231 1 : This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2312: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2313: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2314: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2315: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2316: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2317: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1 .

Table 2318: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2319: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2320: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2321 : This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2322: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2323: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2324: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2325: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2326: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2327: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is methyl, R ₃ is as defined in the Table 1.

Table 2328: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2329: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2330: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2331 : This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2332: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is sec-butyl and R ₃ is as defined in the Table 1. Table 2333: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2334: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2335: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 2336: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1. Table 2337: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2338: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2339: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2340: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1. Table 2341 : This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2342: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2343: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1. Table 2344: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2345: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2346: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2347: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2348: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2349: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1. Table 2350: This table discloses 177 specific compounds of the formula (T-24), wherein R-i is methyl, R ₂ is hydrogen, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2351 : This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2352: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2353: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2354: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2355: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2356: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2357: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2358: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2359: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2360: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1.

Table 2361 : This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2362: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2363: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2364: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2365: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2366: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2367: This table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are methyl, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2368: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are methyl, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table

Table 2369: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are methyl, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2370: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are methyl, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2371 : This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are methyl, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2372: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are methyl, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2373: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are methyl, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2374: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are methyl, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2375: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are methyl, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table 2376: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is hydrogen and R ₃ is as defined in the Table 1.

Table 2377: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is methyl and R ₃ is as defined in the Table 1.

Table 2378: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is ethyl and R ₃ is as defined in the Table 1.

Table 2379: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is propyl and R ₃ is as defined in the Table 1.

Table 2380: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is /so-propyl and R ₃ is as defined in the Table 1.

Table 2381 : This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is ie f-butyl and R ₃ is as defined in the Table 1.

Table 2382: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is sec-butyl and R ₃ is as defined in the Table 1.

Table 2383: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is neo-pentyl and R ₃ is as defined in the Table 1.

Table 2384: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is trimethylsilyl and R ₃ is as defined in the Table 1.

Table 2385: This table discloses 177 specific compounds of the formula (T-24 wherein R-i and R ₂ are fluoride, R ₄ is cyclopropyl and R ₃ is as defined in the Table 1. Table 2386: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is 1 -fluoro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2387: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is 1 -chloro-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2388: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is 1 -hydroxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2389: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is 2-methyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2390: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is 2-/ ^' so-propyl-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2391 : Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is 2-methoxy-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2392: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluor de, R ₄ is 2-trifluoromethoxy-cyclopropyl and R ₃ is as defined in the Table 1. Table 2393: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is 2-cyano-cyclopropyl and R ₃ is as defined in the Table 1.

Table 2394: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is cyclobutyl and R ₃ is as defined in the Table 1.

Table 2395: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is cyclopentyl and R ₃ is as defined in the Table 1.

Table 2396: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is cyclohexyl and R ₃ is as defined in the Table 1.

Table 2397: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is cycloheptyl and R ₃ is as defined in the Table 1.

Table 2398: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is phenyl and R ₃ is as defined in the Table 1.

Table 2399: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is 4-fluoro-phenyl and R ₃ is as defined in the Table 1.

Table 2400: Th s table discloses 177 specific compounds of the formula (T-24), wherein R-i and R ₂ are fluori de, R ₄ is 4-chloro-phenyl and R ₃ is as defined in the Table 1.

Table T1 shows selected m.p. and/or LCMS data and retention times/MW for compounds of Tables 2 to 2400.

Throughout this description, temperatures are given in degrees Celsius and "MP" means melting point.

The analytical methods used are described here below: Method A

ZQ Mass Spectrometer from Waters (Single quadrupole mass spectrometer)

Instrument Parameter: lonisation method: Electrospray ; Polarity: positive (negative) ions Capillary (kV) 3.00, Cone (V) 30.00 , Extractor (V) 2.00, Source Temperature (°C) 100, Desolvation Temperature (°C) 250, Cone Gas Flow (L/Hr) 50, Desolvation Gas Flow (L/Hr) 400

Mass range: 100 to 900 Da (LC8 apolar: 150 - 1000 Da)

HP 1 100 HPLC from Agilent: solvent degasser, quaternary pump (ZCQ) / binary pump

(ZDQ), heated column compartment and diode-array detector.

