Title:
ACTIVE MMP9-BINDING PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2019/017338
Kind Code:
A1
Abstract:
Provided is a novel peptide. This peptide contains the amino acid sequence represented by SEQ ID NO: 18 and binds to an active protease, but does not bind to a precursor protease.
Inventors:
YANO HIDENORI (JP)
NISHIMIYA DAISUKE (JP)
HASHIMOTO RYUJI (JP)
NIITSU YOICHI (JP)
NISHIMIYA DAISUKE (JP)
HASHIMOTO RYUJI (JP)
NIITSU YOICHI (JP)
Application Number:
PCT/JP2018/026732
Publication Date:
January 24, 2019
Filing Date:
July 17, 2018
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12N15/12; A61K35/12; A61K35/76; A61K38/55; A61K48/00; A61P1/04; A61P1/14; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/10; A61P17/14; A61P19/02; A61P21/02; A61P25/00; A61P25/08; A61P25/10; A61P25/14; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P27/02; A61P35/00; A61P37/02; A61P43/00; C07K14/81; C07K16/38; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; G01N33/53
Domestic Patent References:
| WO2014024914A1 | 2014-02-13 | |||
| WO2016023979A1 | 2016-02-18 | |||
| WO2004087042A2 | 2004-10-14 | |||
| WO2008102359A1 | 2008-08-28 | |||
| WO2011092700A1 | 2011-08-04 | |||
| WO2012027721A2 | 2012-03-01 | |||
| WO2013130078A1 | 2013-09-06 | |||
| WO2013130905A1 | 2013-09-06 | |||
| WO2016023972A1 | 2016-02-18 | |||
| WO2016023979A1 | 2016-02-18 | |||
| WO2012105616A1 | 2012-08-09 |
Other References:
GOFFIN, LAURENCE ET AL.: "Anti-MMP-9 antibody: A promising therapeutic strategy for treatment of inflammatory Bowel disease complications with Fibrosis", INFLAMMATORY BOWEL DISEASES, vol. 22, no. 9, 10 August 2016 (2016-08-10), pages 2041 - 2057, XP055455514, DOI: 10.1097/MIB.0000000000000863
KHERRAF, ZINE-EDDINE ET AL.: "SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes", EMBO MOLECULAR MEDICINE, vol. 9, no. 8, 29 May 2017 (2017-05-29), pages 1132 - 1149, XP055581817, DOI: 10.15252/emmm.201607461
NAGASE H ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY (J BIOL CHEM., vol. 274, no. 31, 1999, pages 21491 - 4
OGATA Y ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY (J BIOL CHEM., vol. 267, no. 6, 1992, pages 3581 - 4
LIJNEN HR ET AL., BLOOD, vol. 91, no. 6, 1998, pages 2045 - 53
VANDOOREN J ET AL., CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (CRIT REV BIOCHEM MOL BIOL., vol. 48, no. 3, 2013, pages 222 - 72
CHENG M ET AL., JOURNAL OF MEDICINAL CHEMISTRY (J MED CHEM., vol. 43, no. 3, 2000, pages 369 - 80
COUSSENS LM ET AL., SCIENCE, vol. 295, no. 5564, 2002, pages 2387 - 92
BISSETT D ET AL., JOURNAL OF CLINICAL ONCOLOGY (J CLIN ONCOL., vol. 23, no. 4, 2005, pages 842 - 9
SELA-PASSWELL N ET AL., NATURE MEDICINE (NAT MED., vol. 18, no. 1, 2011, pages 143 - 7
MARSHALL DC ET AL., PLOS ONE, vol. 10, no. 5, 2015, pages e0127063
APPLEBY TC ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY (J BIOL CHEM., vol. 292, no. 16, 2017, pages 6810 - 20
GOFFIN L ET AL., INFLAMMATORY BOWEL DISEASE (INFLAMM BOWEL DIS., vol. 22, no. 9, 2016, pages 2041 - 57
CHEN T ET AL., PROTEINS, vol. 77, no. 1, 2009, pages 209 - 19
L. LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHER, pages: 73 - 75
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
SMITH ET AL., J. MOL. BIOL., vol. 147, 1981, pages 195 - 197
