ACTIVATOR FOR MESENCHYMAL STEM CELLS, ACTIVATED MESENCHYMAL STEM CELLS, AND METHOD FOR PRODUCING SAME

Title:

ACTIVATOR FOR MESENCHYMAL STEM CELLS, ACTIVATED MESENCHYMAL STEM CELLS, AND METHOD FOR PRODUCING SAME

Document Type and Number:

WIPO Patent Application WO/2015/137419

Kind Code:

A1

Abstract:

[Problem] The purpose of the present invention is to activate abnormal mesenchymal stem cells that have experienced a loss or reduction in therapeutic efficacy, or that have a disease-exacerbating effect, and restore the cells to a condition suitable for cell transplant therapy. [Solution] The present invention pertains to an activator for mesenchymal stem cells, mesenchymal stem cells activated by this activator and a method for producing the same, and a drug containing activated mesenchymal stem cells.

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Inventors:

FUJIMIYA MINEKO (JP)
NAGAISHI KANNA (JP)
MIZUE YUKA (JP)
CHIKENJI TAKAKO (JP)

Application Number:

PCT/JP2015/057217

Publication Date:

September 17, 2015

Filing Date:

March 11, 2015

Export Citation:

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Assignee:

UNIV SAPPORO MEDICAL (JP)

International Classes:

C12N5/0775; A61K35/28; A61K35/44; A61P3/10; A61P13/12; A61P25/00; A61P27/02; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C12N1/00; C12N15/09

Domestic Patent References:

WO2013009100A2

2013-01-17

Foreign References:

JP2006034111A	2006-02-09
JP2011067175A	2011-04-07
JP2009284819A	2009-12-10
JP2001072572A	2001-03-21
JP2011160799A	2011-08-25
JP2013147479A	2013-08-01
JP2013155122A	2013-08-15

Other References:

MINEKO FUJIMIYA: "Bone marrow stem cell abnormality and diabetic complications", CARDIOANGIOLOGY, vol. 72, no. 4, 2012, pages 426 - 430, XP008184612
KANNA NAGAISHI ET AL.: "Kotsuzui Kan'yokei Kansaibo o Mochiita Tonyobyosei Jinsho ni Taisuru Shinki Chiryo Senryaku", REGENERATIVE MEDICINE, vol. 13, January 2014 (2014-01-01), pages 330, XP008184913
KIM JOON-KI ET AL.: "Protective Effects of Human Placenta Extract on Cartilage Degradation in Experimental Osteoarthritis", BIOL. PHARM. BULL., vol. 33, no. 6, 2010, pages 1004 - 1010, XP055033405
See also references of EP 3118307A4

Attorney, Agent or Firm:

HITOSHIO Akio et al. (JP)
Much more Akio (JP)

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