Column: Phenomenex Gemini C18, 3 μηη particle size, 1 10 Angstrom, 30 x 3 mm,

Temp: 60 °C

DAD Wavelength range (nm): 200 to 500

Solvent Gradient:

A = water + 0.05 % HCOOH

B= Acetonitril/Methanol (4:1 , v:v) + 0.04 % HCOOH

Method B

Instrumentation

Mass Spectrometer 6410 Triple Quadruple Mass Spectrometer from Agilent Technologies HPLC Agilent 1200 Series HPLC

Optimized Mass Parameter

lonisation method Electrospray (ESI)

Polarity positive and Negative Polarity Switch

Scan Type MS2 Scan

Capillary (kV) : 4.00

Fragmentor (V) 100.00

Gas Temperature (°C) 350 Gas Flow (L/min) : 1 1

Nebulizer Gas (psi) : 35

Mass range : 1 10 to 1000 Da

DAD Wavelength range (nm): 190 to 400

Optimized Chromatographic parameter :

Solvent Gradient:

A = Water + 0.1 % HCOOH

B = Acetonitrile + 0.1 % HCOOH

Column Waters Xterra MS C18

Column length 30 mm

Internal diameter of column 4.6 mm

Particle Size 3.5 μ

Temperature Room Temperature

Method M

SQ Mass Spectrometer from Agilent (G6130B)

Instrument Parameter: lonisation method: Electrospray ; Polarity: positive/negative ions Capillary (kV) 3.00, Fragmentor(V) 70, Source Temperature (°C) 100, Drying Gas Temp (°C) 350, Nebulizer Pressure (psig) 60, Drying Gas Flow (L/min) 10

Mass range: 100 to 800 Da (ESI pos/neg)

HP 1 100 HPLC from Agilent: solvent degasser, Binaire pump (G1312A), heated column compartment and diode-array detector (G1315B).

Column: Waters XBridge (C18, 50x2.1 mm, 3.5μ)

Temp: 25 °C DAD Wavelength range (nm): 200 to 320

Solvent Gradient:

A = 95% acetonitirle + 5% 10 mM ammoniumbicarbonate in water

B= 10 mM ammoniumbicarbonate in water

Method U :

ACQUITY SQD Mass Spectrometer from Waters (Single quadrupole mass spectrometer) lonisation method: Electrospray

Polarity: positive ions

Capillary (kV) 3.00, Cone (V) 20.00, Extractor (V) 3.00, Source Temperature (°C) 150, Desolvation Temperature (°C) 400, Cone Gas Flow (L/Hr) 60, Desolvation Gas Flow (L/Hr) 700

Mass range: 100 to 800 Da

DAD Wavelength range (nm): 210 to 400

Method Waters ACQUITY UPLC with the following HPLC gradient conditions

(Solvent A: Water/Methanol 9:1 ,0.1 % formic acid and Solvent B: Acetonitrile,0.1 % formic acid )

Type of column: Waters ACQUITY UPLC HSS T3; Column length: 30 mm; Internal diameter of column: 2.1 mm; Particle Size: 1 .8 micron; Temperature: 60°C. Table T1 : Melting point data and/or retention times for compounds:

1

0

N

126-

3.92 317 M

127

17 E or Zform

V 0

N ^'

3.49 309

M

3.58 309

18 E and Zform

1

0

N

3.47

317 M

3.54

19 E and Zform

1

0

N ^'

0.44

296 U 0.46

20 E and Zform

-213-

-215-

CI 0

1.40-

285.1 B 1.55

73

I

0

CI N ^'

1.47-

314 B 1.57

74 E and Z form

0 <

CI N ^'

1.56-

328 B 1.63

75 E and Zform

N- ^0H

167- 169

76 E and Zform

I

0

N ^'

1.55-

294.1 B 1.57

77 E and Zform

0

N ^'