FRANCISCO, J. A. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 90, 1993, pages 10444 - 10448
BODER, E.T. ET AL., NAT. BIOTECHNOL., vol. 15, 1997, pages 553 - 557
HO M ET AL., METHODS MOL BIOL., vol. 525, 2009, pages 337 - 52
SMITH, G.P., SCIENCE, vol. 228, 1985, pages 1315 - 1317
MATTHEAKIS LC ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 91, no. 19, 1994, pages 9022 - 9029
NEMOTO N ET AL., FEBS LETT., vol. 414, no. 2, 1997, pages 405 - 408
PINI, A. ET AL., COMB. CHEM. HIGH THROUGHPUT SCREEN., vol. 5, 2002, pages 503 - 510
UEDA, M.TANAKA, A., BIOTECHNOL. ADV., vol. 18, 2000, pages 121
UEDA, M.TANAKA, A., J. BIOSCI. BIOENG., vol. 90, 2000, pages 125
SAMBROOK, J.FRITSCH, E.F.MANIATIS, T.: "Molecular Cloning", 1982, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3656861A4
KHERRAF, ZINE-EDDINE ET AL.: "SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes", EMBO MOLECULAR MEDICINE, vol. 9, no. 8, 29 May 2017 (2017-05-29), pages 1132 - 1149, XP055581817, DOI: 10.15252/emmm.201607461
NAGASE H ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY (J BIOL CHEM., vol. 274, no. 31, 1999, pages 21491 - 4
OGATA Y ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY (J BIOL CHEM., vol. 267, no. 6, 1992, pages 3581 - 4
LIJNEN HR ET AL., BLOOD, vol. 91, no. 6, 1998, pages 2045 - 53
VANDOOREN J ET AL., CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (CRIT REV BIOCHEM MOL BIOL., vol. 48, no. 3, 2013, pages 222 - 72
CHENG M ET AL., JOURNAL OF MEDICINAL CHEMISTRY (J MED CHEM., vol. 43, no. 3, 2000, pages 369 - 80
COUSSENS LM ET AL., SCIENCE, vol. 295, no. 5564, 2002, pages 2387 - 92
BISSETT D ET AL., JOURNAL OF CLINICAL ONCOLOGY (J CLIN ONCOL., vol. 23, no. 4, 2005, pages 842 - 9
SELA-PASSWELL N ET AL., NATURE MEDICINE (NAT MED., vol. 18, no. 1, 2011, pages 143 - 7
MARSHALL DC ET AL., PLOS ONE, vol. 10, no. 5, 2015, pages e0127063
APPLEBY TC ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY (J BIOL CHEM., vol. 292, no. 16, 2017, pages 6810 - 20
GOFFIN L ET AL., INFLAMMATORY BOWEL DISEASE (INFLAMM BOWEL DIS., vol. 22, no. 9, 2016, pages 2041 - 57
CHEN T ET AL., PROTEINS, vol. 77, no. 1, 2009, pages 209 - 19
L. LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHER, pages: 73 - 75
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
SMITH ET AL., J. MOL. BIOL., vol. 147, 1981, pages 195 - 197
FRANCISCO, J. A. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 90, 1993, pages 10444 - 10448
BODER, E.T. ET AL., NAT. BIOTECHNOL., vol. 15, 1997, pages 553 - 557
HO M ET AL., METHODS MOL BIOL., vol. 525, 2009, pages 337 - 52
SMITH, G.P., SCIENCE, vol. 228, 1985, pages 1315 - 1317
MATTHEAKIS LC ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 91, no. 19, 1994, pages 9022 - 9029
NEMOTO N ET AL., FEBS LETT., vol. 414, no. 2, 1997, pages 405 - 408
PINI, A. ET AL., COMB. CHEM. HIGH THROUGHPUT SCREEN., vol. 5, 2002, pages 503 - 510
UEDA, M.TANAKA, A., BIOTECHNOL. ADV., vol. 18, 2000, pages 121
UEDA, M.TANAKA, A., J. BIOSCI. BIOENG., vol. 90, 2000, pages 125
SAMBROOK, J.FRITSCH, E.F.MANIATIS, T.: "Molecular Cloning", 1982, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3656861A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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