1.51-

324.3 B 1.62

83 E and Zform

OH

N

180- 182

84 E and Zform

I

0

N'

105- 107

85 E and Zform

N ^' °

92-

N

94

86 E and Zform

0

N'

2.07-

385.3 B 2.12

99 E and Zform

0

N'

1.58-

368.3 B 1.64

100 E or Zform

1

o

N ^'

1.74-

291.2 B 1.81

101 E or Zform

O

N'

2.07-

367.3 B 2.12

102 E or Zform

0

N

1.81-

428.3 B 1.87

111 E and Zform

0

CI N

1.55-

397.2

1.59

112 E and Zform

1.60-

348.3 B

F ^ ^N

1.82

113 E and Zform

S^NH

HN _^

N

202- 204

114 E or Zform 75- 77

128 E and Zform

0

N ^'

91- 93

129 E and Zform

0

N'

1.59-

411.2 B 1.62

130 E and Zform

0

N ^'

100- 102

131 E and Zform

— 0

^{S N}

HN _^ 1.71-

N 454.3 B

1.74

\^^^^ ^~ ^

136 E or Z form

1

N

0.99 307 U

137 E form

0

N ^'

1.19 347 U

138 Z form

0

0.94 278 U

139

Formulation examples for compounds of formula (I): Example F-1 .1 to F-1.2: Emulsifiable concentrates

Components F-2.1 F-2.2

A compound selected from the Tables 2 to 2400 25% 50% calciumdodecylbenzenesulfonate 5% 6% castoroilpolyethyleneglycolether

(36molethylenoxyunits) 5% - tributylphenolpolyethyleneglycolether

(30molethylenoxyunits) - cyclohexanone - 20%

xylenemixture 65% 20%

Emulsions of any desired concentration can be prepared by diluting such concentrates with water. Example F-2: Emulsifiable concentrate

Emulsions of any desired concentration can be prepared by diluting such concentrates with water. Examples F-3.1 to F-3.4: Solutions

Examples F-4.1 to F-4.4: Granulates

Components F-4.1 F-4.2 F-4.3 F-4.4

A compound selected from the Tables 2 to 2400 5% 10% 8% 21 %

Kaolin 94% - 79% 54% highly dispersed silicic acid 1 % - 13% 7%

Attapulgite - 90% - 18%

The novel compound is dissolved in dichloromethane, the solution is sprayed onto the and the solvent is then removed by distillation under vacuum. Examples F-5.1 and F-5.2: Dusts

Ready for use dusts are obtained by intimately mixing all components.

Examples F-6.1 to F-6.3: Wettable powders

All components are mixed and the mixture is thoroughly ground in a suitable mill to give wettable powders which can be diluted with water to suspensions of any desired concentration. Example F7: Flowable concentrate for seed treatment

Components F-7

A compound selected from the Tables 2 to 2400 40 %

propylene glycol 5 %

copolymer butanol PO/EO 2 % tristyrenephenole with 10-20 moles EO 2 %

1 ,2-benzisothiazolin-3-one 0.5 %

(in the form of a 20% solution in water)

monoazo-pigment calcium salt 5 %

Silicone oil 0.2 %

(in the form of a 75 % emulsion in water)

Water 45.3 %

The finely ground active ingredient is intimately mixed with the adjuvants, giving a

suspension concentrate from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, living plants as well as plant propagation material can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion.

Biological examples:

These examples illustrate the fungicidal properties of the compounds described in table T1.

Biological example 1 : fungicidal activity against Blumeria graminis f. sp. tritici (Erysiphe graminis f. sp. tritici) I wheat / leaf disc preventative (Powdery mildew on wheat)

Wheat leaf segments cv. Kanzler were placed on agar in a multiwell plate (24-well format) and sprayed with the formulated test compound diluted in water. The leaf disks were inoculated by shaking powdery mildew infected plants above the test plates 1 day after application. The inoculated leaf disks were incubated at 20°C and 60% rh under a light regime of 24 h darkness followed by 12 h light / 12 h darkness in a climate chamber and the activity of a compound was assessed as percent disease control compared to untreated when an appropriate level of disease damage appears on untreated check leaf segments (6 - 8 days after application).

Compounds (from table T1 ) 2 , 3 , 5 , 6 , 7 , 8 , 9 , 10 , 1 1 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 43 , 44 , 45 , 46 , 47 , 50 , 51 , 53 , 54 , 56 , 57 , 58 , 59 , 60 , 61 , 70 , 71 , 72 , 73 , 74 , 75 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 95 , 97 , 98 , 101 , 104 , 105 , 106 , 107 , 108 , 109 , 1 10 , 1 12 , 1 13 , 1 16 , 1 17 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 135 , 137 , 139 , 140 , 142 , 143 , 144 , 146 , 147 , 148 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 and 161 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development.

Biological example 2: fungicidal activity against Puccinia recondita f. sp. tritici I wheat / leaf disc preventative (Brown rust)

Wheat leaf segments cv. Kanzler were placed on agar in multiwell plates (24-well format) and sprayed with the formulated test compound diluted in water. The leaf disks were inoculated with a spore suspension of the fungus 1 day after application. The inoculated leaf segments were incubated at 19°C and 75% rh under a light regime of 12 h light / 12 h darkness in a climate cabinet and the activity of a compound was assessed as percent disease control compared to untreated when an appropriate level of disease damage appears in untreated check leaf segments (7 - 9 days after application).

Compounds (from table T1 ) 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 1 1 , 12 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 29 , 30 , 31 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 50 , 52 , 53 , 54 , 56 , 57 , 58 , 59 , 60 , 67 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 94 , 95 , 97 , 98 , 105 , 106 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 14 , 1 16 , 1 17 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 130 , 134 , 137 , 138 , 139 , 140 , 142 , 143 , 144 , 148 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 and 161 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development.

Biological example 3: fungicidal activity against Puccinia recondita f. sp. tritici I wheat / leaf disc curative (Brown rust)

Wheat leaf segments are placed on agar in multiwell plates (24-well format). The leaf disks are then inoculated with a spore suspension of the fungus. One day after inoculation the test solution is applied. After appropriate incubation the activity of a compound is assessed 8 dpi (days after inoculation) as curative fungicidal activity. Dose range: 200-22 ppm.

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 1 1 , 12 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 50 , 51 , 52 , 53 , 54 , 56 , 57 , 58 , 59 , 60 , 61 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 94 , 95 , 97 , 98 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 14 , 1 16 , 1 17 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 126 , 130 , 134 , 137 , 138 , 139 , 140 , 142 , 143 , 144 , 148 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 and 161 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development. Biological example 4: fungicidal activity against Pyrenophora teres I barley / leaf disc preventative (Net blotch)

Barley leaf segments cv. Hasso were placed on agar in a multiwell plate (24-well format) and sprayed with the formulated test compound diluted in water. The leaf segmens were inoculated with a spore suspension of the fungus 2 days after application. The inoculated leaf segments were incubated at 20°C and 65% rh under a light regime of 12 h light / 12 h darkness in a climate cabinet and the activity of a compound was assessed as disease control compared to untreated when an appropriate level of disease damage appears in untreated check leaf segments (5 - 7 days after application).

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 1 1 , 12 , 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 25 , 26 , 27 , 30 , 31 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 43 , 44 , 45 , 46 , 47 , 50 , 51 , 52 , 53 , 54 , 56 , 57 , 59 , 60 , 61 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 77 , 78 , 81 , 82 , 83 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 94 , 95 , 98 , 104 , 105 , 106 , 109 , 1 10 , 1 12 , 1 13 , 1 16 , 1 17 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 125 , 126 , 130 , 137 , 138 , 139 , 143 , 144 , 148 , 150 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 160 and 161 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development. Biological example 5: fungicidal activity against Alternaria solani I tomato / leaf disc (early blight)

Tomato leaf disks cv. Baby were placed on agar in multiwell plates (24-well format) and sprayed with the formulated test compound diluted in water. The leaf disks were inoculated with a spore suspension of the fungus 2 days after application. The inoculated leaf disks were incubated at 23 °C / 21 °C (day/night) and 80% relative humidity (rh) under a light regime of 12/12 h (light/dark) in a climate cabinet and the activity of a compound was assessed as percent disease control compared to untreated when an appropriate level of disease damage appears on untreated check disk leaf disks (5 - 7 days after application). Compounds (from table T1 ) 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 1 1 , 12 , 14 , 15 , 16 , 18 , 19 , 20 , 22 , 25 , 27 , 29 , 31 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 43 , 44 , 45 , 50 , 52 , 53 , 54 , 56 , 59 , 60 , 61 , 74 , 75 , 85 , 86 , 88 , 92 , 104 , 105 , 106 , 1 10 , 1 13 , 1 16 , 1 17 , 1 18 , 1 19 , 121 , 122 , 123 , 130 , 137 , 144 , 148 , 152 , 153 , 154 , 156 , 157 , 158 and 159 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development. Biological example 6: fungicidal activity against Botryotinia fuckeliana (Botrytis cinerea) I liquid culture (Gray mould)

Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (Vogels broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24°C and the inhibition of growth was determined photometrically 3-4 days after application.

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 10 , 12 , 13 , 14 , 15 , 17 , 19 , 20 , 21 , 22 , 23 , 25 , 26 , 27 , 28 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 56 , 57 , 58 , 59 , 60 , 61 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 77 , 78 , 79 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 98 , 100 , 101 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 15 , 1 16 , 1 17 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 135 , 137 , 144 , 146 , 147 , 148 , 150 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 and 160 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development.

Biological example 7: fungicidal activity against Glomerella lagenarium (Colletotrichum lagenarium) I liquid culture (Anthracnose)

Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24°C and the inhibition of growth was measured photometrically 3-4 days after application.

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 8 , 10 , 13 , 15 , 17 , 19 , 20 , 21 , 22 , 23 , 25 , 26 , 27 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 44 , 45 , 46 , 47 , 49 , 50 , 51 , 52 , 53 , 56 , 57 , 58 , 59 , 60 , 61 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 74 , 75 , 77 , 79 , 81 , 82 , 83 , 85 , 86 , 87 , 88 , 89 , 91 , 92 , 95 , 98 , 103 , 104 , 106 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 16 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 144 , 146 , 147 , 148 , 150 , 152 , 153 , 155 , 156 , 157 , 158 , 159 and 160 at 20 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development.

Biological example 8: fungicidal activity against Mycosphaerella arachidis (Cercospora arachidicola) I liquid culture (early leaf spot) Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24°C and the inhibition of growth was determined photometrically 4- 5 days after application.

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 1 1 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 56 , 57 , 58 , 59 , 60 , 61 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 14 , 1 15 , 1 16 , 1 17 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 135 , 137 , 138 , 139 , 140 , 142 , 143 , 144 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 and 161 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development.

Biological example 9: fungicidal activity against Mycosphaerella graminicola (Septoria tritici) I liquid culture (Septoria blotch)

Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24°C and the inhibition of growth was determined photometrically 4- 5 days after application.

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 10 , 12 , 13 , 14 , 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 56 , 57 , 58 , 59 , 60 , 61 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 77 , 78 , 79 , 80 , 81 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 106 , 107 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 14 , 1 15 , 1 16 , 1 17 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 135 , 136 , 137 , 138 , 140 , 142 , 143 , 144 , 146 , 147 , 148 , 149 , 150 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 and 160 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development. Biological example 10: fungicidal activity against Gaeumannomyces graminis I liquid culture (Take-all of cereals)

Mycelial fragments of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores iss added. The test plates were incubated at 24°C and the inhibition of growth was determined photometrically 4-5 days after application.

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 1 1 , 12 , 13 , 14 , 15 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 56 , 57 , 58 , 59 , 60 , 61 , 63 , 64 , 65 , 67 , 68 , 69 , 70 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 81 , 84 , 85 , 86 , 87 , 88 , 89 , 91 , 92 , 94 , 95 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 14 , 1 15 , 1 16 , 1 17 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 135 , 137 , 138 , 140 , 143 , 144 , 145 , 146 , 147 , 148 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 and 163 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development.

Biological example 1 1 : fungicidal activity against Monographella nivalis (Microdochium nivale) / liquid culture (foot rot cereals)

Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal spores was added. The test plates were incubated at 24°C and the inhibition of growth was determined photometrically 4- 5 days after application.

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 8 , 13 , 14 , 15 , 17 , 19 , 20 , 21 , 22 , 23 , 25 , 26 , 27 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 56 , 57 , 58 , 59 , 60 , 61 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 74 , 75 , 77 , 79 , 81 , 85 , 86 , 87 , 88 , 89 , 91 , 92 , 94 , 95 , 97 , 98 , 101 , 103 , 104 , 106 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 16 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 140 , 142 , 144 , 146 , 147 , 148 , 150 , 152 , 153 , 155 , 156 , 157 , 158 , 159 and 160 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development. Biological example 12: fungicidal activity against Fusarium culmorum I liquid culture (root rot) Conidia of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of the test compounds into a microtiter plate (96-well format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 C and the inhibition of growth was determined photometrically after 48 hrs.

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 8 , 12 , 13 , 14 , 15 , 17 , 19 , 20 , 21 , 22 , 23 , 25 , 26 , 27 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 44 , 45 , 46 , 47 , 49 , 50 , 51 , 52 , 53 , 54 , 56 , 57 , 58 , 59 , 60 , 61 , 64 , 65 , 67 , 68 , 69 , 70 , 71 , 72 , 74 , 75 , 77 , 79 , 81 , 85 , 86 , 87 , 88 , 89 , 91 , 92 , 94 , 95 , 97 , 98 , 100 , 101 , 103 , 105 , 106 , 107 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 16 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 144 , 146 , 147 , 148 , 150 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 and 160 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development.

Biological example 13: fungicidal activity against Thanatephorus cucumeris (Rhizoctonia solani) I liquid culture (foot rot, damping-off)

Mycelia fragments of a newly grown liquid culture of the fungus were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of the test compounds into a microtiter plate (96-well format), the nutrient broth containing the fungal material was added. The test plates were incubated at 24°C and the inhibition of growth was determined photometrically 3-4 days after application.

Compounds (from table T1 ) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 1 1 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 34 , 35 , 36 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 95 , 97 , 98 , 100 , 101 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 15 , 1 16 , 1 17 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 135 , 144 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 and 161 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development.

Biological example 14: fungicidal activity against Sclerotinia sclerotiorum I liquid culture (white mold, etc.): Mycelial fragments of the fungus from cryogenic storage were directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of the test compounds into a microtiter plate (96-well format) the nutrient broth containing the fungal spores was added. The test plates were incubated at 24 C and the inhibition of growth was determined photometrically after 72 hrs at 620nm.

Compounds (from table T1 ) 1 , 2 , 4 , 5 , 6 , 8 , 13 , 14 , 15 , 17 , 20 , 21 , 22 , 23 , 25 , 26 , 27 , 30 , 31 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 46 , 47 , 49 , 50 , 51 , 52 , 53 , 54 , 56 , 58 , 59 , 60 , 61 , 64 , 68 , 69 , 70 , 71 , 72 , 74 , 75 , 79 , 81 , 84 , 85 , 86 , 87 , 88 , 89 , 91 , 92 , 94 , 95 , 97 , 98 , 101 , 104 , 106 , 108 , 109 , 1 10 , 1 1 1 , 1 12 , 1 13 , 1 16 , 1 18 , 1 19 , 120 , 121 , 122 , 123 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 144 , 146 , 147 , 148 , 150 , 152 , 153 , 155 , 156 , 157 , 158 , 159 and 160 at 200 ppm give at least 80% disease control in this test when compared to untreated control leaf disks under the same conditions, which show extensive disease development.